Research TopicsSpecies | SHANNON KELLEHERSummaryAffiliation: Pennsylvania State University Country: USA Publications
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Publications
ZnT4 provides zinc to zinc-dependent proteins in the trans-Golgi network critical for cell function and Zn export in mammary epithelial cellsNicholas H McCormick
Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Am J Physiol Cell Physiol 303:C291-7. 2012..We further noted that ZnT4 relocalized to the cell membrane in response to Zn. Together these studies demonstrated that ZnT4 transports Zn into the TGN, which is critical for key secretory functions of the mammary cell...- Zinc in specialized secretory tissues: roles in the pancreas, prostate, and mammary glandShannon L Kelleher
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802 6110, USA
Adv Nutr 2:101-11. 2011..Finally, in each instance, we will reflect upon how this information shapes our current understanding of the role of Zn in these secretory tissues with respect to human health and disease... - Mapping the zinc-transporting system in mammary cells: molecular analysis reveals a phenotype-dependent zinc-transporting network during lactationShannon L Kelleher
Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Cell Physiol 227:1761-70. 2012..These results provide an important framework for understanding the "Zn-transporting network" through which mammary gland Zn pools are redistributed and secreted into milk... 
Introduction to iron works...The John Beard Memorial SymposiumShannon L Kelleher
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16801, USA
J Nutr 141:722S-723S. 2011..This one-day scientific symposium was held in honor of the late John Beard and was organized by Jere Haas, Shannon Kelleher, Terry Etherton, James Connor, and Gordon Jensen...- Mammary gland zinc metabolism: regulation and dysregulationShannon L Kelleher
Department of Nutritional Sciences, The Pennsylvania State University, 222 Chandlee Laboratory, University Park, PA, 16802, USA
Genes Nutr 4:83-94. 2009..In this review, we will summarize the current understanding of the regulation of mammary gland Zn metabolism and its regulation by reproductive hormones, with a discussion of the dysregulation of this process in breast cancer... - Zip3 (Slc39a3) functions in zinc reuptake from the alveolar lumen in lactating mammary glandShannon L Kelleher
Dept of Nutritional Sciences, 222 Chandlee Laboratory, University Park, PA 16802 6110, USA
Am J Physiol Regul Integr Comp Physiol 297:R194-201. 2009.... - Prolactin regulates ZNT2 expression through the JAK2/STAT5 signaling pathway in mammary cellsLinxi Qian
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Am J Physiol Cell Physiol 297:C369-77. 2009..Taken together, these results illustrate that prolactin regulates the transcription of ZnT2 through activation of the Jak2/STAT5 signaling pathway to assist in providing optimal zinc for secretion into milk during lactation... - Zinc transporter-2 (ZnT2) variants are localized to distinct subcellular compartments and functionally transport zincVeronica Lopez
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Biochem J 422:43-52. 2009..Together our data shed further light on the complex integration of cellular zinc transport mechanisms, which may be facilitated by multiple isoforms of specific zinc transporters with unique cellular functions... - X-ray fluorescence microscopy reveals accumulation and secretion of discrete intracellular zinc pools in the lactating mouse mammary glandNicholas McCormick
Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania, USA
PLoS ONE 5:e11078. 2010..It remains unclear as to how the lactating mammary gland dynamically integrates zinc import from maternal circulation with the enormous amount of zinc that is secreted into milk... - Zip6-attenuation promotes epithelial-to-mesenchymal transition in ductal breast tumor (T47D) cellsVeronica Lopez
Department of Nutritional Sciences, The Pennsylvania State University, 222 Chandlee, University Park, PA 16802 6110, USA
Exp Cell Res 316:366-75. 2010..Our data suggest that anti-estrogen treatment regulates Zn level and importantly verify that Zip6 over-expression is not an underlying mechanism initiating breast cancer, but in fact may play a "tumor-constraining" role... - A histidine-rich motif mediates mitochondrial localization of ZnT2 to modulate mitochondrial functionYoung Ah Seo
Department of Nutritional Sciences, Pennsylvania State University, 222 Chandlee, University Park, PA 16802, USA
Am J Physiol Cell Physiol 300:C1479-89. 2011..These results identify the first Zn transporter directly associated with mitochondria and suggest that unique secretory tissues such as the mammary gland require novel mechanisms to modulate mitochondrion-specific functions...
Research Grants
- Regulation of Cellular Zn Redistribution: A Role of ZnT2SHANNON KELLEHER; Fiscal Year: 2009..Thus, this application has significance for improving public health outcomes and advancing our understanding of basic cellular mechanisms. ..
- Regulation of Cellular Zn Redistribution: A Role of ZnT2Shannon L Kelleher; Fiscal Year: 2010..Thus, this application has significance for improving public health outcomes and advancing our understanding of basic cellular mechanisms. ..
- Regulation of Cellular Zn Redistribution: A Role of ZnT2Shannon L Kelleher; Fiscal Year: 2010..Thus, this application has significance for improving public health outcomes and advancing our understanding of basic cellular mechanisms. ..