Research Topics
Genomes and Genes | Kazuhiko KawasakiSummaryAffiliation: Pennsylvania State University Country: USA Publications
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Publications
Genetic basis for the evolution of vertebrate mineralized tissueKazuhiko Kawasaki
Department of Anthropology, 409 Carpenter Building, Pennsylvania State University, University Park, PA 16802, USA
Proc Natl Acad Sci U S A 101:11356-61. 2004..We also suggest that mammalian enamel is distinct from fish enameloid. Their similar nature as a hard structural overlay on exoskeleton and teeth is because of convergent evolution...
Phenogenetic drift in evolution: the changing genetic basis of vertebrate teethKazuhiko Kawasaki
Department of Anthropology, Pennsylvania State University, University Park, 16802, USA
Proc Natl Acad Sci U S A 102:18063-8. 2005..These findings illustrate the complexity of the homology concept in understanding evolution, particularly the evolution of mineralized tissues...
Molecular evolution of matrix metalloproteinase 20Kazuhiko Kawasaki
Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
Eur J Oral Sci 119:247-53. 2011..Thus, we hypothesize that MMP20 could have been used in an ancient hypermineralized tissue, which evolved into enameloid in teleosts and into enamel in tetrapods...
The SCPP gene family and the complexity of hard tissues in vertebratesKazuhiko Kawasaki
Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania, PA, USA
Cells Tissues Organs 194:108-12. 2011..More recently, however, many SCPP genes were lost in toothless birds and mammals. Thus, it appears that, in vertebrates, the phenotypic complexity of hard tissues correlates with gain and loss of SCPP genes...
The evolution of milk casein genes from tooth genes before the origin of mammalsKazuhiko Kawasaki
Department of Anthropology, Pennsylvania State University, USA
Mol Biol Evol 28:2053-61. 2011..The conserved biochemical characteristics in caseins and their immediate ancestors also suggest that many slight genetic modifications have created modern caseins, proteins vital to the sustained success of mammals...
Biomineralization in humans: making the hard choices in lifeKazuhiko Kawasaki
Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
Annu Rev Genet 43:119-42. 2009..These new genes are the basis for a novel genetic system for various mineralized tissues in skeleton and teeth. In addition, any tissue can be abnormally mineralized, and many pathologies of mineralization in humans are known...
The SCPP gene repertoire in bony vertebrates and graded differences in mineralized tissuesKazuhiko Kawasaki
Department of Anthropology, Pennsylvania State University, 409 Carpenter Building, University Park, PA 16802, USA
Dev Genes Evol 219:147-57. 2009..These results show graded differences in mineralized dental tissues and reinforce the hypothesis that bone-dentin-enameloid-enamel constitutes an evolutionary continuum...
Gene duplication and the evolution of vertebrate skeletal mineralizationKazuhiko Kawasaki
Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
Cells Tissues Organs 186:7-24. 2007..As a consequence, phenogenetic drift occurred: while mineralized skeleton is maintained by natural selection, the underlying genetic basis has changed...
Evolutionary genetics of vertebrate tissue mineralization: the origin and evolution of the secretory calcium-binding phosphoprotein familyKazuhiko Kawasaki
Department of Anthropology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Exp Zoolog B Mol Dev Evol 306:295-316. 2006..Thus, the evolution of vertebrate mineralized tissues seems to be explained by phenogenetic drift: while mineralized tissues are retained during vertebrate evolution, the underlying genetic basis has extensively drifted...
Mineralized tissue and vertebrate evolution: the secretory calcium-binding phosphoprotein gene clusterKazuhiko Kawasaki
Department of Anthropology, 409 Carpenter Building, Pennsylvania State University, University Park, PA 16802, USA
Proc Natl Acad Sci U S A 100:4060-5. 2003..The order of duplication events may help delineate early events in mineralized skeletal formation, which is a major characteristic of vertebrates...
