Genomes and Genes
Stephanie M Fullerton
Affiliation: Pennsylvania State University
- Polymorphism and divergence in the beta-globin replication origin initiation regionS M Fullerton
Department of Biology, Pennsylvania State University, University Park 16802, USA
Mol Biol Evol 17:179-88. 2000..The significance of these findings for our understanding of eukaryotic replication origin biology is discussed...
- Apolipoprotein E variation at the sequence haplotype level: implications for the origin and maintenance of a major human polymorphismS M Fullerton
Institute of Molecular Evolutionary Genetics, Department of Biology, and Department of Anthropology, Pennsylvania State University, University Park, PA 16802, USA
Am J Hum Genet 67:881-900. 2000....
- Sequence polymorphism at the human apolipoprotein AII gene ( APOA2): unexpected deficit of variation in an African-American sampleStephanie M Fullerton
Institute of Molecular Evolutionary Genetics, Department of Biology, Pennsylvania State University, University Park 16802, USA
Hum Genet 111:75-87. 2002..The deficit of polymorphism is consistent with a population-specific non-neutral increase in the relative frequency of several haplotypes in Jackson...
- The effects of scale: variation in the APOA1/C3/A4/A5 gene clusterStephanie M Fullerton
Department of Anthropology, Penn State University, 409 Carpenter Bldg, University Park, PA 16802, USA
Hum Genet 115:36-56. 2004..The implications of these findings for other haplotype-based descriptions of human variation are discussed...
- Dissecting complex disease: the quest for the Philosopher's Stone?Anne V Buchanan
Department of Anthropology, Penn State University, University Park, PA 16802, USA
Int J Epidemiol 35:562-71. 2006..Finally, we ask whether most complex diseases are even good candidates for the kind of prediction and prevention that we have come to expect based on experience with infectious and Mendelian disease...
- Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locusStephanie M Fullerton
Department of Human Genetics, The University of Chicago, Chicago, IL 60637, USA
Am J Hum Genet 70:1096-106. 2002..These results suggest a history of positive natural selection at the locus, resulting in significant geographic differences in polymorphism frequencies. The relationship of these differences to disease risk is discussed...
- Racialized genetics and the study of complex diseases: the thrifty genotype revisitedYin C Paradies
Menzies School of Health Research, Institute of Advanced Studies, Charles Darwin University, Casuarina NT, Australia
Perspect Biol Med 50:203-27. 2007..A robust interdisciplinary approach to genetic epidemiological research is proposed...
- Negotiating Complexity: Common Disease & Diverse GenomesSTEPHANIE FULLERTON; Fiscal Year: 2004..Research methods will include extensive archival research (of both primary data reports and related press coverage) as well as semi-structured interviews with human geneticists. ..