Research Topics
| R N CooneySummaryAffiliation: Pennsylvania State University Country: USA Publications
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Detail Information
Publications
The impact of a clinical pathway for gastric bypass surgery on resource utilizationR N Cooney
Department of Surgery, Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA
J Surg Res 98:97-101. 2001..Clinical pathways are believed to improve patient care and reduce costs. Our hypothesis was that a gastric bypass pathway would decrease hospital resource utilization and cost of care without adversely affecting patient care...- Limitations of splenic angioembolization in treating blunt splenic injuryRobert Cooney
Department of Surgery, Penn State Milton S Hershey Medical Center, 17033, USA
J Trauma 59:926-32; discussion 932. 2005..This study examines the use of selective splenic angioembolization (SAE) as part of a management algorithm for adult splenic injury... - Analysis of cost outliers after gastric bypass surgery: what can we learn?Robert N Cooney
Departments of Surgery, The Penn State College of Medicine, Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA
Obes Surg 13:29-36. 2003..However, a reanalysis of GBS hospital costs identified a 16% incidence of "cost outliers". We hypothesized that analysis of clinical variables would identify factors associated with increased hospital costs following GBS... - Limits of body mass index to detect obesity and predict body compositionD C Frankenfield
Department of Clinical Nutrition, Penn State s Milton S Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA
Nutrition 17:26-30. 2001..Therefore, measurement of body fat is a more appropriate way to assess obesity in people with a BMI below 30 kg/m2... - Validation of several established equations for resting metabolic rate in obese and nonobese peopleDavid C Frankenfield
Department of Clinical Nutrition, Milton S Hershey Medical Center, Hershey, PA 17033, USA
J Am Diet Assoc 103:1152-9. 2003..To evaluate several equations for predicting resting metabolic rate against measured values in obese and nonobese people... - Hepatic growth hormone resistance during sepsis is associated with increased suppressors of cytokine signaling expression and impaired growth hormone signalingGladys Yumet
Departments of Surgery, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, PA, USA
Crit Care Med 34:1420-7. 2006..Hepatic messenger RNA expression of SOCS-1, SOCS-3, and CIS was transiently increased during abdominal sepsis and temporally associated with the development of hepatic GH resistance... - The inhibitory effects of interleukin-1 on growth hormone action during catabolic illnessRobert N Cooney
Department of Surgery, The Pennsylvania State University - College of Medicine, Hershey, Pennsylvania 17033, USA
Vitam Horm 74:317-40. 2006..Consequently, a better understanding of the interaction between GH, IL-1, and the regulation of protein metabolism is of great importance for the care of the patient... - Do early ionized calcium levels really matter in trauma patients?Robert A Cherry
Penn State Shock Trauma Center and the Department of Surgery, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
J Trauma 61:774-9. 2006..This study investigates the relationship between ionized calcium (iCa) levels drawn on arrival to the emergency department, with injury severity, acidosis, hypotension, and mortality... - Tubulovillous adenoma with atypia found at gastrojejunal anastomosis 8 years after gastric bypass for morbid obesityAnn M Rogers
Department of Surgery, Penn State College of Medicine, Milton S. Hershey Medical Center, Hershey, Pennsylvania 17033, USA
Surg Obes Relat Dis 3:559-60. 2007 - Trauma team activation and the impact on mortalityRobert A Cherry
Department of Surgery, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
J Trauma 63:326-30. 2007..We examined whether physiologic variables in our three-tier TTA system stratified patients appropriately by injury severity and mortality... 
Obesity-related elevations in plasma leucine are associated with alterations in enzymes involved in branched-chain amino acid metabolismPengxiang She
Dept of Cellular and Molecular Physiology, MC H166, Penn State Univ College of Medicine, 500 University Dr, Hershey, PA 17033, USA
Am J Physiol Endocrinol Metab 293:E1552-63. 2007..Our results are consistent with the idea that tissue-specific alterations in BCAA metabolism, in liver and adipose tissue but not in muscle, may contribute to the rise in plasma BCAAs in obesity...- Interleukin-1 inhibits the induction of insulin-like growth factor-I by growth hormone in CWSV-1 hepatocytesMargaret L Shumate
Dept of Surgery, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
Am J Physiol Gastrointest Liver Physiol 289:G227-39. 2005..Therefore, an inhibitory effect of IL-1 on IGF-I and Spi 2.1 mRNA synthesis by GH represents the most likely mechanism for IL-1-mediated GH resistance... - Variability in trauma center outcomes for patients with moderate intracranial injuryStanley Z Trooskin
University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, NJ, USA
J Trauma 57:998-1005. 2004..This study should stimulate discussions to understand reasons for outcome variability and ways to reduce it... - Tumor necrosis factor mediates hepatic growth hormone resistance during sepsisGladys Yumet
Department of Surgery, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Am J Physiol Endocrinol Metab 283:E472-81. 2002..control) in TNF-treated cells 60 min after GH treatment. Collectively, these results suggest that TNF mediates hepatic GH resistance during sepsis by inhibiting the duration of signaling via the janus kinase-2/STAT5 pathway... - Sepsis-induced muscle growth hormone resistance occurs independently of STAT5 phosphorylationLy Q Hong-Brown
Department of Cellular and Molecular Physiology, Hershey, Pennsylvania 17033, USA
Am J Physiol Endocrinol Metab 285:E63-72. 2003..In conclusion, sepsis produces GH resistance in both muscle and liver, with the locus of this impairment in muscle differing from that in liver and being independent of a defect in STAT5 phosphorylation... - Early results after laparoscopic gastric bypass: EEA vs GIA stapled gastrojejunal anastomosisTimothy R Shope
Department of Surgery, Penn State Milton S. Hershey Medical Center, Hershey, PA 17033, USA
Obes Surg 13:355-9. 2003..Complications, length of stay, weight loss and costs were similar between the groups. Selection of anastomotic technique may be based on surgeon preference, operative time, and potential for serious complications... - Validation of 2 approaches to predicting resting metabolic rate in critically ill patientsDavid Frankenfield
Department of Clinical Nutrition, College of Medicine, Pennsylvania State University, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
JPEN J Parenter Enteral Nutr 28:259-64. 2004..However, calculation equations are more commonly used. In the current study we tested the validity of 2 such calculation systems... - Tumor necrosis factor inhibits growth hormone-mediated gene expression in hepatocytesTamer Ahmed
Department of Surgery, Pennsylvania State University, College of Medicine, Hershey, PA 17033, USA
Am J Physiol Gastrointest Liver Physiol 291:G35-44. 2006..The inhibitory effects of TNF on GH-mediated gene transcription appear independent of STAT5 activity and previously identified abnormalities in JAK2/STAT5 signaling... - Capsaicin-sensitive nerves regulate the metabolic response to abdominal sepsisPatrick Bryant
Department of Surgery, The Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
J Surg Res 112:152-61. 2003..The results suggest an important role for nociceptive SANs and the neuroendocrine system in mediating the host response to abdominal infection... - Interleukin-6 inhibits growth hormone-mediated gene expression in hepatocytesTamer A Ahmed
Dept of Surgery, H070, Pennsylvania State Univ, College of Medicine, Hershey, PA 17033, USA
Am J Physiol Gastrointest Liver Physiol 292:G1793-803. 2007..In summary, IL-6 mediates hepatic GH resistance by a time-dependent inhibition of GH-inducible promoter activity that is associated with reductions in STAT5 DNA binding... - Cytokine signaling in sepsis: redundancy, crosstalk, and regulatory mechanismsRobert N Cooney
Crit Care Med 30:262-3. 2002 - Suppressors of cytokine signaling (SOCS): inhibitors of the JAK/STAT pathwayRobert N Cooney
Department of Surgery, The Pennsylvania State University College of Medicine, Hershey 17033, USA
Shock 17:83-90. 2002.... 
Nuclear factor kappaB mediates the inhibitory effects of interleukin-1 on growth hormone-inducible gene expressionMark D Buzzelli
Departments of Surgery, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
J Trauma 64:1427-35; discussion 1435-6. 2008..The current study examines the role of the nuclear factor kappaB (NFkappaB) pathway and suppressor of cytokine signaling (SOCS)-3 expression as potential mechanisms for IL-1-mediated GH resistance...