Craig Cameron

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Picornavirus genome replication. Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complex
    Miaoqing Shen
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 283:875-88. 2008
  2. pmc Phosphate release contributes to the rate-limiting step for unwinding by an RNA helicase
    Qixin Wang
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Nucleic Acids Res 38:1312-24. 2010
  3. pmc Nucleic acid polymerases use a general acid for nucleotidyl transfer
    Christian Castro
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nat Struct Mol Biol 16:212-8. 2009
  4. pmc Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis
    Jason D Graci
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, USA
    J Virol 86:2869-73. 2012
  5. pmc Stimulation of poliovirus RNA synthesis and virus maturation in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro
    David Franco
    Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11790, USA
    Virol J 2:86. 2005
  6. ncbi request reprint The mechanism of action of ribavirin: lethal mutagenesis of RNA virus genomes mediated by the viral RNA-dependent RNA polymerase
    C E Cameron
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, Pennsylvania 16802, USA
    Curr Opin Infect Dis 14:757-64. 2001
  7. pmc Expanding knowledge of P3 proteins in the poliovirus lifecycle
    Craig E Cameron
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    Future Microbiol 5:867-81. 2010
  8. pmc Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase?
    Craig E Cameron
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, United States
    Curr Opin Struct Biol 19:768-74. 2009
  9. pmc Structure-function relationships of the viral RNA-dependent RNA polymerase: fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket
    Victoria S Korneeva
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 282:16135-45. 2007
  10. pmc Insight into poliovirus genome replication and encapsidation obtained from studies of 3B-3C cleavage site mutants
    Hyung Suk Oh
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, 16802, USA
    J Virol 83:9370-87. 2009

Research Grants

  1. RNA-dependent RNA Polymerase
    Craig Cameron; Fiscal Year: 2009
  2. RNA-dependent RNA Polymerase
    Craig E Cameron; Fiscal Year: 2010
  3. RNA-dependent RNA Polymerase
    Craig E Cameron; Fiscal Year: 2010
  4. Picornavirus Genome Replication
    Craig E Cameron; Fiscal Year: 2010
  5. RNA DEPENDENT RNA POLYMERASE MECHANISM
    Craig Cameron; Fiscal Year: 2007
  6. Lethal Mutagenesis as an Antiviral Strategy
    Craig Cameron; Fiscal Year: 2007
  7. Picornavirus Genome Replication
    Craig Cameron; Fiscal Year: 2007
  8. RNA DEPENDENT RNA POLYMERASE MECHANISM
    Craig Cameron; Fiscal Year: 2003
  9. Picornavirus Genome Replication
    Craig E Cameron; Fiscal Year: 2010
  10. Picornavirus Genome Replication
    Craig Cameron; Fiscal Year: 2009

Collaborators

  • KEVIN D contact RANEY
  • Suresh D Sharma
  • Jamie J Arnold
  • A V Paul
  • Matthias Gotte
  • David Franco
  • Jason D Graci
  • Harsh B Pathak
  • Christian Castro
  • Thomas A Jennings
  • Daniel A Harki
  • Bartek Sikora
  • Blake R Peterson
  • Victoria S Korneeva
  • Alan J Tackett
  • Luyun Huang
  • Qixin Wang
  • Eric D Smidansky
  • Melody K Harrison
  • Miaoqing Shen
  • Yingfeng Chen
  • Hyung Suk Oh
  • Jessica E Galarraga
  • Jocelyn P Edathil
  • Samuel G Mackintosh
  • Michele R S Hargittai
  • David W Gohara
  • Rebecca Toroney
  • Akira Uchida
  • Deniz Sikora
  • Ian G Goodfellow
  • Ibrahim Moustafa
  • Kenneth R Maksimchuk
  • Qi Sun
  • William Konigsberg
  • Daniel M Brown
  • David Loakes
  • Kathleen Too
  • Joshua Sakon
  • John B Jordan
  • Saikat Kumar B Ghosh
  • Patrick D Morris
  • Marco Vignuzzi
  • Nina F Gn├Ądig
  • Joshua A Boyer
  • Subba Rao Nallagatla
  • Philip C Bevilacqua
  • Bhuvanesh Dave
  • Yong Tang
  • Margaret E Fairman
  • Cheryl F Lichti
  • Runzhi Wu
  • Yan Zhao
  • Eckhard Jankowsky
  • Eric W Barr
  • Zachary J Reitman
  • J Martin Bollinger
  • Phillip N Wiegand
  • Stanley M Lemon
  • Eric Smidansky
  • Yan Yang
  • Jeff Zhiqiang Lu
  • William J Chain
  • Jungwook Hwang
  • Mehul Suthar
  • Elena V Sineva
  • Robert Ott
  • Ellen Fanning
  • Allan W Roberts
  • Poonam Tanega
  • David J Barton
  • Zhi Hong
  • Alicia K Byrd
  • Joshua D Yoder

Detail Information

Publications38

  1. pmc Picornavirus genome replication. Identification of the surface of the poliovirus (PV) 3C dimer that interacts with PV 3Dpol during VPg uridylylation and construction of a structural model for the PV 3C2-3Dpol complex
    Miaoqing Shen
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 283:875-88. 2008
    ..These data were used to guide molecular docking of the structures for a poliovirus 3C dimer and 3Dpol, leading to a structural model for the 3C(2)-3Dpol complex that extrapolates well to all picornaviruses...
  2. pmc Phosphate release contributes to the rate-limiting step for unwinding by an RNA helicase
    Qixin Wang
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    Nucleic Acids Res 38:1312-24. 2010
    ..Our studies are consistent with a model in which a single ATP binding and/or hydrolysis event sets the unwinding spring and phosphate dissociation contributes to release of the spring, thereby driving the power stroke used for unwinding...
  3. pmc Nucleic acid polymerases use a general acid for nucleotidyl transfer
    Christian Castro
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Nat Struct Mol Biol 16:212-8. 2009
    ..The existence of an active-site residue that regulates polymerase catalysis may permit manipulation of viral polymerase replication speed and/or fidelity for virus attenuation and vaccine development...
  4. pmc Mutational robustness of an RNA virus influences sensitivity to lethal mutagenesis
    Jason D Graci
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, USA
    J Virol 86:2869-73. 2012
    ..We suggest that mutational robustness may be a useful measure of the sensitivity of a virus to lethal mutagenesis...
  5. pmc Stimulation of poliovirus RNA synthesis and virus maturation in a HeLa cell-free in vitro translation-RNA replication system by viral protein 3CDpro
    David Franco
    Department of Molecular Genetics and Microbiology, School of Medicine, Stony Brook University, Stony Brook, NY 11790, USA
    Virol J 2:86. 2005
    ..Our results indicate that the stimulation of RNA synthesis and virus maturation by 3CDpro in vitro is dependent on the presence of a VPg-linked RNA template...
  6. ncbi request reprint The mechanism of action of ribavirin: lethal mutagenesis of RNA virus genomes mediated by the viral RNA-dependent RNA polymerase
    C E Cameron
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, Pennsylvania 16802, USA
    Curr Opin Infect Dis 14:757-64. 2001
    ....
  7. pmc Expanding knowledge of P3 proteins in the poliovirus lifecycle
    Craig E Cameron
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    Future Microbiol 5:867-81. 2010
    ..Among the least understood steps of the poliovirus lifecycle is encapsidation of genomic RNA. We will also describe data that suggest a role for P3 proteins in this step...
  8. pmc Dynamics: the missing link between structure and function of the viral RNA-dependent RNA polymerase?
    Craig E Cameron
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, United States
    Curr Opin Struct Biol 19:768-74. 2009
    ..Here we review some of the recent work with the RdRp that leads us to suggest that structure provides only a partial understanding of RdRp function and dynamics may be the missing link...
  9. pmc Structure-function relationships of the viral RNA-dependent RNA polymerase: fidelity, replication speed, and initiation mechanism determined by a residue in the ribose-binding pocket
    Victoria S Korneeva
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 282:16135-45. 2007
    ..Although protein-primed initiation and RNA-primed elongation complexes employ the same polymerase active site, the functional differences reported here imply significant structural differences between these complexes...
  10. pmc Insight into poliovirus genome replication and encapsidation obtained from studies of 3B-3C cleavage site mutants
    Hyung Suk Oh
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, 16802, USA
    J Virol 83:9370-87. 2009
    ..This observation supports an interaction between 3CD protein and viral and/or host factors that is critical for genome replication, perhaps formation of replication complexes...
  11. pmc Synthesis and antiviral activity of 5-substituted cytidine analogues: identification of a potent inhibitor of viral RNA-dependent RNA polymerases
    Daniel A Harki
    Department of Chemistry and Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Med Chem 49:6166-9. 2006
    ..Instead of promoting viral mutagenesis, 5-nitrocytidine triphosphate inhibited PV RNA-dependent RNA polymerase (K(d) = 1.1 +/- 0.1 microM), and this inhibition is sufficient to explain the observed antiviral activity...
  12. pmc Picornavirus genome replication: roles of precursor proteins and rate-limiting steps in oriI-dependent VPg uridylylation
    Harsh B Pathak
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 283:30677-88. 2008
    ..Finally, determinants of VPg uridylylation efficiency suggest formation and/or collapse or release of the uridylylated product as the rate-limiting step in vitro depending upon the VPg donor employed...
  13. pmc One-pot synthesis of nucleoside 5'-triphosphates from nucleoside 5'-H-phosphonates
    Qi Sun
    Department of Chemistry, The Pennsylvania State University, University Park, PA 16802, USA
    Org Lett 10:1703-6. 2008
    ..Poliovirus RNA-dependent RNA polymerase efficiently employed 6MePTP as a substrate, suggesting that the cognate nucleoside, a poorly understood antiviral agent, may damage viral RNA...
  14. pmc Remote site control of an active site fidelity checkpoint in a viral RNA-dependent RNA polymerase
    Jamie J Arnold
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 280:25706-16. 2005
    ..The capacity for sites remote from the catalytic center to alter fidelity suggests new possibilities for targeting the viral RdRp for antiviral drug development...
  15. pmc Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mg2+
    Jamie J Arnold
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Biochemistry 43:5126-37. 2004
    ..We discuss the implications of this work on the development of RNA-dependent RNA polymerase inhibitors for use as antiviral agents...
  16. pmc Poliovirus RNA-dependent RNA polymerase (3Dpol): kinetic, thermodynamic, and structural analysis of ribonucleotide selection
    David W Gohara
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Biochemistry 43:5149-58. 2004
    ..We discuss the possibility that all nucleic acid polymerases with the canonical "palm"-based active site employ a similar mechanism to maximize fidelity...
  17. pmc Lethal mutagenesis of picornaviruses with N-6-modified purine nucleoside analogues
    Jason D Graci
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Antimicrob Agents Chemother 52:971-9. 2008
    ..These purine nucleoside analogues represent promising lead compounds in the development of clinically useful antiviral therapies based on the strategy of lethal mutagenesis...
  18. pmc Human rhinovirus type 14 gain-of-function mutants for oriI utilization define residues of 3C(D) and 3Dpol that contribute to assembly and stability of the picornavirus VPg uridylylation complex
    Miaoqing Shen
    Pennsylvania State University, Department of Biochemistry and Molecular Biology, 201 Althouse Laboratory, University Park, PA 16802, USA
    J Virol 81:12485-95. 2007
    ....
  19. pmc Lethal mutagenesis of poliovirus mediated by a mutagenic pyrimidine analogue
    Jason D Graci
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, PA 16802, USA
    J Virol 81:11256-66. 2007
    ....
  20. pmc Hepatitis C virus non-structural protein 3 (HCV NS3): a multifunctional antiviral target
    Kevin D Raney
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 285:22725-31. 2010
    ..Mechanistic and structural studies of helicase have hurled this enzyme into a prominent position in the field of helicase enzymology. Nevertheless, studies of helicase as an antiviral target remain in their infancy...
  21. pmc Picornavirus genome replication: assembly and organization of the VPg uridylylation ribonucleoprotein (initiation) complex
    Harsh B Pathak
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 282:16202-13. 2007
    ..These data provide a glimpse into the organization of the ribonucleoprotein complex that catalyzes this key step in picornavirus genome replication...
  22. pmc Poliovirus RNA-dependent RNA polymerase (3Dpol): pre-steady-state kinetic analysis of ribonucleotide incorporation in the presence of Mn2+
    Jamie J Arnold
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Biochemistry 43:5138-48. 2004
    ..Adventitious interactions in the cofactor-binding site with bound Mn(2+) may diminish fidelity by compensating for interaction losses used to modulate catalytic efficiency when incorrect nucleotides are bound in the presence of Mg(2+)...
  23. ncbi request reprint Incorporation fidelity of the viral RNA-dependent RNA polymerase: a kinetic, thermodynamic and structural perspective
    Christian Castro
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    Virus Res 107:141-9. 2005
    ....
  24. ncbi request reprint Mechanisms of action of ribavirin against distinct viruses
    Jason D Graci
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, USA
    Rev Med Virol 16:37-48. 2006
    ..Evidence exists to support each of the five proposed mechanisms of action, and distinct virus/host combinations may preferentially favour one or more of these mechanisms during antiviral therapy...
  25. ncbi request reprint Synthesis and antiviral evaluation of a mutagenic and non-hydrogen bonding ribonucleoside analogue: 1-beta-D-Ribofuranosyl-3-nitropyrrole
    Daniel A Harki
    Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Biochemistry 41:9026-33. 2002
    ....
  26. ncbi request reprint Structural and biological identification of residues on the surface of NS3 helicase required for optimal replication of the hepatitis C virus
    Samuel G Mackintosh
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 281:3528-35. 2006
    ..Domain 3 of NS3 is implicated in protein-protein interactions that are necessary for HCV replication...
  27. ncbi request reprint Structure-function relationships of the RNA-dependent RNA polymerase from poliovirus (3Dpol). A surface of the primary oligomerization domain functions in capsid precursor processing and VPg uridylylation
    Harsh B Pathak
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 277:31551-62. 2002
    ..We speculate that this interaction may also be critical for assembly of other complexes required for poliovirus genome replication...
  28. pmc Two proton transfers in the transition state for nucleotidyl transfer catalyzed by RNA- and DNA-dependent RNA and DNA polymerases
    Christian Castro
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, 201 Althouse Laboratory, University Park, PA 16802, USA
    Proc Natl Acad Sci U S A 104:4267-72. 2007
    ..These data imply an associative-like transition-state structure...
  29. pmc Regulation of PKR by HCV IRES RNA: importance of domain II and NS5A
    Rebecca Toroney
    Department of Chemistry, Pennsylvania State University, 104 Chemistry Building, University Park, PA 16802, USA
    J Mol Biol 400:393-412. 2010
    ..A model is presented for how domain II of the IRES and NS5A operate to control host and viral translation during HCV infection...
  30. ncbi request reprint Quasispecies, error catastrophe, and the antiviral activity of ribavirin
    Jason D Graci
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    Virology 298:175-80. 2002
    ..The data supporting this new proposal for the mechanism of action of ribavirin are reviewed herein. In addition, we discuss briefly the challenges that remain for development of lethal mutagenesis as an effective antiviral strategy...
  31. ncbi request reprint Purification and characterization of hepatitis C virus non-structural protein 5A expressed in Escherichia coli
    Luyun Huang
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA
    Protein Expr Purif 37:144-53. 2004
    ..The availability of purified HCV NS5A will permit rigorous biochemical and biophysical characterization of this protein, ultimately providing insight into the function of this protein during HCV genome replication...
  32. ncbi request reprint Multiple full-length NS3 molecules are required for optimal unwinding of oligonucleotide DNA in vitro
    Alan J Tackett
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, 4301 W Markham St, Little Rock, Arkansas 72205, USA
    J Biol Chem 280:10797-806. 2005
    ..The unwinding data are discussed in terms of a model whereby multiple molecules of NS3 bound to the single-stranded DNA portion of the substrate are required for optimal unwinding...
  33. pmc NS3 helicase from the hepatitis C virus can function as a monomer or oligomer depending on enzyme and substrate concentrations
    Thomas A Jennings
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 284:4806-14. 2009
    ..Taken together, these data support a model in which monomeric forms of NS3 are active. Oligomerization of NS3 occurs, but subunits can function independently or cooperatively, dependent upon the relative concentration of the DNA...
  34. ncbi request reprint Hepatitis C virus nonstructural protein 5A (NS5A) is an RNA-binding protein
    Luyun Huang
    Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 280:36417-28. 2005
    ..The discovery that NS5A is an RNA-binding protein defines a new functional target for development of agents to treat HCV infection and a new structural class of RNA-binding proteins...
  35. pmc Hepatitis C virus NS3 helicase forms oligomeric structures that exhibit optimal DNA unwinding activity in vitro
    Bartek Sikora
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    J Biol Chem 283:11516-25. 2008
    ..The results indicate that the optimally active form of full-length NS3 is part of an oligomeric species in vitro...
  36. doi request reprint RNA unwinding activity of the hepatitis C virus NS3 helicase is modulated by the NS5B polymerase
    Thomas A Jennings
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Biochemistry 47:1126-35. 2008
    ..Results from this assay support interactions that include a 1:1 complex formed between NS3 and NS5B. The modulation of NS3 by NS5B suggests that these proteins may function together during replication of the HCV genome...
  37. pmc Small ubiquitin-like modifying protein isopeptidase assay based on poliovirus RNA polymerase activity
    Jamie J Arnold
    201 Althouse Laboratory, Pennsylvania State University, University Park, PA 16802, USA
    Anal Biochem 350:214-21. 2006
    ..The assay is sensitive, reproducible, and adaptable to a high-throughput format for use in screens for inhibitors/activators of clinically relevant SUMO proteases and deubiquitinases...
  38. ncbi request reprint Hepatitis C virus NS3 and simian virus 40 T antigen helicases displace streptavidin from 5'-biotinylated oligonucleotides but not from 3'-biotinylated oligonucleotides: evidence for directional bias in translocation on single-stranded DNA
    Patrick D Morris
    Department of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72205, USA
    Biochemistry 41:2372-8. 2002
    ..The dependence of the reaction with NS3 on the oligonucleotide length suggests that multiple NS3 monomers are necessary for optimal activity...

Research Grants24

  1. RNA-dependent RNA Polymerase
    Craig Cameron; Fiscal Year: 2009
    ..Achievement of the goals of the application will provide novel targets and mechanisms for development of vaccines and inhibitors to prevent and to treat infections by RNA viruses. ..
  2. RNA-dependent RNA Polymerase
    Craig E Cameron; Fiscal Year: 2010
    ..Achievement of the goals of the application will provide novel targets and mechanisms for development of vaccines and inhibitors to prevent and to treat infections by RNA viruses. ..
  3. RNA-dependent RNA Polymerase
    Craig E Cameron; Fiscal Year: 2010
    ..Achievement of the goals of the application will provide novel targets and mechanisms for development of vaccines and inhibitors to prevent and to treat infections by RNA viruses. ..
  4. Picornavirus Genome Replication
    Craig E Cameron; Fiscal Year: 2010
    ..Achievement of the goals of the application will provide novel targets and mechanisms for development of inhibitors to treat infections by picornaviruses, especially those for which vaccines are not available. ..
  5. RNA DEPENDENT RNA POLYMERASE MECHANISM
    Craig Cameron; Fiscal Year: 2007
    ..We will pursue two approaches that may permit us to achieve this goal, and, at the same time, provide insight into the mechanisms and surfaces employed by 3Dpol to maximize stability of the 3Dpol-primer/template complex. ..
  6. Lethal Mutagenesis as an Antiviral Strategy
    Craig Cameron; Fiscal Year: 2007
    ..Lethal mutagens should have broad-spectrum activity against RNA viruses, thus better equipping this nation to deal with the potential use of RNA viruses as biological weapons. ..
  7. Picornavirus Genome Replication
    Craig Cameron; Fiscal Year: 2007
    ..Therefore, this information may prove useful in the development of strategies to control picornavirus infections for which vaccines are not available. ..
  8. RNA DEPENDENT RNA POLYMERASE MECHANISM
    Craig Cameron; Fiscal Year: 2003
    ....
  9. Picornavirus Genome Replication
    Craig E Cameron; Fiscal Year: 2010
    ..Achievement of the goals of the application will provide novel targets and mechanisms for development of inhibitors to treat infections by picornaviruses, especially those for which vaccines are not available. ..
  10. Picornavirus Genome Replication
    Craig Cameron; Fiscal Year: 2009
    ..Achievement of the goals of the application will provide novel targets and mechanisms for development of inhibitors to treat infections by picornaviruses, especially those for which vaccines are not available. ..
  11. Picornavirus Genome Replication
    Craig Cameron; Fiscal Year: 2006
    ..Therefore, this information may prove useful in the development of strategies to control picornavirus infections for which vaccines are not available. ..