Research Topics
| Timothy J CraigSummaryAffiliation: Pennsylvania State University Country: USA Publications
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Publications
Treatment response after repeated administration of C1 esterase inhibitor for successive acute hereditary angioedema attacksTimothy J Craig
Penn State University, Hershey, Pennsylvania 17033, USA
Allergy Asthma Proc 33:354-61. 2012..Treatment with 20 U/kg of C1-INH concentrate provided consistent treatment response in patients treated for multiple successive HAE attacks at any body location. (Clinicaltrials.gov identifier: NCT00292981)...
HAE international home therapy consensus documentHilary J Longhurst
Department of Immunology, Barts and The London NHS Trust, London, UK
Allergy Asthma Clin Immunol 6:22. 2010..It represents the opinion of the authors who have a wide range of expert experience in the management of HAE...- C1 esterase inhibitor concentrate in 1085 Hereditary Angioedema attacks--final results of the I.M.P.A.C.T.2 studyT J Craig
Penn State University College of Medicine, Hershey, PA 17033, USA
Allergy 66:1604-11. 2011..M.P.A.C.T.1) demonstrated that 20 U/kg C1 esterase inhibitor (C1-INH) concentrate (Berinert®; CSL Behring, Marburg, Germany) is effective in treating acute abdominal and facial Hereditary Angioedema (HAE) attacks... - Prospective study of rapid relief provided by C1 esterase inhibitor in emergency treatment of acute laryngeal attacks in hereditary angioedemaTimothy J Craig
Asthma and Respiratory Research, Penn State University, 500 University Drive, Hershey, PA 17033, USA
J Clin Immunol 30:823-9. 2010..We assessed the efficacy of C1-INH concentrate in the emergency treatment of rarely occurring acute laryngeal HAE attacks in a prospective, open-label clinical study... - The role of montelukast on perennial allergic rhinitis and associated sleep disturbances and daytime somnolenceCarah B Santos
Penn State College of Medicine, Hershey, PA 17033, USA
Allergy Asthma Proc 29:140-5. 2008..In a small cohort of subjects, montelukast, when compared with placebo, improved the symptoms of PAR and reduced the fatigue and daytime somnolence associated with the disorder... - Per-attack reporting of prodromal symptoms concurrent with c1-inhibitor treatment of hereditary angioedema attacksMichael J Prematta
Allergy, Asthma and Immunology Section, Penn State University, Hershey, Pennsylvania, USA
Adv Ther 29:913-22. 2012..This study was designed to prospectively identify prodomal characteristics in patients voluntarily reporting such information around the time of seeking treatment for an acute HAE attack... - Efficacy of human C1 esterase inhibitor concentrate compared with placebo in acute hereditary angioedema attacksTimothy J Craig
Penn State University College of Medicine, Hershey, PA, USA
J Allergy Clin Immunol 124:801-8. 2009..Hereditary angioedema caused by C1 esterase inhibitor deficiency is a rare disorder... - Sleep impairment in allergic rhinitis, rhinosinusitis, and nasal polyposisTimothy J Craig
Pennsylvania State University College of Medicine, Hershey, PA 17033 0850, USA
Am J Otolaryngol 29:209-17. 2008..Such trials will help to identify the most effective therapies for sleep impairment in these 3 nasal conditions... - Liver enzyme elevation and normal pulmonary function in an adult with a declining forced expiratory volume in 1 secondNicholas L Rider
Division of Allergy and Immunology, The Pennsylvania State University Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
Allergy Asthma Proc 29:345-8. 2008.... - Small bowel intussusception: an unusual presentation of angioedemaKusum Sharma
Division of Pulmonary, Allergy, and Critical Care, Department of Medicine, Penn State University Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
Allergy Asthma Proc 31:84-7. 2010..The patient had a history of multiple episodes of swelling of extremities, face, and genitalia. The Allergy Consult Service was consulted for perioperative management of his angioedema... - Is there a need for clinical guidelines in the United States for the diagnosis of hereditary angioedema and the screening of family members of affected patients?Michael L Lunn
Division of Pulmonary, Allergy, and Critical Care Medicine, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
Ann Allergy Asthma Immunol 104:211-4. 2010.... - Aeroallergen sensitization in asthma: prevalence and correlation with severityTimothy J Craig
Pennsylvania State University College of Medicine, Section of Allergy, Asthma, and Immunology, Hershey, Pennsylvania 17033 0853, USA
Allergy Asthma Proc 31:96-102. 2010..Higher levels of IgE and eNO and lower values of PC(20), are noted in patients with asthma and aeroallergen sensitization... - Congestion and sleep impairment in allergic rhinitisTimothy J Craig
Hershey Medical Center, Penn State University, 500 University Drive, Hershey, PA, 17033 0850, USA
Curr Allergy Asthma Rep 10:113-21. 2010..It explores the adverse effects of disturbed sleep on quality of life and how these conditions can be reduced by therapies that decrease congestion... - Treatment of Hereditary Angioedema: items that need to be addressed in practice parameterCallie Dagen
Section of Allergy Asthma and Immunology, Medicine and Pediatrics, Penn State University, 500 University Drive, Hershey, PA 17033, USA
Allergy Asthma Clin Immunol 6:11. 2010..Treatment of HAE in many parts of the world fall short and certain items need to be addressed in future guidelines... - Appraisal of danazol prophylaxis for hereditary angioedemaTimothy J Craig
Allergy Asthma and Immunology Section, Division of Pulmonary, Allergy, and Critical Care, Penn State University, Hershey, Pennsylvania, USA
Allergy Asthma Proc 29:225-31. 2008.... 
Allergic rhinitis and its effect on sleep, fatigue, and daytime somnolenceCarah B Santos
Allergy Research, Hershey Medical Center, Penn State University, Hershey, Pennsylvania 17033-0850, USA
Ann Allergy Asthma Immunol 97:579-86; quiz 586-9, 671. 2006..These future trials will serve to identify the most effective therapies that target the adverse effects of sleep impairment in this disorder...- Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challengeVernon M Chinchilli
Department of Health Evaluation Sciences, Penn State College of Medicine, Hershey, PA 17033 0855, USA
J Allergy Clin Immunol 115:592-7. 2005..Statistical software packages can be adapted to perform such analyses... - Allergic rhinitis remains an important diseaseTimothy J Craig
Pennsylvania State University College of Medicine, Hershey, USA
J Am Osteopath Assoc 102:S1-2. 2002 - Aeroallergen sensitization correlates with PC(20) and exhaled nitric oxide in subjects with mild-to-moderate asthmaTimothy J Craig
Division of Pulmonary Care, Pennsylvania State University College of Medicine, Hershey, PA 17033 0853, USA
J Allergy Clin Immunol 121:671-7. 2008..Aeroallergen sensitization in adult asthmatic patients from a wide geographic area has not been correlated with patients' characteristics, markers of airways inflammation, and lung function... - Fresh frozen plasma for the treatment of hereditary angioedemaMichael Prematta
Allergy, Asthma and Immunology Section, Penn State University, Hershey Medical Center, Hershey, Pennsylvania, USA
Ann Allergy Asthma Immunol 98:383-8. 2007..However, because FFP also contains other substrates, it has been hypothesized to have the potential to worsen or precipitate an acute attack of HAE... - Nasal obstruction, the airway, and the athleteLaura H Fisher
Department of Asthma, Allergy, and Immunology, The Pennsylvania State University, Milton S. Hershey Medical Center, Hershey, PA, USA
Clin Rev Allergy Immunol 29:151-8. 2005..Treatment of allergic rhinitis can improve sleep and foster productivity. Control of rhinitis and nasal congestion, which is obtained by various therapies, may reverse lower airway tendency to bronchoconstriction... - How do topical nasal corticosteroids improve sleep and daytime somnolence in allergic rhinitis?Timothy J Craig
Allergy, Asthma and Immunology Section, Penn State University, Hershey Medical Center, Hershey, PA 17033, USA
J Allergy Clin Immunol 116:1264-6. 2005..01) and daytime somnolence (P = .01). Thus, topical intranasal corticosteroids should be used to decrease nasal congestion and to improve sleep and daytime somnolence in patients manifesting these symptoms... - The importance of rhinitis on sleep, daytime somnolence, productivity and fatigueLesley Woods
Division of Pulmonary, Allergy and Critical Care, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
Curr Opin Pulm Med 12:390-6. 2006..Recently, montelukast, a leukotriene receptor antagonist, has been added to the therapies approved for allergic rhinitis. Montelukast significantly improves both daytime and nighttime symptoms... - Adverse events associated with intranasal influenza vaccine in the United StatesNeetu Vasu
Division of Pulmonary, Allergy and Critical Care, Penn State College of Medicine, Hershey Medical Center, Hershey, PA 17033, USA
Ther Adv Respir Dis 2:193-8. 2008..PubMed, Ovid, and Google searches were conducted. Searched articles relating to allergic reactions, asthma or food allergy, and LAIV were reviewed... - The effect of topical nasal fluticasone on objective sleep testing and the symptoms of rhinitis, sleep, and daytime somnolence in perennial allergic rhinitisTimothy J Craig
Division of Medicine, Section of Pulmonary, Allergy, Critical Care, Pennsylvania State University, 500 University Drive, P.O. Box 850, Hershey, PA 17033, USA
Allergy Asthma Proc 24:53-8. 2003..However, fluticasone used at approved doses improves subjective sleep in patients with perennial allergic rhinitis without a change in the apnea/hypopnea index... - Associations between air pollution and peak expiratory flow among patients with persistent asthmaZhengmin Qian
Department of Public Health Sciences, Pennsylvania State University, Hershey, Pennsylvania, USA
J Toxicol Environ Health A 72:39-46. 2009..The results show that the two medication regimens protected against the effects of PM(10). However, salmeterol increased the sensitivity to NO2 and triamcinalone enhanced the sensitivity to SO2... - A challenging diagnosis of alpha-1-antitrypsin deficiency: identification of a patient with a novel F/Null phenotypeMichael R Ringenbach
Department of Medicine, Section of Allergy and Immunology, The Pennsylvania State University Milton S, Hershey Medical Center, 500 University Dr, Hershey, PA 17033, USA
Allergy Asthma Clin Immunol 7:18. 2011.... - A 64-year-old man with chronic obstructive pulmonary disease and an atypical rashEthan T Craig
Penn State College of Medicine, Penn State University, Hershey, Pennsylvania 17033, USA
Allergy Asthma Proc 32:325-8. 2011..Basic laboratory workup revealed conflicting information, leading to a diagnostic challenge discussed in this article. Ultimately, careful testing did reveal the diagnosis and the patient was treated accordingly... - Response to ecallantide treatment of acute attacks of hereditary angioedema based on time to intervention: results from the EDEMA clinical trialsErin Banta
Section of Allergy, Asthma, and Immunology, Penn State University, Hershey, Pennsylvania 17033, USA
Allergy Asthma Proc 32:319-24. 2011..4%). As with other therapies for HAE early ecallantide therapy is optimal. Treatment with ecallantide within 6 hours of symptom onset leads to more rapid and sustained improvement of symptoms... - Treatment of hereditary angioedema: current perspectivesSvetlana I Krassilnikova
Section of Allergy, Asthma and Immunology, Penn State University, Milton S Hershey Medical Center, Hershey, PA 17033, USA
Recent Pat Inflamm Allergy Drug Discov 2:166-74. 2008..This review article also discusses some recent patents related to the filed... - Early diagnosis is key in vancomycin-induced linear IgA bullous dermatosis and Stevens-Johnson syndromeDouglas H Jones
Milton S. Hershey Medical Center, Pennsylvania State University, Hershey, PA 17033-0850, USA
J Am Osteopath Assoc 104:157-63. 2004..CONCLUSIONS: In cases of SJS or LABD that are difficult to distinguish clinically, the authors recommend performing a skin biopsy and direct immunofluorescence early to confirm the diagnosis so that effective treatment can be instituted... - Assessing outcomes from the sleep disturbance associated with rhinitisEllen L Pratt
Section of Allergy, Asthma, and Immunology, Penn State Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
Curr Opin Allergy Clin Immunol 7:249-56. 2007.... - A safety review of long-acting beta2-agonists in patients with asthmaNicholas L Rider
Allergy, Asthma, and Immunology Section, Penn State University Milton S. Hershey Medical Center, 500 University Drive, Hershey, PA 17033-2360, USA
J Am Osteopath Assoc 106:562-7. 2006..However, when used in combination with an ICS, they decrease both rescue-medication use and symptoms, increase lung function, and act as steroid-sparing agents... - Frequency, timing, and type of prodromal symptoms associated with hereditary angioedema attacksMichael J Prematta
Penn State Milton S Hershey Medical Center, Section of Allergy and Immunology, Hershey, Pennsylvania 17033 0850, USA
Allergy Asthma Proc 30:506-11. 2009..This high frequency suggests that prodromal symptoms could be a reliable indication to begin treatment to prevent an acute HAE attack, thus decreasing the anxiety associated with having an HAE attack... - Assessment of care and disease management of patients with asthma in an overseas U.S. Army health clinicCherié M Inglis
The Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033 2360, USA
Mil Med 169:558-61. 2004..Although our findings were encouraging, this study has highlighted that there is opportunity for improvement... - Inflammatory responses in allergic rhinitis: traditional approaches and novel treatment strategiesSadeq A Quraishi
Department of Medicine, Section for Pulmonary, Allergy, and Immunology, Pennsylvania State University College of Medicine, Hershey, USA
J Am Osteopath Assoc 104:S7-15. 2004..As newer strategies emerge, treatment regimens for allergic rhinitis should continue to improve not only daytime symptoms, but also nighttime symptoms and sleep with the fewest possible adverse effects... - Asthma and the diverMichael J Davies
Department of Asthma, Allergy, and Immunology, The Pennsylvania State University, Milton S. Hershey Medical Center, Hershey, PA, USA
Clin Rev Allergy Immunol 29:131-8. 2005..Under the right circumstances, the patient with asthma can safely participate in recreational diving without apparent increased risk of an asthma-related event... - Variability of prodromal signs and symptoms associated with hereditary angioedema attacks: a literature reviewJohn G Kemp
Department of Medicine, Section of Allergy, Asthma, and Immunology, Penn State University, College of Medicine, Hershey, Pennsylvania 17033, USA
Allergy Asthma Proc 30:493-9. 2009..There is considerable variability of the prodromal manifestations that may occur before or during HAE attacks. We have not found any evidence that their sensitivity and specificity for accurately predicting such attacks has been studied... - A practical approach to allergic rhinitis and sleep disturbance managementMichael J Davies
Department of Medicine, Division of Pulmonary, Allergy, and Critical Care, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
Allergy Asthma Proc 27:224-30. 2006..Montelukast significantly improves both daytime and nighttime symptoms. AR treatment should endeavor to improve daytime and nighttime symptoms, sleep, and productivity thereby improving quality of life... - The correlation between allergic rhinitis and sleep disturbanceTimothy J Craig
Allergy Section, Department of Medicine, Pennsylvania State University College of Medicine, Hershey, PA, USA
J Allergy Clin Immunol 114:S139-45. 2004..Montelukast significantly improves both daytime and nighttime symptoms. AR treatment should endeavor to improve daytime and nighttime symptoms, sleep, and productivity, thereby improving quality of life...