Research Topics
| Jiafen HuSummaryAffiliation: Pennsylvania State University Country: USA Publications
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Publications
Mucosally delivered peptides prime strong immunity in HLA-A2.1 transgenic rabbitsJiafen Hu
Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Vaccine 28:3706-13. 2010..We conclude that mucosal peptide immunization can be combined with a single DNA vaccination to provide strong protective immunity in rabbits...
GM-CSF enhances protective immunity to cottontail rabbit papillomavirus E8 genetic vaccination in rabbitsJiafen Hu
Department of Pathology, The Jake Gittlen Cancer Research Institute, Pennsylvania State University, Hershey, PA 17033, USA
Vaccine 22:1124-30. 2004..These results demonstrated that mGM-CSF could enhance the effects of E8 immunization in rabbits to CRPV infection through cell-mediated immune responses...- Protective immunity with an E1 multivalent epitope DNA vaccine against cottontail rabbit papillomavirus (CRPV) infection in an HLA-A2.1 transgenic rabbit modelJiafen Hu
Jake Gittlen Cancer Research Foundation, Department of Pathology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Vaccine 26:809-16. 2008..1 transgenic rabbits against viral DNA infection. This study further demonstrated that the HLA-A2.1 transgenic rabbits can be used to test the immunogenicity of HLA-A2.1 restricted epitopes identified by MHCI epitope predication software... - Protective cell-mediated immunity by DNA vaccination against Papillomavirus L1 capsid protein in the Cottontail Rabbit Papillomavirus modelJiafen Hu
Department of Pathology, Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Viral Immunol 19:492-507. 2006..Cross-protective immunity against CRPV L1 and ROPV L1 was elicited in these CRPV L1- and subfragment-vaccinated rabbits... - Detection of L1, infectious virions and anti-L1 antibody in domestic rabbits infected with cottontail rabbit papillomavirusJiafen Hu
Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Gen Virol 88:3286-93. 2007..These studies demonstrated that the CRPV/New Zealand White rabbit model could be used as an in vivo model to study natural virus infection and viral life cycle of CRPV and not be limited to studies on abortive infections... - Increased immunity to cottontail rabbit papillomavirus infection in EIII/JC inbred rabbits after vaccination with a mutant E6 that correlates with spontaneous regressionJiafen Hu
Department of Pathology, Jake Gittlen Cancer Research Foundation, Hershey, Pennsylvania, USA
Viral Immunol 20:320-5. 2007..05, unpaired Student t test). We conclude that a single amino acid change in the CRPV E6 protein (G252E) increased protection against wild-type infectious CRPV... - CRPV genomes with synonymous codon optimizations in the CRPV E7 gene show phenotypic differences in growth and altered immunity upon E7 vaccinationNancy M Cladel
Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
PLoS ONE 3:e2947. 2008..The reduction in growth was most dramatic with the genome containing the greatest number of synonymous codon changes... - Establishment of a cottontail rabbit papillomavirus/HLA-A2.1 transgenic rabbit modelJiafen Hu
Jake Gittlen Cancer Research Foundation, 500 University Dr, Pennsylvania State University, Hershey, PA 17033, USA
J Virol 81:7171-7. 2007..1 rabbit model has the potential to be used to screen HLA-A2.1-restricted immunogenic epitopes from human papillomaviruses in the context of in vivo papillomavirus infection... - An HLA-A2.1-transgenic rabbit model to study immunity to papillomavirus infectionJiafen Hu
Jake Gittlen Cancer Research Foundation, and Department of Pathology, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
J Immunol 177:8037-45. 2006..HLA-A2.1-transgenic rabbits will be an important preclinical animal model system to study virus-host interactions and to assess specific targets for immunotherapy... - Papillomavirus DNA complementation in vivoJiafen Hu
Jake Gittlen Cancer Research Foundation, Department of Pathology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Virus Res 144:117-22. 2009..Individual wild type genes were also shown to rescue the function of corresponding dysfunctional mutants. Therefore, we suggest that complementation occurred between these two non-viable mutant PV genomes in vivo... - Impact of genetic changes to the CRPV genome and their application to the study of pathogenesis in vivoJiafen Hu
Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Virology 358:384-90. 2007..1 transgenic rabbit model, this plasticity allows us to extend the utility of the CRPV/rabbit model to the screening of HLA-A2.1 restricted epitopes from other human viral and tumor antigens... - Large cutaneous rabbit papillomas that persist during cyclosporin A treatment can regress spontaneously after cessation of immunosuppressionJiafen Hu
The Jake Gittlen Cancer Research Institute, Department of Pathology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Gen Virol 86:55-63. 2005..However, returning immunity can lead to regression and clearance of large papillomas (with increased antigenicity) in an outbred population, whilst these same antigenic papillomas persist in inbred rabbits... - Amino acid residues in the carboxy-terminal region of cottontail rabbit papillomavirus E6 influence spontaneous regression of cutaneous papillomasJiafen Hu
Department of Pathology, The Jake Gittlen Cancer Research Institute, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
J Virol 76:11801-8. 2002.... - Wounding prior to challenge substantially improves infectivity of cottontail rabbit papillomavirus and allows for standardization of infectionNancy M Cladel
Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Virol Methods 148:34-9. 2008..This method can be adapted easily by other investigators in the field. The resulting standardization will aid in the evaluation of data from different laboratories... - Characterization of three rabbit oral papillomavirus oncogenesJiafen Hu
Department of Pathology, The Jake Gittlen Cancer Research Institute, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
Virology 325:48-55. 2004..Cells with ROPV E6, E7, or E8 formed colonies in agar and tumors in athymic mice. These observations suggest that ROPV E6, E7, and E8 are oncogenic... - Differences in methodology, but not differences in viral strain, account for variable experimental outcomes in laboratories utilizing the cottontail rabbit papillomavirus modelNancy M Cladel
Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershy, PA 17033, United States
J Virol Methods 165:36-41. 2010..It was concluded that the E8 gene is not required for infection. We suggest that standardized infection methods should be used in laboratories so that inconsistencies in conclusions will be minimized... - Vaccine generated immunity targets an HPV16 E7 HLA-A2.1-restricted CD8(+) T cell epitope relocated to an early gene or a late gene of the cottontail rabbit papillomavirus (CRPV) genome in HLA-A2.1 transgenic rabbitsCallie E Bounds
Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Vaccine 29:1194-200. 2011..This study also highlights the broad utility of the HLAA2.1 transgenic rabbit model for testing numerous immunological factors involved in vaccine generated protective immunity... - Intracutaneous DNA vaccination with the E8 gene of cottontail rabbit papillomavirus induces protective immunity against virus challenge in rabbitsJiafen Hu
Department of Pathology, The Jake Gittlen Cancer Research Institute, College of Medicine, Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA
J Virol 76:6453-9. 2002..01; t test). Delayed-type hypersensitivity skin tests showed that some of the E8-vaccinated rabbits had positive responses to E8-specific peptides...