Vernon M Chinchilli
Affiliation: Pennsylvania State University
- Statistical issues in clinical trials that involve the double-blind, placebo-controlled food challengeVernon M Chinchilli
Department of Health Evaluation Sciences, Penn State College of Medicine, Hershey, PA 17033 0855, USA
J Allergy Clin Immunol 115:592-7. 2005..Statistical software packages can be adapted to perform such analyses...
- A general class of correlation coefficients for the 2 x 2 crossover designVernon M Chinchilli
Department of Health Evaluation Sciences, Penn State College of Medicine, Hershey, PA, USA
Biom J 47:644-53. 2005..We illustrate the methodology using data from the CLIC trial of the Childhood Asthma Research and Education (CARE) Network...
- General principles for systematic reviews and meta-analyses and a critique of a recent systematic review of long-acting beta-agonistsVernon M Chinchilli
Department of Health Evaluation Sciences, Penn State College of Medicine, Hershey, PA 17033 0855, USA
J Allergy Clin Immunol 119:303-6. 2007..Out of the 19 studies included in the systematic review, the Salmeterol Multicenter Asthma Research Trial provided 80% of the data and dominated the meta-analysis component, especially with respect to asthma-related deaths...
- Assessing the agreement of biomarker data in the presence of left-censoringUthumporn Domthong
Department of Public Health Sciences, Penn State College of Medicine, Hershey, PA, USA
BMC Nephrol 15:144. 2014..This is not statistically optimal, because it often leads to biased estimates and overestimates the precision...
- Performance of a malaria microscopy image analysis slide reading deviceWilliam R Prescott
Hydas World Health, Hershey, PA 17033, USA
Malar J 11:155. 2012..Reported here is an evaluation of a diagnostic system (a "device" consisting of a microscope, a scanner, and a computer algorithm) that evaluates scanned images of standard Giemsa-stained slides and reports species and parasitaemia...
- Including multiple imputation in a sensitivity analysis for clinical trials with treatment failuresMichele L Shaffer
Penn State College of Medicine, Department of Health Evaluation Sciences, 600 Centerview Drive, Suite 2200, Hershey, PA 17033, USA
Contemp Clin Trials 28:130-7. 2007..A data set from the Asthma Clinical Research Network is used to demonstrate the methods...
- Associations between air pollution and peak expiratory flow among patients with persistent asthmaZhengmin Qian
Department of Public Health Sciences, Pennsylvania State University, Hershey, Pennsylvania, USA
J Toxicol Environ Health A 72:39-46. 2009..The results show that the two medication regimens protected against the effects of PM(10). However, salmeterol increased the sensitivity to NO2 and triamcinalone enhanced the sensitivity to SO2...
- Evolution of lower respiratory symptoms in New York police officers after 9/11: a prospective longitudinal studyLarisa V Buyantseva
Department of Medicine, Penn State University College of Medicine, Hershey, PA 17033, USA
J Occup Environ Med 49:310-7. 2007..We studied the evolution of lower respiratory symptoms at 1 month (initial) and 19 months (follow-up) after the collapse of the World Trade Center on September 11, 2001 (9/11)...
- Orthopaedic in-training examination scores: a correlation with USMLE resultsKevin P Black
Department of Orthopaedics and Rehabilitation, Penn State Milton S Hershey Medical Center, P O Box 850, M C H089, Hershey, PA 17033, USA
J Bone Joint Surg Am 88:671-6. 2006..In addition, we sought to determine whether a relationship existed between performance on the Orthopaedic In-Training Examination and the United States Medical Licensing Examinations taken while in medical school...
- Association of higher levels of ambient criteria pollutants with impaired cardiac autonomic control: a population-based studyDuanping Liao
Department of Health Evaluation Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Am J Epidemiol 159:768-77. 2004....
- Improving women's preconceptional health: findings from a randomized trial of the Strong Healthy Women intervention in the Central Pennsylvania women's health studyMarianne M Hillemeier
Pennsylvania State University, College of Health and Human Development, University Park, Pennsylvania 16802, USA
Womens Health Issues 18:S87-96. 2008....
- A matched crossover design for clinical trialsLaura J Simon
Penn State University Main Campus, 328 Thomas Building, University Park, PA 16802, USA
Contemp Clin Trials 28:638-46. 2007..This condition should hold in most circumstances, and therefore the paired crossover design deserves serious consideration for any clinical trial in which the crossing over and matching of subjects is deemed simultaneously beneficial...
- A class of repeated measures concordance correlation coefficientsTonya S King
Pennsylvania State University College of Medicine, Pennsylvania 17033, USA
J Biopharm Stat 17:653-72. 2007....
- Sex differences in the impact of ozone on survival and alveolar macrophage function of mice after Klebsiella pneumoniae infectionAnatoly N Mikerov
The Penn State Center for Host defense, Inflammation, and Lung Disease CHILD Research, Department of Pediatrics, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Respir Res 9:24. 2008..The purpose of this study was to determine whether ozone exposure differentially affects: 1) survival of male and female mice infected with Klebsiella pneumoniae, and 2) the phagocytic ability of macrophages from these mice...
- High prevalence of pelvic and hip magnetic resonance imaging findings in asymptomatic collegiate and professional hockey playersMatthew L Silvis
Pennsylvania State Milton S Hershey Medical Center, 17033, USA
Am J Sports Med 39:715-21. 2011..The true prevalence of these findings and association with symptoms in this population is unknown...
- Association of criteria pollutants with plasma hemostatic/inflammatory markers: a population-based studyDuanping Liao
Department of Health Evaluation Sciences, Pennsylvania State University College of Medicine, Hershey, 17033, USA
J Expo Anal Environ Epidemiol 15:319-28. 2005....
- The effects of sex steroids on spatial performance: a review and an experimental clinical investigationLynn S Liben
Department of Psychology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Dev Psychol 38:236-53. 2002..Spatial performance showed traditional sex differences but did not vary with levels of actively circulating sex steroids...
- A likelihood-based, counterfactual approach to accounting for treatment failures in clinical trialsMichele L Shaffer
Department of Health Evaluation Sciences, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
J Biopharm Stat 13:481-94. 2003..An example from the Asthma Clinical Research Network (ACRN) is used to draw comparisons between the standard ITT procedure and the developed supplemental analysis...
- The relationship between menstrual factors and breast cancer according to estrogen receptor status of tumor: a case-control study in African-American womenKangmin Zhu
Department of Health Evaluation Sciences, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania 17033 0855, USA
Ethn Dis 12:S3-23-9. 2002..This case-control study aimed to examine such a relationship according to ER status of breast cancer in African-American women...
- A repeated measures concordance correlation coefficientTonya S King
Division of Biostatistics, Department of Health Evaluation Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
Stat Med 26:3095-113. 2007....
- Guideline-defining asthma clinical trials of the National Heart, Lung, and Blood Institute's Asthma Clinical Research Network and Childhood Asthma Research and Education NetworkLoren C Denlinger
Department of Medicine, College of Medicine, Pennsylvania State University, Hershey, PA, USA
J Allergy Clin Immunol 119:3-11; quiz 12-3. 2007....
- A case-control study of menstrual factors in relation to breast cancer risk in African-American womenJessica S B Beiler
Department of Health Evaluation Sciences, Penn State College of Medicine, Hershey, PA, USA
J Natl Med Assoc 95:930-8. 2003..No significant associations were observed for other menstrual factors. Findings suggest that cycle length has an inverse association with breast cancer in African-American women that may primarily exist for post-menopausal tumors...
- Lead, calcium uptake, and related genetic variants in association with renal cell carcinoma risk in a cohort of male Finnish smokersEmily B Southard
Department of Public Health Sciences, Penn State College of Medicine, Penn State Cancer Institute, 500 University Drive, Mail Code CH69, Hershey, PA 17033, USA
Cancer Epidemiol Biomarkers Prev 21:191-201. 2012..Lead is classified as a probable human carcinogen. However, its role in renal cell cancer (RCC) has not been established. Calcium and vitamin D may off-set toxicity in vivo...
- Alternatives for measuring endogenous adrenocortical activity in asthmatics treated with inhaled corticosteroidsLarisa V Buyantseva
Department of Medicine, Penn State College of Medicine, MC HO41, 500 University Drive, Milton S Hersley Medical Center, Hershey, PA 17033, USA
Endocr Res 31:245-58. 2005..m. (r = 0.94; 0.93, 0.95); every 2 hours (r = 0. 96; 0.96, 0.97); and every 3 hours (r = 0. 91, 0.91, 0.93). The two-sample alternatives (10 p.m/8 a.m. and 9 p.m/7 a.m.) are accurate, as well as more convenient, economical, and practical...
- A conceptual framework for pharmacodynamic genome-wide association studies in pharmacogenomicsRongling Wu
Division of Biostatistics and Bioinformatics, Pennsylvania State University, Hershey, PA, USA
Drug Discov Today 16:884-90. 2011....
- Bayesian inference for randomized clinical trials with treatment failuresMichele L Shaffer
Department of Health Evaluation Sciences, A210, Penn State College of Medicine, 600 Centerview Drive, Suite 2200, Hershey, PA 17033 0855, U S A
Stat Med 23:1215-28. 2004..An example from the Asthma Clinical Research Network (ACRN) is used to illustrate the Bayesian procedure...
- Head injury and pulmonary embolism: a retrospective report based on the Pennsylvania Trauma Outcomes studyRobert B Page
Department of Surgery, Division of Neurosurgery, College of Medicine of the Pennsylvania State University, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
Neurosurgery 54:143-8; discussion 148-9. 2004..of symptomatic pulmonary embolism during hospitalization in a trauma center in patients who have sustained a head injury? Are patients with head injuries more at risk for pulmonary embolism than trauma patients without head injuries?..
- Dual-platform proteomics study of plasma biomarkers in pediatric patients undergoing cardiopulmonary bypassTodd M Umstead
Department of Pediatrics, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
Pediatr Res 67:641-9. 2010..The changes in levels of expression of these proteins may provide insight into the understanding, treatment, and prevention of systemic inflammation, thereby helping to improve the outcomes of pediatric CPB patients...
- Comparison of concordance correlation coefficient estimating approaches with skewed dataJosep L Carrasco
Biostatistics, Public Health Department, University of Barcelona, Barcelona, Spain
J Biopharm Stat 17:673-84. 2007..An example of alcohol consumption is considered and a simulation study is performed...
- Sputum eosinophil counts predict asthma control after discontinuation of inhaled corticosteroidsAaron Deykin
Brigham and Women s Hospital and Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA
J Allergy Clin Immunol 115:720-7. 2005..Although inhaled corticosteroids (ICSs) are effective in preventing deterioration in asthma control, at least half of subjects with mild-to-moderate asthma will remain stable when these agents are discontinued...
- Significant variability in response to inhaled corticosteroids for persistent asthmaStanley J Szefler
National Jewish Medical and Research Center, Department of Pediatrics, Denver, CO 80206, USA
J Allergy Clin Immunol 109:410-8. 2002..A clinical model is needed to compare inhaled corticosteroids (ICSs) with respect to efficacy...
- The Predicting Response to Inhaled Corticosteroid Efficacy (PRICE) trialRichard J Martin
National Jewish Medical and Research Center, Denver, CO 80206, USA
J Allergy Clin Immunol 119:73-80. 2007..Although guidelines recommend anti-inflammatory therapy for persistent asthma, recent studies suggest that 25% to 35% of patients with asthma may not improve lung function with inhaled corticosteroids...
- Systemic effect comparisons of six inhaled corticosteroid preparationsRichard J Martin
National Jewish Medical and Research Center, Denver, Colorado 80206, USA
Am J Respir Crit Care Med 165:1377-83. 2002..This study represents the first step in evaluation of ICS efficacy based on equisystemic (cortisol suppression) effects of a given ICS, rather than doses judged arbitrarily to be comparable on a microgram basis...
- Smoking affects response to inhaled corticosteroids or leukotriene receptor antagonists in asthmaStephen C Lazarus
University of California, San Francisco, 505 Parnassus Avenue, M 1083, San Francisco, CA 94143 0111, USA
Am J Respir Crit Care Med 175:783-90. 2007..One-quarter to one-third of individuals with asthma smoke, which may affect response to therapy and contribute to poor asthma control...
- Long-term comparison of 3 controller regimens for mild-moderate persistent childhood asthma: the Pediatric Asthma Controller TrialChristine A Sorkness
Clinical Science Center, University of Wisconsin, Madison, WI 53792, USA
J Allergy Clin Immunol 119:64-72. 2007..More evidence is needed on which to base recommendations for treatment of mild-moderate persistent asthma in school-aged children...
- Characterization of within-subject responses to fluticasone and montelukast in childhood asthmaStanley J Szefler
Department of Pediatrics, National Jewish Medical and Research Medical Center and University of Colorado Health Sciences Center, Denver, CO 80206, USA
J Allergy Clin Immunol 115:233-42. 2005..Responses to inhaled corticosteroids (ICSs) and leukotriene receptor antagonists (LTRAs) vary among asthmatic patients...
- The Prevention of Early Asthma in Kids study: design, rationale and methods for the Childhood Asthma Research and Education networkTheresa W Guilbert
Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, 1501 N Campbell Avenue, PO Box 245073, Tucson, AZ 85724, USA
Control Clin Trials 25:286-310. 2004..These measures were chosen to reflect the progression of the disease from intermittent wheezing to persistent asthma and measurement of the extent of airflow limitation and airway reactivity...
- Daily versus as-needed corticosteroids for mild persistent asthmaHomer A Boushey
University of California at San Francisco, San Francisco, USA
N Engl J Med 352:1519-28. 2005....
- beta-Adrenergic receptor polymorphisms and response to salmeterolMichael E Wechsler
Brigham and Women s Hospital, 75 Francis Street, Boston, MA, 02115, USA
Am J Respir Crit Care Med 173:519-26. 2006..Several studies suggest that patients with asthma who are homozygous for arginine at the 16th position of the beta2-adrenergic receptor may not benefit from short-acting beta-agonists...
- Titrating and evaluating multi-drug regimens within subjectsMargaret Shih
Department of Biostatistics, Virginia Commonwealth University, Richmond, VA 23298 0032, USA
Stat Med 22:2257-79. 2003..The advantages of this approach include affording every patient the potential to benefit from the combination under study and permitting the consideration of multiple endpoints simultaneously...
- Response profiles to fluticasone and montelukast in mild-to-moderate persistent childhood asthmaRobert S Zeiger
Department of Pediatrics, University of California San Diego, San Diego, CA 92111, USA
J Allergy Clin Immunol 117:45-52. 2006..Outcome data are needed to base recommendations for controller asthma medication use in school-aged children...
- Use of regularly scheduled albuterol treatment in asthma: genotype-stratified, randomised, placebo-controlled cross-over trialElliot Israel
Brigham and Women s Hospital and Harvard Medical School, Boston, MA 02115, USA
Lancet 364:1505-12. 2004..However, the existence of any genotype-dependent difference has not been tested in a prospective clinical trial...
- Long-term inhaled corticosteroids in preschool children at high risk for asthmaTheresa W Guilbert
Division of Pediatric Pulmonary Medicine, Arizona Respiratory Center, University of Arizona, Tucson, AZ 85724, USA
N Engl J Med 354:1985-97. 2006..It is unknown whether inhaled corticosteroids can modify the subsequent development of asthma in preschool children at high risk for asthma...
- Combination therapy with a long-acting beta-agonist and a leukotriene antagonist in moderate asthmaAaron Deykin
Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA
Am J Respir Crit Care Med 175:228-34. 2007..The elements of asthma control achieved by LABAs (improved lung function) and leukotriene receptor antagonists (LTRAs; protection against exacerbations) may be complementary as well...
- Abortions and breast cancer: record-based case-control studyJoel Brind
Int J Cancer 109:945-6; author reply 947-8. 2004
- On the relation between induced abortion and breast cancerJoel Brind
Department of Natural Sciences, Baruch College of the City University of New York, New York, USA
Lancet Oncol 3:266-7; author reply 267-8. 2002
- Relationship of exhaled nitric oxide to clinical and inflammatory markers of persistent asthma in childrenRobert C Strunk
Washington University School of Medicine, St Louis, MO, USA
J Allergy Clin Immunol 112:883-92. 2003..Insufficient information is available concerning correlations between eNO and biologic, physiologic, and clinical characteristics of asthma in children currently not taking controller medications...
- Severe intermittent wheezing in preschool children: a distinct phenotypeLeonard B Bacharier
Department of Pediatrics, Washington University, St Louis Children s Hospital, St Louis, MOO 63110, USA
J Allergy Clin Immunol 119:604-10. 2007....
- Rhinosinusitis: Developing guidance for clinical trialsEli O Meltzer
Allergy and Asthma Medical Group and Research Center Department of Pediatrics, University of California, San Diego, San Diego, California
Otolaryngol Head Neck Surg 135:S31-80. 2006....
- Rhinosinusitis: developing guidance for clinical trialsEli O Meltzer
Allergy and Asthma Medical Group and Research Center and Department of Pediatrics, University of California, San Diego, USA
J Allergy Clin Immunol 118:S17-61. 2006....
- Relationship of serum HER-2/neu and serum CA 15-3 in patients with metastatic breast cancerSuhail M Ali
The M S Hershey Medical Center, PA 17033, USA
Clin Chem 48:1314-20. 2002..We measured serum CA 15-3, a surrogate marker of disease burden, and correlated serum CA 15-3 with serum HER-2/neu and analyzed the association of both markers with clinical outcomes...