Research Topics
Species | THOMAS W contact GARDNERSummaryAffiliation: Pennsylvania State University Country: USA Publications
Research Grants
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Detail Information
Publications
VEGF activation of protein kinase C stimulates occludin phosphorylation and contributes to endothelial permeabilityNicole S Harhaj
Departments of Cellular and Molecular Physiology, Penn State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Invest Ophthalmol Vis Sci 47:5106-15. 2006..Regulation of PKC activity and tight junction protein modifications may have therapeutic implications for treatment of diabetic retinopathy and brain tumors...- New insights into the pathophysiology of diabetic retinopathy: potential cell-specific therapeutic targetsT W Gardner
Department of Ophthalmology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
Diabetes Technol Ther 2:601-8. 2000..Understanding the individual cell-specific and global inflammatory changes in the retina may lead to novel therapeutic approaches to prevent vision loss... 
Diabetic macular oedema and visual loss: relationship to location, severity and durationThomas W Gardner
Department of Ophthalmology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
Acta Ophthalmol 87:709-13. 2009..To assess the relationship between visual acuity (VA) and diabetic macular oedema (DMO) in relation to the location of retinal thickening and the severity and duration of central macular thickening...- An extension of the Early Treatment Diabetic Retinopathy Study (ETDRS) system for grading of diabetic macular edema in the Astemizole Retinopathy TrialThomas W Gardner
Department of Ophthalmology, Penn State College of Medicine, Hershey, PA 17033, USA
Curr Eye Res 31:535-47. 2006.... - Novel potential mechanisms for diabetic macular edema: leveraging new investigational approachesThomas W Gardner
Department of Ophthalmology, Penn State College of Medicine, HU19, 500 University Drive, Hershey, PA 17033, USA
Curr Diab Rep 8:263-9. 2008..Further studies are needed to understand the regulation of normal blood-retinal barrier physiology and the relationship between events in animal models of diabetic retinopathy and humans with diabetes... - Nonobese, insulin-deficient Ins2Akita mice develop type 2 diabetes phenotypes including insulin resistance and cardiac remodelingEun Gyoung Hong
Dept of Cellular and Molecular Physiology, Penn State Univ College of Medicine, 500 University Dr H166 C4600D, Hershey, PA 17033, USA
Am J Physiol Endocrinol Metab 293:E1687-96. 2007..Our findings provide important insights into the pathogenesis of metabolic abnormalities and complications affecting type 1 diabetes and lean type 2 diabetes subjects... - PDGF- and insulin/IGF-1-specific distinct modes of class IA PI 3-kinase activation in normal rat retinas and RGC-5 retinal ganglion cellsSwarajit K Biswas
Penn State Heart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
Invest Ophthalmol Vis Sci 49:3687-98. 2008..To compare PDGF- and insulin/IGF-1-induced class I(A) PI 3-kinase/Akt survival signaling in normal retinas and retinal ganglion cells (RGCs)... - Effect of IL-1beta on survival and energy metabolism of R28 and RGC-5 retinal neuronsSteve F Abcouwer
Department of Surgery, Penn State Diabetic Retinopathy Center, Penn State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033 0850, USA
Invest Ophthalmol Vis Sci 49:5581-92. 2008..This study was conducted to examine the effects of IL-1beta on the metabolism and viability of RGC-5 and R28 retinal neuronal cells... - Diabetic retinopathy: seeing beyond glucose-induced microvascular diseaseDavid A Antonetti
Department of Ophthalmology, Penn State College of Medicine, Hershey, PA 17033, USA
Diabetes 55:2401-11. 2006..Potential means to overcome limitations of current animal models and diagnostic testing are also presented with the goal of accelerating therapies to manage retinopathy in the face of ongoing diabetes... - Neuroprotection for diabetic retinopathyHisanori Imai
Penn State Hershey Eye Center and Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, PA 17033, USA
Dev Ophthalmol 44:56-68. 2009..Finally, we discuss current neuroprotective strategies and future directions for the treatment of DR... - Diabetes reduces basal retinal insulin receptor signaling: reversal with systemic and local insulinChad E N Reiter
Dept. of Cellular and Molecular Physiology, Juvenile Diabetes Research Foundation Diabetic Retinopathy Center, Penn State College of Medicine, Hershey, PA 17033, USA
Diabetes 55:1148-56. 2006.... - The Ins2Akita mouse as a model of early retinal complications in diabetesAlistair J Barber
Penn State Retina Research Group, The Ulerich Ophthalmology Research Laboratory, Penn State College of Medicine, Hershey, 17033, USA
Invest Ophthalmol Vis Sci 46:2210-8. 2005..Male mice heterozygous for this mutation have progressive loss of beta-cell function, decreased pancreatic beta-cell density, and significant hyperglycemia, as early as 4 weeks of age... - Minocycline reduces proinflammatory cytokine expression, microglial activation, and caspase-3 activation in a rodent model of diabetic retinopathyJ Kyle Krady
Dept of Neural and Behavioral Sciences, H109, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Diabetes 54:1559-65. 2005.... 
The significance of vascular and neural apoptosis to the pathology of diabetic retinopathyAlistair J Barber
Department of Ophthalmology, Penn State Hershey Eye Center, Penn State Hershey College of Medicine, Hershey, Pennsylvania 17033, USA
Invest Ophthalmol Vis Sci 52:1156-63. 2011....- Insulin signaling in retinal neurons is regulated within cholesterol-enriched membrane microdomainsTodd E Fox
Dept of Pharmacology, Penn State College of Medicine, Hershey, PA 17033, USA
Am J Physiol Endocrinol Metab 300:E600-9. 2011.... - Analysis of glucose metabolism in diabetic rat retinasM Shamsul Ola
Dept. of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, P.O. Box 850, Hershey, PA 17033, USA
Am J Physiol Endocrinol Metab 290:E1057-67. 2006..Metabolites upstream of glucose such as the sorbitol pathway (which decreases NADPH) and polyol synthesis are increased... - Ablation of 4E-BP1/2 prevents hyperglycemia-mediated induction of VEGF expression in the rodent retina and in Muller cells in cultureTabitha L Schrufer
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
Diabetes 59:2107-16. 2010..Here, we tested the hypothesis that hyperglycemia mediates induction of VEGF expression in a eukaryotic initiation factor 4E (eIF4E) binding protein (4E-BP) 1 and 2 dependent manner... - Diabetic retinopathy: more than meets the eyeThomas W Gardner
Department of Ophthalmology, Penn State University College of Medicine, Hershey, PA 17033, USA
Surv Ophthalmol 47:S253-62. 2002..Together, these new observations provide a broader clinical and research perspective on diabetic retinal vascular dysfunction than previously considered, and provide new avenues for improved treatments to prevent loss of vision... - Characterization of insulin signaling in rat retina in vivo and ex vivoChad E N Reiter
Department of Cellular and Molecular Physiology, Penn State University College of Medicine, 500 University Drive H166, Hershey, PA 17033, USA
Am J Physiol Endocrinol Metab 285:E763-74. 2003..These findings may have implications in understanding normal and dysfunctional retinal physiology... - Diabetes alters sphingolipid metabolism in the retina: a potential mechanism of cell death in diabetic retinopathyTodd E Fox
Department of Pharmacology H078, Penn State College of Medicine, Hershey, PA 17033, USA
Diabetes 55:3573-80. 2006..Thus, dysfunctional glycosphingolipid metabolism may contribute to metabolic stress in diabetes, and therapeutic strategies to restore normal sphingolipid metabolism may be a viable approach for treatment of diabetic retinopathy... - Functions of insulin and insulin receptor signaling in retina: possible implications for diabetic retinopathyChad E N Reiter
Department of Cellular and Molecular Physiology, The Ulerich Ophthalmology Research Center, M.S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033 USA
Prog Retin Eye Res 22:545-62. 2003..The review also addresses the hypothesis that dysfunctional insulin receptor signaling in the retina contributes to cell dysfunction and death in retinal diseases... - An eye on insulinSarah K Bronson
Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
J Clin Invest 111:1817-9. 2003..Insulin and IGF-1 signaling are now shown to contribute to retinal neovascularization, in part, by modulating the expression of various vascular mediators... - Insulin promotes rat retinal neuronal cell survival in a p70S6K-dependent mannerXiaohua Wu
Department of Ophthalmology and Ulerich Ophthalmology Research Center, the JDRF Diabetic Retinopathy Center at Pennsylvania State University, Hershey, PA 17033, USA
J Biol Chem 279:9167-75. 2004..Together, these results suggest that p70S6K plays a key role in insulin stimulated retinal neuronal cell survival... - The retinal proteome in experimental diabetic retinopathy: up-regulation of crystallins and reversal by systemic and periocular insulinPatrice E Fort
Department of Ophthalmology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
Mol Cell Proteomics 8:767-79. 2009..Altogether this work shows the importance of proteomics discovery methods coupled with targeted approaches to unveil new disease mechanistic details and therapeutic targets... - Retinal angiogenesis in development and diseaseRay F Gariano
Department of Ophthalmology, A 157, 300 Pasteur Drive, Stanford University School of Medicine, Palo Alto, California 94305, USA
Nature 438:960-6. 2005..The retina and its clinical disorders have a pivotal role in angiogenesis research and provide model systems in which to investigate neurovascular relationships and angiogenic diseases... - Optic disk drusen, peripapillary choroidal neovascularization, and POEMS syndromeJorge M Diduszyn
Department of Ophthalmology, Pennsylvania State University, Hershey, Pennsylvania, USA
Am J Ophthalmol 133:275-6. 2002..RESULTS: Laser photocoagulation resolved the peripapillary choroidal neovascularization. CONCLUSION: This is the first documented case of optic disk drusen and peripapillary choroidal neovascularization associated with POEMS... - Retinopathy in diabetesDonald S Fong
Diabetes Care 27:S84-7. 2004 - Diabetic retinopathyDonald S Fong
Diabetes Care 26:S99-S102. 2003 - Diabetic retinopathyDonald S Fong
Diabetes Care 26:226-9. 2003 - Optical coherence tomography measurements and analysis methods in optical coherence tomography studies of diabetic macular edemaDavid J Browning
Jaeb Center for Health Research, 15310 Amberly Drive, Suite 350, Tampa, FL 33647, USA
Ophthalmology 115:1366-71, 1371.e1. 2008..To evaluate optical coherence tomography (OCT) measurements and methods of analysis of OCT data in studies of diabetic macular edema (DME)... - Light scatter causes the grayness of detached retinas: implications for vision loss in retinal detachmentShizhuo Yin
Department of Electrical Engineering, Pennsylvania State University, University Park, USA
Arch Ophthalmol 121:1002-8. 2003..Clinical Relevance The findings suggest that visual loss in retinal detachment may result, in part, from optical properties of the detached retina and have implications for visual recovery and subretinal surgery... - A prize catch for diabetic retinopathyThomas W Gardner
Nat Med 13:131-2. 2007 - Ruboxistaurin for diabetic retinopathyThomas W Gardner
Ophthalmology 113:2135-6. 2006
Research Grants
- MECHANISMS OF RETINAL VASCULAR PERMEABILITY IN DIABETESThomas Gardner; Fiscal Year: 2002..This combination of molecular and functional analyses will provide new insights into the pathogenesis of vascular permeability in diabetes and other retinopathies. ..
- MECHANISMS OF RETINAL VASCULAR PERMEABILITY IN DIABETESThomas Gardner; Fiscal Year: 2004..abstract_text> ..
- Regulation of Retinal Cell Death in DiabetesTHOMAS W contact GARDNER; Fiscal Year: 2010..The projected outcome is to have better means to maintain the health of retinal nerve cells in persons with diabetes to preserve vision and reduce the need for laser treatments. ..