Research Topics
Genomes and Genes | John BeardSummaryAffiliation: Pennsylvania State University Country: USA Publications
Research Grants
| Collaborators
|
Detail Information
Publications
Moderate iron deficiency in infancy: biology and behavior in young ratsJohn L Beard
Department of Nutrition, Penn State University, PA 16802, USA
Behav Brain Res 170:224-32. 2006..Similar developmental delays in iron deficient human infants suggest to us that alterations in iron status during this developmental period likely affects developing brain monaminergic systems in these infants...- Iron absorption: comparison of prediction equations and reality. Results from a feeding trial in the PhilippinesJohn L Beard
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Int J Vitam Nutr Res 77:199-204. 2007..Throughout the course of conducting a large feeding trial in convents in Manila, we collected weighed food-intake data and have the opportunity to directly compare the performance of these prediction equations... - Iron absorption prediction equations lack agreement and underestimate iron absorptionJohn L Beard
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
J Nutr 137:1741-6. 2007..The causes of the lack of agreement between change in iron status estimated by SF change and absorption predicted by algorithms are open to discussion and will need to be resolved... - Brain iron uptake in hypotransferrinemic mice: influence of systemic iron statusJohn L Beard
Department of Nutritional Science, Nutrition Science Option, Pennsylvania State University, University Park, PA 16802, USA
J Neurosci Res 79:254-61. 2005..The proteins and mechanisms responsible for additional iron uptake into specific regions, or perhaps the redistribution are unclear though the data are supportive of a non-transferrin-bound iron uptake pathway... - Maternal iron deficiency anemia affects postpartum emotions and cognitionJohn L Beard
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
J Nutr 135:267-72. 2005..There are likely ramifications of this poorer "functioning" on mother-child interactions and infant development, but the constraints around this relation will have to be defined in larger studies... - Early postnatal iron repletion overcomes lasting effects of gestational iron deficiency in ratsJohn L Beard
Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
J Nutr 137:1176-82. 2007..These data suggest that a window of opportunity exists for reversing the detrimental effects of iron deficiency in utero in rats and provides strong support of intervention approaches in humans with iron deficiency during pregnancy... - Recent evidence from human and animal studies regarding iron status and infant developmentJohn Beard
Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
J Nutr 137:524S-530S. 2007..These cross-species studies indicate a vulnerable period in early development that may result in long-lasting damage... - Interpretation of serum ferritin concentrations as indicators of total-body iron stores in survey populations: the role of biomarkers for the acute phase responseJohn L Beard
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Am J Clin Nutr 84:1498-505. 2006..Few, however, have examined which biomarker better identifies persons with spurious elevations in iron status markers... 
Why iron deficiency is important in infant developmentJohn L Beard
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
J Nutr 138:2534-6. 2008..These studies indicate that gestation and early lactation are likely critical periods when iron deficiency will result in long-lasting damage...- Cellular iron concentrations directly affect the expression levels of norepinephrine transporter in PC12 cells and rat brain tissueJohn L Beard
Department of Nutritional Science, S 128 Henderson South Building, The Pennsylvania State University, University Park, PA 16802, USA
Brain Res 1092:47-58. 2006.... - Pre- and postweaning iron deficiency alters myelination in Sprague-Dawley ratsJohn L Beard
Nutrition Sciences, Integrative Biosciences Graduate Program, Pennsylvania State University, S 126 Henderson Building, University Park, PA 16802, USA
Dev Neurosci 25:308-15. 2003..This suggests that iron deficiency in later life, as well as during early postnatal growth, can effect the production and maintenance of myelin... - Diurnal cycle influences peripheral and brain iron levels in miceErica L Unger
Department of Nutrition Sciences, The Pennsylvania State University, University Park, PA 16802, USA
J Appl Physiol 106:187-93. 2009..Importantly, variations in brain iron may have temporal implications regarding neural functioning and may contribute to the diurnal cycle-dependent symptoms of RLS... - Iron deficiency affects acoustic startle response and latency, but not prepulse inhibition in young adult ratsMaggie S Burhans
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
Physiol Behav 87:917-24. 2006..Future studies, perhaps pharmacologic in nature, are necessary to ascertain whether iron deficiency modifies the contribution of monoaminergic systems to responses to environmental stimuli... 
Iron deficiency alters the day-night variation in monoamine levels in miceLaura E Bianco
Department of Nutrition Sciences, The Pennsylvania State University, University Park, PA 16892, USA
Chronobiol Int 26:447-63. 2009....- Early iron deficiency alters sensorimotor development and brain monoamines in ratsErica L Unger
Department of Nutrition Sciences, The Pennsylvania State University, University Park, PA 16802, USA
J Nutr 137:118-24. 2007..These results indicate that iron deficiency begun at G15 affects early dopamine neurobiology, the development of specific developmental milestones, and behavior in preweaned rats... - Iron supplementation does not affect the susceptibility of LDL to oxidative modification in women with low iron statusAmy E Binkoski
Graduate Program in Nutrition, The Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
J Nutr 134:99-103. 2004..As expected, lag time was increased after the women consumed the low fat, low SFA diet. Therefore, the results of this study do not support a relationship between iron status and LDL oxidation... - Transgenic rice is a source of iron for iron-depleted ratsLaura E Murray-Kolb
Department of Nutrition, The Pennsylvania State University, University Park, PA, USA
J Nutr 132:957-60. 2002..These data suggest that Mendelian and biotechnological approaches to manipulating ferritin expression of seed iron in rice may contribute to a sustainable solution to global problems of iron deficiency... - Dopamine D2 receptor expression is altered by changes in cellular iron levels in PC12 cells and rat brain tissueErica L Unger
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
J Nutr 138:2487-94. 2008.... - Quantitative genetic analysis of brain copper and zinc in BXD recombinant inbred miceLeslie C Jones
Nutritional Neuroscience Program, The Pennsylvania State University, University Park, PA 16802, USA
Nutr Neurosci 9:81-92. 2006..More importantly, revelation of the genetic underpinnings of copper and zinc brain homeostasis will aid our understanding of neurological diseases that are related to copper and zinc imbalance... - Genetic analysis reveals polygenic influences on iron, copper, and zinc in mouse hippocampus with neurobiological implicationsLeslie C Jones
Intercollege Graduate Degree Program in Neuroscience, The Huck Life Sciences Institute, The Pennsylvania State University, University Park, Pennsylvania, USA
Hippocampus 18:398-410. 2008..Future work will elucidate the genes underlying the two QTL identified, to aid in identifying homologous genetic variants in human populations, which may underlie altered trace metal homeostasis and related neurological disease... - Gene expression of transferrin and transferrin receptor in brains of control vs. iron-deficient ratsJian Han
Department of Nutrition, The Pennsylvania State University, S 126, Henderson Building, University Park, PA 16802, USA
Nutr Neurosci 6:1-10. 2003..This capacity may be associated with increased iron-Tf uptake from plasma, stabilization of TfR mRNA, or increased Tf mRNA translation efficiency in specific cell types within the brain... - Iron deficiency alters dopamine uptake and response to L-DOPA injection in Sprague-Dawley ratsLaura E Bianco
Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Neurochem 106:205-15. 2008..These experiments provide new evidence that ID results in altered synthesis and functioning of DAT and perhaps suggests some compensatory changes in NE metabolism... - Comparative study of the influence of Thy1 deficiency and dietary iron deficiency on dopaminergic profiles in the mouse striatumJames R Connor
Department of Neurosurgery, MS Hershey Medical Center, Penn State College of Medicine, Hershey, PA 17033, USA
J Neurosci Res 86:3194-202. 2008..Furthermore, the results reveal consistent differences in the dopaminergic profile in Thy1 knockout mice compared with iron-deficient mice, indicating that the effects of iron deficiency are not due only to a change in Thy1 expression... - Neonatal iron deficiency results in irreversible changes in dopamine function in ratsJohn Beard
Graduate Program in Nutrition, Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Nutr 133:1174-9. 2003..Changes in DA-related behaviors that were persistent after postweaning iron repletion suggest the existence of a critical neonatal developmental period that is expressed by alterations in DA functioning... - Systems genetic analysis of peripheral iron parameters in the mouseByron C Jones
Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA 16827, USA
Am J Physiol Regul Integr Comp Physiol 293:R116-24. 2007..The results show that iron homeostasis is a complex trait and is influenced by multiple genes... - What matters most: an investigation of predictors of perceived stress among young mothers in KhayelitshaRhonda Belue
The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Health Care Women Int 29:638-48. 2008.... - Iron regulation in C57BLI6 and DBA/2 mice subjected to iron overloadErica L Unger
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Nutr Neurosci 10:89-95. 2007..We conclude that genetic background influences the accumulation of excess iron in the periphery and iron regulation in the central nervous system... - Acoustic startle response is disrupted in iron-deficient ratsErica L Unger
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Pharmacol Biochem Behav 84:378-84. 2006..These results thus demonstrate that iron deficiency moderately alters ASR signaling although the inhibitory pathways of ASR do not appear to be affected... - Altered dopaminergic profile in the putamen and substantia nigra in restless leg syndromeJames R Connor
Department of Neurosurgery, Penn State College of Medicine, Hershey, PA 17033 0850, USA
Brain 132:2403-12. 2009..The results are consistent with the hypothesis that a primary iron insufficiency produces a dopaminergic abnormality characterized as an overly activated dopaminergic system as part of the RLS pathology... - Women with low iron stores absorb iron from soybeansLaura E Murray-Kolb
Department of Nutrition, The Pennsylvania State University, University Park, USA
Am J Clin Nutr 77:180-4. 2003..More study is needed on the effect of plant nodulation on the form of soybean iron, aimed at enhancing bioavailability to combat iron deficiency in at-risk populations... - Iron status and neural functioningJohn L Beard
Department of Nutritional Sciences The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Annu Rev Nutr 23:41-58. 2003..Future studies with more specific measures of neurodevelopment in iron-deficient human infants, and animal models, will allow investigators to more clearly define causal roles of brain iron in neural development and functioning... - Low hemoglobin level is a risk factor for postpartum depressionElizabeth J Corwin
Intercollege Physiology Program and The School of Nursing, The Pennsylvania State University, University Park, PA 16802, USA
J Nutr 133:4139-42. 2003..90 +/- 1.04) than those of women with Hb levels < or = 120 g/L (12 g/dL) [16.36 +/- 3.34; t(35) = -3.632, P = 0.001]. Thus, women suffering early postpartum anemia may be at increased risk of developing PPD... - Neurobehavioral analysis of developmental iron deficiency in ratsJohn L Beard
Graduate Program in Nutrition, Department of Nutrition, The Pennsylvania State University, S 126 Henderson Bldg, University Park, PA 16802, USA
Behav Brain Res 134:517-24. 2002..These observations also strengthen the argument that the Fe-dopamine link is fundamental to understanding biobehavioral difficulties seen in children with ID anemia... - Iron deficiency in rats decreases acquisition of and suppresses responding for cocaineByron C Jones
Department of Biobehavioral Health, The Pennsylvania State University, 315 East Health and Human Development Building, University Park, PA 16802 6508, USA
Pharmacol Biochem Behav 73:813-9. 2002..The question raised by this research thus, is whether iron deficiency alters hedonic-like responses only to dopamine-related behaviors and the degree to which willingness to "work" contributes to the effect... - Quantitative genetic analysis of ventral midbrain and liver iron in BXD recombinant inbred miceByron C Jones
Department of Biobehavioral Health, The Pennsylvania State University, 315 HHD Building, University Park, PA 16802, USA
Nutr Neurosci 6:369-77. 2003..This work shows the value of quantitative genetic analysis in the neurobiology of iron and in showing the close association between ventral midbrain iron and nigrostriatal/mesolimbic dopamine function... - Nutrient adequacy and food group consumption of Filipino novices and religious sisters over a nine month periodJessica A Grieger
Department of Nutritional Sciences, Pennsylvania State University, University Park, PA, USA
Asia Pac J Clin Nutr 17:566-72. 2008..For the overweight women, these nutrient dense foods also are recommended, however it is important that they be substituted for energy dense foods to promote weight loss and prevent weight gain... - Iron deficiency and marginal vitamin A deficiency affect growth, hematological indices and the regulation of iron metabolism genes in ratsYi Ning J Strube
The Graduate Program in Nutrition and the Department of Nutritional Sciences, The Pennsylvania State University, University Park 16802, USA
J Nutr 132:3607-15. 2002..These results are consistent with an impaired mobilization of liver retinol during iron deficiency as well as multiple alterations in iron metabolism... - Iron treatment normalizes cognitive functioning in young womenLaura E Murray-Kolb
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
Am J Clin Nutr 85:778-87. 2007..Women of reproductive age are among those most vulnerable to iron deficiency and may be at high risk for cognitive alterations due to iron deficiency... - Iron deficiency alters brain development and functioningJohn Beard
Graduate Program in Nutrition, The Pennsylvania State University, University Park, PA 16802, USA
J Nutr 133:1468S-72S. 2003..The growing body of evidence suggests that brain iron deficiency in early life has multiple consequences in neurochemistry and neurobiology... - Systemic iron statusJohn Beard
The Pennsylvania State University, USA
Biochim Biophys Acta 1790:584-8. 2009..A finely tuned feedback control system functions to limit this excessive accumulation by limiting absorption of iron. This chapter will discuss systemic and brain iron homeostasis... - Iron deficiency: differential effects on monoamine transportersMaggie S Burhans
Department of Nutritional Sciences, The Pennsylvania State University, University Park, PA, USA
Nutr Neurosci 8:31-8. 2005..These findings show that iron deficiency affects monoamine systems related to homeostasis and in most cases males appear to be more vulnerable than females... - H and L ferritin subunit mRNA expression differs in brains of control and iron-deficient ratsJian Han
Department of Nutrition, The Pennsylvania State University, University Park, PA 16802, USA
J Nutr 132:2769-74. 2002..All of these data suggest that regulation of ferritin subunits is cellular and/or regional specific... - Iron status in association with cardiovascular disease risk in 3 controlled feeding studiesJessica L Derstine
Department of Nutrition, The Pennsylvania State University, University Park 16802, USA
Am J Clin Nutr 77:56-62. 2003..Thus, the results do not support a relation between iron status and LDL oxidative susceptibility, a possible risk factor for cardiovascular disease... - Down-regulation of dopamine transporter by iron chelation in vitro is mediated by altered trafficking, not synthesisJason A Wiesinger
Department of Nutritional Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Neurochem 100:167-79. 2007.... - Systems genetics analysis of iron regulation in the brainLeslie C Jellen
Neuroscience Graduate Program, Pennsylvania State University, University Park, PA, USA
Biochimie 91:1255-9. 2009..The following is a discussion of iron regulation in the brain and the contributions a systems genetics approach can make toward understanding the genetic underpinnings and relation to neurological disease... - Iron-deficient mice fail to develop autoimmune encephalomyelitisSharon M Grant
Department of Nutrition, The Pennsylvania State University, 126 South Henderson, University Park, PA 16802, USA
J Nutr 133:2635-8. 2003..The mechanism of EAE inhibition in iron-deficient mice likely involves the delivery and metabolism of iron for optimal CD4+ T-cell development... - Diet-induced iron deficiency anemia and pregnancy outcome in rhesus monkeysMari S Golub
University of California, Davis, Davis, CA 95616, USA
Am J Clin Nutr 83:647-56. 2006..Iron deficiency anemia (IDA) is relatively common in the third trimester of pregnancy, but causal associations with low birth weight and compromised neonatal iron status are difficult to establish in human populations... - Genetic differences in hepatic lipid peroxidation potential and iron levels in miceGlenn S Gerhard
Department of Pathology, Penn State College of Medicine, Hershey, PA, USA
Mech Ageing Dev 123:167-76. 2002..0006. At least two potentially relevant candidate genes reside close to this chromosomal position. Hepatic lipid peroxidation potential appears to be a strain related trait in mice that is amenable to QTL analysis... - Persistent neurochemical and behavioral abnormalities in adulthood despite early iron supplementation for perinatal iron deficiency anemia in ratsBarbara T Felt
Center for Human Growth and Development and Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor, 48109, USA
Behav Brain Res 171:261-70. 2006..We recently reported that rats with chronic perinatal IDA, had altered regional brain iron, monoamines, and sensorimotor skill emergence during early development... - Iron-biofortified rice improves the iron stores of nonanemic Filipino womenJere D Haas
Division of Nutritional Sciences, Cornell University, Ithaca, NY 14853, USA
J Nutr 135:2823-30. 2005..Consumption of biofortified rice, without any other changes in diet, is efficacious in improving iron stores of women with iron-poor diets in the developing world... - Iron bioavailability: UK Food Standards Agency workshop reportMamta Singh
Food Standards Agency, Aviation House, 125 Kingsway, London WC2B 6NH, UK
Br J Nutr 96:985-90. 2006..In the presence of abundant and varied food supplies, the health consequences of lower iron bioavailability are unclear and require further investigation... - CSF proteomic analysis reveals persistent iron deficiency-induced alterations in non-human primate infantsRamaz N Geguchadze
Department of Neurosurgery, The Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
J Neurochem 105:127-36. 2008..Furthermore, alterations in the CSF proteome despite normal hematologic parameters indicate that there is a hierarchical system that prioritizes repletion of red cell mass at the expense of the brain... - Neurobehavioral evaluation of rhesus monkey infants fed cow's milk formula, soy formula, or soy formula with added manganeseMari S Golub
Department of Internal Medicine, CNPRC, Rm 1925, University of California, One Shields Ave, Davis, CA 95616, USA
Neurotoxicol Teratol 27:615-27. 2005..This experiment suggests that components of soy formula, including Mn, may influence brain development as reflected in behavioral measures... - Hemoglobin and ferritin are currently the most efficient indicators of population response to iron interventions: an analysis of nine randomized controlled trialsZuguo Mei
Division of Nutrition and Physical Activity, Centers for Disease Control and Prevention, Atlanta, GA, USA
J Nutr 135:1974-80. 2005..It is possible that the optimal indicator(s) may differ with age, sex, and pregnancy. There were too few trials in each age and sex group to allow us to explore this question... - Mother-infant interactions and infant development are altered by maternal iron deficiency anemiaEva M Perez
School of Child and Adolescent Health, University of Cape Town, Cape Town, South Africa
J Nutr 135:850-5. 2005..In conclusion, IDA altered mother-child interactions at both 10 wk and 9 mo postpartum. Additionally, infants whose mothers were anemic in the early postpartum scored worse on developmental tests at 10 wk and 9 mo of age... - Interactions and reactions of ferritin with DNANodar Surguladze
Departments of Neural and Behavioral Science and Biochemistry and Molecular Biology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
J Biol Chem 279:14694-702. 2004..These results suggest that the release of iron from ferritin is an important part of the nicking mechanism. The potential role of ferritin as a protector of the genome is discussed in the context of these results... - Ferritin subunits in CSF are decreased in restless legs syndromeStacey L Clardy
Department of Neurosurgery, M.S. Hershey Medical Center, Hershey, Pennsylvania 17033, USA
J Lab Clin Med 147:67-73. 2006..These data suggest that CSF ferritin levels may provide a biomarker for assisting in the diagnosis of RLS... - Altered iron metabolism in lymphocytes from subjects with restless legs syndromeChristopher J Earley
Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
Sleep 31:847-52. 2008..Thus the study aim was to determine whether patients with RLS and control subjects show differences in lymphocyte iron regulator proteins... - Ferritin levels in the cerebrospinal fluid and restless legs syndrome: effects of different clinical phenotypesChristopher J Earley
Department of Neurology, Johns Hopkins School of Medicine, Johns Hopkins Bayview Medical Center, Baltimore, MD 21224, USA
Sleep 28:1069-75. 2005....
Research Grants
- IRON DEFICIENCY AND DOPAMINEJohn Beard; Fiscal Year: 2000..The significance of this work is that it investigates a biologic basis for understanding the behavioral alterations frequently observed in the hundreds of thousands of iron deficient children around the world. ..
- IRON DEFICIENCY AND DOPAMINEJohn Beard; Fiscal Year: 2004..This expansion of study to other neurotransmitters will significantly contribute to our knowledge of the effects of iron deficiency on brain functioning in early life. ..