S R Kimball

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Purification and characterization of eukaryotic initiation factor 2 and a guanine nucleotide exchange factor from rat liver
    S R Kimball
    J Biol Chem 262:2220-7. 1987
  2. ncbi request reprint Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6
    S R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 274:11647-52. 1999
  3. ncbi request reprint Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes
    C J Lynch
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cell Biochem 77:234-51. 2000
  4. ncbi request reprint Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B
    S R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 273:3039-44. 1998
  5. ncbi request reprint Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4E
    C H Lang
    Departments of Cellular and Molecular Physiology and Surgery, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol 277:E268-76. 1999
  6. ncbi request reprint Chronic alcohol feeding impairs hepatic translation initiation by modulating eIF2 and eIF4E
    C H Lang
    Department of Cellular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol 277:E805-14. 1999
  7. ncbi request reprint Feeding stimulates protein synthesis in muscle and liver of neonatal pigs through an mTOR-dependent process
    S R Kimball
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 279:E1080-7. 2000
  8. ncbi request reprint Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation
    T G Anthony
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Biochim Biophys Acta 1492:56-62. 2000
  9. ncbi request reprint Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats
    T G Anthony
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Nutr 131:1171-6. 2001
  10. ncbi request reprint Endotoxin-induced decrease in muscle protein synthesis is associated with changes in eIF2B, eIF4E, and IGF-I
    C H Lang
    Departments of Cellular and Molecular Physiology, and Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 278:E1133-43. 2000

Collaborators

Detail Information

Publications47

  1. ncbi request reprint Purification and characterization of eukaryotic initiation factor 2 and a guanine nucleotide exchange factor from rat liver
    S R Kimball
    J Biol Chem 262:2220-7. 1987
    ..Taken together, these data demonstrate species-associated variability in the beta-subunit of eIF-2 and suggest a crucial role for the beta-subunit in the functional interaction of eIF-2 and GEF...
  2. ncbi request reprint Leucine regulates translation of specific mRNAs in L6 myoblasts through mTOR-mediated changes in availability of eIF4E and phosphorylation of ribosomal protein S6
    S R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 274:11647-52. 1999
    ..Thus, leucine acting through an mTOR-dependent pathway stimulates the translation of specific mRNAs both by increasing the availability of eIF4E and by stimulating phosphorylation of S6...
  3. ncbi request reprint Regulation of amino acid-sensitive TOR signaling by leucine analogues in adipocytes
    C J Lynch
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cell Biochem 77:234-51. 2000
    ....
  4. ncbi request reprint Identification of interprotein interactions between the subunits of eukaryotic initiation factors eIF2 and eIF2B
    S R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 273:3039-44. 1998
    ....
  5. ncbi request reprint Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4E
    C H Lang
    Departments of Cellular and Molecular Physiology and Surgery, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol 277:E268-76. 1999
    ..In summary, these data suggest that chronic alcohol consumption impairs translation initiation in muscle by altering multiple regulatory sites, including eIF2B activity and eIF4E availability...
  6. ncbi request reprint Chronic alcohol feeding impairs hepatic translation initiation by modulating eIF2 and eIF4E
    C H Lang
    Department of Cellular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol 277:E805-14. 1999
    ..In summary, these data suggest that chronic alcohol consumption impairs translation initiation in liver by altering eIF2B activity as well as eIF4F function via changes in eIF4E availability...
  7. ncbi request reprint Feeding stimulates protein synthesis in muscle and liver of neonatal pigs through an mTOR-dependent process
    S R Kimball
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 279:E1080-7. 2000
    ..However, in skeletal muscle, these two processes may account for only part of the stimulation of protein synthesis, and thus additional steps may be involved in the response...
  8. ncbi request reprint Identification of domains within the epsilon-subunit of the translation initiation factor eIF2B that are necessary for guanine nucleotide exchange activity and eIF2B holoprotein formation
    T G Anthony
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Biochim Biophys Acta 1492:56-62. 2000
    ..In contrast, the C-terminal domain of eIF2B epsilon is sufficient alone for binding the beta-subunit of its substrate, eIF2, in vitro...
  9. ncbi request reprint Oral administration of leucine stimulates ribosomal protein mRNA translation but not global rates of protein synthesis in the liver of rats
    T G Anthony
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Nutr 131:1171-6. 2001
    ..Furthermore, the translation of rp mRNA is disjointed from rates of total protein synthesis in liver and related to the degree of S6K1 phosphorylation...
  10. ncbi request reprint Endotoxin-induced decrease in muscle protein synthesis is associated with changes in eIF2B, eIF4E, and IGF-I
    C H Lang
    Departments of Cellular and Molecular Physiology, and Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 278:E1133-43. 2000
    ....
  11. ncbi request reprint Assessment of cell-signaling pathways in the regulation of mammalian target of rapamycin (mTOR) by amino acids in rat adipocytes
    P T Pham
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cell Biochem 79:427-41. 2000
    ..Overall, our study emphasizes the need for caution when extending results obtained using established cell lines to the differentiated nondividing cells found in most tissues...
  12. ncbi request reprint Role of eIF4E in stimulation of protein synthesis by IGF-I in perfused rat skeletal muscle
    T C Vary
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 278:E58-64. 2000
    ..In contrast, the amount of eIF4E bound to eIF4G was increased threefold by IGF-I. We conclude that IGF-I regulates protein synthesis in skeletal muscle by enhancing formation of the active eIF4E x eIF4G complex...
  13. ncbi request reprint Implication of eIF2B rather than eIF4E in the regulation of global protein synthesis by amino acids in L6 myoblasts
    S R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 273:30945-53. 1998
    ..Furthermore, under the conditions employed herein, alterations in eIF4E availability are not rate-controlling for global protein synthesis but might be necessary for regulation of translation of specific mRNAs...
  14. ncbi request reprint Mechanism of inhibition of peptide chain initiation by amino acid deprivation in perfused rat liver. Regulation involving inhibition of eukaryotic initiation factor 2 alpha phosphatase activity
    S R Kimball
    Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey 17033
    J Biol Chem 266:1969-76. 1991
    ....
  15. ncbi request reprint Regulation of guanine nucleotide exchange through phosphorylation of eukaryotic initiation factor eIF2alpha. Role of the alpha- and delta-subunits of eiF2b
    S R Kimball
    Department of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 273:12841-5. 1998
    ..The results provide the first direct biochemical evidence that the alpha- and delta-subunits of eIF2B are involved in mediating the effect of substrate phosphorylation...
  16. ncbi request reprint Regulation of translation initiation by amino acids in eukaryotic cells
    S R Kimball
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Prog Mol Subcell Biol 26:155-84. 2001
    ..Thus, by preventing activation of GCN2, amino acids preserve eIF2B activity, which promotes translation of all mRNAs, i.e., global protein synthesis is enhanced...
  17. ncbi request reprint Amino acid regulation of gene expression
    L S Jefferson
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Nutr 131:2460S-6S; discussion 2486S-7S. 2001
    ..It concludes with a consideration of some of the important unanswered questions in this rapidly advancing area of research...
  18. ncbi request reprint Insulin fails to stimulate muscle protein synthesis in sepsis despite unimpaired signaling to 4E-BP1 and S6K1
    T C Vary
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 10733, USA
    Am J Physiol Endocrinol Metab 281:E1045-53. 2001
    ..Thus the inability of insulin to stimulate protein synthesis during sepsis may be related to a defect in signaling to a step in translation initiation involved in assembly of an active eIF4F complex...
  19. ncbi request reprint Subunit assembly and guanine nucleotide exchange activity of eukaryotic initiation factor-2B expressed in Sf9 cells
    J R Fabian
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 272:12359-65. 1997
    ..Furthermore, eIF-2Bepsilon is necessary and is perhaps sufficient for GEF activity in vitro...
  20. ncbi request reprint Alterations in interprotein interactions between translation initiation factors assessed by fluorescence resonance energy transfer
    S R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, P O Box 850, Hershey, PA 17033, USA
    Int J Biochem Cell Biol 33:797-806. 2001
    ..Overall, the results demonstrate that fluorescence resonance energy transfer between EYFP--4E-BP1 and ECFP--eIF4E is a valuable tool in directly measuring alterations in the interaction of the two proteins...
  21. ncbi request reprint Regulation of protein synthesis after acute resistance exercise in diabetic rats
    P A Farrell
    Noll Physiological Research Center and Department of Kinesiology, University Park 16802 and Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol 276:E721-7. 1999
    ..This preserved response may be due to a compensatory increase in muscle IGF-I content and a maintained ability to activate eIF2B...
  22. ncbi request reprint Glycogen synthase kinase-3 is the predominant insulin-regulated eukaryotic initiation factor 2B kinase in skeletal muscle
    L S Jefferson
    Department of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, Hershey 17033, USA
    Int J Biochem Cell Biol 31:191-200. 1999
    ..Thus, insulin-mediated changes in eIF2B activity are likely to involve GSK-3...
  23. ncbi request reprint Deficiency of dietary EAA preferentially inhibits mRNA translation of ribosomal proteins in liver of meal-fed rats
    T G Anthony
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 281:E430-9. 2001
    ..Additionally, the translation of rp mRNAs is preferentially repressed in association with decreased S6K1 phosphorylation...
  24. ncbi request reprint Cloning and characterization of complementary and genomic DNAs encoding the epsilon-subunit of rat translation initiation factor-2B
    K M Flowers
    Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
    Biochim Biophys Acta 1307:318-24. 1996
    ..Examination of the promoter region of the gene reveals a consensus binding site for the alpha-Pal transcription factor as well as possible cytokine-response elements and binding sites for testis-specific transcription factors...
  25. ncbi request reprint Signaling pathways involved in translational control of protein synthesis in skeletal muscle by leucine
    J C Anthony
    Department of Cellular and Molecular Physiology, P.O. Box 850, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Nutr 131:856S-860S. 2001
    ..The stimulatory effects of leucine on translation initiation are mediated in part through the protein kinase mammalian target of rapamycin (mTOR), where both insulin signaling and leucine signaling converge to promote a maximal response...
  26. ncbi request reprint Cloning and characterization of cDNA encoding rat hemin-sensitive initiation factor-2 alpha (eIF-2 alpha) kinase. Evidence for multitissue expression
    H Mellor
    Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey 17033
    J Biol Chem 269:10201-4. 1994
    ..These findings raise the possibility of additional, uncharacterized roles for HCR in non-erythroid cells...
  27. pmc Molecular cloning and characterization of cDNA encoding the alpha subunit of the rat protein synthesis initiation factor eIF-2B
    K M Flowers
    Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey 17033, USA
    Proc Natl Acad Sci U S A 92:4274-8. 1995
    ..Southern blots indicate that the eIF-2B alpha cDNA also recognizes genomic DNA fragments from several other species, suggesting significant homology between the rat eIF-2B alpha gene and that from other species...
  28. ncbi request reprint Effect of sepsis on eIE4E availability in skeletal muscle
    T C Vary
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033
    Am J Physiol Endocrinol Metab 279:E1178-84. 2000
    ..Instead, on the basis of our previous studies, changes in eIF2B appear to be responsible for limiting protein synthesis in skeletal muscle during sepsis...
  29. ncbi request reprint Regulation of protein synthesis by branched-chain amino acids
    S R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    Curr Opin Clin Nutr Metab Care 4:39-43. 2001
    ....
  30. ncbi request reprint Alcohol myopathy: impairment of protein synthesis and translation initiation
    C H Lang
    Department of Cellular and Molecular Physiology H166, Penn State College of Medicine, Hershey, PA 17033, USA
    Int J Biochem Cell Biol 33:457-73. 2001
    ..However, defects in the availability or effectiveness of various anabolic hormones, particularly insulin-like growth factor-I, are consistent with the alcohol-induced decrease in protein synthesis and translation initiation...
  31. ncbi request reprint Regulation of eukaryotic initiation factor-2B activity in muscle of diabetic rats
    A M Karinch
    Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey 17033
    Am J Physiol 264:E101-8. 1993
    ..Modulation of casein kinase II activity may be a factor in the regulation of protein synthesis in muscle during acute diabetes. The activity of eIF-2B in heart might be maintained by the increased NADPH/NADP+...
  32. ncbi request reprint Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase
    H Mellor
    Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey 17033
    Biochim Biophys Acta 1219:693-6. 1994
    ..In addition, sequence elements in the 5'- and 3'-untranslated regions are also conserved between species...
  33. ncbi request reprint Amino acid-induced stimulation of translation initiation in rat skeletal muscle
    T C Vary
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol 277:E1077-86. 1999
    ..eIF4G complex controls protein synthesis in skeletal muscle when the amino acid concentration is above the physiological range, whereas removal of leucine reduces protein synthesis through changes in both eIF2B and eIF4E...
  34. ncbi request reprint Translational control of protein synthesis: implications for understanding changes in skeletal muscle mass
    L S Jefferson
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Int J Sport Nutr Exerc Metab 11:S143-9. 2001
    ..Potential mechanisms for exercise-induced increase in muscle mass are discussed...
  35. ncbi request reprint Zinc stimulates the activity of the insulin- and nutrient-regulated protein kinase mTOR
    C J Lynch
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 281:E25-34. 2001
    ....
  36. ncbi request reprint The role of nutrition in stimulating muscle protein accretion at the molecular level
    S R Kimball
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, U S A
    Biochem Soc Trans 35:1298-301. 2007
    ..In addition, downstream effectors of TORC1 action on mRNA translation will be briefly presented. Finally, a previously unrecognized effector of TORC1 signalling in regulating protein synthesis will be described...
  37. ncbi request reprint Structure and sequence of the gene encoding the alpha-subunit of rat translation initiation factor-2B
    K M Flowers
    Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey 17033, USA
    Biochim Biophys Acta 1264:163-7. 1995
    ....
  38. ncbi request reprint Eukaryotic initiation factor eIF2
    S R Kimball
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Int J Biochem Cell Biol 31:25-9. 1999
    ..GTP.Met-tRNAi complex and inhibits global protein synthesis. Phosphorylation of eIF2 alpha occurs under a variety of conditions including viral infection, apoptosis, nutrient deprivation, heme-deprivation, and certain stresses...
  39. doi request reprint A multistep validation process of biomarkers for preclinical drug development
    W M Freeman
    Functional Genomics Core Facility, Penn State College of Medicine, Hershey, PA 17033, USA
    Pharmacogenomics J 10:385-95. 2010
    ....
  40. ncbi request reprint Signal transduction pathways that contribute to increased protein synthesis during T-cell activation
    S Miyamoto
    Molecular Hematology Branch, NHLBI, Bethesda, MD 20892 1654, USA
    Biochim Biophys Acta 1494:28-42. 2000
    ....
  41. pmc Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo
    A J Waskiewicz
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA
    Mol Cell Biol 19:1871-80. 1999
    ..This suggests that phosphorylation of eIF4E is catalyzed by Mnk1 or a very similar kinase in cells and is independent of other mitogenic signals that release eIF4E from 4EBP1...
  42. pmc eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and delta subunits of eIF2B from mammals and yeast
    N T Price
    Department of Biochemistry, University of Bristol, U K
    Biochem J 318:637-43. 1996
    ..This represents the first analysis of the levels of expression of mRNA species encoding the different subunits of eIF2B...
  43. pmc Cloning of cDNA for the gamma-subunit of mammalian translation initiation factor 2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2
    N T Price
    Department of Biochemistry, University of Bristol, U K
    Biochem J 318:631-6. 1996
    ..The roles of these motifs are discussed in relation to the known properties of eIF2B...
  44. ncbi request reprint Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human
    A I Asuru
    Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater 74078, USA
    Biochim Biophys Acta 1307:309-17. 1996
    ..8 kilobase mRNA species which is ubiquitously expressed...
  45. ncbi request reprint Somatotropin regulation of protein metabolism in pigs
    T A Davis
    USDA ARS Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    J Anim Sci 82:E207-213. 2004
    ..Thus, the protein synthetic response to somatotropin treatment is tissue-specific and dependent on nutritional state...
  46. pmc Persistent redistribution of poly-adenylated mRNAs correlates with translation arrest and cell death following global brain ischemia and reperfusion
    J T Jamison
    Department of Physiology, Wayne State University School of Medicine, Detroit, MI 48201, USA
    Neuroscience 154:504-20. 2008
    ..Thus, differential compartmentalization of mRNA away from the 40S subunit correlated with translation arrest in post-ischemic neurons, providing a concise mechanism of persistent translation arrest in post-ischemic CA1...
  47. ncbi request reprint Severe diabetes inhibits resistance exercise-induced increase in eukaryotic initiation factor 2B activity
    J C Kostyak
    Noll Physiological Research Center and Department of Kinesiology, Pennsylvania State University, University Park 16802, USA
    J Appl Physiol 91:79-84. 2001
    ..05) than in nondiabetic animals. These data suggest that severe hypoinsulinemia is associated with an inability to increase eIF2B activity in response to exercise...