Hua Cheng

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc New insight into the oncogenic mechanism of the retroviral oncoprotein Tax
    Hua Cheng
    Penn State Hershey Cancer Institute, Hershey, PA 17033, USA
    Protein Cell 3:581-9. 2012
  2. doi request reprint Use of K-Ras as a predictive biomarker for selecting anti-EGF receptor/pathway treatment
    Yixing Jiang
    Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA
    Biomark Med 4:535-41. 2010
  3. pmc Developing an in vitro model of T cell type of large granular lymphocyte leukemia
    Tong Ren
    Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, PA 17033, United States
    Leuk Res 37:1737-43. 2013
  4. doi request reprint New pharmacological developments in the treatment of hepatocellular cancer
    Niraj J Gusani
    Penn State Hershey Cancer Institute, Hershey, Pennsylvania, USA
    Drugs 69:2533-40. 2009
  5. pmc HTLV-2 Tax immortalizes human CD4+ memory T lymphocytes by oncogenic activation and dysregulation of autophagy
    Tong Ren
    Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 287:34683-93. 2012
  6. doi request reprint HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB
    Jiannan Huang
    Penn State Cancer Institute, Department of Medicine, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 284:6208-17. 2009
  7. ncbi request reprint Anal carcinoma therapy: can we improve on 5-fluorouracil/mitomycin/radiotherapy?
    Yixing Jiang
    Penn State College of Medicine, Penn State Cancer Institute, Hershey, Pennsylvania, USA
    J Natl Compr Canc Netw 8:135-44. 2010

Collaborators

Detail Information

Publications7

  1. pmc New insight into the oncogenic mechanism of the retroviral oncoprotein Tax
    Hua Cheng
    Penn State Hershey Cancer Institute, Hershey, PA 17033, USA
    Protein Cell 3:581-9. 2012
    ..Understanding Tax-mediated pathogenesis will provide insights into development of new therapeutics in controlling HTLV-1-associated diseases...
  2. doi request reprint Use of K-Ras as a predictive biomarker for selecting anti-EGF receptor/pathway treatment
    Yixing Jiang
    Penn State Hershey Cancer Institute, Penn State College of Medicine, Hershey, PA 17033, USA
    Biomark Med 4:535-41. 2010
    ..These observations have provoked an interest in utilizing K-Ras as a predictive biomarker, allowing clinicians to direct the therapy of cancer patients based on their mutational status of the k-ras gene...
  3. pmc Developing an in vitro model of T cell type of large granular lymphocyte leukemia
    Tong Ren
    Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, PA 17033, United States
    Leuk Res 37:1737-43. 2013
    ..This model should be useful for investigating molecular pathogenesis of the disease and for developing new therapeutics targeting T-LGL leukemia. ..
  4. doi request reprint New pharmacological developments in the treatment of hepatocellular cancer
    Niraj J Gusani
    Penn State Hershey Cancer Institute, Hershey, Pennsylvania, USA
    Drugs 69:2533-40. 2009
    ..Although the survival benefit demonstrated by sorafenib is moderate, molecular targeted therapy has brought new hope in the management of HCC...
  5. pmc HTLV-2 Tax immortalizes human CD4+ memory T lymphocytes by oncogenic activation and dysregulation of autophagy
    Tong Ren
    Penn State Hershey Cancer Institute, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 287:34683-93. 2012
    ..The present study demonstrated the oncogenic properties of Tax2 in human T cells and also implicated Tax2 in serving as a molecular tool to generate distinct T cell subtype lines...
  6. doi request reprint HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB
    Jiannan Huang
    Penn State Cancer Institute, Department of Medicine, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 284:6208-17. 2009
    ..These findings indicate that Tax1 actively recruits IKK to the lipid raft microdomains for persistent activation of NF-kappaB, thereby contributing to HTLV-1 oncogenesis...
  7. ncbi request reprint Anal carcinoma therapy: can we improve on 5-fluorouracil/mitomycin/radiotherapy?
    Yixing Jiang
    Penn State College of Medicine, Penn State Cancer Institute, Hershey, Pennsylvania, USA
    J Natl Compr Canc Netw 8:135-44. 2010
    ..Further improvement is likely depending on an increased understanding of the molecular biology of anal carcinoma and the addition of relevant biologic agents to chemoradiation to overcome chemoradiation resistance...

Research Grants1

  1. Linking IKKbeta activation to anti-autophagy in viral protein Tax-mediated oncoge
    Hua Cheng; Fiscal Year: 2010
    ..We plan to investigate the mechanism that Tax mediates persistent activation of NF-(B and anti-autophagy function during development of T cell leukemia. ..