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Genomes and Genes | R A FrostSummaryAffiliation: Pennsylvania State University Country: USA Publications
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Publications
Multifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscleRobert A Frost
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Endocrinol Metab Clin North Am 41:297-322, vi. 2012....
Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscleRobert A Frost
Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Physiol Regul Integr Comp Physiol 283:R698-709. 2002..Our data suggest that LPS stimulates cytokine expression not only in classical immune tissues but also in skeletal muscle...- Regulation of IGF-I mRNA and signal transducers and activators of transcription-3 and -5 (Stat-3 and -5) by GH in C2C12 myoblastsRobert A Frost
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Endocrinology 143:492-503. 2002..In addition, C2C12 cells appear to be a good model system to examine GH regulation of Janus kinase/Stat signaling and the regulation of IGF-I mRNA... - Protein kinase B/Akt: a nexus of growth factor and cytokine signaling in determining muscle massRobert A Frost
Department of Cellular and Molecular Physiology, The Penn State University College of Medicine, Hershey, PA 17033, USA
J Appl Physiol 103:378-87. 2007..Activation of Akt stimulates muscle hypertrophy and antagonizes the loss of muscle protein. Here we review the many signals that funnel through Akt to alter muscle mass... - Multiple Toll-like receptor ligands induce an IL-6 transcriptional response in skeletal myocytesRobert A Frost
Department of Cellular and Molecular Physiology H166, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, Pennsylvania 17033, USA
Am J Physiol Regul Integr Comp Physiol 290:R773-84. 2006..The data suggest that skeletal muscle and muscle cells recognize pathogen-associated molecules with specific TLRs to initiate an IL-6 transcriptional response... - Regulation of insulin-like growth factor-I in skeletal muscle and muscle cellsR A Frost
Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University Hershey, PA 17033, USA
Minerva Endocrinol 28:53-73. 2003..A special emphasis will be placed on the interaction of IGF-I and proinflammatory cytokines in skeletal muscle and muscle cells... - Skeletal muscle cytokines: regulation by pathogen-associated molecules and catabolic hormonesRobert A Frost
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, 17033, USA
Curr Opin Clin Nutr Metab Care 8:255-63. 2005..A special emphasis is placed on recent studies that examine the interaction of insulin-like growth factor 1 and proinflammatory cytokines as positive and negative regulators of muscle mass... - Tumor necrosis factor-alpha decreases insulin-like growth factor-I messenger ribonucleic acid expression in C2C12 myoblasts via a Jun N-terminal kinase pathwayRobert A Frost
Department of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
Endocrinology 144:1770-9. 2003..These data suggest that LPS stimulates TNF alpha expression in mouse skeletal muscle and autocrine-derived cytokines may contribute to the reduced expression of IGF-I in this tissue... - Alteration of somatotropic function by proinflammatory cytokinesR A Frost
Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey 17033, USA
J Anim Sci 82:E100-109. 2004..Current work is focused on deciphering the mechanism by which muscle becomes GH resistant and the development of therapies to maintain muscle protein stores during infection... - Lipopolysaccharide and proinflammatory cytokines stimulate interleukin-6 expression in C2C12 myoblasts: role of the Jun NH2-terminal kinaseRobert A Frost
Dept of Cellular and Molecular Physiology, Penn State Univ College of Medicine, Hershey Medical Center H166, Hershey, PA 17033, USA
Am J Physiol Regul Integr Comp Physiol 285:R1153-64. 2003..Yet, only SP-600125 and not MG-132 blocked LPS-induced IL-6 mRNA expression. This suggests that IL-6 gene expression is a downstream target of JNK in C2C12 myoblasts... - Lipopolysaccharide stimulates nitric oxide synthase-2 expression in murine skeletal muscle and C(2)C(12) myoblasts via Toll-like receptor-4 and c-Jun NH(2)-terminal kinase pathwaysRobert A Frost
Department of Cellular and Molecular Physiology, College of Medicine, The Pennsylvania State University, Hershey Medical Center H166, 500 University Dr, Hershey, PA 17033, USA
Am J Physiol Cell Physiol 287:C1605-15. 2004..Moreover, the JNK inhibitor prevented the LPS-induced increase in NO synthesis. These data indicate that LPS increases NOS2 mRNA expression in muscle via a TLR4-dependent mechanism... 
Regulation of muscle growth by pathogen-associated moleculesR A Frost
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Anim Sci 86:E84-93. 2008..The interplay between inflammatory components and growth factor signaling clearly places muscle at the interface between growth and immunity...- Epinephrine stimulates IL-6 expression in skeletal muscle and C2C12 myoblasts: role of c-Jun NH2-terminal kinase and histone deacetylase activityRobert A Frost
Department of Cellular and Molecular Physiology, Penn State Univ College of Medicine, Hershey Medical Center H166, Hershey, PA 17033, USA
Am J Physiol Endocrinol Metab 286:E809-17. 2004..Endotoxin and epinephrine synergize to increase IL-6 mRNA expression. Optimal IL-6 synthesis may require both stress kinase and histone deacetylase activity... - Endotoxin and interferon-gamma inhibit translation in skeletal muscle cells by stimulating nitric oxide synthase activityRobert A Frost
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Shock 32:416-26. 2009.... - Regulation of REDD1 by insulin-like growth factor-I in skeletal muscle and myotubesRobert A Frost
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Cell Biochem 108:1192-202. 2009..We conclude that IGF-I stimulates REDD1 expression in skeletal muscle and myotubes but under these conditions the REDD1 response is not sufficient to repress protein synthesis... - Ethyl pyruvate preserves IGF-I sensitivity toward mTOR substrates and protein synthesis in C2C12 myotubesRobert A Frost
Department of Cellular and Molecular Physiology H166, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA
Endocrinology 152:151-63. 2011..Lipophilic pyruvate derivatives and antioxidants show promise at rescuing mTOR activity and muscle protein synthesis by maintaining IGF-I sensitivity in this model... - Differential effects of insulin-like growth factor I (IGF-I) and IGF-binding protein-1 on protein metabolism in human skeletal muscle cellsR A Frost
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey 17033, USA
Endocrinology 140:3962-70. 1999..BP-1, acting independently of IGF-I, inhibits protein degradation. The IGF-independent response occurs via beta1 integrin binding and stimulation of a rapamycin-sensitive signal transduction pathway... - Stimulation of insulin-like growth factor binding protein-1 synthesis by interleukin-1beta: requirement of the mitogen-activated protein kinase pathwayR A Frost
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey 17033, USA
Endocrinology 141:3156-64. 2000..Our data demonstrate that the MAP kinase signal transduction pathway plays an important role in the regulation of IGFBP-1 synthesis by IL-1beta... - Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4EC H Lang
Departments of Cellular and Molecular Physiology and Surgery, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Physiol 277:E268-76. 1999..In summary, these data suggest that chronic alcohol consumption impairs translation initiation in muscle by altering multiple regulatory sites, including eIF2B activity and eIF4E availability... - Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscleVinayshree Kumar
Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Physiol Endocrinol Metab 283:E917-28. 2002..Hence, acute alcohol intoxication alters selected aspects of translational control under both basal and anabolic hormone-stimulated conditions in skeletal muscle in a glucocorticoid-independent manner... - Impaired protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4E in muscle and eIF2B in liverC H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey 17033 0850, USA
Alcohol Clin Exp Res 24:322-31. 2000..Acute alcohol intoxication in rats decreases protein synthesis in skeletal muscle and, to a lesser extent, in liver. The purpose of the present study was to examine potential mechanisms for the inhibitory effect of acute ethanol exposure... - Endotoxin-induced decrease in muscle protein synthesis is associated with changes in eIF2B, eIF4E, and IGF-IC H Lang
Departments of Cellular and Molecular Physiology, and Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Physiol Endocrinol Metab 278:E1133-43. 2000.... - Chronic alcohol feeding impairs hepatic translation initiation by modulating eIF2 and eIF4EC H Lang
Department of Cellular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Physiol 277:E805-14. 1999..In summary, these data suggest that chronic alcohol consumption impairs translation initiation in liver by altering eIF2B activity as well as eIF4F function via changes in eIF4E availability... - Indinavir alters regulators of protein anabolism and catabolism in skeletal muscleLy Q Hong-Brown
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Physiol Endocrinol Metab 289:E382-90. 2005..In conclusion, indinavir acutely impairs basal protein synthesis and translation initiation in skeletal muscle but, in contrast to muscle glucose uptake, does not impair insulin-stimulated signaling of protein synthetic pathways... - Acute response of IGF-I and IGF binding proteins induced by thermal injuryC H Lang
Departments of Cellular and Molecular Physiology, and Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA
Am J Physiol Endocrinol Metab 278:E1087-96. 2000..These results characterize burn-induced changes in various components of the IGF system in select tissues and thereby provide potential mechanisms for alterations in the circulating IGF system and for changes in tissue metabolism... - Acute alcohol intoxication increases atrogin-1 and MuRF1 mRNA without increasing proteolysis in skeletal muscleThomas C Vary
Department of Cellular and Molecular Physiology H166, Penn State College Medicine, 500 University Dr, Hershey, PA 17033, USA
Am J Physiol Regul Integr Comp Physiol 294:R1777-89. 2008..Therefore, the loss of muscle mass/protein in response to chronic alcohol abuse appears to result primarily from a decrement in muscle protein synthesis, not an increase in degradation... - Skeletal and cardiac myopathy in HIV-1 transgenic ratsAnne M Pruznak
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Physiol Endocrinol Metab 295:E964-73. 2008..Hence, HIV-1 Tg rats develop atrophy of cardiac and skeletal muscle, the latter of which results primarily from an increased protein degradation and may be related to the marked reduction in muscle insulin-like growth factor I... - Impaired myocardial protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4FC H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Physiol Endocrinol Metab 279:E1029-38. 2000.... - Alcohol myopathy: impairment of protein synthesis and translation initiationC H Lang
Department of Cellular and Molecular Physiology H166, Penn State College of Medicine, Hershey, PA 17033, USA
Int J Biochem Cell Biol 33:457-73. 2001..However, defects in the availability or effectiveness of various anabolic hormones, particularly insulin-like growth factor-I, are consistent with the alcohol-induced decrease in protein synthesis and translation initiation... - Tissue-specific regulation of IGF-I and IGF-binding proteins in response to TNFalphaC H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033 0850, USA
Growth Horm IGF Res 11:250-60. 2001.... - Hormone, cytokine, and nutritional regulation of sepsis-induced increases in atrogin-1 and MuRF1 in skeletal muscleRobert A Frost
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Am J Physiol Endocrinol Metab 292:E501-12. 2007..Thus, under in vivo conditions in mature adult rats, the sepsis-induced increase in muscle atrogin-1 and MuRF1 mRNA appears both glucocorticoid and TNF independent and is unresponsive to leucine... - Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin-1beta, -6, and high-mobility-group protein-1 in skeletal muscleCharles H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
Shock 19:538-46. 2003..Collectively these data indicate that skeletal muscle possesses many of the components of the innate immune system, including increases in both early- and late-phase cytokines and the presence of toll-like receptors... - Temporal differences in the ability of ethanol to modulate endotoxin-induced increases in inflammatory cytokines in muscle under in vivo conditionsRobert A Frost
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Alcohol Clin Exp Res 29:1247-56. 2005..Delaying the exposure of animals to LPS for 24 hr after EtOH, however, accentuated the increase in IL-6 and HMGB1, and for IL-6, this increased sensitivity appeared localized to striated muscle... - Alcohol impairs protein synthesis and degradation in cultured skeletal muscle cellsL Q Hong-Brown
Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
Alcohol Clin Exp Res 25:1373-82. 2001..We investigated whether ethanol (EtOH) and its major metabolites, acetaldehyde and acetate, can directly modulate protein balance under in vitro conditions... - Local insulin-like growth factor I prevents sepsis-induced muscle atrophyGerald Nystrom
Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
Metabolism 58:787-97. 2009.... - AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cellsBrian J Krawiec
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
Am J Physiol Endocrinol Metab 292:E1555-67. 2007.... - Acute alterations in growth hormone-insulin-like growth factor axis in humans injected with endotoxinC H Lang
Department of Surgery, State University of New York at Stony Brook 11794 8191, USA
Am J Physiol 273:R371-8. 1997..These data indicate that the acute changes in the GH-IGF axis in humans in response to LPS are comparable with those observed in humans in other traumatic conditions and in animal models of endotoxemia and infection... - Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independently of ethanol metabolismCharles H Lang
Pennsylvania State College of Medicine, Department of Cellular and Molecular Physiology H166, Hershey, PA 17033, USA
Alcohol Clin Exp Res 28:1758-67. 2004.... - Regulation of muscle protein synthesis during sepsis and inflammationCharles H Lang
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Physiol Endocrinol Metab 293:E453-9. 2007.... - TNF-alpha impairs heart and skeletal muscle protein synthesis by altering translation initiationCharles H Lang
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Physiol Endocrinol Metab 282:E336-47. 2002.... - Beta-adrenergic blockade exacerbates sepsis-induced changes in tumor necrosis factor alpha and interleukin-6 in skeletal muscle and is associated with impaired translation initiationCharles H Lang
Departments of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, Hershey, PA, USA
J Trauma 64:477-86. 2008.... - Acute alcohol intoxication increases REDD1 in skeletal muscleCharles H Lang
Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
Alcohol Clin Exp Res 32:796-805. 2008..In this regard, mTOR activity is impaired after over expression of the regulatory protein REDD1. Hence, the present study assessed the ability of REDD1 as a potential mediator of the EtOH-induced decrease in muscle protein synthesis... - Leucine acutely reverses burn-induced alterations in translation initiation in heartCharles H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Shock 22:326-32. 2004..These data suggest that oral administration of leucine can acutely reverse multiple defects in cardiac translation initiation produced by thermal injury... - Burn-induced changes in IGF-I and IGF-binding proteins are partially glucocorticoid dependentCharles H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Physiol Regul Integr Comp Physiol 282:R207-15. 2002..TNFBP failed to completely ameliorate any of the burn-induced changes in the IGF system. These results demonstrate that glucocorticoids, but not TNF, mediate many but not all of the burn-induced changes in the IGF system... - Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscleAnne M Pruznak
Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, PA 17033, USA
J Nutr 138:1887-94. 2008.... - Acute in vivo elevation of insulin-like growth factor (IGF) binding protein-1 decreases plasma free IGF-I and muscle protein synthesisCharles H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Endocrinology 144:3922-33. 2003..Hence, elevations in circulating and tissue levels of IGFBP-1 may be an important mediator for the muscle catabolism observed in various stress conditions... - Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscleCharles H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Physiol Endocrinol Metab 285:E1205-15. 2003..Hence, ethanol produces a leucine resistance in skeletal muscle, as evidenced by the impaired phosphorylation of 4E-BP1, eIF4G, S6K1, and mTOR, that is independent of elevations in endogenous glucocorticoids... - Differential effect of sepsis on ability of leucine and IGF-I to stimulate muscle translation initiationCharles H Lang
Department of Cellular and Molecular Physiology, H166, Pennsylvania State University College of Medicine, 500 University Dr, Hershey 17033, USA
Am J Physiol Endocrinol Metab 287:E721-30. 2004..Hence, sepsis produces a relatively specific Leu resistance in skeletal muscle that impairs the ability of this amino acid to stimulate translation initiation and protein synthesis... - Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucineCharles H Lang
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Am J Physiol Endocrinol Metab 298:E1283-94. 2010..These data support the idea that the LPS-induced reduction in mTOR activity is relatively more important in regulating skeletal muscle mass in response to nutrient stimulation than under basal conditions... - IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed ratsCharles H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Am J Physiol Endocrinol Metab 286:E916-26. 2004..The data support the role of IGF-I as a mediator of chronic alcohol myopathy in rats... - Glucocorticoids and TNFalpha interact cooperatively to mediate sepsis-induced leucine resistance in skeletal muscleCharles H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Mol Med 12:291-9. 2006..Our data demonstrate the sepsis-induced leucine resistance in skeletal muscle results from the cooperative interaction of both TNFalpha and glucocorticoids... - Role of growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins in the catabolic response to injury and infectionCharles H Lang
Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
Curr Opin Clin Nutr Metab Care 5:271-9. 2002..This review focuses on recent developments pertaining to the importance of alterations in the growth hormone-insulin-like growth factor-I axis as a mechanism for the observed defects in muscle protein balance... - Cytokine inhibition of JAK-STAT signaling: a new mechanism of growth hormone resistanceCharles H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Pediatr Nephrol 20:306-12. 2005..Collectively, these changes act to limit IGF-I availability in muscle, which disturbs protein balance and results in the loss of protein stores in catabolic and inflammatory conditions... - Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylationLy Q Hong-Brown
Department of Cellular and Molecular Physiology, Hershey, Pennsylvania 17033, USA
Am J Physiol Endocrinol Metab 285:E63-72. 2003..In conclusion, sepsis produces GH resistance in both muscle and liver, with the locus of this impairment in muscle differing from that in liver and being independent of a defect in STAT5 phosphorylation... - Molecular mechanisms responsible for alcohol-induced myopathy in skeletal muscle and heartCharles H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Int J Biochem Cell Biol 37:2180-95. 2005..Overall, the biochemical mechanisms contributing to the pathogenesis of loss of skeletal and cardiac muscle are reviewed... - Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesisBrian J Krawiec
Dept of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Am J Physiol Endocrinol Metab 289:E969-80. 2005.... - TNFalpha mediates sepsis-induced impairment of basal and leucine-stimulated signaling via S6K1 and eIF4E in cardiac muscleCharles H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Cell Biochem 94:419-31. 2005..Finally, TNFalpha, either directly or indirectly, appears to mediate the sepsis-induced defects in myocardial translation initiation... - Sepsis and inflammatory insults downregulate IGFBP-5, but not IGFBP-4, in skeletal muscle via a TNF-dependent mechanismCharles H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, PA 17033, USA
Am J Physiol Regul Integr Comp Physiol 290:R963-72. 2006..Finally, IGF-I appears to be a dominant positive regulator of IGFBP-5 gene expression in muscle under both normal and catabolic conditions... - Burn-induced increase in atrogin-1 and MuRF-1 in skeletal muscle is glucocorticoid independent but downregulated by IGF-ICharles H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Am J Physiol Regul Integr Comp Physiol 292:R328-36. 2007..In summary, the acute muscle wasting accompanying thermal injury is associated with a glucocorticoid-independent increase in the expression of several Ub E3 ligases that can be downregulated by IGF-I... - Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscleCharles H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Cell Physiol 203:144-55. 2005..Hence, LPS working via a glucocorticoid-independent mechanism produces a leucine resistance in skeletal muscle that might be expected to impair the ability of this amino acid to stimulate translation initiation and protein synthesis... - Sepsis-induced suppression of skeletal muscle translation initiation mediated by tumor necrosis factor alphaCharles H Lang
Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Metabolism 56:49-57. 2007..Hence, the decreased constitutive protein synthesis observed in fast-twitch skeletal muscle in response to peritonitis is mediated by a TNF-dependent mechanism affecting mTOR regulation of translation initiation... - Skeletal muscle protein synthesis and degradation exhibit sexual dimorphism after chronic alcohol consumption but not acute intoxicationCharles H Lang
Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, PA 17033, USA
Am J Physiol Endocrinol Metab 292:E1497-506. 2007.... - Thermal injury impairs cardiac protein synthesis and is associated with alterations in translation initiationCharles H Lang
Department of Cellular and Molecular Physiology H166, Penn State College of Medicine, Hershey, PA 17033, USA
Am J Physiol Regul Integr Comp Physiol 286:R740-50. 2004.... - Alcohol-induced increases in insulin-like growth factor binding protein-1 are partially mediated by TNFVinayshree Kumar
Department of Cellular and Molecular Phsysiology, and Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Alcohol Clin Exp Res 26:1574-83. 2002..CONCLUSIONS: These data suggest that the acute alcohol-induced increase in IGFBP-1 is mediated, at least in part, by TNF and is independent of EtOH metabolism and increases in endogenous glucocorticoids... - IGF-I induced phosphorylation of S6K1 and 4E-BP1 in heart is impaired by acute alcohol intoxicationCharles H Lang
Prevention Research Center, 2150 Shattuck Avenue, Suite 900, Berkeley, CA 94704, USA
Alcohol Clin Exp Res 27:485-94. 2003..The purpose of the present study was to determine whether acute alcohol (EtOH) intoxication impairs the signal transduction pathway used to coordinate insulin-like growth factor (IGF)-I stimulation of myocardial protein synthesis...