THOMAS W contact GARDNER

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability
    Nicole S Harhaj
    Departments of Cellular and Molecular Physiology, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Invest Ophthalmol Vis Sci 47:5106-15. 2006
  2. ncbi request reprint New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets
    T W Gardner
    Department of Ophthalmology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Diabetes Technol Ther 2:601-8. 2000
  3. doi request reprint Diabetic macular oedema and visual loss: relationship to location, severity and duration
    Thomas W Gardner
    Department of Ophthalmology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Acta Ophthalmol 87:709-13. 2009
  4. ncbi request reprint An extension of the Early Treatment Diabetic Retinopathy Study (ETDRS) system for grading of diabetic macular edema in the Astemizole Retinopathy Trial
    Thomas W Gardner
    Department of Ophthalmology, Penn State College of Medicine, Hershey, PA 17033, USA
    Curr Eye Res 31:535-47. 2006
  5. ncbi request reprint Novel potential mechanisms for diabetic macular edema: leveraging new investigational approaches
    Thomas W Gardner
    Department of Ophthalmology, Penn State College of Medicine, HU19, 500 University Drive, Hershey, PA 17033, USA
    Curr Diab Rep 8:263-9. 2008
  6. ncbi request reprint Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling
    Eun Gyoung Hong
    Dept of Cellular and Molecular Physiology, Penn State Univ College of Medicine, 500 University Dr H166 C4600D, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 293:E1687-96. 2007
  7. doi request reprint PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells
    Swarajit K Biswas
    Penn State Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Invest Ophthalmol Vis Sci 49:3687-98. 2008
  8. doi request reprint Effect of IL-1beta on survival and energy metabolism of R28 and RGC-5 retinal neurons
    Steve F Abcouwer
    Department of Surgery, Penn State Diabetic Retinopathy Center, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033 0850, USA
    Invest Ophthalmol Vis Sci 49:5581-92. 2008
  9. ncbi request reprint Diabetic retinopathy: seeing beyond glucose-induced microvascular disease
    David A Antonetti
    Department of Ophthalmology, Penn State College of Medicine, Hershey, PA 17033, USA
    Diabetes 55:2401-11. 2006
  10. doi request reprint Neuroprotection for diabetic retinopathy
    Hisanori Imai
    Penn State Hershey Eye Center and Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA
    Dev Ophthalmol 44:56-68. 2009

Research Grants

  1. MECHANISMS OF RETINAL VASCULAR PERMEABILITY IN DIABETES
    Thomas Gardner; Fiscal Year: 2002
  2. MECHANISMS OF RETINAL VASCULAR PERMEABILITY IN DIABETES
    Thomas Gardner; Fiscal Year: 2004
  3. Regulation of Retinal Cell Death in Diabetes
    THOMAS W contact GARDNER; Fiscal Year: 2010

Detail Information

Publications34

  1. ncbi request reprint VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeability
    Nicole S Harhaj
    Departments of Cellular and Molecular Physiology, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Invest Ophthalmol Vis Sci 47:5106-15. 2006
    ..This study was conducted to examine how VEGF and diabetes alter occludin phosphorylation and endothelial cell permeability...
  2. ncbi request reprint New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targets
    T W Gardner
    Department of Ophthalmology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Diabetes Technol Ther 2:601-8. 2000
    ..Understanding the individual cell-specific and global inflammatory changes in the retina may lead to novel therapeutic approaches to prevent vision loss...
  3. doi request reprint Diabetic macular oedema and visual loss: relationship to location, severity and duration
    Thomas W Gardner
    Department of Ophthalmology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Acta Ophthalmol 87:709-13. 2009
    ..To assess the relationship between visual acuity (VA) and diabetic macular oedema (DMO) in relation to the location of retinal thickening and the severity and duration of central macular thickening...
  4. ncbi request reprint An extension of the Early Treatment Diabetic Retinopathy Study (ETDRS) system for grading of diabetic macular edema in the Astemizole Retinopathy Trial
    Thomas W Gardner
    Department of Ophthalmology, Penn State College of Medicine, Hershey, PA 17033, USA
    Curr Eye Res 31:535-47. 2006
    ....
  5. ncbi request reprint Novel potential mechanisms for diabetic macular edema: leveraging new investigational approaches
    Thomas W Gardner
    Department of Ophthalmology, Penn State College of Medicine, HU19, 500 University Drive, Hershey, PA 17033, USA
    Curr Diab Rep 8:263-9. 2008
    ..Further studies are needed to understand the regulation of normal blood-retinal barrier physiology and the relationship between events in animal models of diabetic retinopathy and humans with diabetes...
  6. ncbi request reprint Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodeling
    Eun Gyoung Hong
    Dept of Cellular and Molecular Physiology, Penn State Univ College of Medicine, 500 University Dr H166 C4600D, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 293:E1687-96. 2007
    ..Our findings provide important insights into the pathogenesis of metabolic abnormalities and complications affecting type 1 diabetes and lean type 2 diabetes subjects...
  7. doi request reprint PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cells
    Swarajit K Biswas
    Penn State Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Invest Ophthalmol Vis Sci 49:3687-98. 2008
    ..To compare PDGF- and insulin/IGF-1-induced class I(A) PI 3-kinase/Akt survival signaling in normal retinas and retinal ganglion cells (RGCs)...
  8. doi request reprint Effect of IL-1beta on survival and energy metabolism of R28 and RGC-5 retinal neurons
    Steve F Abcouwer
    Department of Surgery, Penn State Diabetic Retinopathy Center, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033 0850, USA
    Invest Ophthalmol Vis Sci 49:5581-92. 2008
    ..This study was conducted to examine the effects of IL-1beta on the metabolism and viability of RGC-5 and R28 retinal neuronal cells...
  9. ncbi request reprint Diabetic retinopathy: seeing beyond glucose-induced microvascular disease
    David A Antonetti
    Department of Ophthalmology, Penn State College of Medicine, Hershey, PA 17033, USA
    Diabetes 55:2401-11. 2006
    ..Potential means to overcome limitations of current animal models and diagnostic testing are also presented with the goal of accelerating therapies to manage retinopathy in the face of ongoing diabetes...
  10. doi request reprint Neuroprotection for diabetic retinopathy
    Hisanori Imai
    Penn State Hershey Eye Center and Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA
    Dev Ophthalmol 44:56-68. 2009
    ..Finally, we discuss current neuroprotective strategies and future directions for the treatment of DR...
  11. ncbi request reprint Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulin
    Chad E N Reiter
    Dept of Cellular and Molecular Physiology, Juvenile Diabetes Research Foundation Diabetic Retinopathy Center, Penn State College of Medicine, Hershey, PA 17033, USA
    Diabetes 55:1148-56. 2006
    ....
  12. ncbi request reprint The Ins2Akita mouse as a model of early retinal complications in diabetes
    Alistair J Barber
    Penn State Retina Research Group, The Ulerich Ophthalmology Research Laboratory, Penn State College of Medicine, Hershey, 17033, USA
    Invest Ophthalmol Vis Sci 46:2210-8. 2005
    ..Male mice heterozygous for this mutation have progressive loss of beta-cell function, decreased pancreatic beta-cell density, and significant hyperglycemia, as early as 4 weeks of age...
  13. ncbi request reprint Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathy
    J Kyle Krady
    Dept of Neural and Behavioral Sciences, H109, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Diabetes 54:1559-65. 2005
    ....
  14. pmc The significance of vascular and neural apoptosis to the pathology of diabetic retinopathy
    Alistair J Barber
    Department of Ophthalmology, Penn State Hershey Eye Center, Penn State Hershey College of Medicine, Hershey, Pennsylvania 17033, USA
    Invest Ophthalmol Vis Sci 52:1156-63. 2011
    ....
  15. pmc Insulin signaling in retinal neurons is regulated within cholesterol-enriched membrane microdomains
    Todd E Fox
    Dept of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 300:E600-9. 2011
    ....
  16. ncbi request reprint Analysis of glucose metabolism in diabetic rat retinas
    M Shamsul Ola
    Dept of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, P O Box 850, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 290:E1057-67. 2006
    ..Metabolites upstream of glucose such as the sorbitol pathway (which decreases NADPH) and polyol synthesis are increased...
  17. pmc Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in culture
    Tabitha L Schrufer
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Diabetes 59:2107-16. 2010
    ..Here, we tested the hypothesis that hyperglycemia mediates induction of VEGF expression in a eukaryotic initiation factor 4E (eIF4E) binding protein (4E-BP) 1 and 2 dependent manner...
  18. ncbi request reprint Diabetic retinopathy: more than meets the eye
    Thomas W Gardner
    Department of Ophthalmology, Penn State University College of Medicine, Hershey, PA 17033, USA
    Surv Ophthalmol 47:S253-62. 2002
    ..Together, these new observations provide a broader clinical and research perspective on diabetic retinal vascular dysfunction than previously considered, and provide new avenues for improved treatments to prevent loss of vision...
  19. ncbi request reprint Characterization of insulin signaling in rat retina in vivo and ex vivo
    Chad E N Reiter
    Department of Cellular and Molecular Physiology, Penn State University College of Medicine, 500 University Drive H166, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 285:E763-74. 2003
    ..These findings may have implications in understanding normal and dysfunctional retinal physiology...
  20. pmc Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathy
    Todd E Fox
    Department of Pharmacology H078, Penn State College of Medicine, Hershey, PA 17033, USA
    Diabetes 55:3573-80. 2006
    ..Thus, dysfunctional glycosphingolipid metabolism may contribute to metabolic stress in diabetes, and therapeutic strategies to restore normal sphingolipid metabolism may be a viable approach for treatment of diabetic retinopathy...
  21. ncbi request reprint Functions of insulin and insulin receptor signaling in retina: possible implications for diabetic retinopathy
    Chad E N Reiter
    Department of Cellular and Molecular Physiology, The Ulerich Ophthalmology Research Center, M S Hershey Medical Center, 500 University Drive, Hershey, PA 17033 USA
    Prog Retin Eye Res 22:545-62. 2003
    ..The review also addresses the hypothesis that dysfunctional insulin receptor signaling in the retina contributes to cell dysfunction and death in retinal diseases...
  22. pmc An eye on insulin
    Sarah K Bronson
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Invest 111:1817-9. 2003
    ..Insulin and IGF-1 signaling are now shown to contribute to retinal neovascularization, in part, by modulating the expression of various vascular mediators...
  23. ncbi request reprint Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent manner
    Xiaohua Wu
    Department of Ophthalmology and Ulerich Ophthalmology Research Center, the JDRF Diabetic Retinopathy Center at Pennsylvania State University, Hershey, PA 17033, USA
    J Biol Chem 279:9167-75. 2004
    ..Together, these results suggest that p70S6K plays a key role in insulin stimulated retinal neuronal cell survival...
  24. pmc The retinal proteome in experimental diabetic retinopathy: up-regulation of crystallins and reversal by systemic and periocular insulin
    Patrice E Fort
    Department of Ophthalmology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Mol Cell Proteomics 8:767-79. 2009
    ..Altogether this work shows the importance of proteomics discovery methods coupled with targeted approaches to unveil new disease mechanistic details and therapeutic targets...
  25. ncbi request reprint Retinal angiogenesis in development and disease
    Ray F Gariano
    Department of Ophthalmology, A 157, 300 Pasteur Drive, Stanford University School of Medicine, Palo Alto, California 94305, USA
    Nature 438:960-6. 2005
    ..The retina and its clinical disorders have a pivotal role in angiogenesis research and provide model systems in which to investigate neurovascular relationships and angiogenic diseases...
  26. ncbi request reprint Optic disk drusen, peripapillary choroidal neovascularization, and POEMS syndrome
    Jorge M Diduszyn
    Department of Ophthalmology, Pennsylvania State University, Hershey, Pennsylvania, USA
    Am J Ophthalmol 133:275-6. 2002
    ....
  27. ncbi request reprint Retinopathy in diabetes
    Donald S Fong
    Diabetes Care 27:S84-7. 2004
  28. ncbi request reprint Diabetic retinopathy
    Donald S Fong
    Diabetes Care 26:S99-S102. 2003
  29. ncbi request reprint Diabetic retinopathy
    Donald S Fong
    Diabetes Care 26:226-9. 2003
  30. pmc Optical coherence tomography measurements and analysis methods in optical coherence tomography studies of diabetic macular edema
    David J Browning
    Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA
    Ophthalmology 115:1366-71, 1371.e1. 2008
    ..To evaluate optical coherence tomography (OCT) measurements and methods of analysis of OCT data in studies of diabetic macular edema (DME)...
  31. ncbi request reprint Light scatter causes the grayness of detached retinas: implications for vision loss in retinal detachment
    Shizhuo Yin
    Department of Electrical Engineering, Pennsylvania State University, University Park, USA
    Arch Ophthalmol 121:1002-8. 2003
    ..To investigate the cause of the gray appearance of the detached retina...
  32. ncbi request reprint A prize catch for diabetic retinopathy
    Thomas W Gardner
    Nat Med 13:131-2. 2007
  33. ncbi request reprint Ruboxistaurin for diabetic retinopathy
    Thomas W Gardner
    Ophthalmology 113:2135-6. 2006

Research Grants8

  1. MECHANISMS OF RETINAL VASCULAR PERMEABILITY IN DIABETES
    Thomas Gardner; Fiscal Year: 2002
    ..This combination of molecular and functional analyses will provide new insights into the pathogenesis of vascular permeability in diabetes and other retinopathies. ..
  2. MECHANISMS OF RETINAL VASCULAR PERMEABILITY IN DIABETES
    Thomas Gardner; Fiscal Year: 2004
    ..abstract_text> ..
  3. Regulation of Retinal Cell Death in Diabetes
    THOMAS W contact GARDNER; Fiscal Year: 2010
    ..The projected outcome is to have better means to maintain the health of retinal nerve cells in persons with diabetes to preserve vision and reduce the need for laser treatments. ..