P A Grant

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi The ATM-related cofactor Tra1 is a component of the purified SAGA complex
    P A Grant
    Howard Hughes Medical Institute, Pennsylvania State University, University Park 16802 4500, USA
    Mol Cell 2:863-7. 1998
  2. ncbi A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation
    P A Grant
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802 4500, USA
    Cell 94:45-53. 1998
  3. ncbi Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex
    P A Grant
    Department of Biochemistry and Molecular Biology and The Center for Gene Regulation, The Pennsylvania State University, University Park 16802 4500, USA
    Genes Dev 11:1640-50. 1997
  4. ncbi Transcriptional activators direct histone acetyltransferase complexes to nucleosomes
    R T Utley
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802 4500, USA
    Nature 394:498-502. 1998
  5. ncbi Expanded lysine acetylation specificity of Gcn5 in native complexes
    P A Grant
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802 4500, USA
    J Biol Chem 274:5895-900. 1999
  6. ncbi Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3[middle dot]Rpd3 histone deacetylase complex and is required for histone deacetylase activity
    T Lechner
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802 4500, USA
    J Biol Chem 275:40961-6. 2000
  7. ncbi Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction
    D E Sterner
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 19:86-98. 1999
  8. ncbi The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex
    S John
    Howard Hughes Medical Institute HHMI, Penn State University, University Park, Pennsylvania 16802 4500, USA
    Genes Dev 14:1196-208. 2000
  9. ncbi Insulin-like growth factor binding proteins in follicular fluid from morphologically distinct healthy and atretic bovine antral follicles
    H F Irving-Rodgers
    Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide, SA, Australia
    Reprod Fertil Dev 15:241-8. 2003
  10. ncbi A T cell controlled molecular pathway regulating the IgH locus: CD40-mediated activation of the IgH 3' enhancer
    P A Grant
    Center for Biotechnology, Karolinska Institute, Novum, Huddinge, Sweden
    EMBO J 15:6691-700. 1996

Collaborators

Detail Information

Publications11

  1. ncbi The ATM-related cofactor Tra1 is a component of the purified SAGA complex
    P A Grant
    Howard Hughes Medical Institute, Pennsylvania State University, University Park 16802 4500, USA
    Mol Cell 2:863-7. 1998
    ..These results indicate a role for Tra1 in the regulation of transcriptional activation through the recruitment of HAT activity to an activator-bound promoter...
  2. ncbi A subset of TAF(II)s are integral components of the SAGA complex required for nucleosome acetylation and transcriptional stimulation
    P A Grant
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802 4500, USA
    Cell 94:45-53. 1998
    ..These results illustrate a role for certain TAF(II) proteins in the regulation of gene expression at the level of chromatin modification that is distinct from the TFIID complex and TAF(II)145...
  3. ncbi Yeast Gcn5 functions in two multisubunit complexes to acetylate nucleosomal histones: characterization of an Ada complex and the SAGA (Spt/Ada) complex
    P A Grant
    Department of Biochemistry and Molecular Biology and The Center for Gene Regulation, The Pennsylvania State University, University Park 16802 4500, USA
    Genes Dev 11:1640-50. 1997
    ..e., tbp)...
  4. ncbi Transcriptional activators direct histone acetyltransferase complexes to nucleosomes
    R T Utley
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park 16802 4500, USA
    Nature 394:498-502. 1998
    ..Our results demonstrate the targeting of native HAT complexes by a transcription-activation domain to nucleosomes in order to activate transcription...
  5. ncbi Expanded lysine acetylation specificity of Gcn5 in native complexes
    P A Grant
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802 4500, USA
    J Biol Chem 274:5895-900. 1999
    ..Furthermore Ada and SAGA have overlapping, yet distinct, patterns of acetylation, suggesting that the association of specific subunits determines site specificity...
  6. ncbi Sds3 (suppressor of defective silencing 3) is an integral component of the yeast Sin3[middle dot]Rpd3 histone deacetylase complex and is required for histone deacetylase activity
    T Lechner
    Howard Hughes Medical Institute, Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802 4500, USA
    J Biol Chem 275:40961-6. 2000
    ..Moreover, the remaining Rpd3p complex in the sds3Delta strain had little or no histone deacetylase activity. Thus, Sds3p plays important roles in the integrity and catalytic activity of the Rpd3p.Sin3p complex...
  7. ncbi Functional organization of the yeast SAGA complex: distinct components involved in structural integrity, nucleosome acetylation, and TATA-binding protein interaction
    D E Sterner
    The Wistar Institute, Philadelphia, Pennsylvania 19104, USA
    Mol Cell Biol 19:86-98. 1999
    ..Loss of either of these causes slight impairment in vivo, but loss of both is highly detrimental to growth and transcription...
  8. ncbi The something about silencing protein, Sas3, is the catalytic subunit of NuA3, a yTAF(II)30-containing HAT complex that interacts with the Spt16 subunit of the yeast CP (Cdc68/Pob3)-FACT complex
    S John
    Howard Hughes Medical Institute HHMI, Penn State University, University Park, Pennsylvania 16802 4500, USA
    Genes Dev 14:1196-208. 2000
    ..This interaction suggests that the NuA3 complex might function in concert with FACT-CP to stimulate transcription or replication elongation through nucleosomes by providing a coupled acetyltransferase activity...
  9. ncbi Insulin-like growth factor binding proteins in follicular fluid from morphologically distinct healthy and atretic bovine antral follicles
    H F Irving-Rodgers
    Department of Obstetrics and Gynaecology, University of Adelaide, Adelaide, SA, Australia
    Reprod Fertil Dev 15:241-8. 2003
    ..Thus, IGFBP levels are not related to the different types of healthy or atretic follicles...
  10. ncbi A T cell controlled molecular pathway regulating the IgH locus: CD40-mediated activation of the IgH 3' enhancer
    P A Grant
    Center for Biotechnology, Karolinska Institute, Novum, Huddinge, Sweden
    EMBO J 15:6691-700. 1996
    ....
  11. ncbi The SAGA continues: expanding the cellular role of a transcriptional co-activator complex
    S P Baker
    Department of Biochemistry and Molecular Genetics, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Oncogene 26:5329-40. 2007
    ..8-MDa complex in multiple cellular processes, and how misregulation of the homologous complexes in humans may ultimately play a role in development of disease...