S Blair Hedges

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint The high-level classification of skinks (Reptilia, Squamata, Scincomorpha)
    S Blair Hedges
    Department of Biology, Pennsylvania State University, 208 Mueller Lab, University Park, PA 16802, USA Email
    Zootaxa 3765:317-38. 2014
  2. pmc Wormholes record species history in space and time
    S Blair Hedges
    Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
    Biol Lett 9:20120926. 2013
  3. pmc Amniote phylogeny and the position of turtles
    S Blair Hedges
    Department of Biology, Pennsylvania State University, University Park, PA 16802 5301, USA
    BMC Biol 10:64. 2012
  4. ncbi request reprint Molecular phylogeny and biogeography of West Indian frogs of the genus Leptodactylus (Anura, Leptodactylidae)
    S Blair Hedges
    Department of Biology, 208 Mueller Laboratory, Pennsylvania State University, University Park, PA 16802 5301, USA
    Mol Phylogenet Evol 44:308-14. 2007
  5. ncbi request reprint TimeTree: a public knowledge-base of divergence times among organisms
    S Blair Hedges
    Department of Biology, Pennsylvania State University, University Park, PA 16802 5301, USA
    Bioinformatics 22:2971-2. 2006
  6. ncbi request reprint A molecular phylogeny of reptiles
    S B Hedges
    Department of Biology, Institute of Molecular Evolutionary Genetics, and Astrobiology Research Center, 208 Mueller Laboratory, Pennsylvania State University, University Park, PA 16802, USA
    Science 283:998-1001. 1999
  7. ncbi request reprint Precision of molecular time estimates
    S Blair Hedges
    NASA Astrobiology Institute and Department of Biology, Pennsylvania State University, University Park, PA 16802 5301, USA
    Trends Genet 20:242-7. 2004
  8. pmc A molecular timescale of eukaryote evolution and the rise of complex multicellular life
    S Blair Hedges
    NASA Astrobiology Institute and Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Evol Biol 4:2. 2004
  9. pmc Comparison of mode estimation methods and application in molecular clock analysis
    S Blair Hedges
    NASA Astrobiology Institute and Department of Biology, Pennsylvania State University, 208 Mueller Laboratory, University Park, PA 16802 5301, U, S, A
    BMC Bioinformatics 4:31. 2003
  10. ncbi request reprint The origin and evolution of model organisms
    S Blair Hedges
    NASA Astrobiology Institute and Department of Biology, 208 Mueller Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nat Rev Genet 3:838-49. 2002

Detail Information

Publications36

  1. ncbi request reprint The high-level classification of skinks (Reptilia, Squamata, Scincomorpha)
    S Blair Hedges
    Department of Biology, Pennsylvania State University, 208 Mueller Lab, University Park, PA 16802, USA Email
    Zootaxa 3765:317-38. 2014
    ..nov. (14 sp.) and Ateuchosauridae fam. nov. (2 sp.). Morphological diagnoses and species content for all nine families of skinks (Scincomorpha) are presented. ..
  2. pmc Wormholes record species history in space and time
    S Blair Hedges
    Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
    Biol Lett 9:20120926. 2013
    ..These data also provide evidence for historians in determining the place of origin or movement of a woodblock, book, document or art print...
  3. pmc Amniote phylogeny and the position of turtles
    S Blair Hedges
    Department of Biology, Pennsylvania State University, University Park, PA 16802 5301, USA
    BMC Biol 10:64. 2012
    ..in BMC Biology, place turtles with birds and crocodilians. Molecular studies have not wavered as the numbers of genes and species have increased, but morphologists have been reluctant to embrace the molecular tree...
  4. ncbi request reprint Molecular phylogeny and biogeography of West Indian frogs of the genus Leptodactylus (Anura, Leptodactylidae)
    S Blair Hedges
    Department of Biology, 208 Mueller Laboratory, Pennsylvania State University, University Park, PA 16802 5301, USA
    Mol Phylogenet Evol 44:308-14. 2007
    ..The relatively minor genetic differentiation of populations of L. albilabris can be explained by vicariance and dispersal in the Pleistocene and Holocene, although human introduction of some populations cannot be ruled out...
  5. ncbi request reprint TimeTree: a public knowledge-base of divergence times among organisms
    S Blair Hedges
    Department of Biology, Pennsylvania State University, University Park, PA 16802 5301, USA
    Bioinformatics 22:2971-2. 2006
    ..Results are presented and summarized, allowing users to quickly determine the range and robustness of time estimates and the degree of consensus from the published literature...
  6. ncbi request reprint A molecular phylogeny of reptiles
    S B Hedges
    Department of Biology, Institute of Molecular Evolutionary Genetics, and Astrobiology Research Center, 208 Mueller Laboratory, Pennsylvania State University, University Park, PA 16802, USA
    Science 283:998-1001. 1999
    ..Morphological and paleontological evidence for this molecular phylogeny is unclear. Molecular time estimates support a Triassic origin for the major groups of living reptiles...
  7. ncbi request reprint Precision of molecular time estimates
    S Blair Hedges
    NASA Astrobiology Institute and Department of Biology, Pennsylvania State University, University Park, PA 16802 5301, USA
    Trends Genet 20:242-7. 2004
  8. pmc A molecular timescale of eukaryote evolution and the rise of complex multicellular life
    S Blair Hedges
    NASA Astrobiology Institute and Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Evol Biol 4:2. 2004
    ..Here, we used all available protein sequence data and molecular clock methods to place constraints on the increase in complexity through time...
  9. pmc Comparison of mode estimation methods and application in molecular clock analysis
    S Blair Hedges
    NASA Astrobiology Institute and Department of Biology, Pennsylvania State University, 208 Mueller Laboratory, University Park, PA 16802 5301, U, S, A
    BMC Bioinformatics 4:31. 2003
    ..We compared these methods in simulations to determine their strengths and weaknesses and further assessed their performance when applied to real data sets from a molecular clock study...
  10. ncbi request reprint The origin and evolution of model organisms
    S Blair Hedges
    NASA Astrobiology Institute and Department of Biology, 208 Mueller Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nat Rev Genet 3:838-49. 2002
    ..This emerging comparative framework and the emphasis on historical patterns is helping to bridge barriers among organism-based research communities...
  11. ncbi request reprint Genomic clocks and evolutionary timescales
    S Blair Hedges
    NASA Astrobiology Institute and Department of Biology, 208 Mueller Laboratory, Pennsylvania State University, University Park, PA 16802 5301, USA
    Trends Genet 19:200-6. 2003
    ..Fortunately, time estimates inferred using many genes or proteins have greater precision and appear to be robust to different approaches...
  12. pmc A genomic timescale for the origin of eukaryotes
    S B Hedges
    Astrobiology Research Center and Department of Biology, 208 Mueller Laboratory, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    BMC Evol Biol 1:4. 2001
    ..We used refined methods of sequence alignment, site selection, and time estimation to address these questions with protein sequences from complete genomes of prokaryotes and eukaryotes...
  13. pmc Evolutionary sequence analysis of complete eukaryote genomes
    Jaime E Blair
    NASA Astrobiology Institute, Department of Biology, The Pennsylvania State University, 208 Mueller Laboratory, University Park, Pennsylvania 16802 5301, USA
    BMC Bioinformatics 6:53. 2005
    ..We apply this approach to complete sets of proteins from published eukaryote genomes specifically for phylogeny and time estimation...
  14. ncbi request reprint The phylogeny of squamate reptiles (lizards, snakes, and amphisbaenians) inferred from nine nuclear protein-coding genes
    Nicolas Vidal
    Department of Biology, Astrobiology Research Center, Pennsylvania State University, University Park, PA 16802 5301, USA
    C R Biol 328:1000-8. 2005
    ..Molecular time estimates show that the Triassic and Jurassic (from 250 to 150 Myr) were important times for squamate evolution and diversification...
  15. pmc Major Caribbean and Central American frog faunas originated by ancient oceanic dispersal
    Matthew P Heinicke
    Department of Biology, Pennsylvania State University, University Park, PA 16802 5301, USA
    Proc Natl Acad Sci U S A 104:10092-7. 2007
    ..Origin by dispersal, probably over water from South America in the early Cenozoic (47-29 million years ago, Mya), is more likely...
  16. ncbi request reprint Molecular phylogeny and divergence times of deuterostome animals
    Jaime E Blair
    NASA Astrobiology Institute and Department of Biology, The Pennsylvania State University, University Park, USA
    Mol Biol Evol 22:2275-84. 2005
    ..We found that most major lineages of deuterostomes arose prior to the Cambrian Explosion of fossils (approximately 520 MYA) and that several lineages had originated before periods of global glaciation in the Precambrian...
  17. ncbi request reprint Genomics. Vertebrate genomes compared
    S Blair Hedges
    NASA Astrobiology Institute and Department of Biology, 208 Mueller Laboratory, Pennsylvania State University, University Park, PA 16802 5301, USA
    Science 297:1283-5. 2002
  18. doi request reprint A major clade of prokaryotes with ancient adaptations to life on land
    Fabia U Battistuzzi
    Department of Biology, Pennsylvania State University, USA
    Mol Biol Evol 26:335-43. 2009
    ..These results now leave open the possibility that terrestrial adaptations may have played a larger role in prokaryote evolution than currently understood...
  19. ncbi request reprint Molecular phylogeny and biogeography of the Antillean geckos Phyllodactylus wirshingi, Tarentola americana, and Hemidactylus haitianus (Reptilia, Squamata)
    Andrew J Weiss
    Department of Biology, 208 Mueller Lab, Pennsylvania State University, University Park, PA 16802, USA
    Mol Phylogenet Evol 45:409-16. 2007
  20. pmc The colonization of land by animals: molecular phylogeny and divergence times among arthropods
    Davide Pisani
    NASA Astrobiology Institute and Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Biol 2:1. 2004
    ..Nine nuclear and 15 mitochondrial genes were used in phylogenetic analyses and 61 genes were used in molecular clock analyses...
  21. pmc Molecular evidence for a terrestrial origin of snakes
    Nicolas Vidal
    NASA Astrobiology Institute and Department of Biology, 208 Mueller Laboratory, Pennsylvania State University, University Park, PA 16802, USA
    Proc Biol Sci 271:S226-9. 2004
    ..Here, we show that DNA sequence evidence does not support a close relationship between snakes and monitor lizards, and thus supports a terrestrial origin of snakes...
  22. ncbi request reprint The phylogeny and classification of caenophidian snakes inferred from seven nuclear protein-coding genes
    Nicolas Vidal
    Department of Biology and NASA Astrobiology Institute, 208 Mueller Lab, Pennsylvania State University, University Park, PA 16802 5301, USA
    C R Biol 330:182-7. 2007
    ..The phylogeny also indicates that, ancestrally, caenophidian snakes are Asian and nocturnal in origin, although living species occur on nearly all continents and are ecologically diverse...
  23. pmc A genomic timescale of prokaryote evolution: insights into the origin of methanogenesis, phototrophy, and the colonization of land
    Fabia U Battistuzzi
    NASA Astrobiology Institute and Department of Biology, 208 Mueller Laboratory, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Evol Biol 4:44. 2004
    ..We assembled a data set of sequences from 32 proteins (approximately 7600 amino acids) common to 72 species and estimated phylogenetic relationships and divergence times with a local clock method...
  24. ncbi request reprint Molecular phylogeny and historical biogeography of West Indian boid snakes (Chilabothrus)
    R Graham Reynolds
    Department of Biology, University of Massachusetts Boston, 100 Morrissey Blvd, Boston, MA 02125 3393, USA
    Mol Phylogenet Evol 68:461-70. 2013
    ..We also find evidence for a remarkable diversification within the Bahamian archipelago suggesting that the recognition of another Bahamian endemic species C. strigilatus is warranted...
  25. pmc Origin of invasive Florida frogs traced to Cuba
    Matthew P Heinicke
    Department of Biology, 208 Mueller Laboratory, The Pennsylvania State University, University Park, PA 16802, USA
    Biol Lett 7:407-10. 2011
    ..The subtropical Keys may have served as an adaptive stepping stone for the successful invasion of the North American continent...
  26. pmc The evolutionary position of nematodes
    Jaime E Blair
    Astrobiology Research Center and Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Evol Biol 2:7. 2002
    ..Traditionally, nematodes have occupied a basal position, in part because they lack a true body cavity. However, the leading hypothesis now joins nematodes with arthropods in a molting clade, Ecdysozoa, based on data from several genes...
  27. ncbi request reprint Constraining fossil calibrations for molecular clocks
    S Blair Hedges
    Bioessays 28:770-1; author reply 772-3. 2006
  28. ncbi request reprint Higher-level relationships of snakes inferred from four nuclear and mitochondrial genes
    Nicolas Vidal
    Service de systématique moléculaire, Institut de systématique CNRS FR 1541, Museum national d histoire naturelle, 43, rue Cuvier, 75231 Paris, France
    C R Biol 325:977-85. 2002
    ..Consequently, the macrostomatan condition should not be treated a priori as a derived character state devoid of homoplasy...
  29. ncbi request reprint Molecular clocks do not support the Cambrian explosion
    Jaime E Blair
    Mol Biol Evol 22:387-90. 2005
    ..With these results aside, molecular clocks continue to support a long period of animal evolution before the Cambrian explosion of fossils...
  30. ncbi request reprint Higher-level relationships of caenophidian snakes inferred from four nuclear and mitochondrial genes
    Nicolas Vidal
    Service de systématique moléculaire, Institut de systématique CNRS FR 1541, Museum national d histoire naturelle, 43, rue Cuvier, 75231 Paris, France
    C R Biol 325:987-95. 2002
    ..The front-fanged venom system appeared three times independently. The active diurnal foraging mode (associated with a high metabolic rate) appears in a derived position among colubroids...
  31. ncbi request reprint Biogeography: the coelacanth of frogs
    S Blair Hedges
    Nature 425:669-70. 2003
  32. ncbi request reprint Early evolution of the venom system in lizards and snakes
    Bryan G Fry
    Australian Venom Research Unit, Level 8, School of Medicine, University of Melbourne, Parkville, Victoria 3010, Australia
    Nature 439:584-8. 2006
    ..These results provide new insights into the evolution of the venom system in squamate reptiles and open new avenues for biomedical research and drug design using hitherto unexplored venom proteins...
  33. pmc Placing confidence limits on the molecular age of the human-chimpanzee divergence
    Sudhir Kumar
    Center for Evolutionary Functional Genomics, Biodesign Institute, and School of Life Sciences, Arizona State University, Tempe, AZ 85287 5301, USA
    Proc Natl Acad Sci U S A 102:18842-7. 2005
    ..We conclude that tests of hypotheses about the timing of human-chimpanzee divergence demand more precise fossil-based calibrations...
  34. ncbi request reprint Pushing back the expansion of introns in animal genomes
    Sudhir Kumar
    Center for Evolutionary Functional Genomics, Biodesign Institute, and School of Life Sciences, Arizona State University, Tempe, AZ 85287, USA
    Cell 123:1182-4. 2005
    ..These observations suggest that the common ancestor of most animal phyla had intron-rich genes and reinforce the notion that introns proliferated early in the evolutionary history of eukaryotes...
  35. pmc Origin of tropical American burrowing reptiles by transatlantic rafting
    Nicolas Vidal
    Departement Systematique et Evolution, UMR 7138, Systématique, Evolution, Adaptation, Case Postale 26, Museum national d histoire naturelle, 57 rue Cuvier, 75231 Paris Cedex 05, France
    Biol Lett 4:115-8. 2008
    ..Until now, only four or five transatlantic dispersal events were known in terrestrial vertebrates. Significantly, this is the first such dispersal event to involve a group that burrows, an unexpected lifestyle for an oceanic disperser...
  36. ncbi request reprint The platypus is in its place: nuclear genes and indels confirm the sister group relation of monotremes and Therians
    Teun van Rheede
    Department of Biochemistry, Radboud University Nijmegen, Nijmegen, The Netherlands
    Mol Biol Evol 23:587-97. 2006
    ..The morphological evidence for a basal position of Monotremata, well separated from Theria, is thus fully supported by the available molecular data from nuclear genes...