PATRICIA GRIGSON

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Gene expression changes following extinction testing in a heroin behavioral incubation model
    Kara L Kuntz-Melcavage
    Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA
    BMC Neurosci 10:95. 2009
  2. ncbi request reprint Conditioned taste aversions and drugs of abuse: a reinterpretation
    P S Grigson
    Department of Behavioral Science, College of Medicine, The Pennsylvania State University, Hershey 17033, USA
    Behav Neurosci 111:129-36. 1997
  3. pmc The state of the reward comparison hypothesis: theoretical comment on Huang and Hsiao (2008)
    Patricia Sue Grigson
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Behav Neurosci 122:1383-90. 2008
  4. ncbi request reprint Once is too much: conditioned changes in accumbens dopamine following a single saccharin-morphine pairing
    Patricia Sue Grigson
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Behav Neurosci 121:1234-42. 2007
  5. ncbi request reprint Like drugs for chocolate: separate rewards modulated by common mechanisms?
    Patricia Sue Grigson
    Department of Behavioral Science, Penn State College of Medicine, Hershey, PA 17033, USA
    Physiol Behav 76:389-95. 2002
  6. ncbi request reprint Cocaine-induced suppression of saccharin intake: a model of drug-induced devaluation of natural rewards
    Patricia Sue Grigson
    Department of Behavioral Science, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Behav Neurosci 116:321-33. 2002
  7. ncbi request reprint The suppressive effects of intraperitoneal cocaine are augmented when evaluated in nondeprived rats
    P S Grigson
    Department of Behavioral Science, Pennsylvania State College of Medicine, Hershey, PA 17033, USA
    Pharmacol Biochem Behav 69:117-23. 2001
  8. ncbi request reprint Chronic morphine treatment exaggerates the suppressive effects of sucrose and cocaine, but not lithium chloride, on saccharin intake in Sprague-Dawley rats
    P S Grigson
    Department of Behavioral Science, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Behav Neurosci 115:403-16. 2001
  9. ncbi request reprint The suppressive effects of sucrose and cocaine, but not lithium chloride, are greater in Lewis than in Fischer rats: evidence for the reward comparison hypothesis
    P S Grigson
    Department of Behavioral Science, College of Medicine, Pennsylvania State University, Hershey 17033, USA
    Behav Neurosci 114:353-63. 2000
  10. ncbi request reprint Bilateral lesions of the gustatory thalamus disrupt morphine- but not LiCl-induced intake suppression in rats: evidence against the conditioned taste aversion hypothesis
    P S Grigson
    Department of Behavioral Science, Penn State College of Medicine, H181, 500 University Drive, Hershey, PA 17033 2390, USA
    Brain Res 858:327-37. 2000

Research Grants

  1. DRUGS OF ABUSE, REWARD COMPARISON, AND THE THALAMUS
    PATRICIA GRIGSON; Fiscal Year: 2007
  2. DRUGS OF ABUSE, REWARD COMPARISON, AND THE THALAMUS
    PATRICIA GRIGSON; Fiscal Year: 2009
  3. DRUGS OF ABUSE AND LEARNED AVERSIONS: SOLVING A PARADOX
    PATRICIA GRIGSON; Fiscal Year: 2009
  4. DRUGS OF ABUSE, REWARD COMPARISON, AND THE THALAMUS
    PATRICIA GRIGSON; Fiscal Year: 2004
  5. DRUGS OF ABUSE AND LEARNED AVERSIONS: SOLVING A PARADOX
    PATRICIA GRIGSON; Fiscal Year: 2003
  6. DRUGS OF ABUSE, REWARD COMPARISON, AND THE THALAMUS
    Patricia Sue Grigson; Fiscal Year: 2010

Detail Information

Publications20

  1. pmc Gene expression changes following extinction testing in a heroin behavioral incubation model
    Kara L Kuntz-Melcavage
    Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, PA, USA
    BMC Neurosci 10:95. 2009
    ..Extinction sessions were conducted on groups after either 1 d or 14 d of drug-free enforced abstinence to demonstrate behavioral incubation...
  2. ncbi request reprint Conditioned taste aversions and drugs of abuse: a reinterpretation
    P S Grigson
    Department of Behavioral Science, College of Medicine, The Pennsylvania State University, Hershey 17033, USA
    Behav Neurosci 111:129-36. 1997
    ..Suppression of CS intake, then, is a consequence of the well-documented positive reinforcing, rather than the hypothetical aversive, properties of drugs of abuse...
  3. pmc The state of the reward comparison hypothesis: theoretical comment on Huang and Hsiao (2008)
    Patricia Sue Grigson
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Behav Neurosci 122:1383-90. 2008
    ..This commentary addresses the current state of the reward comparison hypothesis in the context of the experiments completed by Huang and Hsiao and their new task-dependent drug effects hypothesis...
  4. ncbi request reprint Once is too much: conditioned changes in accumbens dopamine following a single saccharin-morphine pairing
    Patricia Sue Grigson
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Behav Neurosci 121:1234-42. 2007
    ..Reward comparison effects, then, are cross-modal, bidirectional, and immediate, resulting in both unconditioned and conditioned changes in brain and behavior...
  5. ncbi request reprint Like drugs for chocolate: separate rewards modulated by common mechanisms?
    Patricia Sue Grigson
    Department of Behavioral Science, Penn State College of Medicine, Hershey, PA 17033, USA
    Physiol Behav 76:389-95. 2002
  6. ncbi request reprint Cocaine-induced suppression of saccharin intake: a model of drug-induced devaluation of natural rewards
    Patricia Sue Grigson
    Department of Behavioral Science, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Behav Neurosci 116:321-33. 2002
    ..As such, this paradigm may be useful as a model of cue-induced craving and drug-induced devaluation of natural rewards...
  7. ncbi request reprint The suppressive effects of intraperitoneal cocaine are augmented when evaluated in nondeprived rats
    P S Grigson
    Department of Behavioral Science, Pennsylvania State College of Medicine, Hershey, PA 17033, USA
    Pharmacol Biochem Behav 69:117-23. 2001
    ..Taken together, these data show that rats will readily avoid intake of a saccharin cue when paired with the intraperitoneal administration of cocaine and that the magnitude of the effect is augmented when examined in a need-free state...
  8. ncbi request reprint Chronic morphine treatment exaggerates the suppressive effects of sucrose and cocaine, but not lithium chloride, on saccharin intake in Sprague-Dawley rats
    P S Grigson
    Department of Behavioral Science, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Behav Neurosci 115:403-16. 2001
    ..These data provide further support for the reward comparison hypothesis...
  9. ncbi request reprint The suppressive effects of sucrose and cocaine, but not lithium chloride, are greater in Lewis than in Fischer rats: evidence for the reward comparison hypothesis
    P S Grigson
    Department of Behavioral Science, College of Medicine, Pennsylvania State University, Hershey 17033, USA
    Behav Neurosci 114:353-63. 2000
    ..These data argue against a CTA account and in favor of the reward comparison hypothesis...
  10. ncbi request reprint Bilateral lesions of the gustatory thalamus disrupt morphine- but not LiCl-induced intake suppression in rats: evidence against the conditioned taste aversion hypothesis
    P S Grigson
    Department of Behavioral Science, Penn State College of Medicine, H181, 500 University Drive, Hershey, PA 17033 2390, USA
    Brain Res 858:327-37. 2000
    ..Specifically, the data suggest that rats suppress intake of a saccharin CS in anticipation of the availability of a preferred drug of abuse and that the gustatory thalamus is essential for this type of reward comparison process...
  11. ncbi request reprint Water-deprivation prevents morphine-, but not LiCl-induced, suppression of sucrose intake
    P S Grigson
    Department of Behavioral Science, The Penn State College of Medicine, Hershey, PA 17033, USA
    Physiol Behav 67:277-86. 1999
    ..This finding dissociates the suppressive effects of morphine and LiCl and, in so doing, aligns the suppressive effects of morphine with those of an appetitive sucrose US...
  12. ncbi request reprint The parabrachial nucleus is essential for acquisition of a conditioned odor aversion in rats
    P S Grigson
    Department of Behavioral Science, College of Medicine, Pennsylvania State University, Hershey 17033, USA
    Behav Neurosci 112:1104-13. 1998
    ..Together, the results demonstrate that, as with CTA learning, PBN cell bodies are essential for the establishment of a specific association between an olfactory conditioned stimulus and a lithium chloride unconditioned stimulus...
  13. ncbi request reprint Brainstem lesions and gustatory function: II. The role of the nucleus of the solitary tract in Na+ appetite, conditioned taste aversion, and conditioned odor aversion in rats
    P S Grigson
    Department of Behavioral Science, College of Medicine, The Pennsylvania State University, Hershey 17033, USA
    Behav Neurosci 111:169-79. 1997
    ..Together, the data suggest that the rostral NST is essential for responding appropriately to increasing concentrations of a tastant, but not for the chemical identification necessary for sodium appetite and CTA learning...
  14. ncbi request reprint Brainstem lesions and gustatory function: III. The role of the nucleus of the solitary tract and the parabrachial nucleus in retention of a conditioned taste aversion in rats
    P S Grigson
    Department of Behavioral Science, College of Medicine, The Pennsylvania State University, Hershey 17033, USA
    Behav Neurosci 111:180-7. 1997
    ..Thus, the PBN is essential for the acquisition of a CTA, but neither of the brainstem gustatory nuclei need be intact for the retention of a preoperatively acquired CTA...
  15. ncbi request reprint Ibotenic acid lesions of the parabrachial nucleus and conditioned taste aversion: further evidence for an associative deficit in rats
    P S Grigson
    Department of Behavioral Science, College of Medicine, Pennsylvania State University, Hershey 17033, USA
    Behav Neurosci 112:160-71. 1998
    ..This pattern of results supports the view that cell bodies within the PBN are essential for the associative processes that govern CTA learning...
  16. pmc Ethanol-induced conditioned taste avoidance: reward or aversion?
    Chuang Liu
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Alcohol Clin Exp Res 33:522-30. 2009
    ....
  17. ncbi request reprint Brief access to sweets protect against relapse to cocaine-seeking
    Chuang Liu
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, H181, 500 University Drive, Hershey, PA 17033, USA
    Brain Res 1049:128-31. 2005
    ..The results suggest that presentation of an alternative reward may be useful as a therapeutic intervention for cocaine seeking and relapse...
  18. ncbi request reprint A mixed design reveals that glucose moieties facilitate extinction of a conditioned taste aversion in rats
    Michael E Smith
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Learn Behav 32:454-62. 2004
    ..Intake of glucose moieties recovered rapidly, often in two cycles; the other CSs took four to six cycles. Thus, CTA extinction varies with the nature of the taste CS...
  19. ncbi request reprint Iron deficiency in rats decreases acquisition of and suppresses responding for cocaine
    Byron C Jones
    Department of Biobehavioral Health, The Pennsylvania State University, 315 East Health and Human Development Building, University Park, PA 16802 6508, USA
    Pharmacol Biochem Behav 73:813-9. 2002
    ..The question raised by this research thus, is whether iron deficiency alters hedonic-like responses only to dopamine-related behaviors and the degree to which willingness to "work" contributes to the effect...
  20. pmc Acute sleep deprivation increases the rate and efficiency of cocaine self-administration, but not the perceived value of cocaine reward in rats
    Matthew D Puhl
    Department of Neural and Behavioral Sciences, Pennsylvania State University College of Medicine, USA
    Pharmacol Biochem Behav 94:262-70. 2009
    ..These data are the first to demonstrate a direct link between sleep deprivation and responding for cocaine, particularly in subjects that would otherwise respond little for drug...

Research Grants23

  1. DRUGS OF ABUSE, REWARD COMPARISON, AND THE THALAMUS
    PATRICIA GRIGSON; Fiscal Year: 2007
    ..If confirmed, we will have challenged the limits of the traditional "reward circuitry" and better elucidated the mechanisms of reward comparison. ..
  2. DRUGS OF ABUSE, REWARD COMPARISON, AND THE THALAMUS
    PATRICIA GRIGSON; Fiscal Year: 2009
    ..e., cocaine and heroin); and (c) Reveal that the nucleus accumbens depends upon an intact thalamocoritical loop to track cocaine's devaluation of a sweet. ..
  3. DRUGS OF ABUSE AND LEARNED AVERSIONS: SOLVING A PARADOX
    PATRICIA GRIGSON; Fiscal Year: 2009
    ..aversion to cocaine-induced suppression of CS intake and, in so doing, begin to elucidate underlying substrates. ..
  4. DRUGS OF ABUSE, REWARD COMPARISON, AND THE THALAMUS
    PATRICIA GRIGSON; Fiscal Year: 2004
    ....
  5. DRUGS OF ABUSE AND LEARNED AVERSIONS: SOLVING A PARADOX
    PATRICIA GRIGSON; Fiscal Year: 2003
    ..abstract_text> ..
  6. DRUGS OF ABUSE, REWARD COMPARISON, AND THE THALAMUS
    Patricia Sue Grigson; Fiscal Year: 2010
    ..e., cocaine and heroin);and (c) Reveal that the nucleus accumbens depends upon an intact thalamocoritical loop to track cocaine's devaluation of a sweet. ..