B C Jones

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Contribution of sex and genetics to neuroendocrine adaptation to stress in mice
    B C Jones
    Department of Biobehavioral Health, Pennsylvania State University, University Park 16802 6508, USA
    Psychoneuroendocrinology 23:505-17. 1998
  2. ncbi request reprint Iron deficiency affects acoustic startle response and latency, but not prepulse inhibition in young adult rats
    Maggie S Burhans
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    Physiol Behav 87:917-24. 2006
  3. ncbi request reprint The perplexing paradox of paraquat: the case for host-based susceptibility and postulated neurodegenerative effects
    Byron C Jones
    Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA Department of Pharmacology, The Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA, USA
    J Biochem Mol Toxicol 28:191-7. 2014
  4. doi request reprint Systems analysis of genetic variation in MPTP neurotoxicity in mice
    Byron C Jones
    Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA
    Neurotoxicology 37:26-34. 2013
  5. pmc Systems genetic analysis of multivariate response to iron deficiency in mice
    Lina Yin
    Graduate Program in Neuroscience, The Pennsylvania State University, PA 16802, USA
    Am J Physiol Regul Integr Comp Physiol 302:R1282-96. 2012
  6. ncbi request reprint Systems genetic analysis of peripheral iron parameters in the mouse
    Byron C Jones
    Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16827, USA
    Am J Physiol Regul Integr Comp Physiol 293:R116-24. 2007
  7. ncbi request reprint Quantitative genetic analysis of ventral midbrain and liver iron in BXD recombinant inbred mice
    Byron C Jones
    Department of Biobehavioral Health, The Pennsylvania State University, 315 HHD Building, University Park, PA 16802, USA
    Nutr Neurosci 6:369-77. 2003
  8. ncbi request reprint A genetic developmental model of iron deficiency: biological aspects
    A C Morse
    Department of Biobehavioral Health, College of Health and Human Development, Pennsylvania State University, University Park 16802, USA
    Proc Soc Exp Biol Med 220:147-52. 1999
  9. pmc Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice
    L C Jellen
    Neuroscience Institute, The Pennsylvania State University, University Park, PA, USA
    Neuroscience 252:13-23. 2013
  10. ncbi request reprint Early iron deficiency alters sensorimotor development and brain monoamines in rats
    Erica L Unger
    Department of Nutrition Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 137:118-24. 2007

Detail Information

Publications46

  1. ncbi request reprint Contribution of sex and genetics to neuroendocrine adaptation to stress in mice
    B C Jones
    Department of Biobehavioral Health, Pennsylvania State University, University Park 16802 6508, USA
    Psychoneuroendocrinology 23:505-17. 1998
    ..These findings lend preliminary evidence for involvement of sex and genetics as sources of individual differences in bioadaptation to stress...
  2. ncbi request reprint Iron deficiency affects acoustic startle response and latency, but not prepulse inhibition in young adult rats
    Maggie S Burhans
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    Physiol Behav 87:917-24. 2006
    ..Future studies, perhaps pharmacologic in nature, are necessary to ascertain whether iron deficiency modifies the contribution of monoaminergic systems to responses to environmental stimuli...
  3. ncbi request reprint The perplexing paradox of paraquat: the case for host-based susceptibility and postulated neurodegenerative effects
    Byron C Jones
    Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA Department of Pharmacology, The Pennsylvania State University Milton S Hershey Medical Center, Hershey, PA, USA
    J Biochem Mol Toxicol 28:191-7. 2014
    ....
  4. doi request reprint Systems analysis of genetic variation in MPTP neurotoxicity in mice
    Byron C Jones
    Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16802, USA
    Neurotoxicology 37:26-34. 2013
    ..This systems approach to the study of environmental neurotoxicants holds promise to define individual genetic differences that contribute to variability in susceptibility to risk factors for diseases such as Parkinson's disease...
  5. pmc Systems genetic analysis of multivariate response to iron deficiency in mice
    Lina Yin
    Graduate Program in Neuroscience, The Pennsylvania State University, PA 16802, USA
    Am J Physiol Regul Integr Comp Physiol 302:R1282-96. 2012
    ..Systems genetics analysis of iron homeostasis holds promise for developing new methods for prevention and treatment of iron deficiency anemia and related diseases...
  6. ncbi request reprint Systems genetic analysis of peripheral iron parameters in the mouse
    Byron C Jones
    Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16827, USA
    Am J Physiol Regul Integr Comp Physiol 293:R116-24. 2007
    ..The results show that iron homeostasis is a complex trait and is influenced by multiple genes...
  7. ncbi request reprint Quantitative genetic analysis of ventral midbrain and liver iron in BXD recombinant inbred mice
    Byron C Jones
    Department of Biobehavioral Health, The Pennsylvania State University, 315 HHD Building, University Park, PA 16802, USA
    Nutr Neurosci 6:369-77. 2003
    ..This work shows the value of quantitative genetic analysis in the neurobiology of iron and in showing the close association between ventral midbrain iron and nigrostriatal/mesolimbic dopamine function...
  8. ncbi request reprint A genetic developmental model of iron deficiency: biological aspects
    A C Morse
    Department of Biobehavioral Health, College of Health and Human Development, Pennsylvania State University, University Park 16802, USA
    Proc Soc Exp Biol Med 220:147-52. 1999
    ..Future studies should continue to examine the contributions of both genetics and sex to the development of iron deficiency...
  9. pmc Iron deficiency alters expression of dopamine-related genes in the ventral midbrain in mice
    L C Jellen
    Neuroscience Institute, The Pennsylvania State University, University Park, PA, USA
    Neuroscience 252:13-23. 2013
    ..This work not only demonstrates a wide genetic variation in the transcriptional response to ID in the brain, but also reveals two novel biochemical pathways by which iron may potentially alter dopamine function...
  10. ncbi request reprint Early iron deficiency alters sensorimotor development and brain monoamines in rats
    Erica L Unger
    Department of Nutrition Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 137:118-24. 2007
    ..These results indicate that iron deficiency begun at G15 affects early dopamine neurobiology, the development of specific developmental milestones, and behavior in preweaned rats...
  11. ncbi request reprint Differential effects of stress-induced adrenal function on components of the herpes simplex virus-specific memory cytotoxic T-lymphocyte response
    R H Bonneau
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey 17033, USA
    J Neuroimmunol 82:191-9. 1998
    ..Overall, these studies provide insight into the mechanisms by which psychological stress modulates immune responsiveness to viral pathogens...
  12. ncbi request reprint Iron regulation in C57BLI6 and DBA/2 mice subjected to iron overload
    Erica L Unger
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Nutr Neurosci 10:89-95. 2007
    ..We conclude that genetic background influences the accumulation of excess iron in the periphery and iron regulation in the central nervous system...
  13. ncbi request reprint Early postnatal iron repletion overcomes lasting effects of gestational iron deficiency in rats
    John L Beard
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 137:1176-82. 2007
    ..These data suggest that a window of opportunity exists for reversing the detrimental effects of iron deficiency in utero in rats and provides strong support of intervention approaches in humans with iron deficiency during pregnancy...
  14. ncbi request reprint Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred mice
    Leslie C Jones
    Nutritional Neuroscience Program, The Pennsylvania State University, University Park, PA 16802, USA
    Nutr Neurosci 9:81-92. 2006
    ..More importantly, revelation of the genetic underpinnings of copper and zinc brain homeostasis will aid our understanding of neurological diseases that are related to copper and zinc imbalance...
  15. doi request reprint Genetic analysis reveals polygenic influences on iron, copper, and zinc in mouse hippocampus with neurobiological implications
    Leslie C Jones
    Intercollege Graduate Degree Program in Neuroscience, The Huck Life Sciences Institute, The Pennsylvania State University, University Park, Pennsylvania, USA
    Hippocampus 18:398-410. 2008
    ..Future work will elucidate the genes underlying the two QTL identified, to aid in identifying homologous genetic variants in human populations, which may underlie altered trace metal homeostasis and related neurological disease...
  16. ncbi request reprint Acoustic startle response is disrupted in iron-deficient rats
    Erica L Unger
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Pharmacol Biochem Behav 84:378-84. 2006
    ..These results thus demonstrate that iron deficiency moderately alters ASR signaling although the inhibitory pathways of ASR do not appear to be affected...
  17. ncbi request reprint Cellular iron concentrations directly affect the expression levels of norepinephrine transporter in PC12 cells and rat brain tissue
    John L Beard
    Department of Nutritional Science, S 128 Henderson South Building, The Pennsylvania State University, University Park, PA 16802, USA
    Brain Res 1092:47-58. 2006
    ....
  18. ncbi request reprint Iron deficiency: differential effects on monoamine transporters
    Maggie S Burhans
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
    Nutr Neurosci 8:31-8. 2005
    ..These findings show that iron deficiency affects monoamine systems related to homeostasis and in most cases males appear to be more vulnerable than females...
  19. ncbi request reprint Neurobehavioral analysis of developmental iron deficiency in rats
    John L Beard
    Graduate Program in Nutrition, Department of Nutrition, The Pennsylvania State University, S 126 Henderson Bldg, University Park, PA 16802, USA
    Behav Brain Res 134:517-24. 2002
    ..These observations also strengthen the argument that the Fe-dopamine link is fundamental to understanding biobehavioral difficulties seen in children with ID anemia...
  20. ncbi request reprint Iron deficiency in rats decreases acquisition of and suppresses responding for cocaine
    Byron C Jones
    Department of Biobehavioral Health, The Pennsylvania State University, 315 East Health and Human Development Building, University Park, PA 16802 6508, USA
    Pharmacol Biochem Behav 73:813-9. 2002
    ..The question raised by this research thus, is whether iron deficiency alters hedonic-like responses only to dopamine-related behaviors and the degree to which willingness to "work" contributes to the effect...
  21. ncbi request reprint Neonatal iron deficiency results in irreversible changes in dopamine function in rats
    John Beard
    Graduate Program in Nutrition, Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 133:1174-9. 2003
    ..Changes in DA-related behaviors that were persistent after postweaning iron repletion suggest the existence of a critical neonatal developmental period that is expressed by alterations in DA functioning...
  22. doi request reprint Diurnal variations in brain iron concentrations in BXD RI mice
    E L Unger
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Neuroscience 263:54-9. 2014
    ..The study provides an animal model for future work into determining the biological and genetic basis of circadian influences on VMB iron homeostasis. ..
  23. doi request reprint Effects of IV iron isomaltoside-1000 treatment on regional brain iron status in an iron-deficient animal
    E L Unger
    The Pennsylvania State University, Department of Nutritional Sciences, 110 Chandlee Laboratory, University Park, PA 16802, United States
    Neuroscience 246:179-85. 2013
    ..Preclinical study of IV iron in the iron-deficient (ID) murine model is needed to evaluate and develop IV iron treatments for brain iron deficiency...
  24. ncbi request reprint Genetic-environment analysis of sensitivity and acute tolerance to ethanol in mice
    C L Reed
    Department of Biobehavioral Health, 315 East Health and Human Development Building, Pennsylvania State University, University Park, PA 16802, USA
    Pharmacol Biochem Behav 69:461-7. 2001
    ..The line of the subject also influenced the magnitude of expression of these phenotypes. These findings suggest that environmental and genetic influences interact to influence acute tolerance and rate of tolerance development...
  25. doi request reprint Iron deficiency alters dopamine uptake and response to L-DOPA injection in Sprague-Dawley rats
    Laura E Bianco
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Neurochem 106:205-15. 2008
    ..These experiments provide new evidence that ID results in altered synthesis and functioning of DAT and perhaps suggests some compensatory changes in NE metabolism...
  26. doi request reprint Of mice and men, periodic limb movements and iron: how the human genome informs the mouse genome
    L C Jones
    Neuroscience Institute, The Pennsylvania State University, University Park, PA, USA
    Genes Brain Behav 7:513-4. 2008
    ..In a homologous region in mouse, an area containing btbd9 was also identified as being related to iron homeostasis. This finding is important as iron status in brain has been implicated in restless legs syndrome...
  27. ncbi request reprint Iron deficiency decreases dopamine D1 and D2 receptors in rat brain
    K M Erikson
    Department of Nutrition, Graduate Program in Nutrition, The Pennsylvania State University, S-126 Henderson Building, University Park, PA 16802, USA
    Pharmacol Biochem Behav 69:409-18. 2001
    ..Importantly, the impact of ID on dopamine was more pronounced in males than females, demonstrating sex-related different sensitivities to nutrient deprivation...
  28. doi request reprint Effects of ethanol and ecstasy on conditioned place preference in the rat
    B C Jones
    Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, USA
    J Psychopharmacol 24:275-9. 2010
    ..Thus, administration of EtOH might increase the risk for compulsive use of MDMA, an issue that warrants further study...
  29. ncbi request reprint Genotypic selection provides experimental confirmation for an alcohol consumption quantitative trait locus in mouse
    G E McClearn
    Center for Developmental and Health Genetics, Department of Biobehavioral Health, The Pennsylvania State University, University Park 16802, USA
    Mol Psychiatry 2:486-9. 1997
    ..We present here results from a third experimental method-that of marker-based genotypic selection--in evaluation of two nominated QTLs for alcohol acceptance in mice...
  30. ncbi request reprint Down-regulation of dopamine transporter by iron chelation in vitro is mediated by altered trafficking, not synthesis
    Jason A Wiesinger
    Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Neurochem 100:167-79. 2007
    ....
  31. pmc Systems genetics analysis of iron regulation in the brain
    Leslie C Jellen
    Neuroscience Graduate Program, Pennsylvania State University, University Park, PA, USA
    Biochimie 91:1255-9. 2009
    ..The following is a discussion of iron regulation in the brain and the contributions a systems genetics approach can make toward understanding the genetic underpinnings and relation to neurological disease...
  32. doi request reprint Interactions between 3,4-methylenedioxymethamphetamine and ethanol in humans and rodents
    Wael M Y Mohamed
    Neuroscience Institute, Penn State University, University Park, PA, USA
    Neuropsychobiology 60:188-94. 2009
    ..In this short review, we focus on the known interactions between MDMA and EtOH in humans and rodents...
  33. ncbi request reprint MDMA (ecstasy) effects in pubescent rats: Males are more sensitive than females
    Julie Koenig
    Laboratoire de Neurosciences Comportementales et Cognitives, UMR 7521 CNRS Université Louis Pasteur, IFR 37 Neurosciences, GDR CNRS 2905, 12 rue Goethe, F 67000 Strasbourg, France
    Pharmacol Biochem Behav 81:635-44. 2005
    ....
  34. ncbi request reprint Handling, genetic and housing effects on the mouse stress system, dopamine function, and behavior
    Jean Louis Gariepy
    Center for Developmental Science, University of North Carolina at Chapel Hill, 27599 8115, USA
    Pharmacol Biochem Behav 73:7-17. 2002
    ..Our findings also showed that the effects of handling vary when assessed across different physiological systems and across social and nonsocial testing conditions...
  35. ncbi request reprint Ethanol, 3,4-methylenedioxymethamphetamine (ecstasy) and their combination: long-term behavioral, neurochemical and neuropharmacological effects in the rat
    Jean Christophe Cassel
    Laboratoire de Neurosciences Comportementales et Cognitives, UMR 7521, CNRS Université Louis Pasteur, GDR 2905 CNRS, IFR 37 Neurosciences, 12 rue Goethe, F 67000 Strasbourg, France
    Neuropsychopharmacology 30:1870-82. 2005
    ..Thus, it is likely that the psycho(patho)logical problems reported by ecstasy users drinking alcohol are not solely due to the consumption of MDMA...
  36. ncbi request reprint Interactions between ethanol and cocaine, amphetamine, or MDMA in the rat: thermoregulatory and locomotor effects
    Sami Ben Hamida
    LINC UMR 7191, CNRS Université Louis Pasteur, Institut Fédérératif de Recherche 37 GDR CNRS 2905, 12 rue Goethe, F 67000, Strasbourg, France
    Psychopharmacology (Berl) 197:67-82. 2008
    ..3,4-methylenedioxymethamphetamine (MDMA, ecstasy) is often taken recreationally with ethanol (EtOH). In rats, EtOH may potentiate MDMA-induced hyperactivity, but attenuate hyperthermia...
  37. ncbi request reprint The High-Ethanol Preferring rat as a model to study the shift between alcohol abuse and dependence
    Elena Terenina-Rigaldie
    Laboratoire de Neurogénétique et Stress, UMR 1243 INRA Université Victor Segalen, 33076 Bordeaux, France
    Eur J Pharmacol 504:199-206. 2004
    ..Resistance to ethanol dependence may in fact be genetically influenced and the HEP rat appears as a valuable model to search for factors involved in the transition from alcohol abuse to dependence...
  38. ncbi request reprint Ethanol-ecstasy (MDMA) interactions in rats: preserved attenuation of hyperthermia and potentiation of hyperactivity by ethanol despite prior ethanol treatment
    Sami Ben Hamida
    LN2C FRE 2855 Université Louis Pasteur CNRS, Institut Fédérératif de Recherche 37 GDR CNRS 2905, 12 rue Goethe, F 67000 Strasbourg, France
    Pharmacol Biochem Behav 84:162-8. 2006
    ..This indicates that tolerance to ethanol per se does not account for what appears to be tolerance to the ethanol-MDMA combination, thus indicating that ethanol-MDMA combination likely has unique pharmacological effects...
  39. ncbi request reprint High ethanol preferring rats fail to show dependence following short- or long-term ethanol exposure
    Pierre Mormede
    Laboratoire de Neurogénétique et Stress UMR 1243 INRA INSERM U471, Universite Victor Segalen Bordeaux 2, Institut Francois Magendie, Bordeaux, France
    Alcohol Alcohol 39:183-9. 2004
    ....
  40. pmc The nature and identification of quantitative trait loci: a community's view
    Oduola Abiola
    Nat Rev Genet 4:911-6. 2003
    ..Quantitative trait loci (QTLs) can be identified in several ways, but is there a definitive test of whether a candidate locus actually corresponds to a specific QTL?..
  41. ncbi request reprint Genetics of behaviour: phenotypic and molecular study of rats derived from high- and low-alcohol consuming lines
    Elena Terenina-Rigaldie
    Laboratoire de Neurogénétique et Stress, UMR 1243 INRA Université Victor Segalen, INSERM U471, Institut Francois Magendie, Bordeaux, France
    Pharmacogenetics 13:543-54. 2003
    ..9 and explaining 46% of the variance of the trait. Other significant QTL were found for plus maze behaviour and open field activity on chromosome 1. Current research aims to identify the gene(s) involved...
  42. ncbi request reprint Ethanol and MDMA: a comment on the paper by Izco et al
    Byron C Jones
    Psychopharmacology (Berl) 191:387-8. 2007
  43. ncbi request reprint Ethanol-MDMA interactions in rats: the importance of interval between repeated treatments in biobehavioral tolerance and sensitization to the combination
    Sami Ben Hamida
    LINC UMR 7191, Université Louis Pasteur CNRS, Institut Fédérératif de Recherche 37, GDR CNRS 2905, Strasbourg, France
    Psychopharmacology (Berl) 192:555-69. 2007
    ..The latter effect was previously thought to reflect tolerance to ethanol or the combination, per se...
  44. ncbi request reprint Conditioned place aversion is a highly sensitive index of acute opioid dependence and withdrawal
    Marc R Azar
    Department of Anesthesiology, UC San Diego School of Medicine and VA San Diego Healthcare System, 3350 La Jolla Village Drive, MC 125, San Diego, CA 92161 5085, USA
    Psychopharmacology (Berl) 170:42-50. 2003
    ..Conditioned place aversion (CPA) is known to be a sensitive measure of the aversive motivational state produced by opioid withdrawal in rats made chronically dependent on opioids...
  45. ncbi request reprint Attenuation of MDMA-induced hyperthermia by ethanol in rats depends on ambient temperature
    Jean Christophe Cassel
    LINC UMR 7191, Université Louis Pasteur CNRS, Institut Fédérératif de Recherche 37 GDR CNRS 2905, 12 rue Goethe, F 67000 Strasbourg, France
    Eur J Pharmacol 571:152-5. 2007
    ..At 23 degrees C, however, there was no lethality and ethanol reduced the hyperthermia. Thus, the effects of ethanol on MDMA-induced hyperthermia are related to ambient temperature...
  46. ncbi request reprint Locomotor and pyretic effects of MDMA-ethanol associations in rats
    Jean Christophe Cassel
    Laboratoire de Neurosciences Comportementales et Cognitives, UMR 7521 CNRS Université Louis Pasteur, IFR 37 Neurosciences, 12 rue Goethe, F 67000 Strasbourg, France
    Alcohol 34:285-9. 2004
    ..Results of our study have important implications for understanding the motivation and the health risks of polydrug abusers combining ecstasy and ethanol...