Ly Q Hong-Brown

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Am J Physiol Cell Physiol 302:C1557-65. 2012
  2. ncbi request reprint Alcohol impairs protein synthesis and degradation in cultured skeletal muscle cells
    L Q Hong-Brown
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Alcohol Clin Exp Res 25:1373-82. 2001
  3. pmc Alcohol-induced modulation of rictor and mTORC2 activity in C2C12 myoblasts
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA
    Alcohol Clin Exp Res 35:1445-53. 2011
  4. pmc Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    J Cell Biochem 109:1172-84. 2010
  5. pmc Lopinavir impairs protein synthesis and induces eEF2 phosphorylation via the activation of AMP-activated protein kinase
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Penn State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cell Biochem 105:814-23. 2008
  6. ncbi request reprint Alcohol regulates eukaryotic elongation factor 2 phosphorylation via an AMP-activated protein kinase-dependent mechanism in C2C12 skeletal myocytes
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 282:3702-12. 2007
  7. ncbi request reprint Alcohol and indinavir adversely affect protein synthesis and phosphorylation of MAPK and mTOR signaling pathways in C2C12 myocytes
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology H166, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Alcohol Clin Exp Res 30:1297-307. 2006
  8. ncbi request reprint HIV antiretroviral agents inhibit protein synthesis and decrease ribosomal protein S6 and 4EBP1 phosphorylation in C2C12 myocytes
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology H166, Penn State University College of Medicine, Hershey, PA 17033, USA
    AIDS Res Hum Retroviruses 21:854-62. 2005
  9. ncbi request reprint Indinavir impairs protein synthesis and phosphorylations of MAPKs in mouse C2C12 myocytes
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Cell Physiol 287:C1482-92. 2004
  10. ncbi request reprint Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 285:E63-72. 2003

Detail Information

Publications13

  1. pmc Rag GTPases and AMPK/TSC2/Rheb mediate the differential regulation of mTORC1 signaling in response to alcohol and leucine
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, 500 University Dr, Hershey, PA 17033, USA
    Am J Physiol Cell Physiol 302:C1557-65. 2012
    ..Collectively, our results indicate that EtOH inhibits the anabolic effects that Leu has on protein synthesis and mTORC1 activity by modulating both Rag GTPase function and AMPK/TSC2/Rheb signaling...
  2. ncbi request reprint Alcohol impairs protein synthesis and degradation in cultured skeletal muscle cells
    L Q Hong-Brown
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Alcohol Clin Exp Res 25:1373-82. 2001
    ..We investigated whether ethanol (EtOH) and its major metabolites, acetaldehyde and acetate, can directly modulate protein balance under in vitro conditions...
  3. pmc Alcohol-induced modulation of rictor and mTORC2 activity in C2C12 myoblasts
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA
    Alcohol Clin Exp Res 35:1445-53. 2011
    ..In this study, we investigated whether mTORC2 functions as part of a feedback regulator in response to EtOH, acting to maintain the balance between the functions of Akt, mTORC2, and mTORC1...
  4. pmc Alcohol and PRAS40 knockdown decrease mTOR activity and protein synthesis via AMPK signaling and changes in mTORC1 interaction
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    J Cell Biochem 109:1172-84. 2010
    ..These data suggest a possible mechanism for the inhibitory effects of EtOH on mTOR kinase activity and protein synthesis in myocytes...
  5. pmc Lopinavir impairs protein synthesis and induces eEF2 phosphorylation via the activation of AMP-activated protein kinase
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Penn State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cell Biochem 105:814-23. 2008
    ..Collectively, these results indicate that LPV decreases protein synthesis, at least in part, via inhibition of eEF2. This appears regulated by AMPK which can act directly on eEF2 or indirectly via the action of eEF2K...
  6. ncbi request reprint Alcohol regulates eukaryotic elongation factor 2 phosphorylation via an AMP-activated protein kinase-dependent mechanism in C2C12 skeletal myocytes
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 282:3702-12. 2007
    ..Collectively, the induction of eEF2 phosphorylation by EtOH is controlled by an increase in AMPK and a decrease in protein phosphatase 2A activity...
  7. ncbi request reprint Alcohol and indinavir adversely affect protein synthesis and phosphorylation of MAPK and mTOR signaling pathways in C2C12 myocytes
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology H166, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Alcohol Clin Exp Res 30:1297-307. 2006
    ..The goal of the present study was to identify signaling mechanisms responsible for the inhibitory effect of ethanol (EtOH) and Ind on protein synthesis...
  8. ncbi request reprint HIV antiretroviral agents inhibit protein synthesis and decrease ribosomal protein S6 and 4EBP1 phosphorylation in C2C12 myocytes
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology H166, Penn State University College of Medicine, Hershey, PA 17033, USA
    AIDS Res Hum Retroviruses 21:854-62. 2005
    ..In conclusion, nelfinavir, nevirapine, and zidovudine treatments decreased protein synthesis in myocytes and this effect was correlated with a reduction in the phosphorylation level of proteins that regulate translation initiation...
  9. ncbi request reprint Indinavir impairs protein synthesis and phosphorylations of MAPKs in mouse C2C12 myocytes
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Cell Physiol 287:C1482-92. 2004
    ..This decrease was associated with the disruption of the ERK1/2 and p38 MAPK pathways and a reduction in both the level of functional eIF4F complex and rpS6 phosphorylation...
  10. ncbi request reprint Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 285:E63-72. 2003
    ..In conclusion, sepsis produces GH resistance in both muscle and liver, with the locus of this impairment in muscle differing from that in liver and being independent of a defect in STAT5 phosphorylation...
  11. ncbi request reprint Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 289:E382-90. 2005
    ..In conclusion, indinavir acutely impairs basal protein synthesis and translation initiation in skeletal muscle but, in contrast to muscle glucose uptake, does not impair insulin-stimulated signaling of protein synthetic pathways...
  12. pmc Activation of AMPK/TSC2/PLD by alcohol regulates mTORC1 and mTORC2 assembly in C2C12 myocytes
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania
    Alcohol Clin Exp Res 37:1849-61. 2013
    ..Herein, we examine the role that PLD and PA play in EtOH-mediated mTOR signaling...
  13. pmc Mechanisms mediating the effects of alcohol and HIV anti-retroviral agents on mTORC1, mTORC2 and protein synthesis in myocytes
    Ly Q Hong-Brown
    Ly Q Hong Brown, Abid A Kazi, Charles H Lang, Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, United States
    World J Biol Chem 3:110-20. 2012
    ..Gaining a better understanding of these molecular mechanisms could have important implications for preventing changes in lean body mass in patients with catabolic conditions or illnesses...