JUDITH BOND

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Expression of meprins in health and disease
    Lourdes P Norman
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA
    Curr Top Dev Biol 54:145-66. 2003
  2. pmc Meprin A impairs epithelial barrier function, enhances monocyte migration, and cleaves the tight junction protein occludin
    Jialing Bao
    Dept of Biochemistry and Molecular Biology, The Pennsylvania State Univ College of Medicine, 500 University Dr, H171, Hershey, PA 17033
    Am J Physiol Renal Physiol 305:F714-26. 2013
  3. pmc Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment
    Monica M Richert
    Department of Pathology, Comprehensive Cancer Center, National Foundation for Cancer Research Center for Metastasis Research, University of Alabama at Birmingham, Alabama, USA
    Breast Cancer Res 7:R819-27. 2005
  4. ncbi request reprint Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer
    Judith S Bond
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    FEBS Lett 579:3317-22. 2005
  5. pmc Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease
    Sanjita Banerjee
    Dept of Biochemistry and Molecular Biology, The Pennsylvania State Univ College of Medicine, 500 Univ Drive, H171, Hershey, PA 17033, USA
    Am J Physiol Gastrointest Liver Physiol 300:G273-82. 2011
  6. pmc Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells
    Qi Sun
    Pediatric Hematology Oncology, Department of Pediatrics, Penn State University Children s Hospital, Hershey, PA, USA
    Exp Hematol 37:346-56. 2009
  7. pmc Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge
    Renee E Yura
    Dept of Biochemistry and Molecular Biology, The Pennsylvania State Univ College of Medicine, 500 Univ Drive, H171, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 296:F135-44. 2009
  8. doi request reprint Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice
    John Bylander
    Deparment of Biochemistry and Molecular Biology, Penn State University College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 294:F480-90. 2008
  9. ncbi request reprint Zinc ligands in an astacin family metalloprotease meprin A
    Bruce A Doll
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey 17033 0850, USA
    Biol Chem 383:1167-73. 2002
  10. pmc Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation
    Sanjita Banerjee
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 283:31371-7. 2008

Collaborators

  • G Ramesh
  • Qing Li
  • Qi Sun
  • Stephen Futterweit
  • Gail L Matters
  • Greg P Bertenshaw
  • Sanjita Banerjee
  • Lourdes P Norman
  • S Gaylen Bradley
  • Jacqueline M Crisman
  • Renee E Yura
  • W Brian Reeves
  • Faoud T Ishmael
  • Jeremy A Hengst
  • James P Villa
  • John E Bylander
  • Susan S Ishmael
  • Jialing Bao
  • Elimelda Moige Ongeri
  • John Bylander
  • Binzhi Zhang
  • Roy Mathew
  • Alexander R Red Eagle
  • Andrea Manni
  • Monica M Richert
  • Xiaoli Han
  • Weiping Jiang
  • Bruce A Doll
  • Takayuki Tsukuba
  • Pan Shi
  • Fang Tian
  • Odinaka Anyanwu
  • Ge Jin
  • Ryan D Gailey
  • Simon J Hubbard
  • A Daniel Jones
  • Antonio A Tarectecan
  • Pushkar A Phadke
  • Vincent K Shier
  • William C Knowler
  • Howard Trachtman
  • Danny R Welch
  • Sharlene Washington
  • Laurence M Demers
  • Giuseppina Imperatore
  • Robert L Hanson
  • Elsa Valderrama
  • Douglas J DiGirolamo
  • Gail Matters
  • Thomas L Saunders
  • Mona T Norcum
  • Tomoko Kadowaki

Detail Information

Publications24

  1. ncbi request reprint Expression of meprins in health and disease
    Lourdes P Norman
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA
    Curr Top Dev Biol 54:145-66. 2003
  2. pmc Meprin A impairs epithelial barrier function, enhances monocyte migration, and cleaves the tight junction protein occludin
    Jialing Bao
    Dept of Biochemistry and Molecular Biology, The Pennsylvania State Univ College of Medicine, 500 University Dr, H171, Hershey, PA 17033
    Am J Physiol Renal Physiol 305:F714-26. 2013
    ..These results demonstrate the capability of meprin A to disrupt epithelial barriers and implicate occludin as one of the important targets of meprin A that may modulate inflammation. ..
  3. pmc Metastasis of hormone-independent breast cancer to lung and bone is decreased by alpha-difluoromethylornithine treatment
    Monica M Richert
    Department of Pathology, Comprehensive Cancer Center, National Foundation for Cancer Research Center for Metastasis Research, University of Alabama at Birmingham, Alabama, USA
    Breast Cancer Res 7:R819-27. 2005
    ..This study tested the effects of DFMO on orthotopic tumor growth and lung colonization of another breast cancer cell line (MDA-MB-231) and the effects on bone metastasis of MDA-MB-435 cells...
  4. ncbi request reprint Meprin metalloprotease expression and regulation in kidney, intestine, urinary tract infections and cancer
    Judith S Bond
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    FEBS Lett 579:3317-22. 2005
    ....
  5. pmc Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease
    Sanjita Banerjee
    Dept of Biochemistry and Molecular Biology, The Pennsylvania State Univ College of Medicine, 500 Univ Drive, H171, Hershey, PA 17033, USA
    Am J Physiol Gastrointest Liver Physiol 300:G273-82. 2011
    ..The data indicate that the absence of meprin A aggravates chronic inflammation and the lack of meprin B affords some protection from injury. Manipulation of the expression of meprin gene products may have therapeutic potential...
  6. pmc Disruption of the meprin alpha and beta genes in mice alters homeostasis of monocytes and natural killer cells
    Qi Sun
    Pediatric Hematology Oncology, Department of Pediatrics, Penn State University Children s Hospital, Hershey, PA, USA
    Exp Hematol 37:346-56. 2009
    ..Our findings are the first report to demonstrate that metalloproteases affect homeostasis of leukocytes, which have important implications for understanding physiology of and pathogenesis in the hematological system...
  7. pmc Meprin A metalloproteases enhance renal damage and bladder inflammation after LPS challenge
    Renee E Yura
    Dept of Biochemistry and Molecular Biology, The Pennsylvania State Univ College of Medicine, 500 Univ Drive, H171, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 296:F135-44. 2009
    ..These data indicate that meprin A contributes to the renal and urogenital pathogenesis of endotoxicity...
  8. doi request reprint Targeted disruption of the meprin metalloproteinase beta gene protects against renal ischemia-reperfusion injury in mice
    John Bylander
    Deparment of Biochemistry and Molecular Biology, Penn State University College of Medicine, 500 Univ Drive, Hershey, PA 17033, USA
    Am J Physiol Renal Physiol 294:F480-90. 2008
    ..These studies indicate that meprin-beta is important in the pathogenesis of renal injury following I/R and that the redistribution of active meprin-alpha/beta is a major contributor to renal injury and subsequent inflammation...
  9. ncbi request reprint Zinc ligands in an astacin family metalloprotease meprin A
    Bruce A Doll
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey 17033 0850, USA
    Biol Chem 383:1167-73. 2002
    ..The results indicate that Y226 is not essential for zinc binding, but Y226 and H167 are essential for full enzymatic activity and stability of the metalloproteinase...
  10. pmc Prointerleukin-18 is activated by meprin beta in vitro and in vivo in intestinal inflammation
    Sanjita Banerjee
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 283:31371-7. 2008
    ..This study identifies proIL-18 as a biologically important substrate for meprin beta and implicates meprins in the modulation of inflammation...
  11. pmc Targeted disruption of the meprin beta gene in mice leads to underrepresentation of knockout mice and changes in renal gene expression profiles
    Lourdes P Norman
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, Hershey, Pennsylvania 17033 0850, USA
    Mol Cell Biol 23:1221-30. 2003
    ..Thus, disruption of the meprin beta allele in mice affects embryonic viability, birth weight, renal gene expression profiles, and the distribution of meprin alpha in kidney and intestine...
  12. ncbi request reprint Deletion of the mouse meprin beta metalloprotease gene diminishes the ability of leukocytes to disseminate through extracellular matrix
    Jacqueline M Crisman
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Immunol 172:4510-9. 2004
    ..Thus, the expression of meprins by leukocytes of the intestinal immune system may have important implications for diseases such as inflammatory bowel diseases, which are aggravated by leukocyte infiltration...
  13. pmc Critical amino acids in the active site of meprin metalloproteinases for substrate and peptide bond specificity
    James P Villa
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Biol Chem 278:42545-50. 2003
    ..These studies shed light on the molecular basis for the substrate specificity differences of astacin metalloproteinases...
  14. ncbi request reprint Protease domain glycans affect oligomerization, disulfide bond formation, and stability of the meprin A metalloprotease homo-oligomer
    Susan S Ishmael
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 281:37404-15. 2006
    ..These studies provide insights into the role of glycans in the biosynthesis, activity, and stability of this extracellular protease...
  15. pmc Villin and actin in the mouse kidney brush-border membrane bind to and are degraded by meprins, an interaction that contributes to injury in ischemia-reperfusion
    Elimelda Moige Ongeri
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Physiol Renal Physiol 301:F871-82. 2011
    ..The levels of the 37-kDa actin fragment were significantly higher in kidneys subjected to IR. The data establish that meprins interact with and cleave villin and actin, and these cytoskeletal proteins are substrates for meprins...
  16. ncbi request reprint Human and mouse homo-oligomeric meprin A metalloendopeptidase: substrate and inhibitor specificities
    John E Bylander
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, PA 17033 0850, USA
    Biol Chem 388:1163-72. 2007
    ..This work provides valuable data to improve predictability for human systems based on meprin functions in mouse models...
  17. ncbi request reprint Inhibitors of polyamine biosynthesis decrease the expression of the metalloproteases meprin alpha and MMP-7 in hormone-independent human breast cancer cells
    Gail L Matters
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, H171, Hershey, PA 17033 0850, USA
    Clin Exp Metastasis 22:331-9. 2005
    ..The decrease in meprin alpha expression in DFMO and SAM486A-treated cells indicates a means by which these compounds can decrease the invasiveness of metastatic breast cancer cells...
  18. ncbi request reprint Chaperone interactions of the metalloproteinase meprin A in the secretory or proteasomal-degradative pathway
    Takayuki Tsukuba
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033 0850, USA
    Arch Biochem Biophys 397:191-8. 2002
    ....
  19. ncbi request reprint Intersubunit and domain interactions of the meprin B metalloproteinase. Disulfide bonds and protein-protein interactions in the MAM and TRAF domains
    Faoud T Ishmael
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 280:13895-901. 2005
    ..From these observations, a model of the meprin B dimer structure is proposed that provides insight into the relationship between structure and function of this isoform...
  20. ncbi request reprint Transport of meprin subunits through the secretory pathway: role of the transmembrane and cytoplasmic domains and oligomerization
    Jeremy A Hengst
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033 0850, USA
    J Biol Chem 279:34856-64. 2004
    ..Taken together, the data indicate that the meprin alphaT and alphaC domains together contain a weak signal for retention within the ER/cis-Golgi compartments that is strengthened by oligomerization...
  21. ncbi request reprint Probing the active sites and mechanisms of rat metalloproteases meprin A and B
    Greg P Bertenshaw
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey 17033, USA
    Biol Chem 383:1175-83. 2002
    ..This could have profound implications because meprins are exposed to a range of conditions in the extracellular milieu of renal and intestinal tissues and in inflammation and cancer...
  22. ncbi request reprint Structure of homo- and hetero-oligomeric meprin metalloproteases. Dimers, tetramers, and high molecular mass multimers
    Greg P Bertenshaw
    Department of Biochemistry and Molecular Biology, Pennsylvania State University College of Medicine, Hershey 17033, USA
    J Biol Chem 278:2522-32. 2003
    ..The work indicates that different mechanisms exist to localize and concentrate the proteolytic activity of membrane-bound and secreted meprin metalloproteinases...
  23. ncbi request reprint Meprin-alpha in chronic diabetic nephropathy: interaction with the renin-angiotensin axis
    Roy Mathew
    Schneider s Children s Hospital, Division of Nephrology, SCH 365, 269 01 76th Ave, New Hyde Park, NY 11040 1432, USA
    Am J Physiol Renal Physiol 289:F911-21. 2005
    ..MEP-alpha may play a role in the pathogenesis of DN and the benefits of ACE inhibitor therapy on the progression of diabetic kidney disease may be related, in part, to its impact on renal MEP-alpha expression...
  24. ncbi request reprint Meprin beta metalloprotease gene polymorphisms associated with diabetic nephropathy in the Pima Indians
    Alexander R Red Eagle
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Phoenix, AZ, 85014, USA
    Hum Genet 118:12-22. 2005
    ..These results could be explained by functional effects of one or more of these SNPs or by linkage disequilibrium with a nearby functional locus...

Research Grants23

  1. Preparing for research careers related to diabetes, digestive & kidney diseases
    JUDITH BOND; Fiscal Year: 2007
    ....
  2. MEPRINS-METALLOPROTEINSASES OF THE KIDNEY AND INTESTINE
    JUDITH BOND; Fiscal Year: 2007
    ..abstract_text> ..
  3. MEPRINS-METALLOPROTEINASES OF THE KIDNEY AND INTESTINE
    Judith S Bond; Fiscal Year: 2010
    ....
  4. MEPRINS-METALLOPROTEINASES OF THE KIDNEY AND INTESTINE
    JUDITH BOND; Fiscal Year: 2004
    ..The studies will establish functions of meprins in developing, young and mature mice, and in cancer, inflammation and renal disease, and factors critical to regulating the enzymes. ..
  5. CANDIDATE GENE FOR DIABETIC NEPHROPATHY--MEPRIN BETA
    JUDITH BOND; Fiscal Year: 2002
    ..These studies will establish whether the meprin-b gene is associated with susceptibility to DN in humans, and provide animal models to determine the role of this proteinase in normal kidney and in susceptibility to renal disease. ..
  6. INTRACELLULAR PROTEIN CATABOLISM IN DIABETES MELLITUS
    JUDITH BOND; Fiscal Year: 2000
    ....
  7. MEPRINS-METALLOPROTEINASES OF THE KIDNEY AND INTESTINE
    JUDITH BOND; Fiscal Year: 2009
    ....