E O Bixler

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Insomnia in central Pennsylvania
    E O Bixler
    Department of Psychiatry, Sleep Research and Treatment Center, Pennsylvania State University, College of Medicine, Hershey, PA, USA
    J Psychosom Res 53:589-92. 2002
  2. ncbi request reprint Association of hypertension and sleep-disordered breathing
    E O Bixler
    Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey 17033
    Arch Intern Med 160:2289-95. 2000
  3. ncbi request reprint Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression
    E O Bixler
    Department of Psychiatry MC H073, Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 90:4510-5. 2005
  4. ncbi request reprint Prevalence of sleep-disordered breathing in women: effects of gender
    E O Bixler
    Sleep Research and Treatment Center, Department of Psychiatry and Health Evaluation Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Respir Crit Care Med 163:608-13. 2001
  5. ncbi request reprint Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University, Hershey 17033, USA
    J Clin Endocrinol Metab 85:1151-8. 2000
  6. ncbi request reprint Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 86:3787-94. 2001
  7. ncbi request reprint Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men: clinical implications
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 86:1489-95. 2001
  8. doi request reprint Selective effects of CPAP on sleep apnoea-associated manifestations
    A N Vgontzas
    Penn State University College of Medicine, Department of Psychiatry, Hershey, PA 17033, USA
    Eur J Clin Invest 38:585-95. 2008
  9. ncbi request reprint Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 86:517-20. 2001
  10. ncbi request reprint Daytime napping after a night of sleep loss decreases sleepiness, improves performance, and causes beneficial changes in cortisol and interleukin-6 secretion
    A N Vgontzas
    Penn State Univ College of Medicine, Dept of Psychiatry H073, 500 University Dr, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 292:E253-61. 2007

Collaborators

Detail Information

Publications56

  1. ncbi request reprint Insomnia in central Pennsylvania
    E O Bixler
    Department of Psychiatry, Sleep Research and Treatment Center, Pennsylvania State University, College of Medicine, Hershey, PA, USA
    J Psychosom Res 53:589-92. 2002
    ..Establish the association between insomnia and various physical and mental health symptoms as well as objective measures of sleep disturbance while controlling for age, gender and BMI in a large random sample of the general public...
  2. ncbi request reprint Association of hypertension and sleep-disordered breathing
    E O Bixler
    Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey 17033
    Arch Intern Med 160:2289-95. 2000
    ....
  3. ncbi request reprint Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression
    E O Bixler
    Department of Psychiatry MC H073, Sleep Research and Treatment Center, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 90:4510-5. 2005
    ..Excessive daytime sleepiness (EDS) is commonly considered a cardinal sign of sleep apnea; however, the mechanism underlying the association is unclear...
  4. ncbi request reprint Prevalence of sleep-disordered breathing in women: effects of gender
    E O Bixler
    Sleep Research and Treatment Center, Department of Psychiatry and Health Evaluation Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Am J Respir Crit Care Med 163:608-13. 2001
    ..001). These data combined indicate that menopause is a significant risk factor for sleep apnea in women and that hormone replacement appears to be associated with reduced risk...
  5. ncbi request reprint Sleep apnea and daytime sleepiness and fatigue: relation to visceral obesity, insulin resistance, and hypercytokinemia
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University, Hershey 17033, USA
    J Clin Endocrinol Metab 85:1151-8. 2000
    ..We conclude that there is a strong independent association among sleep apnea, visceral obesity, insulin resistance and hypercytokinemia, which may contribute to the pathological manifestations and somatic sequelae of this condition...
  6. ncbi request reprint Chronic insomnia is associated with nyctohemeral activation of the hypothalamic-pituitary-adrenal axis: clinical implications
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 86:3787-94. 2001
    ..The therapeutic goal in insomnia should be to decrease the overall level of physiologic and emotional arousal, and not just to improve the nighttime sleep...
  7. ncbi request reprint Middle-aged men show higher sensitivity of sleep to the arousing effects of corticotropin-releasing hormone than young men: clinical implications
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 86:1489-95. 2001
    ..We suggest that changes in sleep physiology associated with middle-age play a significant role in the marked increase of prevalence of insomnia in middle-age...
  8. doi request reprint Selective effects of CPAP on sleep apnoea-associated manifestations
    A N Vgontzas
    Penn State University College of Medicine, Department of Psychiatry, Hershey, PA 17033, USA
    Eur J Clin Invest 38:585-95. 2008
    ..The objectives of this study are to simultaneously test these associations at baseline and after 3 months of continuous positive airway pressure (CPAP) therapy...
  9. ncbi request reprint Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 86:517-20. 2001
    ..These data support our proposal that, independently of gender, sleep apnea might be a manifestation of an endocrine/metabolic abnormality in which insulin resistance plays a principal role...
  10. ncbi request reprint Daytime napping after a night of sleep loss decreases sleepiness, improves performance, and causes beneficial changes in cortisol and interleukin-6 secretion
    A N Vgontzas
    Penn State Univ College of Medicine, Dept of Psychiatry H073, 500 University Dr, Hershey, PA 17033, USA
    Am J Physiol Endocrinol Metab 292:E253-61. 2007
    ..The redistribution of cortisol secretion and the prolonged suppression of IL-6 secretion are beneficial, as they improve alertness and performance...
  11. ncbi request reprint Hypothalamic-pituitary-adrenal axis activity in obese men with and without sleep apnea: effects of continuous positive airway pressure therapy
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, H073, Penn State University College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 92:4199-207. 2007
    ..Previous studies on the association between the hypothalamic-pituitary-adrenal axis activity and sleep apnea (SA) and obesity are inconsistent and/or limited...
  12. ncbi request reprint Adverse effects of modest sleep restriction on sleepiness, performance, and inflammatory cytokines
    A N Vgontzas
    Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 89:2119-26. 2004
    ..Given the potential association of these behavioral and physical alterations with health, well-being, and public safety, the idea that sleep or parts of it are optional should be regarded with caution...
  13. ncbi request reprint IL-6 and its circadian secretion in humans
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Penn State College of Medicine, Hershey, PA 17033, USA
    Neuroimmunomodulation 12:131-40. 2005
    ..We conclude that IL-6 is a mediator of sleepiness and its circadian pattern reflects the homeostatic drive for sleep...
  14. ncbi request reprint Circadian interleukin-6 secretion and quantity and depth of sleep
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University, Hershey 17033, USA
    J Clin Endocrinol Metab 84:2603-7. 1999
    ..Sleep deprivation increases daytime IL-6 and causes somnolence and fatigue during the next day, whereas postdeprivation decreases nighttime IL-6 and is associated with deeper sleep...
  15. doi request reprint Short sleep duration and obesity: the role of emotional stress and sleep disturbances
    A N Vgontzas
    Department of Psychiatry, Sleep Research and Treatment Center, Penn State University College of Medicine, Hershey, PA 17033, USA
    Int J Obes (Lond) 32:801-9. 2008
    ..How the degree of obesity or other clinical characteristics of the obese individuals, such as sleep disturbances or emotional stress, define this relation is not known...
  16. ncbi request reprint Marked decrease in sleepiness in patients with sleep apnea by etanercept, a tumor necrosis factor-alpha antagonist
    A N Vgontzas
    Department of Psychiatry H073, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 89:4409-13. 2004
    ..9 vs. 3.1 min), suggests that proinflammatory cytokines contribute to the pathogenesis of OSA/sleepiness...
  17. ncbi request reprint Metabolic disturbances in obesity versus sleep apnoea: the importance of visceral obesity and insulin resistance
    A N Vgontzas
    Department of Psychiatry, Penn State College of Medicine, Hershey, PA 17033, USA
    J Intern Med 254:32-44. 2003
    ....
  18. ncbi request reprint Differences in nocturnal and daytime sleep between primary and psychiatric hypersomnia: diagnostic and treatment implications
    A N Vgontzas
    Sleep Research and Treatment Center and Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey 17033, USA
    Psychosom Med 62:220-6. 2000
    ..The aim of this study was to assess whether polysomnography aids in the differential diagnosis of these two disorders...
  19. ncbi request reprint Age-related macular degeneration is associated with incident myocardial infarction among elderly Americans
    Yinkang Duan
    Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Ophthalmology 114:732-7. 2007
    ..To investigate whether age-related macular degeneration (AMD) is associated with the development of myocardial infarction (MI) among elderly Americans...
  20. ncbi request reprint Chronic insomnia is associated with a shift of interleukin-6 and tumor necrosis factor secretion from nighttime to daytime
    A N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, and Health Evaluation Sciences, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Metabolism 51:887-92. 2002
    ..The daytime shift of IL-6 and TNF secretion, combined with a 24-hour hypersecretion of cortisol, an arousal hormone, may explain the insomniacs' daytime fatigue and difficulty falling asleep...
  21. ncbi request reprint Postoperative sleep disturbance: influences of opioids and pain in humans
    A J Cronin
    Department of Anesthesiology, The Pennsylvania State University, Hershey 17033 0850, USA
    Sleep 24:39-44. 2001
    ....
  22. ncbi request reprint Exploring uncertainty of the change from ICD-9 to ICD-10 on acute mortality effects of air pollution
    Zhengmin Qian
    Penn State College of Medicine, USA
    Environ Int 34:248-53. 2008
    ....
  23. pmc Acute adverse effects of fine particulate air pollution on ventricular repolarization
    Duanping Liao
    Department of Public Health Sciences, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Environ Health Perspect 118:1010-5. 2010
    ..The mechanisms for the relationship between particulate pollution and cardiac disease are not fully understood...
  24. pmc Sleep-disordered breathing in children is associated with impairment of sleep stage-specific shift of cardiac autonomic modulation
    Duanping Liao
    Department of Public Health Sciences, Penn State University College of Medicine, Hershey, PA 17033, USA
    J Sleep Res 19:358-65. 2010
    ....
  25. ncbi request reprint The transradial approach is associated with lower risk of adverse outcomes following percutaneous coronary intervention: a single-center experience
    Chuntao Wu
    Department of Public Health Sciences, Penn State Hershey College of Medicine, 600 Centerview Drive, Hershey, PA 17033, USA
    J Invasive Cardiol 23:88-92. 2011
    ....
  26. pmc Blood pressure associated with sleep-disordered breathing in a population sample of children
    Edward O Bixler
    Department of Psychiatry, Penn State University College of Medicine, Sleep Research and Treatment Center, Hershey, PA 17033, USA
    Hypertension 52:841-6. 2008
    ..Clinically, the data support the threshold of AHI >or=5 for the initiation of treatment for SDB. Additional research is indicated to assess the efficacy of SDB treatment on reducing blood pressure...
  27. pmc Insomnia with objective short sleep duration is associated with type 2 diabetes: A population-based study
    Alexandros N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Diabetes Care 32:1980-5. 2009
    ..We examined the joint effects of insomnia and objective short sleep duration, the combination of which is associated with higher morbidity, on diabetes risk...
  28. doi request reprint Metabolic syndrome clusters and the risk of incident stroke: the atherosclerosis risk in communities (ARIC) study
    Sol M Rodriguez-Colon
    Department of Public Health Sciences, The Pennsylvania State University College of Medicine, A210, 600 Centerview Dr, Hershey, PA 17033, USA
    Stroke 40:200-5. 2009
    ..Little is known about the metabolic syndrome (MetS) and the risk of incident stroke. This study is designed to identify particular clusters of MetS components that carry the highest risk of incident stroke...
  29. pmc Ambient particulate air pollution and ectopy--the environmental epidemiology of arrhythmogenesis in Women's Health Initiative Study, 1999-2004
    Duanping Liao
    Department of Public Health Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Toxicol Environ Health A 72:30-8. 2009
    ..Acute PM(2.5) and PM(10) exposure is directly associated with the odds of VE among smokers, suggesting that they are more vulnerable to the arrhythmogenic effects of PM...
  30. doi request reprint Effect of air quality on assisted human reproduction
    Richard S Legro
    Department of Obstetrics and Gynecology, Pennsylvania State University College of Medicine, 500 University Drive, H103, Hershey, PA 17033, USA
    Hum Reprod 25:1317-24. 2010
    ..Air pollution has been associated with reproductive complications. We hypothesized that declining air quality during in vitro fertilization (IVF) would adversely affect live birth rates...
  31. pmc Sleep disordered breathing in children in a general population sample: prevalence and risk factors
    Edward O Bixler
    Sleep Research and Treatment Center, Department of Psychiatry, Penn State University College of Medicine, Hershey, PA 17033, USA
    Sleep 32:731-6. 2009
    ..Assess the prevalence based on clinically meaningful criteria (i.e., blood pressure) and identify risk factors of sleep disordered breathing (SDB) in a representative sample of elementary school children...
  32. pmc Insomnia with short sleep duration and mortality: the Penn State cohort
    Alexandros N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Sleep 33:1159-64. 2010
    ..Because insomnia with objective short sleep duration is associated with increased morbidity, we examined the effects of this insomnia subtype on all-cause mortality...
  33. pmc Insomnia with objective short sleep duration is associated with deficits in neuropsychological performance: a general population study
    Julio Fernandez-Mendoza
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Sleep 33:459-65. 2010
    ..To examine the joint effect of insomnia and objective short sleep duration on neuropsychological performance...
  34. pmc Insomnia with objective short sleep duration is associated with a high risk for hypertension
    Alexandros N Vgontzas
    Sleep Research and Treatment Center Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Sleep 32:491-7. 2009
    ..To examine the joint effect of insomnia and objective short sleep duration on hypertension risk...
  35. ncbi request reprint Short-term effects of gaseous pollutants on cause-specific mortality in Wuhan, China
    Zhengmin Qian
    Health Evaluation Sciences, Pennsylvania State College of Medicine, Hershey, PA 17033 0855, USA
    J Air Waste Manag Assoc 57:785-93. 2007
    ..We conclude that there is consistent evidence of acute effects of NO2 on mortality and suggest that a no-threshold linear relationship exists between NO2 and mortality...
  36. ncbi request reprint Association of daily cause-specific mortality with ambient particle air pollution in Wuhan, China
    Zhengmin Qian
    Health Evaluation Sciences, Penn State College of Medicine, A210, 600 Centerview Drive, P O Box 855, Hershey, PA 17033 0855, USA
    Environ Res 105:380-9. 2007
    ..We conclude that there is consistent evidence of acute effects of PM(10) on cardiopulmonary mortality. A linear no threshold exposure-response relationship is suggested between PM(10) and the studied cause-specific mortality...
  37. ncbi request reprint Lung function and long-term exposure to air pollutants in middle-aged American adults
    Zhengmin Qian
    Department of Health Evaluation Sciences, Pennsylvania State University College of Medicine, 17033 0855, USA
    Arch Environ Occup Health 60:156-63. 2005
    ..Moreover, center-specific associations between PM10 and pulmonary function were not significant, possibly as a result of the homogeneity of within-center exposures...
  38. ncbi request reprint Lower heart rate variability is associated with the development of coronary heart disease in individuals with diabetes: the atherosclerosis risk in communities (ARIC) study
    Duanping Liao
    Department of Health Evaluation Sciences, Pennsylvania State University Medical College, A210, 600 Centerview Drive, Hershey, PA 17033, USA
    Diabetes 51:3524-31. 2002
    ..These data suggest a contribution of an impaired cardiac autonomic control to the risk of CHD among individuals with diabetes...
  39. ncbi request reprint Relationship between carotid artery stiffness and retinal arteriolar narrowing in healthy middle-aged persons
    Duanping Liao
    Department of Health Evaluation Sciences, Pennsylvania State University College of Medicine, A210, 600 Centerview Dr, Hershey, PA 17033, USA
    Stroke 35:837-42. 2004
    ..We examined the association between carotid artery stiffness, a marker of early atherosclerosis, and retinal arteriolar narrowing, a marker of arteriolosclerosis, in healthy middle-aged people...
  40. pmc GIS approaches for the estimation of residential-level ambient PM concentrations
    Duanping Liao
    Department of Health Evaluation Sciences, Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    Environ Health Perspect 114:1374-80. 2006
    ..Semiautomated daily kriging estimations and semivariogram cross-validations are feasible on a national scale. Lognormal ordinary kriging with a spherical model is valid for estimating daily ambient PM at geocoded residential addresses...
  41. ncbi request reprint Association of higher levels of ambient criteria pollutants with impaired cardiac autonomic control: a population-based study
    Duanping Liao
    Department of Health Evaluation Sciences, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Am J Epidemiol 159:768-77. 2004
    ....
  42. ncbi request reprint Association of criteria pollutants with plasma hemostatic/inflammatory markers: a population-based study
    Duanping Liao
    Department of Health Evaluation Sciences, Pennsylvania State University College of Medicine, Hershey, 17033, USA
    J Expo Anal Environ Epidemiol 15:319-28. 2005
    ....
  43. pmc Sleep-disordered breathing and cardiac autonomic modulation in children
    Duanping Liao
    Department of Public Health Sciences, Penn State University College of Medicine, Hershey, PA 17033, USA
    Sleep Med 11:484-8. 2010
    ..To investigate the adverse cardiac autonomic effects of sleep-disordered breathing (SDB) in a large population-based sample and a clinical sample of children...
  44. pmc Associations between air pollution and peak expiratory flow among patients with persistent asthma
    Zhengmin Qian
    Department of Public Health Sciences, Pennsylvania State University, Hershey, Pennsylvania, USA
    J Toxicol Environ Health A 72:39-46. 2009
    ..The results show that the two medication regimens protected against the effects of PM(10). However, salmeterol increased the sensitivity to NO2 and triamcinalone enhanced the sensitivity to SO2...
  45. ncbi request reprint Threats of school violence in Pennsylvania after media coverage of the Columbine High School massacre: examining the role of imitation
    S Kostinsky
    Department of Psychiatry, Penn State College of Medicine, Mail stop MCH073, 500 University Dr, Hershey, PA 17033, USA
    Arch Pediatr Adolesc Med 155:994-1001. 2001
    ..CONCLUSIONS: Successive threats of violence follow a publicized act of school violence. The media should recognize that imitation threats can occur and craft their stories accordingly...
  46. doi request reprint Remifentanil inhibits rapid eye movement sleep but not the nocturnal melatonin surge in humans
    Christopher P Bonafide
    The Children s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA
    Anesthesiology 108:627-33. 2008
    ..In addition, this study tests the hypothesis that opioid-induced sleep disturbance is caused by a circadian pacemaker disturbance, reflected by suppressed nocturnal plasma concentration of melatonin...
  47. ncbi request reprint Impaired nighttime sleep in healthy old versus young adults is associated with elevated plasma interleukin-6 and cortisol levels: physiologic and therapeutic implications
    Alexandros N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Clin Endocrinol Metab 88:2087-95. 2003
    ....
  48. doi request reprint Insomnia and sleep quality among primary care physicians with low and high burnout levels
    Antonio Vela-Bueno
    Department of Psychiatry, School of Medicine, Autonomous University of Madrid, Spain
    J Psychosom Res 64:435-42. 2008
    ..The aim of this study was to assess insomnia and sleep quality in primary care physicians with low and high burnout scores...
  49. doi request reprint Nonsignificance of sleep relative to IQ and neuropsychological scores in predicting academic achievement
    Susan Dickerson Mayes
    Department of Psychiatry, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Dev Behav Pediatr 29:206-12. 2008
    ..The goal of the study was to determine the relative importance of sleep, IQ, neuropsychological, and attention-deficit/hyperactivity disorder (ADHD) scores in predicting academic achievement...
  50. pmc Sleep is increased by weight gain and decreased by weight loss in mice
    Zhiwei Guan
    Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    Sleep 31:627-33. 2008
    ..To determine whether weight loss could reverse excessive sleep in high-fat diet-induced obesity...
  51. ncbi request reprint Obesity-related sleepiness and fatigue: the role of the stress system and cytokines
    Alexandros N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry, Penn State College of Medicine, Hershey, Pennsylvania 17033, USA
    Ann N Y Acad Sci 1083:329-44. 2006
    ....
  52. ncbi request reprint Sleep apnea is a manifestation of the metabolic syndrome
    Alexandros N Vgontzas
    Department of Psychiatry H073, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Sleep Med Rev 9:211-24. 2005
    ....
  53. ncbi request reprint Plasma interleukin 6 levels are elevated in polycystic ovary syndrome independently of obesity or sleep apnea
    Alexandros N Vgontzas
    Sleep Research and Treatment Center, Department of Psychiatry H073, Penn State University College of Medicine, Hershey, PA 17033, USA
    Metabolism 55:1076-82. 2006
    ..We conclude that IL-6 levels are elevated in obese women with PCOS independently of obesity or sleep apnea and may represent a pathophysiologic link to insulin resistance...
  54. ncbi request reprint Sleep is increased in mice with obesity induced by high-fat food
    Joe B Jenkins
    Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, Room C5654, 500 University Drive, PA 17033, USA
    Physiol Behav 87:255-62. 2006
    ..These results indicate that the obese animals have increased sleep pressure and difficulties in maintaining wakefulness during the active phase...
  55. ncbi request reprint Pennsylvania State Hospital system's seclusion and restraint reduction program
    Gregory M Smith
    Office of Mental Health and Substance Abuse Services of the Commonwealth of Pennsylvania, Harrisburg, Pennsylvania 18109 2498, USA
    Psychiatr Serv 56:1115-22. 2005
    ..This study examined the use of seclusion and mechanical restraint from 1990 to 2000 and the rate of staff injuries from patient assaults from 1998 to 2000 in a state hospital system...
  56. ncbi request reprint Interleukin-6 levels fluctuate with the light-dark cycle in the brain and peripheral tissues in rats
    Zhiwei Guan
    Department of Psychiatry, Pennsylvania State University College of Medicine, Hershey, PA 10733, USA
    Brain Behav Immun 19:526-9. 2005
    ....

Research Grants6

  1. PREVALENCE OF SLEEP DISORDERED BREATHING IN CHILDREN
    Edward Bixler; Fiscal Year: 2005
    ..The parents of this group will be interviewed for the family history of risk factors associated with SDB in children. This strategy will yield adequate power to establish the prevalence and clinical significance of SDB in children. ..
  2. Sleep and cardio-metabolic risk factors: a prospective study of adolescents
    Duanping Liao; Fiscal Year: 2010
    ..The knowledge gained from this study will better position our intervention strategies to reduce the public health burden of childhood obesity. ..