Loren E Clarke

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi Plaque-like myofibroblastic tumor of infancy
    Jennie T Clarke
    Department of Dermatology, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Pediatr Dermatol 24:E83-7. 2007
  2. doi Expression of CK7, Cam 5.2 and Ber-Ep4 in cutaneous squamous cell carcinoma
    Loren E Clarke
    Department of Pathology, The Penn State Hershey Medical Center, Hershey, PA 17033, USA
    J Cutan Pathol 40:646-50. 2013
  3. doi Fibrous and fibrohistiocytic neoplasms: an update
    Loren E Clarke
    Department of Pathology, Penn State Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Dermatol Clin 30:643-56, vi. 2012
  4. doi Dermal dendritic cells in psoriasis, nummular dermatitis, and normal-appearing skin
    Loren E Clarke
    Department of Dermatology, Penn State Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Am Acad Dermatol 66:98-105. 2012
  5. doi Dysplastic nevi
    Loren E Clarke
    Department of Pathology, The Penn State Hershey Medical Center, Hershey, PA 17033, USA
    Clin Lab Med 31:255-65. 2011
  6. doi CD10-positive myxofibrosarcomas: a pitfall in the differential diagnosis of atypical fibroxanthoma
    Loren E Clarke
    Department of Pathology, Penn State Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    J Cutan Pathol 37:737-43. 2010
  7. doi Cdc7 expression in melanomas, Spitz tumors and melanocytic nevi
    Loren E Clarke
    Department of Pathology, Penn State Milton S Hershey Medical Center College of Medicine, Hershey, PA 17033, USA
    J Cutan Pathol 36:433-8. 2009
  8. doi Myxofibrosarcoma in the skin
    Loren E Clarke
    Department of Pathology, The Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA
    J Cutan Pathol 35:935-40. 2008
  9. doi Cutaneous epithelioid hemangioendothelioma
    Loren E Clarke
    Department of Pathology, Penn State Milton S Hershey Medical Center, Hershey, PA, USA
    J Cutan Pathol 35:236-40. 2008
  10. doi Cutaneous CD34+ spindle cell neoplasms: Histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans
    Lance Wood
    Department of Dermatology, The Penn State Hershey Medical Center, Hershey, PA 17033, USA
    Am J Dermatopathol 32:764-8. 2010

Collaborators

Detail Information

Publications25

  1. ncbi Plaque-like myofibroblastic tumor of infancy
    Jennie T Clarke
    Department of Dermatology, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Pediatr Dermatol 24:E83-7. 2007
    ..The features of these neoplasms are discussed and the differential of other spindle cell tumors of infancy is reviewed...
  2. doi Expression of CK7, Cam 5.2 and Ber-Ep4 in cutaneous squamous cell carcinoma
    Loren E Clarke
    Department of Pathology, The Penn State Hershey Medical Center, Hershey, PA 17033, USA
    J Cutan Pathol 40:646-50. 2013
    ..However, we have encountered CK7+ and Cam 5.2+ SCCs...
  3. doi Fibrous and fibrohistiocytic neoplasms: an update
    Loren E Clarke
    Department of Pathology, Penn State Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Dermatol Clin 30:643-56, vi. 2012
    ....
  4. doi Dermal dendritic cells in psoriasis, nummular dermatitis, and normal-appearing skin
    Loren E Clarke
    Department of Dermatology, Penn State Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Am Acad Dermatol 66:98-105. 2012
    ..The reason psoriasis (PSO) favors extensor skin is unknown. We hypothesized that PSO may involve extensor skin preferentially because of differences in the number or type of dermal dendritic cells (dDCs) between flexural and extensor skin...
  5. doi Dysplastic nevi
    Loren E Clarke
    Department of Pathology, The Penn State Hershey Medical Center, Hershey, PA 17033, USA
    Clin Lab Med 31:255-65. 2011
    ..This article discusses the gross, clinical and microscopic features; diagnosis; and prognosis of dysplastic nevi. The key features and pitfalls of diagnosing malignant melanoma, congenital nevus, and recurrent nevus are given...
  6. doi CD10-positive myxofibrosarcomas: a pitfall in the differential diagnosis of atypical fibroxanthoma
    Loren E Clarke
    Department of Pathology, Penn State Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    J Cutan Pathol 37:737-43. 2010
    ..Myxofibrosarcomas commonly present in the skin and may be difficult to distinguish from AFX on small biopsies and CD10 positivity may confound the diagnostic difficulty...
  7. doi Cdc7 expression in melanomas, Spitz tumors and melanocytic nevi
    Loren E Clarke
    Department of Pathology, Penn State Milton S Hershey Medical Center College of Medicine, Hershey, PA 17033, USA
    J Cutan Pathol 36:433-8. 2009
    ..Cdc7 is a serine-threonine kinase required for initiation of DNA replication that may play a role in the development and progression of melanoma...
  8. doi Myxofibrosarcoma in the skin
    Loren E Clarke
    Department of Pathology, The Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA
    J Cutan Pathol 35:935-40. 2008
    ..These cases illustrate the clinicopathologic spectrum encompassed by myxofibrosarcoma in the skin and highlight the diagnostic difficulties it may present...
  9. doi Cutaneous epithelioid hemangioendothelioma
    Loren E Clarke
    Department of Pathology, Penn State Milton S Hershey Medical Center, Hershey, PA, USA
    J Cutan Pathol 35:236-40. 2008
    ..We discuss the clinical and histopathologic differential diagnoses for these tumors and review additional cases in which EHE has been mistaken for benign entities clinically...
  10. doi Cutaneous CD34+ spindle cell neoplasms: Histopathologic features distinguish spindle cell lipoma, solitary fibrous tumor, and dermatofibrosarcoma protuberans
    Lance Wood
    Department of Dermatology, The Penn State Hershey Medical Center, Hershey, PA 17033, USA
    Am J Dermatopathol 32:764-8. 2010
    ..We conclude that careful attention to these histopathologic features enables reliable distinction among these tumors...
  11. doi Interstitial granulomatous drug reaction to anakinra
    Christie G Regula
    Department of Dermatology, Milton S Hershey Medical Center, Penn State University College of Medicine, Hershey, Pennsylvania, USA
    J Am Acad Dermatol 59:S25-7. 2008
    ..Withdrawal of anakinra led to complete resolution of the lesions. Interstitial granulomatous drug reactions are increasing in frequency and we add anakinra to the list of causative agents...
  12. ncbi Reactive angioendotheliomatosis in association with a well-differentiated angiosarcoma
    Loren E Clarke
    Department of Pathology, The Penn State College of Medicine Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Am J Dermatopathol 27:422-7. 2005
    ..Excision of the lesion was performed, and fifteen months of follow-up have shown no recurrence or metastasis...
  13. ncbi Death receptor apoptosis signaling mediated by FADD in CD30-positive lymphoproliferative disorders involving the skin
    Loren E Clarke
    Departments of Pathology, Penn State University College of Medicine Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Am J Surg Pathol 29:452-9. 2005
    ..In this study, we used newly developed activation state-specific antibodies to demonstrate apoptosis signaling through the death receptor-mediated pathway regulated by FADD and caspase 3...
  14. doi Persistent melanocytic nevi: a review and analysis of 205 cases
    Lacy L Sommer
    Temple University School of Medicine, Philadelphia, PA, USA
    J Cutan Pathol 38:503-7. 2011
    ..Melanocytic nevi can recur or persist if not completely excised and are capable of mimicking malignant melanoma, both clinically and histologically...
  15. doi Multiple cutaneous monoclonal B-cell proliferations as harbingers of systemic angioimmunoblastic T-cell lymphoma
    Michael G Bayerl
    Department of Pathology, Penn State Hershey Medical Center, Hershey, PA 17033, USA
    J Cutan Pathol 37:777-86. 2010
    ..Biologically, this case offers unique insight into the interactions between B-cell and T-cell lineages in lymphoid neoplasia...
  16. ncbi Lymphoepithelioma-like carcinoma of the skin with spindle cell differentiation
    Loren E Clarke
    Department of Pathology, Penn State Univerity of Medicine Hershey Medical Centre, Hershey, PA 17033, USA
    J Cutan Pathol 32:419-23. 2005
    ..It is extremely rare, with only approximately 30 cases reported in the literature...
  17. ncbi Actinomyces viscosus endocarditis requiring aortic valve replacement
    Kathleen G Julian
    Division of Infectious Diseases, BMR Bldg, Room C6833, Mailcode H036, Penn State Milton S Hershey Medical Center, 500 University Drive, Hershey, PA 17033 USA
    J Infect 50:359-62. 2005
    ..Months later when she required aortic valve and root replacement, histologic exam of the diseased valve revealed branching filamentous organisms and the original blood isolates were retrospectively confirmed to be Actinomyces viscosus...
  18. ncbi Cutaneous B-cell lymphoma with loss of CD20 immunoreactivity after rituximab therapy
    Loren E Clarke
    Department of Pathology, The Pennsylvania State University College of Medicine Hershey Medical Center, C7633 Hershey Medical Center H083 Box 850, Hershey, PA 17033, USA
    J Cutan Pathol 30:459-62. 2003
    ..Antibodies to the B-cell-specific antigen CD20 are widely used for immunohistochemical identification of B-cell lymphomas, approximately 95% of which are strongly CD20-positive...
  19. doi Basal cell carcinoma characteristics as predictors of depth of invasion
    Michael Jude Welsch
    Department of Pathology, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    J Am Acad Dermatol 67:47-53. 2012
    ..Pretreatment risk stratification of basal cell carcinoma (BCC) is largely based on histologic subtype reported from biopsy specimens...
  20. ncbi Primary cutaneous adenomyoepithelioma
    Loren E Clarke
    Division of Dermatopathology, Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, PA 19104, USA
    J Cutan Pathol 34:654-7. 2007
    ..This rare tumor may mimic malignant lesions including metastatic adenocarcinoma. Like its breast counterpart, primary cutaneous adenomyoepithelioma should probably be regarded as a neoplasm of borderline malignant potential...
  21. ncbi Methotrexate-associated lymphoproliferative disorder in a patient with rheumatoid arthritis presenting in the skin
    Loren E Clarke
    Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, USA
    J Am Acad Dermatol 56:686-90. 2007
    ..This case illustrates the rare occurrence of methotrexate-associated lymphoproliferative disorder with primary presentation in the skin and documents clinical and histopathologic progression from early changes to fully developed lesions...
  22. ncbi Giant cell angiofibroma or localized periorbital lymphedema?
    Michael C Lynch
    Department of Pathology, The Penn State Hershey Medical Center, Hershey, PA, USA
    J Cutan Pathol 40:1059-62. 2013
    ..The potential overlap of these two conditions should be recognized, as should other entities that may enter the differential diagnosis. ..
  23. pmc Robust activation of the human but not mouse telomerase gene during the induction of pluripotency
    Renjith Mathew
    Department of Cellular and Molecular Physiology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    FASEB J 24:2702-15. 2010
    ..Because telomere elongation is crucial for self-renewal of hPSCs and replicative aging of their differentiated progeny, these findings have important implications in the generation and applications of iPSCs...
  24. ncbi Petrified ears: calcification of the auricular cartilage
    Jennie T Clarke
    Department of Dermatology, Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania, USA
    J Am Acad Dermatol 51:799-800. 2004
  25. ncbi Epidermal growth factor receptor mRNA in peripheral blood of patients with pancreatic, lung, and colon carcinomas detected by RT-PCR
    Loren E Clarke
    The Pennsylvania State University College of Medicine Hershey Medical Center, Hershey, PA 17033, USA
    Int J Oncol 22:425-30. 2003
    ....