Christopher S Freet
Affiliation: Pennsylvania State University
Freet C, Lawrence A. Ceftriaxone attenuates acquisition and facilitates extinction of cocaine-induced suppression of saccharin intake in C57BL/6J mice. Physiol Behav. 2015;149:174-80 pubmed publisher
..These data suggest that changes in glutamate homeostasis may be involved in the formation and expression of cocaine-induced suppression of saccharin intake in mice. ..
Freet C, Ballard S, Alexander D, Cox T, Imperio C, Anosike N, et al
. Cocaine-induced suppression of saccharin intake and morphine modulation of CaÂ²âº channel currents in sensory neurons of OPRM1 A118G mice. Physiol Behav. 2015;139:216-23 pubmed publisher
..These results suggest that cocaine exposure of mice carrying the 118G allele leads to a heightened sensitivity of the reward system and a blunted modulation of Ca(2+) channels by morphine in sensory neurons. ..
Twining R, Freet C, Wheeler R, Reich C, Tompers D, Wolpert S, et al
. The role of dose and restriction state on morphine-, cocaine-, and LiCl-induced suppression of saccharin intake: A comprehensive analysis. Physiol Behav. 2016;161:104-115 pubmed publisher
..In the present case, the suppressive effects of morphine and cocaine are found to differ from those of LiCl and, in some respects, from one another as well. ..
Freet C, Steffen C, Nestler E, Grigson P. Overexpression of DeltaFosB is associated with attenuated cocaine-induced suppression of saccharin intake in mice. Behav Neurosci. 2009;123:397-407 pubmed publisher
..It is hypothesized that elevation of DeltaFosB not only increases the reward value of drug, but the reward value of the saccharin cue as well. ..
Freet C, Alexander D, Imperio C, Ruiz Velasco V, Grigson P. Heroin-induced suppression of saccharin intake in OPRM1 A118G mice. Brain Res Bull. 2018;138:73-79 pubmed publisher
..These alternative hypotheses are addressed. ..
Freet C, Tesche J, Tompers D, Riegel K, Grigson P. Lewis rats are more sensitive than Fischer rats to successive negative contrast, but less sensitive to the anxiolytic and appetite-stimulating effects of chlordiazepoxide. Pharmacol Biochem Behav. 2006;85:378-84 pubmed
..Together, the results show that, while both Lewis and Fischer rats demonstrate SNC, the effect is more sustained in the Lewis rats and these rats are insensitive to both the anxiolytic and the appetite-stimulating effects of CDP. ..