R A Frost

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Multifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscle
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Endocrinol Metab Clin North Am 41:297-322, vi. 2012
  2. ncbi Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle
    Robert A Frost
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Regul Integr Comp Physiol 283:R698-709. 2002
  3. ncbi Regulation of IGF-I mRNA and signal transducers and activators of transcription-3 and -5 (Stat-3 and -5) by GH in C2C12 myoblasts
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Endocrinology 143:492-503. 2002
  4. ncbi Protein kinase B/Akt: a nexus of growth factor and cytokine signaling in determining muscle mass
    Robert A Frost
    Department of Cellular and Molecular Physiology, The Penn State University College of Medicine, Hershey, PA 17033, USA
    J Appl Physiol (1985) 103:378-87. 2007
  5. ncbi Multiple Toll-like receptor ligands induce an IL-6 transcriptional response in skeletal myocytes
    Robert A Frost
    Department of Cellular and Molecular Physiology H166, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, Pennsylvania 17033, USA
    Am J Physiol Regul Integr Comp Physiol 290:R773-84. 2006
  6. ncbi Regulation of insulin-like growth factor-I in skeletal muscle and muscle cells
    R A Frost
    Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University Hershey, PA 17033, USA
    Minerva Endocrinol 28:53-73. 2003
  7. ncbi Skeletal muscle cytokines: regulation by pathogen-associated molecules and catabolic hormones
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, 17033, USA
    Curr Opin Clin Nutr Metab Care 8:255-63. 2005
  8. ncbi Tumor necrosis factor-alpha decreases insulin-like growth factor-I messenger ribonucleic acid expression in C2C12 myoblasts via a Jun N-terminal kinase pathway
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    Endocrinology 144:1770-9. 2003
  9. ncbi Alteration of somatotropic function by proinflammatory cytokines
    R A Frost
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey 17033, USA
    J Anim Sci 82:E100-109. 2004
  10. ncbi Lipopolysaccharide and proinflammatory cytokines stimulate interleukin-6 expression in C2C12 myoblasts: role of the Jun NH2-terminal kinase
    Robert A Frost
    Dept of Cellular and Molecular Physiology, Penn State Univ College of Medicine, Hershey Medical Center H166, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1153-64. 2003

Detail Information

Publications65

  1. pmc Multifaceted role of insulin-like growth factors and mammalian target of rapamycin in skeletal muscle
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Endocrinol Metab Clin North Am 41:297-322, vi. 2012
    ....
  2. ncbi Lipopolysaccharide regulates proinflammatory cytokine expression in mouse myoblasts and skeletal muscle
    Robert A Frost
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Regul Integr Comp Physiol 283:R698-709. 2002
    ..Our data suggest that LPS stimulates cytokine expression not only in classical immune tissues but also in skeletal muscle...
  3. ncbi Regulation of IGF-I mRNA and signal transducers and activators of transcription-3 and -5 (Stat-3 and -5) by GH in C2C12 myoblasts
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Endocrinology 143:492-503. 2002
    ..In addition, C2C12 cells appear to be a good model system to examine GH regulation of Janus kinase/Stat signaling and the regulation of IGF-I mRNA...
  4. ncbi Protein kinase B/Akt: a nexus of growth factor and cytokine signaling in determining muscle mass
    Robert A Frost
    Department of Cellular and Molecular Physiology, The Penn State University College of Medicine, Hershey, PA 17033, USA
    J Appl Physiol (1985) 103:378-87. 2007
    ..Activation of Akt stimulates muscle hypertrophy and antagonizes the loss of muscle protein. Here we review the many signals that funnel through Akt to alter muscle mass...
  5. ncbi Multiple Toll-like receptor ligands induce an IL-6 transcriptional response in skeletal myocytes
    Robert A Frost
    Department of Cellular and Molecular Physiology H166, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, Pennsylvania 17033, USA
    Am J Physiol Regul Integr Comp Physiol 290:R773-84. 2006
    ..The data suggest that skeletal muscle and muscle cells recognize pathogen-associated molecules with specific TLRs to initiate an IL-6 transcriptional response...
  6. ncbi Regulation of insulin-like growth factor-I in skeletal muscle and muscle cells
    R A Frost
    Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University Hershey, PA 17033, USA
    Minerva Endocrinol 28:53-73. 2003
    ..A special emphasis will be placed on the interaction of IGF-I and proinflammatory cytokines in skeletal muscle and muscle cells...
  7. ncbi Skeletal muscle cytokines: regulation by pathogen-associated molecules and catabolic hormones
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, 17033, USA
    Curr Opin Clin Nutr Metab Care 8:255-63. 2005
    ..A special emphasis is placed on recent studies that examine the interaction of insulin-like growth factor 1 and proinflammatory cytokines as positive and negative regulators of muscle mass...
  8. ncbi Tumor necrosis factor-alpha decreases insulin-like growth factor-I messenger ribonucleic acid expression in C2C12 myoblasts via a Jun N-terminal kinase pathway
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, Hershey, Pennsylvania 17033, USA
    Endocrinology 144:1770-9. 2003
    ..These data suggest that LPS stimulates TNF alpha expression in mouse skeletal muscle and autocrine-derived cytokines may contribute to the reduced expression of IGF-I in this tissue...
  9. ncbi Alteration of somatotropic function by proinflammatory cytokines
    R A Frost
    Department of Cellular and Molecular Physiology, The Pennsylvania State University, College of Medicine, Hershey 17033, USA
    J Anim Sci 82:E100-109. 2004
    ..Current work is focused on deciphering the mechanism by which muscle becomes GH resistant and the development of therapies to maintain muscle protein stores during infection...
  10. ncbi Lipopolysaccharide and proinflammatory cytokines stimulate interleukin-6 expression in C2C12 myoblasts: role of the Jun NH2-terminal kinase
    Robert A Frost
    Dept of Cellular and Molecular Physiology, Penn State Univ College of Medicine, Hershey Medical Center H166, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 285:R1153-64. 2003
    ..Yet, only SP-600125 and not MG-132 blocked LPS-induced IL-6 mRNA expression. This suggests that IL-6 gene expression is a downstream target of JNK in C2C12 myoblasts...
  11. ncbi Lipopolysaccharide stimulates nitric oxide synthase-2 expression in murine skeletal muscle and C(2)C(12) myoblasts via Toll-like receptor-4 and c-Jun NH(2)-terminal kinase pathways
    Robert A Frost
    Department of Cellular and Molecular Physiology, College of Medicine, The Pennsylvania State University, Hershey Medical Center H166, 500 University Dr, Hershey, PA 17033, USA
    Am J Physiol Cell Physiol 287:C1605-15. 2004
    ..Moreover, the JNK inhibitor prevented the LPS-induced increase in NO synthesis. These data indicate that LPS increases NOS2 mRNA expression in muscle via a TLR4-dependent mechanism...
  12. doi Regulation of muscle growth by pathogen-associated molecules
    R A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Anim Sci 86:E84-93. 2008
    ..The interplay between inflammatory components and growth factor signaling clearly places muscle at the interface between growth and immunity...
  13. ncbi Epinephrine stimulates IL-6 expression in skeletal muscle and C2C12 myoblasts: role of c-Jun NH2-terminal kinase and histone deacetylase activity
    Robert A Frost
    Department of Cellular and Molecular Physiology, Penn State Univ College of Medicine, Hershey Medical Center H166, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 286:E809-17. 2004
    ..Endotoxin and epinephrine synergize to increase IL-6 mRNA expression. Optimal IL-6 synthesis may require both stress kinase and histone deacetylase activity...
  14. pmc Endotoxin and interferon-gamma inhibit translation in skeletal muscle cells by stimulating nitric oxide synthase activity
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Shock 32:416-26. 2009
    ....
  15. pmc Regulation of REDD1 by insulin-like growth factor-I in skeletal muscle and myotubes
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cell Biochem 108:1192-202. 2009
    ..We conclude that IGF-I stimulates REDD1 expression in skeletal muscle and myotubes but under these conditions the REDD1 response is not sufficient to repress protein synthesis...
  16. pmc Ethyl pyruvate preserves IGF-I sensitivity toward mTOR substrates and protein synthesis in C2C12 myotubes
    Robert A Frost
    Department of Cellular and Molecular Physiology H166, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA
    Endocrinology 152:151-63. 2011
    ..Lipophilic pyruvate derivatives and antioxidants show promise at rescuing mTOR activity and muscle protein synthesis by maintaining IGF-I sensitivity in this model...
  17. ncbi Differential effects of insulin-like growth factor I (IGF-I) and IGF-binding protein-1 on protein metabolism in human skeletal muscle cells
    R A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Endocrinology 140:3962-70. 1999
    ..BP-1, acting independently of IGF-I, inhibits protein degradation. The IGF-independent response occurs via beta1 integrin binding and stimulation of a rapamycin-sensitive signal transduction pathway...
  18. ncbi Stimulation of insulin-like growth factor binding protein-1 synthesis by interleukin-1beta: requirement of the mitogen-activated protein kinase pathway
    R A Frost
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey 17033, USA
    Endocrinology 141:3156-64. 2000
    ..Our data demonstrate that the MAP kinase signal transduction pathway plays an important role in the regulation of IGFBP-1 synthesis by IL-1beta...
  19. ncbi Inhibition of muscle protein synthesis by alcohol is associated with modulation of eIF2B and eIF4E
    C H Lang
    Departments of Cellular and Molecular Physiology and Surgery, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol 277:E268-76. 1999
    ..In summary, these data suggest that chronic alcohol consumption impairs translation initiation in muscle by altering multiple regulatory sites, including eIF2B activity and eIF4E availability...
  20. ncbi Alcohol impairs insulin and IGF-I stimulation of S6K1 but not 4E-BP1 in skeletal muscle
    Vinayshree Kumar
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 283:E917-28. 2002
    ..Hence, acute alcohol intoxication alters selected aspects of translational control under both basal and anabolic hormone-stimulated conditions in skeletal muscle in a glucocorticoid-independent manner...
  21. ncbi Impaired protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4E in muscle and eIF2B in liver
    C H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey 17033 0850, USA
    Alcohol Clin Exp Res 24:322-31. 2000
    ..Acute alcohol intoxication in rats decreases protein synthesis in skeletal muscle and, to a lesser extent, in liver. The purpose of the present study was to examine potential mechanisms for the inhibitory effect of acute ethanol exposure...
  22. ncbi Endotoxin-induced decrease in muscle protein synthesis is associated with changes in eIF2B, eIF4E, and IGF-I
    C H Lang
    Departments of Cellular and Molecular Physiology, and Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 278:E1133-43. 2000
    ....
  23. ncbi Chronic alcohol feeding impairs hepatic translation initiation by modulating eIF2 and eIF4E
    C H Lang
    Department of Cellular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol 277:E805-14. 1999
    ..In summary, these data suggest that chronic alcohol consumption impairs translation initiation in liver by altering eIF2B activity as well as eIF4F function via changes in eIF4E availability...
  24. ncbi Indinavir alters regulators of protein anabolism and catabolism in skeletal muscle
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 289:E382-90. 2005
    ..In conclusion, indinavir acutely impairs basal protein synthesis and translation initiation in skeletal muscle but, in contrast to muscle glucose uptake, does not impair insulin-stimulated signaling of protein synthetic pathways...
  25. ncbi Acute response of IGF-I and IGF binding proteins induced by thermal injury
    C H Lang
    Departments of Cellular and Molecular Physiology, and Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA
    Am J Physiol Endocrinol Metab 278:E1087-96. 2000
    ..These results characterize burn-induced changes in various components of the IGF system in select tissues and thereby provide potential mechanisms for alterations in the circulating IGF system and for changes in tissue metabolism...
  26. pmc Acute alcohol intoxication increases atrogin-1 and MuRF1 mRNA without increasing proteolysis in skeletal muscle
    Thomas C Vary
    Department of Cellular and Molecular Physiology H166, Penn State College Medicine, 500 University Dr, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 294:R1777-89. 2008
    ..Therefore, the loss of muscle mass/protein in response to chronic alcohol abuse appears to result primarily from a decrement in muscle protein synthesis, not an increase in degradation...
  27. pmc Skeletal and cardiac myopathy in HIV-1 transgenic rats
    Anne M Pruznak
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 295:E964-73. 2008
    ..Hence, HIV-1 Tg rats develop atrophy of cardiac and skeletal muscle, the latter of which results primarily from an increased protein degradation and may be related to the marked reduction in muscle insulin-like growth factor I...
  28. ncbi Impaired myocardial protein synthesis induced by acute alcohol intoxication is associated with changes in eIF4F
    C H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 279:E1029-38. 2000
    ....
  29. ncbi Alcohol myopathy: impairment of protein synthesis and translation initiation
    C H Lang
    Department of Cellular and Molecular Physiology H166, Penn State College of Medicine, Hershey, PA 17033, USA
    Int J Biochem Cell Biol 33:457-73. 2001
    ..However, defects in the availability or effectiveness of various anabolic hormones, particularly insulin-like growth factor-I, are consistent with the alcohol-induced decrease in protein synthesis and translation initiation...
  30. ncbi Tissue-specific regulation of IGF-I and IGF-binding proteins in response to TNFalpha
    C H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033 0850, USA
    Growth Horm IGF Res 11:250-60. 2001
    ....
  31. ncbi Hormone, cytokine, and nutritional regulation of sepsis-induced increases in atrogin-1 and MuRF1 in skeletal muscle
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 292:E501-12. 2007
    ..Thus, under in vivo conditions in mature adult rats, the sepsis-induced increase in muscle atrogin-1 and MuRF1 mRNA appears both glucocorticoid and TNF independent and is unresponsive to leucine...
  32. ncbi Endotoxin stimulates in vivo expression of inflammatory cytokines tumor necrosis factor alpha, interleukin-1beta, -6, and high-mobility-group protein-1 in skeletal muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Shock 19:538-46. 2003
    ..Collectively these data indicate that skeletal muscle possesses many of the components of the innate immune system, including increases in both early- and late-phase cytokines and the presence of toll-like receptors...
  33. ncbi Temporal differences in the ability of ethanol to modulate endotoxin-induced increases in inflammatory cytokines in muscle under in vivo conditions
    Robert A Frost
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Alcohol Clin Exp Res 29:1247-56. 2005
    ....
  34. ncbi Alcohol impairs protein synthesis and degradation in cultured skeletal muscle cells
    L Q Hong-Brown
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    Alcohol Clin Exp Res 25:1373-82. 2001
    ..We investigated whether ethanol (EtOH) and its major metabolites, acetaldehyde and acetate, can directly modulate protein balance under in vitro conditions...
  35. pmc Local insulin-like growth factor I prevents sepsis-induced muscle atrophy
    Gerald Nystrom
    Department of Cellular and Molecular Physiology, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
    Metabolism 58:787-97. 2009
    ....
  36. ncbi AMP-activated protein kinase agonists increase mRNA content of the muscle-specific ubiquitin ligases MAFbx and MuRF1 in C2C12 cells
    Brian J Krawiec
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 292:E1555-67. 2007
    ....
  37. ncbi Acute alterations in growth hormone-insulin-like growth factor axis in humans injected with endotoxin
    C H Lang
    Department of Surgery, State University of New York at Stony Brook 11794 8191, USA
    Am J Physiol 273:R371-8. 1997
    ..These data indicate that the acute changes in the GH-IGF axis in humans in response to LPS are comparable with those observed in humans in other traumatic conditions and in animal models of endotoxemia and infection...
  38. ncbi Alcohol intoxication impairs phosphorylation of S6K1 and S6 in skeletal muscle independently of ethanol metabolism
    Charles H Lang
    Pennsylvania State College of Medicine, Department of Cellular and Molecular Physiology H166, Hershey, PA 17033, USA
    Alcohol Clin Exp Res 28:1758-67. 2004
    ....
  39. ncbi Regulation of muscle protein synthesis during sepsis and inflammation
    Charles H Lang
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 293:E453-9. 2007
    ....
  40. ncbi TNF-alpha impairs heart and skeletal muscle protein synthesis by altering translation initiation
    Charles H Lang
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 282:E336-47. 2002
    ....
  41. doi Beta-adrenergic blockade exacerbates sepsis-induced changes in tumor necrosis factor alpha and interleukin-6 in skeletal muscle and is associated with impaired translation initiation
    Charles H Lang
    Departments of Cellular and Molecular Physiology, Pennsylvania State University, College of Medicine, Hershey, PA, USA
    J Trauma 64:477-86. 2008
    ....
  42. doi Acute alcohol intoxication increases REDD1 in skeletal muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Alcohol Clin Exp Res 32:796-805. 2008
    ..In this regard, mTOR activity is impaired after over expression of the regulatory protein REDD1. Hence, the present study assessed the ability of REDD1 as a potential mediator of the EtOH-induced decrease in muscle protein synthesis...
  43. ncbi Leucine acutely reverses burn-induced alterations in translation initiation in heart
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Shock 22:326-32. 2004
    ..These data suggest that oral administration of leucine can acutely reverse multiple defects in cardiac translation initiation produced by thermal injury...
  44. ncbi Burn-induced changes in IGF-I and IGF-binding proteins are partially glucocorticoid dependent
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Regul Integr Comp Physiol 282:R207-15. 2002
    ..TNFBP failed to completely ameliorate any of the burn-induced changes in the IGF system. These results demonstrate that glucocorticoids, but not TNF, mediate many but not all of the burn-induced changes in the IGF system...
  45. pmc Activation of AMP-activated protein kinase by 5-aminoimidazole-4-carboxamide-1-beta-D-ribonucleoside prevents leucine-stimulated protein synthesis in rat skeletal muscle
    Anne M Pruznak
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, PA 17033, USA
    J Nutr 138:1887-94. 2008
    ....
  46. ncbi Acute in vivo elevation of insulin-like growth factor (IGF) binding protein-1 decreases plasma free IGF-I and muscle protein synthesis
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Endocrinology 144:3922-33. 2003
    ..Hence, elevations in circulating and tissue levels of IGFBP-1 may be an important mediator for the muscle catabolism observed in various stress conditions...
  47. ncbi Alcohol impairs leucine-mediated phosphorylation of 4E-BP1, S6K1, eIF4G, and mTOR in skeletal muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 285:E1205-15. 2003
    ..Hence, ethanol produces a leucine resistance in skeletal muscle, as evidenced by the impaired phosphorylation of 4E-BP1, eIF4G, S6K1, and mTOR, that is independent of elevations in endogenous glucocorticoids...
  48. ncbi Differential effect of sepsis on ability of leucine and IGF-I to stimulate muscle translation initiation
    Charles H Lang
    Department of Cellular and Molecular Physiology, H166, Pennsylvania State University College of Medicine, 500 University Dr, Hershey 17033, USA
    Am J Physiol Endocrinol Metab 287:E721-30. 2004
    ..Hence, sepsis produces a relatively specific Leu resistance in skeletal muscle that impairs the ability of this amino acid to stimulate translation initiation and protein synthesis...
  49. pmc Skeletal muscle protein balance in mTOR heterozygous mice in response to inflammation and leucine
    Charles H Lang
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 298:E1283-94. 2010
    ..These data support the idea that the LPS-induced reduction in mTOR activity is relatively more important in regulating skeletal muscle mass in response to nutrient stimulation than under basal conditions...
  50. ncbi IGF-I/IGFBP-3 ameliorates alterations in protein synthesis, eIF4E availability, and myostatin in alcohol-fed rats
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 286:E916-26. 2004
    ..The data support the role of IGF-I as a mediator of chronic alcohol myopathy in rats...
  51. pmc Glucocorticoids and TNFalpha interact cooperatively to mediate sepsis-induced leucine resistance in skeletal muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Mol Med 12:291-9. 2006
    ..Our data demonstrate the sepsis-induced leucine resistance in skeletal muscle results from the cooperative interaction of both TNFalpha and glucocorticoids...
  52. ncbi Role of growth hormone, insulin-like growth factor-I, and insulin-like growth factor binding proteins in the catabolic response to injury and infection
    Charles H Lang
    Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Curr Opin Clin Nutr Metab Care 5:271-9. 2002
    ..This review focuses on recent developments pertaining to the importance of alterations in the growth hormone-insulin-like growth factor-I axis as a mechanism for the observed defects in muscle protein balance...
  53. ncbi Cytokine inhibition of JAK-STAT signaling: a new mechanism of growth hormone resistance
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Pediatr Nephrol 20:306-12. 2005
    ..Collectively, these changes act to limit IGF-I availability in muscle, which disturbs protein balance and results in the loss of protein stores in catabolic and inflammatory conditions...
  54. ncbi Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylation
    Ly Q Hong-Brown
    Department of Cellular and Molecular Physiology, Hershey, Pennsylvania 17033, USA
    Am J Physiol Endocrinol Metab 285:E63-72. 2003
    ..In conclusion, sepsis produces GH resistance in both muscle and liver, with the locus of this impairment in muscle differing from that in liver and being independent of a defect in STAT5 phosphorylation...
  55. ncbi Molecular mechanisms responsible for alcohol-induced myopathy in skeletal muscle and heart
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Int J Biochem Cell Biol 37:2180-95. 2005
    ..Overall, the biochemical mechanisms contributing to the pathogenesis of loss of skeletal and cardiac muscle are reviewed...
  56. ncbi Hindlimb casting decreases muscle mass in part by proteasome-dependent proteolysis but independent of protein synthesis
    Brian J Krawiec
    Dept of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 289:E969-80. 2005
    ....
  57. ncbi TNFalpha mediates sepsis-induced impairment of basal and leucine-stimulated signaling via S6K1 and eIF4E in cardiac muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cell Biochem 94:419-31. 2005
    ..Finally, TNFalpha, either directly or indirectly, appears to mediate the sepsis-induced defects in myocardial translation initiation...
  58. ncbi Sepsis and inflammatory insults downregulate IGFBP-5, but not IGFBP-4, in skeletal muscle via a TNF-dependent mechanism
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 290:R963-72. 2006
    ..Finally, IGF-I appears to be a dominant positive regulator of IGFBP-5 gene expression in muscle under both normal and catabolic conditions...
  59. ncbi Burn-induced increase in atrogin-1 and MuRF-1 in skeletal muscle is glucocorticoid independent but downregulated by IGF-I
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 292:R328-36. 2007
    ..In summary, the acute muscle wasting accompanying thermal injury is associated with a glucocorticoid-independent increase in the expression of several Ub E3 ligases that can be downregulated by IGF-I...
  60. ncbi Endotoxin disrupts the leucine-signaling pathway involving phosphorylation of mTOR, 4E-BP1, and S6K1 in skeletal muscle
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cell Physiol 203:144-55. 2005
    ..Hence, LPS working via a glucocorticoid-independent mechanism produces a leucine resistance in skeletal muscle that might be expected to impair the ability of this amino acid to stimulate translation initiation and protein synthesis...
  61. ncbi Sepsis-induced suppression of skeletal muscle translation initiation mediated by tumor necrosis factor alpha
    Charles H Lang
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Metabolism 56:49-57. 2007
    ..Hence, the decreased constitutive protein synthesis observed in fast-twitch skeletal muscle in response to peritonitis is mediated by a TNF-dependent mechanism affecting mTOR regulation of translation initiation...
  62. ncbi Skeletal muscle protein synthesis and degradation exhibit sexual dimorphism after chronic alcohol consumption but not acute intoxication
    Charles H Lang
    Department of Cellular and Molecular Physiology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, PA 17033, USA
    Am J Physiol Endocrinol Metab 292:E1497-506. 2007
    ....
  63. ncbi Thermal injury impairs cardiac protein synthesis and is associated with alterations in translation initiation
    Charles H Lang
    Department of Cellular and Molecular Physiology H166, Penn State College of Medicine, Hershey, PA 17033, USA
    Am J Physiol Regul Integr Comp Physiol 286:R740-50. 2004
    ....
  64. ncbi Alcohol-induced increases in insulin-like growth factor binding protein-1 are partially mediated by TNF
    Vinayshree Kumar
    Department of Cellular and Molecular Phsysiology, and Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Alcohol Clin Exp Res 26:1574-83. 2002
    ..Based on initial results subsequent studies were performed to assess potential mechanisms by which EtOH increased IGFBP-1...
  65. ncbi IGF-I induced phosphorylation of S6K1 and 4E-BP1 in heart is impaired by acute alcohol intoxication
    Charles H Lang
    Prevention Research Center, 2150 Shattuck Avenue, Suite 900, Berkeley, CA 94704, USA
    Alcohol Clin Exp Res 27:485-94. 2003
    ..The purpose of the present study was to determine whether acute alcohol (EtOH) intoxication impairs the signal transduction pathway used to coordinate insulin-like growth factor (IGF)-I stimulation of myocardial protein synthesis...