Nancy M Cladel

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Synonymous codon changes in the oncogenes of the cottontail rabbit papillomavirus lead to increased oncogenicity and immunogenicity of the virus
    Nancy M Cladel
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Virology 438:70-83. 2013
  2. pmc Human alpha and beta papillomaviruses use different synonymous codon profiles
    Nancy M Cladel
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Virus Genes 40:329-40. 2010
  3. ncbi request reprint Detection of L1, infectious virions and anti-L1 antibody in domestic rabbits infected with cottontail rabbit papillomavirus
    Jiafen Hu
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Gen Virol 88:3286-93. 2007
  4. ncbi request reprint Protective cell-mediated immunity by DNA vaccination against Papillomavirus L1 capsid protein in the Cottontail Rabbit Papillomavirus model
    Jiafen Hu
    Department of Pathology, Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Viral Immunol 19:492-507. 2006
  5. ncbi request reprint GM-CSF enhances protective immunity to cottontail rabbit papillomavirus E8 genetic vaccination in rabbits
    Jiafen Hu
    Department of Pathology, The Jake Gittlen Cancer Research Institute, Pennsylvania State University, Hershey, PA 17033, USA
    Vaccine 22:1124-30. 2004
  6. ncbi request reprint Gene gun-mediated intracutaneous vaccination with papillomavirus E7 gene delays cancer development of papillomavirus-induced skin papillomas on rabbits
    Ricai Han
    Department of Pathology, Jake Gittlen Cancer Research Institute, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Cancer Detect Prev 26:458-67. 2002
  7. ncbi request reprint Characterization of three rabbit oral papillomavirus oncogenes
    Jiafen Hu
    Department of Pathology, The Jake Gittlen Cancer Research Institute, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
    Virology 325:48-55. 2004
  8. pmc Establishment of a cottontail rabbit papillomavirus/HLA-A2.1 transgenic rabbit model
    Jiafen Hu
    Jake Gittlen Cancer Research Foundation, 500 University Dr, Pennsylvania State University, Hershey, PA 17033, USA
    J Virol 81:7171-7. 2007
  9. pmc CRPV genomes with synonymous codon optimizations in the CRPV E7 gene show phenotypic differences in growth and altered immunity upon E7 vaccination
    Nancy M Cladel
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
    PLoS ONE 3:e2947. 2008
  10. ncbi request reprint Increased immunity to cottontail rabbit papillomavirus infection in EIII/JC inbred rabbits after vaccination with a mutant E6 that correlates with spontaneous regression
    Jiafen Hu
    Department of Pathology, Jake Gittlen Cancer Research Foundation, Hershey, Pennsylvania, USA
    Viral Immunol 20:320-5. 2007

Collaborators

  • Jiafen Hu
  • Christopher B Buck
  • Todd D Schell
  • Neil D Christensen
  • Lynn R Budgeon
  • Timothy D Culp
  • Andres F Mejia
  • Callie E Bounds
  • Karla K Balogh
  • Audrey L Jenkins
  • Cynthia A Reed
  • Ricai Han
  • Karla Balogh
  • C Max Lang
  • Audrey J Jenkins
  • Danny R Welch
  • Xuwen Peng
  • Martin D Pickel

Detail Information

Publications23

  1. pmc Synonymous codon changes in the oncogenes of the cottontail rabbit papillomavirus lead to increased oncogenicity and immunogenicity of the virus
    Nancy M Cladel
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Virology 438:70-83. 2013
    ....
  2. pmc Human alpha and beta papillomaviruses use different synonymous codon profiles
    Nancy M Cladel
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Virus Genes 40:329-40. 2010
    ....
  3. ncbi request reprint Detection of L1, infectious virions and anti-L1 antibody in domestic rabbits infected with cottontail rabbit papillomavirus
    Jiafen Hu
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Gen Virol 88:3286-93. 2007
    ..These studies demonstrated that the CRPV/New Zealand White rabbit model could be used as an in vivo model to study natural virus infection and viral life cycle of CRPV and not be limited to studies on abortive infections...
  4. ncbi request reprint Protective cell-mediated immunity by DNA vaccination against Papillomavirus L1 capsid protein in the Cottontail Rabbit Papillomavirus model
    Jiafen Hu
    Department of Pathology, Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Viral Immunol 19:492-507. 2006
    ..Cross-protective immunity against CRPV L1 and ROPV L1 was elicited in these CRPV L1- and subfragment-vaccinated rabbits...
  5. ncbi request reprint GM-CSF enhances protective immunity to cottontail rabbit papillomavirus E8 genetic vaccination in rabbits
    Jiafen Hu
    Department of Pathology, The Jake Gittlen Cancer Research Institute, Pennsylvania State University, Hershey, PA 17033, USA
    Vaccine 22:1124-30. 2004
    ..These results demonstrated that mGM-CSF could enhance the effects of E8 immunization in rabbits to CRPV infection through cell-mediated immune responses...
  6. ncbi request reprint Gene gun-mediated intracutaneous vaccination with papillomavirus E7 gene delays cancer development of papillomavirus-induced skin papillomas on rabbits
    Ricai Han
    Department of Pathology, Jake Gittlen Cancer Research Institute, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Cancer Detect Prev 26:458-67. 2002
    ..These results suggested that gene gun-mediated intracutaneous immunization with papillomavirus early gene E7 but not E6 delayed carcinoma development of papillomavirus-induced lesions...
  7. ncbi request reprint Characterization of three rabbit oral papillomavirus oncogenes
    Jiafen Hu
    Department of Pathology, The Jake Gittlen Cancer Research Institute, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
    Virology 325:48-55. 2004
    ..Cells with ROPV E6, E7, or E8 formed colonies in agar and tumors in athymic mice. These observations suggest that ROPV E6, E7, and E8 are oncogenic...
  8. pmc Establishment of a cottontail rabbit papillomavirus/HLA-A2.1 transgenic rabbit model
    Jiafen Hu
    Jake Gittlen Cancer Research Foundation, 500 University Dr, Pennsylvania State University, Hershey, PA 17033, USA
    J Virol 81:7171-7. 2007
    ..1 rabbit model has the potential to be used to screen HLA-A2.1-restricted immunogenic epitopes from human papillomaviruses in the context of in vivo papillomavirus infection...
  9. pmc CRPV genomes with synonymous codon optimizations in the CRPV E7 gene show phenotypic differences in growth and altered immunity upon E7 vaccination
    Nancy M Cladel
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, United States of America
    PLoS ONE 3:e2947. 2008
    ..The reduction in growth was most dramatic with the genome containing the greatest number of synonymous codon changes...
  10. ncbi request reprint Increased immunity to cottontail rabbit papillomavirus infection in EIII/JC inbred rabbits after vaccination with a mutant E6 that correlates with spontaneous regression
    Jiafen Hu
    Department of Pathology, Jake Gittlen Cancer Research Foundation, Hershey, Pennsylvania, USA
    Viral Immunol 20:320-5. 2007
    ..05, unpaired Student t test). We conclude that a single amino acid change in the CRPV E6 protein (G252E) increased protection against wild-type infectious CRPV...
  11. pmc Papillomavirus DNA complementation in vivo
    Jiafen Hu
    Jake Gittlen Cancer Research Foundation, Department of Pathology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Virus Res 144:117-22. 2009
    ..Individual wild type genes were also shown to rescue the function of corresponding dysfunctional mutants. Therefore, we suggest that complementation occurred between these two non-viable mutant PV genomes in vivo...
  12. pmc Preclinical model to test human papillomavirus virus (HPV) capsid vaccines in vivo using infectious HPV/cottontail rabbit papillomavirus chimeric papillomavirus particles
    Andres F Mejia
    Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, 500 University Dr, Hershey, PA 17033 2390, USA
    J Virol 80:12393-7. 2006
    ..Strong type-specific protection was observed, demonstrating the potential application of this approach...
  13. ncbi request reprint Large cutaneous rabbit papillomas that persist during cyclosporin A treatment can regress spontaneously after cessation of immunosuppression
    Jiafen Hu
    The Jake Gittlen Cancer Research Institute, Department of Pathology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Gen Virol 86:55-63. 2005
    ..However, returning immunity can lead to regression and clearance of large papillomas (with increased antigenicity) in an outbred population, whilst these same antigenic papillomas persist in inbred rabbits...
  14. pmc Amino acid residues in the carboxy-terminal region of cottontail rabbit papillomavirus E6 influence spontaneous regression of cutaneous papillomas
    Jiafen Hu
    Department of Pathology, The Jake Gittlen Cancer Research Institute, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Virol 76:11801-8. 2002
    ....
  15. pmc Papillomavirus particles assembled in 293TT cells are infectious in vivo
    Timothy D Culp
    Jake Gittlen Cancer Research Foundation, College of Medicine, Pennsylvania State University, Hershey, PA 17033 2390, USA
    J Virol 80:11381-4. 2006
    ....
  16. ncbi request reprint An HLA-A2.1-transgenic rabbit model to study immunity to papillomavirus infection
    Jiafen Hu
    Jake Gittlen Cancer Research Foundation, and Department of Pathology, College of Medicine, Pennsylvania State University, Hershey, PA 17033, USA
    J Immunol 177:8037-45. 2006
    ..HLA-A2.1-transgenic rabbits will be an important preclinical animal model system to study virus-host interactions and to assess specific targets for immunotherapy...
  17. pmc Wounding prior to challenge substantially improves infectivity of cottontail rabbit papillomavirus and allows for standardization of infection
    Nancy M Cladel
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Virol Methods 148:34-9. 2008
    ..This method can be adapted easily by other investigators in the field. The resulting standardization will aid in the evaluation of data from different laboratories...
  18. pmc Impact of genetic changes to the CRPV genome and their application to the study of pathogenesis in vivo
    Jiafen Hu
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Virology 358:384-90. 2007
    ..1 transgenic rabbit model, this plasticity allows us to extend the utility of the CRPV/rabbit model to the screening of HLA-A2.1 restricted epitopes from other human viral and tumor antigens...
  19. pmc Differences in methodology, but not differences in viral strain, account for variable experimental outcomes in laboratories utilizing the cottontail rabbit papillomavirus model
    Nancy M Cladel
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine, Hershy, PA 17033, United States
    J Virol Methods 165:36-41. 2010
    ..It was concluded that the E8 gene is not required for infection. We suggest that standardized infection methods should be used in laboratories so that inconsistencies in conclusions will be minimized...
  20. pmc Intracutaneous DNA vaccination with the E8 gene of cottontail rabbit papillomavirus induces protective immunity against virus challenge in rabbits
    Jiafen Hu
    Department of Pathology, The Jake Gittlen Cancer Research Institute, College of Medicine, Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA
    J Virol 76:6453-9. 2002
    ..01; t test). Delayed-type hypersensitivity skin tests showed that some of the E8-vaccinated rabbits had positive responses to E8-specific peptides...
  21. pmc Vaccine generated immunity targets an HPV16 E7 HLA-A2.1-restricted CD8(+) T cell epitope relocated to an early gene or a late gene of the cottontail rabbit papillomavirus (CRPV) genome in HLA-A2.1 transgenic rabbits
    Callie E Bounds
    Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Vaccine 29:1194-200. 2011
    ..This study also highlights the broad utility of the HLAA2.1 transgenic rabbit model for testing numerous immunological factors involved in vaccine generated protective immunity...
  22. ncbi request reprint Mucosally-derived HPV-40 can infect both human genital foreskin and cutaneous hand skin tissues grafted into athymic mice
    Audrey L Jenkins
    Department of Comparative Medicine, College of Medicine, The Milton S Hershey Medical Center of the Pennsylvania State University, 500 University Drive, Hershey, PA 17033, USA
    Virus Res 93:109-14. 2003
    ..The results demonstrated that hand skin can support HPV-40(H) infection thereby indicating that this viral type has the capacity to infect both genital mucosal and cutaneous tissues...
  23. pmc Secondary Infections, Expanded Tissue Tropism, and Evidence for Malignant Potential in Immunocompromised Mice Infected with Mus musculus Papillomavirus 1 DNA and Virus
    Nancy M Cladel
    Jake Gittlen Cancer Research Foundation, Pennsylvania State University College of Medicine
    J Virol 87:9391-5. 2013
    ..In these early studies, we have demonstrated both primary and secondary infections, expanded tissue tropism, and extensive dysplasia. ..