J L Beard
Affiliation: Pennsylvania State University
- Neonatal iron deficiency results in irreversible changes in dopamine function in ratsJohn Beard
Graduate Program in Nutrition, Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
J Nutr 133:1174-9. 2003..Changes in DA-related behaviors that were persistent after postweaning iron repletion suggest the existence of a critical neonatal developmental period that is expressed by alterations in DA functioning...
- Changes in iron status during weight loss with very-low-energy dietsJ Beard
Nutrition Department, Pennsylvania State University, University Park 16803, USA
Am J Clin Nutr 66:104-10. 1997..The transitory fall in iron delivery to bone marrow was not associated with anemia. These data suggest that higher thyroid hormone concentrations can be maintained during VLEDs that provide higher iron intakes...
- Iron status and neural functioningJohn L Beard
Department of Nutritional Sciences The Pennsylvania State University, University Park, Pennsylvania 16802, USA
Annu Rev Nutr 23:41-58. 2003..Future studies with more specific measures of neurodevelopment in iron-deficient human infants, and animal models, will allow investigators to more clearly define causal roles of brain iron in neural development and functioning...
- Iron deficiency alters brain development and functioningJohn Beard
Graduate Program in Nutrition, The Pennsylvania State University, University Park, PA 16802, USA
J Nutr 133:1468S-72S. 2003..The growing body of evidence suggests that brain iron deficiency in early life has multiple consequences in neurochemistry and neurobiology...
- Neurobehavioral analysis of developmental iron deficiency in ratsJohn L Beard
Graduate Program in Nutrition, Department of Nutrition, The Pennsylvania State University, S 126 Henderson Bldg, University Park, PA 16802, USA
Behav Brain Res 134:517-24. 2002..These observations also strengthen the argument that the Fe-dopamine link is fundamental to understanding biobehavioral difficulties seen in children with ID anemia...
- Effectiveness and strategies of iron supplementation during pregnancyJ L Beard
Nutrition Department, The Pennsylvania State University, University Park 16802, USA
Am J Clin Nutr 71:1288S-94S. 2000..Currently, no single approach may be universally acceptable, although a moderate iron dosage protocol will likely provide the most benefit to those who require supplemental iron...
- Iron deficiency alters H- and L-ferritin expression in rat brainJ Han
Department of Nutrition, The Pennsylvania State University, University Park 16802, USA
Cell Mol Biol (Noisy-le-grand) 46:517-28. 2000..These data indicate that ferritin H and L subunits within the brain respond differently to iron status and suggest post transcription regulation as a key event...
- Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brainE A Malecki
Department of Pediatrics, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA
J Neurol Sci 170:112-8. 1999..Additionally, these data suggest that endogenous synthesis of Tf is necessary for Fe transport from the choroid plexus...
- Resistance training affects iron status in older men and womenL E Murray-Kolb
Department of Nutrition, The Pennsylvania State University, University Park, PA 16802, USA
Int J Sport Nutr Exerc Metab 11:287-98. 2001..030). CONCLUSIONS: With resistance training, iron status of older men and women changes in a sex specific way...
- Iron deficiency decreases dopamine D1 and D2 receptors in rat brainK M Erikson
Department of Nutrition, Graduate Program in Nutrition, The Pennsylvania State University, S-126 Henderson Building, University Park, PA 16802, USA
Pharmacol Biochem Behav 69:409-18. 2001..Importantly, the impact of ID on dopamine was more pronounced in males than females, demonstrating sex-related different sensitivities to nutrient deprivation...
- Iron biology in immune function, muscle metabolism and neuronal functioningJ L Beard
Nutrition Department, College of Human Development, The Pennsylvania State State University, University Park, PA 16802, USA
J Nutr 131:568S-579S; discussion 580S. 2001....
- A genetic developmental model of iron deficiency: biological aspectsA C Morse
Department of Biobehavioral Health, College of Health and Human Development, Pennsylvania State University, University Park 16802, USA
Proc Soc Exp Biol Med 220:147-52. 1999..Future studies should continue to examine the contributions of both genetics and sex to the development of iron deficiency...
- New insights into the mechanism and actions of growth hormone (GH) in poultryR Vasilatos-Younken
Department of Poultry Science, The Pennsylvania State University, University Park 16802, USA
Domest Anim Endocrinol 17:181-90. 1999..Based upon these studies, it is now evident that GH does in fact have significant effects in poultry, but metabolic responses may confound the anabolic potential of the hormone...
- Transferrin response in normal and iron-deficient mice heterozygotic for hypotransferrinemia; effects on iron and manganese accumulationE A Malecki
Department of Pediatrics, College of Medicine, Pennsylvania State University, Hershey 17033, USA
Biometals 11:265-76. 1998..Furthermore, we observed no differences in tissue distribution of 54Mn despite the differences in circulating Tf concentrations and body iron stores; this suggests that there are non-Tf dependent mechanisms for Mn transport...
- Iron deficiency anemia and steady-state work performance at high altitudeJ L Beard
Nutrition Program, Pennsylvania State University, University Park 16802
J Appl Physiol 64:1878-84. 1988..In conclusion, O2 transport during exercise at high altitude seems unaffected by the Hb concentrations as low as the 10th percentile of the population mean.(ABSTRACT TRUNCATED AT 250 WORDS)..
- Iron levels in human retina: sex difference and increase with agePaul Hahn
The F M Kirby Center for Molecular Ophthalmology, University of Pennsylvania, Philadelphia, USA
Neuroreport 17:1803-6. 2006..We found that retinal iron increases with age, similar to serum ferritin levels. Women had more retinal iron than men at all ages, suggesting that there may be gender-specific influences on iron regulation...
- Regulation of the profile of iron-management proteins in brain microvasculatureJoseph R Burdo
Department of Neural and Behavioral Sciences, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
J Cereb Blood Flow Metab 24:67-74. 2004..The results also indicate that brain iron status dictates the response of the microvascular protein profile to systemic iron manipulation...
- Recent evidence from human and animal studies regarding iron status and infant developmentJohn Beard
Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
J Nutr 137:524S-530S. 2007..These cross-species studies indicate a vulnerable period in early development that may result in long-lasting damage...
- Gestational and lactational iron deficiency alters the developing striatal metabolome and associated behaviors in young ratsKay L Ward
Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
J Nutr 137:1043-9. 2007..These novel data imply that alterations in the metabolite profile of the striatum likely influence later neural functioning in early iron deficiency...
- Dietary iron intakes and elevated iron stores in the elderly: is it time to abandon the set-point hypothesis of regulation of iron absorption?John Beard
Am J Clin Nutr 76:1189-90. 2002
- Long-lasting neural and behavioral effects of iron deficiency in infancyBetsy Lozoff
Center for Human Growth and Development and the Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor 48109, USA
Nutr Rev 64:S34-43; discussion S72-91. 2006..Research in animal models points to mechanisms for such long-lasting effects. Potential mechanisms relate to effects of iron deficiency during brain development on neurometabolism, myelination, and neurotransmitter function...
- Correlation of proton transverse relaxation rates (R2) with iron concentrations in postmortem brain tissue from alzheimer's disease patientsMichael J House
School of Physics, University of Western Australia, Perth, Australia
Magn Reson Med 57:172-80. 2007..High-field MRI may therefore be a useful research tool for assessing brain iron changes associated with AD...
- Iron status of inner-city African-American infantsBetsy Lozoff
Center for Human Growth and Development, University of Michigan, Ann Arbor, Michigan 48109, USA
Am J Hematol 82:112-21. 2007..Functional indicators of poor iron status in young infants are urgently needed...
- Cohort profile: the 45 and up studyEmily Banks
Sax Institute, Sydney, Australia
Int J Epidemiol 37:941-7. 2008
- Subcellular localization of iron regulatory proteins to Golgi and ER membranesStephanie M Patton
Department of Neurosurgery, G M Leader Family Laboratory for Alzheimer s Disease Research, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
J Cell Sci 118:4365-73. 2005..As a result of this study we propose a novel model for intracellular distribution of IRPs and identify differences between the two iron regulatory proteins...
- Thy1 expression in the brain is affected by iron and is decreased in Restless Legs SyndromeXinsheng Wang
Department of Neural and Behavioral Science (H109, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
J Neurol Sci 220:59-66. 2004....
- Health impacts of pesticide exposure in a cohort of outdoor workersJohn Beard
Southern Cross Institute of Health Research, Southern Cross University, Lismore, New South Wales, Australia
Environ Health Perspect 111:724-30. 2003..Diabetes was reported more commonly by subjects reporting occupational use of herbicides. These findings lend weight to other studies suggesting an association between adverse health effects and exposure to pesticides...
- Hemochromatosis protein (HFE) and tumor necrosis factor receptor 2 (TNFR2) influence tissue iron levels: elements of a common gut pathway?Paul N Meyer
H107, Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
Blood Cells Mol Dis 29:274-85. 2002..These data suggest that HFE and TNFR2 may contribute to a common pathway of the iron stores regulator insuring the controlled efflux of gut iron...
- Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stressKhristy Thompson
Department of Neuroscience and Anatomy, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
J Neurosci Res 71:46-63. 2003..These results suggest that this mouse may be a model to determine the role of iron mismanagement in neurodegenerative disorders and for testing antioxidant therapeutic strategies...
- Substance use disorders in an Australian community surveyMaree Teesson
National Drug and Alcohol Research Centre, University of New South Wales, Australia
Drug Alcohol Rev 21:275-80. 2002..A third (33%) of those people with an alcohol use disorder and 42% of those with a drug use disorder had consulted a health professional in the past 12 months for their substance use disorder...
- Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMDMajda Hadziahmetovic
FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA
Invest Ophthalmol Vis Sci 49:2728-36. 2008..In this study, the location and timing of iron accumulation, the rate and reproducibility of retinal degeneration, and the roles of oxidative stress and complement activation were determined...