MARGHERITA CANTORNA

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. doi request reprint Dominant effects of the diet on the microbiome and the local and systemic immune response in mice
    Jot Hui Ooi
    Center for Molecular Immunology and Infectious Disease, Department of Biochemistry and Molecular Biology, Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS ONE 9:e86366. 2014
  2. pmc Therapeutic effect of vitamin d supplementation in a pilot study of Crohn's patients
    Linlin Yang
    Department of Veterinary and Biomedical Science, Center for Molecular Immunology and Infectious Disease, University Park, Pennsylvania, USA
    Clin Transl Gastroenterol 4:e33. 2013
  3. ncbi request reprint Vitamin D receptor expression controls proliferation of naïve CD8+ T cells and development of CD8 mediated gastrointestinal inflammation
    Jing Chen
    Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Immunol 15:6. 2014
  4. pmc Vitamin D, multiple sclerosis and inflammatory bowel disease
    Margherita T Cantorna
    Department of Veterinary and Biomedical Science, The Center for Molecular Immunology and Infectious Disease, 115 Henning Bldg, The Pennsylvania State University, University Park, PA 16802, USA
    Arch Biochem Biophys 523:103-6. 2012
  5. pmc Vitamin D, invariant natural killer T-cells and experimental autoimmune disease
    Margherita T Cantorna
    Department of Veterinary and Biomedical Science, Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA 16802, USA
    Proc Nutr Soc 71:62-6. 2012
  6. pmc Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury
    Monica Froicu
    Department of Veterinary and Biomedical Sciences, Pathobiology Graduate Program, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Immunol 8:5. 2007
  7. pmc The effects of whole mushrooms during inflammation
    Sanhong Yu
    Center for Immunology and Infectious Disease, Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA, USA
    BMC Immunol 10:12. 2009
  8. ncbi request reprint Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence?
    M T Cantorna
    Department of Nutrition, The Pennsylvania State University, University Park 16802, USA
    Proc Soc Exp Biol Med 223:230-3. 2000
  9. ncbi request reprint A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases
    Monica Froicu
    Department of Nutrition, 126 South Henderson Building, University Park, Pennsylvania 16802, USA
    Mol Endocrinol 17:2386-92. 2003
  10. pmc Why do T cells express the vitamin D receptor?
    Margherita T Cantorna
    Department of Veterinary and Biomedical Sciences, The Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, Pennsylvania, USA
    Ann N Y Acad Sci 1217:77-82. 2011

Research Grants

  1. VITAMIN D REGULATION OF TYPE-2 HELPER T CELL RESPONSES
    MARGHERITA CANTORNA; Fiscal Year: 2001
  2. Vitamin D and NKT Cell Regulation of Multiple Sclerosis
    Margherita T Cantorna; Fiscal Year: 2010
  3. Vitamin D Fluctuations and the Mucosal Immune Response
    Margherita T Cantorna; Fiscal Year: 2010
  4. Vitamin D Fluctuations and the Mucosal Immune Response
    MARGHERITA CANTORNA; Fiscal Year: 2009
  5. Vitamin D Fluctuations and the Mucosal Immune Response
    Margherita T Cantorna; Fiscal Year: 2010
  6. VITAMIN D REGULATION OF TYPE-2 HELPER T CELL RESPONSES
    MARGHERITA CANTORNA; Fiscal Year: 2004
  7. Vitamin D Regulation of Inflammatory Bowel Disease
    MARGHERITA CANTORNA; Fiscal Year: 2006
  8. VITAMIN D REGULATION OF TYPE-2 HELPER T CELL RESPONSES
    MARGHERITA CANTORNA; Fiscal Year: 2003
  9. VITAMIN D REGULATION OF TYPE-2 HELPER T CELL RESPONSES
    MARGHERITA CANTORNA; Fiscal Year: 2002
  10. Vitamin D Regulation of Inflammatory Bowel Disease
    MARGHERITA CANTORNA; Fiscal Year: 2007

Collaborators

Detail Information

Publications31

  1. doi request reprint Dominant effects of the diet on the microbiome and the local and systemic immune response in mice
    Jot Hui Ooi
    Center for Molecular Immunology and Infectious Disease, Department of Biochemistry and Molecular Biology, Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS ONE 9:e86366. 2014
    ..These findings highlight the potential of using dietary manipulation to control the microbiome and prevent/treat immune-mediated disease. ..
  2. pmc Therapeutic effect of vitamin d supplementation in a pilot study of Crohn's patients
    Linlin Yang
    Department of Veterinary and Biomedical Science, Center for Molecular Immunology and Infectious Disease, University Park, Pennsylvania, USA
    Clin Transl Gastroenterol 4:e33. 2013
    ..Low vitamin D status may be associated with Crohn's disease. A pilot study was performed in patients with mild-to-moderate Crohn's disease to determine the dose of vitamin D needed to raise serum vitamin D levels above 40 ng/ml...
  3. ncbi request reprint Vitamin D receptor expression controls proliferation of naïve CD8+ T cells and development of CD8 mediated gastrointestinal inflammation
    Jing Chen
    Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Immunol 15:6. 2014
    ..T cells have been shown to express the VDR, and T cells are targets of vitamin D. In this article we determined the effects of VDR expression on CD8+ T cells...
  4. pmc Vitamin D, multiple sclerosis and inflammatory bowel disease
    Margherita T Cantorna
    Department of Veterinary and Biomedical Science, The Center for Molecular Immunology and Infectious Disease, 115 Henning Bldg, The Pennsylvania State University, University Park, PA 16802, USA
    Arch Biochem Biophys 523:103-6. 2012
    ..Nonetheless, current evidence suggests that improving vitamin D status and/or using vitamin D receptor agonists may be useful in MS and IBD...
  5. pmc Vitamin D, invariant natural killer T-cells and experimental autoimmune disease
    Margherita T Cantorna
    Department of Veterinary and Biomedical Science, Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA 16802, USA
    Proc Nutr Soc 71:62-6. 2012
    ..The important role of vitamin D on iNKT cells could impact the development of human immune-mediated diseases including multiple sclerosis and asthma...
  6. pmc Vitamin D and the vitamin D receptor are critical for control of the innate immune response to colonic injury
    Monica Froicu
    Department of Veterinary and Biomedical Sciences, Pathobiology Graduate Program, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Immunol 8:5. 2007
    ..The active form of vitamin D (1,25(OH)2D3) has been shown to inhibit development of inflammatory bowel disease (IBD) in IL-10 KO mice. Here, the role of the vitamin D receptor (VDR) and 1,25(OH)2D3 in acute experimental IBD was probed...
  7. pmc The effects of whole mushrooms during inflammation
    Sanhong Yu
    Center for Immunology and Infectious Disease, Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA, USA
    BMC Immunol 10:12. 2009
    ..A number of isolated mushroom constituents have been shown to modulate immunity. Five commonly consumed edible mushrooms were tested to determine whether whole mushrooms stimulate the immune system in vitro and in vivo...
  8. ncbi request reprint Vitamin D and autoimmunity: is vitamin D status an environmental factor affecting autoimmune disease prevalence?
    M T Cantorna
    Department of Nutrition, The Pennsylvania State University, University Park 16802, USA
    Proc Soc Exp Biol Med 223:230-3. 2000
    ..This review discusses the possibility that vitamin D status is an environmental factor, which by shaping the immune system affects the prevalence rate for autoimmune diseases such as multiple sclerosis, arthritis, and juvenile diabetes...
  9. ncbi request reprint A crucial role for the vitamin D receptor in experimental inflammatory bowel diseases
    Monica Froicu
    Department of Nutrition, 126 South Henderson Building, University Park, Pennsylvania 16802, USA
    Mol Endocrinol 17:2386-92. 2003
    ..The data establishes an essential role for VDR signaling in the regulation of inflammation in the gastrointestinal tract...
  10. pmc Why do T cells express the vitamin D receptor?
    Margherita T Cantorna
    Department of Veterinary and Biomedical Sciences, The Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, Pennsylvania, USA
    Ann N Y Acad Sci 1217:77-82. 2011
    ..Available evidence suggests that NKT and CD8αα T cells express the VDR as part of the selection process to protect against the generation of autoimmunity, particularly in the gut...
  11. pmc Mechanisms underlying the effect of vitamin D on the immune system
    Margherita T Cantorna
    Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Science, The Pennsylvania State University, 115 Henning Bldg, University Park, PA 16802, USA
    Proc Nutr Soc 69:286-9. 2010
    ..In the absence of vitamin D and the VDR, autoimmunity occurs in the gastrointestinal tract due to increased numbers of IL-17 and IFN-gamma secreting T-cells and a concomitant reduction in regulatory T-cells...
  12. pmc Vitamin D and multiple sclerosis: an update
    Margherita T Cantorna
    The Center for Immunology and Infectious Disease, Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nutr Rev 66:S135-8. 2008
    ....
  13. pmc The paradoxical effects of vitamin D on type 1 mediated immunity
    Margherita T Cantorna
    Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Diseases, The Pennsylvania State University, University Park, PA 16802, USA
    Mol Aspects Med 29:369-75. 2008
    ..The interplay of these vitamin D targets and their impact on the host-immune response then dictate the outcome...
  14. ncbi request reprint Vitamin D and its role in immunology: multiple sclerosis, and inflammatory bowel disease
    Margherita T Cantorna
    Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Diseases, The Pennsylvania State University, 115 Henning Bldg, University Park, PA 16802, USA
    Prog Biophys Mol Biol 92:60-4. 2006
    ....
  15. ncbi request reprint Mounting evidence for vitamin D as an environmental factor affecting autoimmune disease prevalence
    Margherita T Cantorna
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
    Exp Biol Med (Maywood) 229:1136-42. 2004
    ..This review discusses the accumulating evidence pointing to a link between vitamin D and autoimmunity. Increased vitamin D intakes might decrease the incidence and severity of autoimmune diseases and the rate of bone fracture...
  16. ncbi request reprint Vitamin D status, 1,25-dihydroxyvitamin D3, and the immune system
    Margherita T Cantorna
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
    Am J Clin Nutr 80:1717S-20S. 2004
    ..Both the type of immune response and the calcium status of the host determine the effects of vitamin D status and 1,25(OH)2D3 on immunity...
  17. ncbi request reprint D-hormone and the immune system
    Margherita T Cantorna
    Department of Nutritional Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Rheumatol Suppl 76:11-20. 2005
    ..D-hormone is a selective regulator of the immune system, and the outcome of D-hormone treatment depends on the nature (infectious disease, asthma, autoimmune disease, etc.) of the immune response...
  18. ncbi request reprint Calcium and 1 alpha,25-dihydroxyvitamin D3 target the TNF-alpha pathway to suppress experimental inflammatory bowel disease
    Yan Zhu
    Department of Nutrition, College of Human Health and Development, The Pennsylvania State University, University Park, PA 16802, USA
    Eur J Immunol 35:217-24. 2005
    ..The data support a model where dietary calcium and 1,25D3 treatment directly and indirectly inhibit the TNF-alpha pathway and suppress IBD...
  19. ncbi request reprint Interleukin-2 is one of the targets of 1,25-dihydroxyvitamin D3 in the immune system
    Candace J Bemiss
    Department of Nutrition, College of Health and Human Development, The Pennsylvania State University, University Park, PA 16802, USA
    Arch Biochem Biophys 402:249-54. 2002
    ..In the absence of IL-2, vitamin D was ineffective for suppressing colitis and ineffective for the in vitro downregulation of IL-10 or IFN-gamma production. One target of 1,25-dihydroxyvitamin D3 in the immune system is the IL-2 gene...
  20. pmc Vitamin D receptor is required to control gastrointestinal immunity in IL-10 knockout mice
    Monica Froicu
    Immunology Research Laboratories, The Pathobioilogy and Nutrition Graduate Programs, Department of Veterinary Science, The Pennsylvania State University, University Park, PA 16802, USA
    Immunology 117:310-8. 2006
    ..VDR expression is required for the T cells and other immune cells to control inflammation in the IL-10 KO mice...
  21. pmc Vitamin D receptor expression by the lung micro-environment is required for maximal induction of lung inflammation
    Anja Wittke
    Department of Veterinary and Biomedical Science, The Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA 16802, USA
    Arch Biochem Biophys 460:306-13. 2007
    ....
  22. pmc Elevated non-specific immunity and normal Listeria clearance in young and old vitamin D receptor knockout mice
    Danny Bruce
    Department of Veterinary and Biomedical Science, Center for Immunology and Infectious Disease, Pennsylvania State University, University Park, PA 16802, USA
    Int Immunol 21:113-22. 2009
    ..The increased antibody and cytokine responses in the old VDR KO mice are consistent with the increased susceptibility of these mice to autoimmunity...
  23. ncbi request reprint Vitamin D receptor-deficient mice fail to develop experimental allergic asthma
    Anja Wittke
    Department of Nutrition, Immunology Research Laboratory, Pennsylvania State University, University Park 16802, USA
    J Immunol 173:3432-6. 2004
    ..However, VDR-deficient mice failed to develop experimental allergic asthma, suggesting an important role for the vitamin D endocrine system in the generation of Th2-driven inflammation in the lung...
  24. ncbi request reprint Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthma
    Cynthia Mueller
    Department of Veterinary Science, The Pennsylvania State University, University Park, PA 16802, USA
    Arch Biochem Biophys 418:186-96. 2003
    ..T cells from these ciglitazone treated mice also produced less IFNgamma, IL-4, and IL-2 upon rechallenge in vitro with the model allergen. Our results suggest that ligands for PPARgamma may be effective treatments for asthmatic patients...
  25. pmc The vitamin D receptor is required for iNKT cell development
    Sanhong Yu
    Department of Veterinary and Biomedical Sciences, Immunobiology Graduate Program, Center for Molecular Immunology and Infectious Diseases, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 105:5207-12. 2008
    ..In addition, VDR KO iNKT cells were intrinsically defective even when WT antigen-presenting cells were used to stimulate them...
  26. ncbi request reprint Nutrients, nuclear receptors, inflammation, immunity lipids, PPAR, and allergic asthma
    Avery August
    Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, 16802, USA
    J Nutr 136:695-9. 2006
    ..In vitro, T cells from ciglitazone-treated mice secreted significantly less IL-4 and IFN-gamma in response to restimulation. These data suggest that PPARgamma agonists may be useful for the treatment of allergic asthma...
  27. pmc Failure of T cell homing, reduced CD4/CD8alphaalpha intraepithelial lymphocytes, and inflammation in the gut of vitamin D receptor KO mice
    Sanhong Yu
    Center for Immunology and Infectious Disease, Department of Veterinary and Biomedical Science, Pennsylvania State University, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 105:20834-9. 2008
    ....
  28. ncbi request reprint The targets of vitamin D depend on the differentiation and activation status of CD4 positive T cells
    Brett D Mahon
    Department of Nutrition, The Pennsylvania State University, University Park, PA 16802, USA
    J Cell Biochem 89:922-32. 2003
    ..Clearly CD4+ T cells can be direct targets of vitamin D. The targets of vitamin D in CD4+ T cells depend on the state of activation and differentiation status of the cells...
  29. pmc Vitamin D and host resistance to infection? Putting the cart in front of the horse
    Danny Bruce
    Department of Veterinary and Biomedical Science, Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, 16802, USA
    Exp Biol Med (Maywood) 235:921-7. 2010
    ..Experiments have not been done in cells, mice or humans to evaluate the effect of vitamin D on influenza virus. At this time it would be premature to claim that vitamin D has an effect on TB, influenza or any other infection...
  30. pmc Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell
    Qian Qi
    Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 286:138-46. 2011
    ....
  31. ncbi request reprint Iron-deficient mice fail to develop autoimmune encephalomyelitis
    Sharon M Grant
    Department of Nutrition, The Pennsylvania State University, 126 South Henderson, University Park, PA 16802, USA
    J Nutr 133:2635-8. 2003
    ..The mechanism of EAE inhibition in iron-deficient mice likely involves the delivery and metabolism of iron for optimal CD4+ T-cell development...

Research Grants11

  1. VITAMIN D REGULATION OF TYPE-2 HELPER T CELL RESPONSES
    MARGHERITA CANTORNA; Fiscal Year: 2001
    ..A better understanding of how vitamin D effectively blocks EAE is necessary for proper nutritional counseling and optimal treatment of multiple sclerosis patients. ..
  2. Vitamin D and NKT Cell Regulation of Multiple Sclerosis
    Margherita T Cantorna; Fiscal Year: 2010
    ....
  3. Vitamin D Fluctuations and the Mucosal Immune Response
    Margherita T Cantorna; Fiscal Year: 2010
    ....
  4. Vitamin D Fluctuations and the Mucosal Immune Response
    MARGHERITA CANTORNA; Fiscal Year: 2009
    ....
  5. Vitamin D Fluctuations and the Mucosal Immune Response
    Margherita T Cantorna; Fiscal Year: 2010
    ....
  6. VITAMIN D REGULATION OF TYPE-2 HELPER T CELL RESPONSES
    MARGHERITA CANTORNA; Fiscal Year: 2004
    ..A better understanding of how vitamin D effectively blocks EAE is necessary for proper nutritional counseling and optimal treatment of multiple sclerosis patients. ..
  7. Vitamin D Regulation of Inflammatory Bowel Disease
    MARGHERITA CANTORNA; Fiscal Year: 2006
    ..A better understanding of the mechanisms underlying vitamin D regulation of T cells and IBD may lead to improved therapies for patients with IBD. ..
  8. VITAMIN D REGULATION OF TYPE-2 HELPER T CELL RESPONSES
    MARGHERITA CANTORNA; Fiscal Year: 2003
    ..A better understanding of how vitamin D effectively blocks EAE is necessary for proper nutritional counseling and optimal treatment of multiple sclerosis patients. ..
  9. VITAMIN D REGULATION OF TYPE-2 HELPER T CELL RESPONSES
    MARGHERITA CANTORNA; Fiscal Year: 2002
    ..A better understanding of how vitamin D effectively blocks EAE is necessary for proper nutritional counseling and optimal treatment of multiple sclerosis patients. ..
  10. Vitamin D Regulation of Inflammatory Bowel Disease
    MARGHERITA CANTORNA; Fiscal Year: 2007
    ..A better understanding of the mechanisms underlying vitamin D regulation of T cells and IBD may lead to improved therapies for patients with IBD. ..