S A Grigoryev

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Nucleosome spacing and chromatin higher-order folding
    Sergei A Grigoryev
    Department of Biochemistry and Molecular Biology Pennsylvania State University, College of Medicine, Hershey, PA USA
    Nucleus 3:493-9. 2012
  2. pmc Evidence for heteromorphic chromatin fibers from analysis of nucleosome interactions
    Sergei A Grigoryev
    Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, H171, Milton S Hershey Medical Center, PO Box 850, 500 University Drive, Hershey, PA 17033, USA
    Proc Natl Acad Sci U S A 106:13317-22. 2009
  3. ncbi request reprint Higher-order folding of heterochromatin: protein bridges span the nucleosome arrays
    S A Grigoryev
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey 17033, USA
    Biochem Cell Biol 79:227-41. 2001
  4. ncbi request reprint The end adjusts the means: heterochromatin remodelling during terminal cell differentiation
    Sergei A Grigoryev
    Department of Biochemistry and Molecular Biology, H171, Penn State University College of Medicine, Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Chromosome Res 14:53-69. 2006
  5. ncbi request reprint Keeping fingers crossed: heterochromatin spreading through interdigitation of nucleosome arrays
    Sergei A Grigoryev
    Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Milton S Hershey Medical Center, Rm C5757, Hershey, PA 17033, USA
    FEBS Lett 564:4-8. 2004
  6. pmc Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation
    Evgenya Y Popova
    Biochemistry and Molecular Biology, College of Medicine, Penn State University, Hershey, PA 17033, USA
    Chromosome Res 17:47-64. 2009
  7. ncbi request reprint Role of the M-loop and reactive center loop domains in the folding and bridging of nucleosome arrays by MENT
    Evelyn M Springhetti
    Department of Biochemistry and Molecular Biology, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 278:43384-93. 2003
  8. pmc Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation
    Yanming Wang
    Center for Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    J Cell Biol 184:205-13. 2009
  9. ncbi request reprint Dynamic relocation of epigenetic chromatin markers reveals an active role of constitutive heterochromatin in the transition from proliferation to quiescence
    Sergei A Grigoryev
    Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Hershey, PA 17033, USA
    J Cell Sci 117:6153-62. 2004
  10. ncbi request reprint Epigenetic heterochromatin markers distinguish terminally differentiated leukocytes from incompletely differentiated leukemia cells in human blood
    Evgenya Y Popova
    Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, 17033, USA
    Exp Hematol 34:453-62. 2006

Collaborators

Detail Information

Publications17

  1. pmc Nucleosome spacing and chromatin higher-order folding
    Sergei A Grigoryev
    Department of Biochemistry and Molecular Biology Pennsylvania State University, College of Medicine, Hershey, PA USA
    Nucleus 3:493-9. 2012
    ..We suggest that incomplete folding of the nucleosome arrays may promote global inter-array interactions that lead to chromatin condensation in metaphase chromosomes and heterochromatin...
  2. pmc Evidence for heteromorphic chromatin fibers from analysis of nucleosome interactions
    Sergei A Grigoryev
    Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, H171, Milton S Hershey Medical Center, PO Box 850, 500 University Drive, Hershey, PA 17033, USA
    Proc Natl Acad Sci U S A 106:13317-22. 2009
    ....
  3. ncbi request reprint Higher-order folding of heterochromatin: protein bridges span the nucleosome arrays
    S A Grigoryev
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey 17033, USA
    Biochem Cell Biol 79:227-41. 2001
    ..This review discusses the molecular and structural determinants of chromatin higher-order folding in relation to mechanism(s) of heterochromatin formation and genetic silencing during cell differentiation and tissue development...
  4. ncbi request reprint The end adjusts the means: heterochromatin remodelling during terminal cell differentiation
    Sergei A Grigoryev
    Department of Biochemistry and Molecular Biology, H171, Penn State University College of Medicine, Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Chromosome Res 14:53-69. 2006
    ....
  5. ncbi request reprint Keeping fingers crossed: heterochromatin spreading through interdigitation of nucleosome arrays
    Sergei A Grigoryev
    Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Milton S Hershey Medical Center, Rm C5757, Hershey, PA 17033, USA
    FEBS Lett 564:4-8. 2004
    ..Here I review the molecular and structural determinants of chromatin compaction and discuss how heterochromatin spreading may be mediated by lateral self-association of zigzag nucleosome arrays...
  6. pmc Chromatin condensation in terminally differentiating mouse erythroblasts does not involve special architectural proteins but depends on histone deacetylation
    Evgenya Y Popova
    Biochemistry and Molecular Biology, College of Medicine, Penn State University, Hershey, PA 17033, USA
    Chromosome Res 17:47-64. 2009
    ....
  7. ncbi request reprint Role of the M-loop and reactive center loop domains in the folding and bridging of nucleosome arrays by MENT
    Evelyn M Springhetti
    Department of Biochemistry and Molecular Biology, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 278:43384-93. 2003
    ..Ordered binding of MENT to linker DNA via its unique M-loop domain promotes the folding of chromatin, whereas bridging of chromatin fibers is facilitated by MENT oligomerization mediated by the RCL...
  8. pmc Histone hypercitrullination mediates chromatin decondensation and neutrophil extracellular trap formation
    Yanming Wang
    Center for Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    J Cell Biol 184:205-13. 2009
    ..Together, these results suggest that histone hypercitrullination has important functions in chromatin decondensation in granulocytes/neutrophils...
  9. ncbi request reprint Dynamic relocation of epigenetic chromatin markers reveals an active role of constitutive heterochromatin in the transition from proliferation to quiescence
    Sergei A Grigoryev
    Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Hershey, PA 17033, USA
    J Cell Sci 117:6153-62. 2004
    ..Our results suggest that constitutive centromeric heterochromatin plays an active role in cell differentiation and reactivation...
  10. ncbi request reprint Epigenetic heterochromatin markers distinguish terminally differentiated leukocytes from incompletely differentiated leukemia cells in human blood
    Evgenya Y Popova
    Department of Biochemistry and Molecular Biology, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, 17033, USA
    Exp Hematol 34:453-62. 2006
    ....
  11. pmc Cathepsin L stabilizes the histone modification landscape on the Y chromosome and pericentromeric heterochromatin
    Yaroslava A Bulynko
    Penn State University College of Medicine, Department of Biochemistry and Molecular Biology, H171, Milton S Hershey Medical Center, P O Box 850, 500 University Drive, Hershey, PA 17033, USA
    Mol Cell Biol 26:4172-84. 2006
    ....
  12. pmc Insulation of the chicken beta-globin chromosomal domain from a chromatin-condensing protein, MENT
    Natalia E Istomina
    Department of Biochemistry and Molecular Biology, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Mol Cell Biol 23:6455-68. 2003
    ....
  13. pmc Rearrangement of upstream sequences of the hTERT gene during cellular immortalization
    Yuanjun Zhao
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA, USA
    Genes Chromosomes Cancer 48:963-74. 2009
    ..The chromosomal rearrangements likely occurred during cellular crisis and facilitated by telomere dysfunction. Such translocations allowed the hTERT promoter to escape from the native condensed chromatin environment...
  14. ncbi request reprint MeCP2-chromatin interactions include the formation of chromatosome-like structures and are altered in mutations causing Rett syndrome
    Tatiana Nikitina
    Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003, USA
    J Biol Chem 282:28237-45. 2007
    ....
  15. pmc X-ray crystal structure of MENT: evidence for functional loop-sheet polymers in chromatin condensation
    Sheena McGowan
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia
    EMBO J 25:3144-55. 2006
    ....
  16. ncbi request reprint Inhibitory activity of a heterochromatin-associated serpin (MENT) against papain-like cysteine proteinases affects chromatin structure and blocks cell proliferation
    James A Irving
    Department of Biochemistry and Molecular Biology, Clayton Campus, Monash University, P O Box 13D, Victoria 3800, Australia
    J Biol Chem 277:13192-201. 2002
    ..We conclude that the repressive effect of MENT on chromatin is mediated by its direct interaction with a nuclear protein that has a papain-like cysteine proteinase active site...
  17. ncbi request reprint DNA accelerates the inhibition of human cathepsin V by serpins
    Poh Chee Ong
    Department of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria 3800, Australia
    J Biol Chem 282:36980-6. 2007
    ..This represents the first example of modulation of serpin inhibition of cysteine proteases by a co-factor and reveals a mechanism for differential regulation of cathepsin proteolytic activity in a DNA-rich environment...