KENNETH KEILER

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Screen for localized proteins in Caulobacter crescentus
    Jay H Russell
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS ONE 3:e1756. 2008
  2. pmc tmRNA is essential in Shigella flexneri
    Nitya S Ramadoss
    Pennsylvania State University, Department of Biochemistry and Molecular Biology, University Park, Pennsylvania, United States of America
    PLoS ONE 8:e57537. 2013
  3. doi request reprint Localization of the bacterial RNA infrastructure
    Kenneth C Keiler
    Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA, USA
    Adv Exp Med Biol 722:231-8. 2011
  4. pmc Bifunctional transfer-messenger RNA
    Kenneth C Keiler
    Pennsylvania State University, Department of Biochemistry and Molecular Biology, 401 Althouse Lab, University Park, PA 16802, USA
    Biochimie 93:1993-7. 2011
  5. doi request reprint Biology of trans-translation
    Kenneth C Keiler
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Annu Rev Microbiol 62:133-51. 2008
  6. pmc TmRNA is required for correct timing of DNA replication in Caulobacter crescentus
    Kenneth C Keiler
    Department of Developmental Biology, Stanford University, California 94305, USA
    J Bacteriol 185:573-80. 2003
  7. ncbi request reprint Physiology of tmRNA: what gets tagged and why?
    Kenneth C Keiler
    401 Althouse Laboratory, Penn State University, University Park, PA 16827, USA
    Curr Opin Microbiol 10:169-75. 2007
  8. pmc tmRNA in Caulobacter crescentus is cell cycle regulated by temporally controlled transcription and RNA degradation
    Kenneth C Keiler
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Bacteriol 185:1825-30. 2003
  9. pmc Correct timing of dnaA transcription and initiation of DNA replication requires trans translation
    Lin Cheng
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA
    J Bacteriol 191:4268-75. 2009
  10. pmc Subcellular localization of a bacterial regulatory RNA
    Jay H Russell
    The Pennsylvania State University, Department of Biochemistry and Molecular Biology, 401 Althouse Lab, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 106:16405-9. 2009

Research Grants

  1. The role of tmRNA in development of C. crescentus
    KENNETH KEILER; Fiscal Year: 2004
  2. The role of tmRNA in development of C. crescentus
    KENNETH KEILER; Fiscal Year: 2005
  3. The role of tmRNA in development of C. crescentus
    KENNETH KEILER; Fiscal Year: 2004
  4. The role of tmRNA in development of C. crescentus
    KENNETH KEILER; Fiscal Year: 2006
  5. The role of tmRNA in development of C. crescentus
    KENNETH KEILER; Fiscal Year: 2007
  6. The role of tmRNA in development of C. crescentus
    KENNETH KEILER; Fiscal Year: 2009

Collaborators

  • LUCILLE SHAPIRO
  • STEPHEN BENKOVIC
  • Jay H Russell
  • Sue Jean Hong
  • Lin Cheng
  • Faith H Lessner
  • Nitya S Ramadoss
  • Bryan J Venters
  • Xin Zhou
  • John W Tomsho
  • Todd A Naumann
  • Alexander R Horswill
  • Elisabeth M Mahen
  • Quyen Anh Tran

Detail Information

Publications15

  1. pmc Screen for localized proteins in Caulobacter crescentus
    Jay H Russell
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS ONE 3:e1756. 2008
    ..The screen described here could be used in most bacterial species...
  2. pmc tmRNA is essential in Shigella flexneri
    Nitya S Ramadoss
    Pennsylvania State University, Department of Biochemistry and Molecular Biology, University Park, Pennsylvania, United States of America
    PLoS ONE 8:e57537. 2013
    ..flexneri, indicating that tmRNA is essential in S. flexneri because there is no functional backup system. These data suggest that resolution of nonstop translation complexes is required for most bacteria...
  3. doi request reprint Localization of the bacterial RNA infrastructure
    Kenneth C Keiler
    Department of Biochemistry and Molecular Biology, Penn State University, University Park, PA, USA
    Adv Exp Med Biol 722:231-8. 2011
    ..This chapter focuses on what is known about subcellular localization of the bacterial RNA network and what insights localization provides to regulation of the RNA infrastructure of the cell...
  4. pmc Bifunctional transfer-messenger RNA
    Kenneth C Keiler
    Pennsylvania State University, Department of Biochemistry and Molecular Biology, 401 Althouse Lab, University Park, PA 16802, USA
    Biochimie 93:1993-7. 2011
    ..Mutants lacking tmRNA activity typically have severe phenotypes, including defects in viability, virulence, and responses to environmental stresses...
  5. doi request reprint Biology of trans-translation
    Kenneth C Keiler
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Annu Rev Microbiol 62:133-51. 2008
    ..Diverse bacteria require trans-translation when they execute large changes in their genetic programs, including responding to stress, pathogenesis, and differentiation...
  6. pmc TmRNA is required for correct timing of DNA replication in Caulobacter crescentus
    Kenneth C Keiler
    Department of Developmental Biology, Stanford University, California 94305, USA
    J Bacteriol 185:573-80. 2003
    ..This uncoupling of initiation of replication from CtrA degradation indicates that there is an SsrA-dependent pathway required for correct timing of DNA replication...
  7. ncbi request reprint Physiology of tmRNA: what gets tagged and why?
    Kenneth C Keiler
    401 Althouse Laboratory, Penn State University, University Park, PA 16827, USA
    Curr Opin Microbiol 10:169-75. 2007
    ..Recent studies clarify how the tmRNA system is targeted to ribosomes and suggest that tmRNA-tagging is used for both quality control and specific regulation of cellular physiology...
  8. pmc tmRNA in Caulobacter crescentus is cell cycle regulated by temporally controlled transcription and RNA degradation
    Kenneth C Keiler
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Bacteriol 185:1825-30. 2003
    ..This degradation is surprising, since SsrA RNA is both highly structured and highly abundant. This is the first observation of a structural RNA that is cell cycle regulated...
  9. pmc Correct timing of dnaA transcription and initiation of DNA replication requires trans translation
    Lin Cheng
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania, USA
    J Bacteriol 191:4268-75. 2009
    ..These results suggest that the trans translation capacity of the cell is sensed through the dnaA promoter to control the timing of DNA replication initiation...
  10. pmc Subcellular localization of a bacterial regulatory RNA
    Jay H Russell
    The Pennsylvania State University, Department of Biochemistry and Molecular Biology, 401 Althouse Lab, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 106:16405-9. 2009
    ..These results suggest a model in which tmRNA-SmpB is localized to sequester tmRNA from RNase R, and localization might also regulate tmRNA-SmpB interactions with ribosomes...
  11. pmc Cell cycle-regulated degradation of tmRNA is controlled by RNase R and SmpB
    Sue Jean Hong
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Mol Microbiol 57:565-75. 2005
    ..This model explains the regulation of SsrA RNA in other bacteria, and suggests that a highly conserved regulatory mechanism controls SsrA activity...
  12. pmc Proteolytic adaptor for transfer-messenger RNA-tagged proteins from alpha-proteobacteria
    Faith H Lessner
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 401 Althouse Laboratory, University Park, PA 16802, USA
    J Bacteriol 189:272-5. 2007
    ..C. crescentus SspB shares limited sequence similarity with Escherichia coli SspB but binds the tmRNA tag in vitro and is required for optimal proteolysis of tagged proteins in vivo...
  13. pmc Peptide signals encode protein localization
    Jay H Russell
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, 401 Althouse, University Park, PA 16827, USA
    J Bacteriol 189:7581-5. 2007
    ....
  14. pmc Discovery of antibacterial cyclic peptides that inhibit the ClpXP protease
    Lin Cheng
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Protein Sci 16:1535-42. 2007
    ..The screen used here could be adapted to identify cyclic peptide inhibitors of any enzyme that can be expressed in E. coli in conjunction with a fluorescent reporter...
  15. pmc Proteomic identification of tmRNA substrates
    Sue Jean Hong
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 104:17128-33. 2007
    ..Analysis of the tagging sites within these substrates revealed a conserved nucleotide motif 5' of the tagging site, which is required for wild-type tmRNA tagging...

Research Grants7

  1. The role of tmRNA in development of C. crescentus
    KENNETH KEILER; Fiscal Year: 2004
    ....
  2. The role of tmRNA in development of C. crescentus
    KENNETH KEILER; Fiscal Year: 2005
    ....
  3. The role of tmRNA in development of C. crescentus
    KENNETH KEILER; Fiscal Year: 2004
    ....
  4. The role of tmRNA in development of C. crescentus
    KENNETH KEILER; Fiscal Year: 2006
    ....
  5. The role of tmRNA in development of C. crescentus
    KENNETH KEILER; Fiscal Year: 2007
    ....
  6. The role of tmRNA in development of C. crescentus
    KENNETH KEILER; Fiscal Year: 2009
    ....