J L Beard

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. ncbi request reprint Neonatal iron deficiency results in irreversible changes in dopamine function in rats
    John Beard
    Graduate Program in Nutrition, Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 133:1174-9. 2003
  2. ncbi request reprint Changes in iron status during weight loss with very-low-energy diets
    J Beard
    Nutrition Department, Pennsylvania State University, University Park 16803, USA
    Am J Clin Nutr 66:104-10. 1997
  3. ncbi request reprint Iron status and neural functioning
    John L Beard
    Department of Nutritional Sciences The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Annu Rev Nutr 23:41-58. 2003
  4. ncbi request reprint Iron deficiency alters brain development and functioning
    John Beard
    Graduate Program in Nutrition, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 133:1468S-72S. 2003
  5. ncbi request reprint Neurobehavioral analysis of developmental iron deficiency in rats
    John L Beard
    Graduate Program in Nutrition, Department of Nutrition, The Pennsylvania State University, S 126 Henderson Bldg, University Park, PA 16802, USA
    Behav Brain Res 134:517-24. 2002
  6. ncbi request reprint Effectiveness and strategies of iron supplementation during pregnancy
    J L Beard
    Nutrition Department, The Pennsylvania State University, University Park 16802, USA
    Am J Clin Nutr 71:1288S-94S. 2000
  7. ncbi request reprint Iron deficiency alters H- and L-ferritin expression in rat brain
    J Han
    Department of Nutrition, The Pennsylvania State University, University Park 16802, USA
    Cell Mol Biol (Noisy-le-grand) 46:517-28. 2000
  8. ncbi request reprint Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brain
    E A Malecki
    Department of Pediatrics, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA
    J Neurol Sci 170:112-8. 1999
  9. ncbi request reprint Resistance training affects iron status in older men and women
    L E Murray-Kolb
    Department of Nutrition, The Pennsylvania State University, University Park, PA 16802, USA
    Int J Sport Nutr Exerc Metab 11:287-98. 2001
  10. ncbi request reprint Iron deficiency decreases dopamine D1 and D2 receptors in rat brain
    K M Erikson
    Department of Nutrition, Graduate Program in Nutrition, The Pennsylvania State University, S-126 Henderson Building, University Park, PA 16802, USA
    Pharmacol Biochem Behav 69:409-18. 2001

Collaborators

Detail Information

Publications31

  1. ncbi request reprint Neonatal iron deficiency results in irreversible changes in dopamine function in rats
    John Beard
    Graduate Program in Nutrition, Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr 133:1174-9. 2003
    ..Changes in DA-related behaviors that were persistent after postweaning iron repletion suggest the existence of a critical neonatal developmental period that is expressed by alterations in DA functioning...
  2. ncbi request reprint Changes in iron status during weight loss with very-low-energy diets
    J Beard
    Nutrition Department, Pennsylvania State University, University Park 16803, USA
    Am J Clin Nutr 66:104-10. 1997
    ..The transitory fall in iron delivery to bone marrow was not associated with anemia. These data suggest that higher thyroid hormone concentrations can be maintained during VLEDs that provide higher iron intakes...
  3. ncbi request reprint Iron status and neural functioning
    John L Beard
    Department of Nutritional Sciences The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    Annu Rev Nutr 23:41-58. 2003
    ..Future studies with more specific measures of neurodevelopment in iron-deficient human infants, and animal models, will allow investigators to more clearly define causal roles of brain iron in neural development and functioning...
  4. ncbi request reprint Iron deficiency alters brain development and functioning
    John Beard
    Graduate Program in Nutrition, The Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 133:1468S-72S. 2003
    ..The growing body of evidence suggests that brain iron deficiency in early life has multiple consequences in neurochemistry and neurobiology...
  5. ncbi request reprint Neurobehavioral analysis of developmental iron deficiency in rats
    John L Beard
    Graduate Program in Nutrition, Department of Nutrition, The Pennsylvania State University, S 126 Henderson Bldg, University Park, PA 16802, USA
    Behav Brain Res 134:517-24. 2002
    ..These observations also strengthen the argument that the Fe-dopamine link is fundamental to understanding biobehavioral difficulties seen in children with ID anemia...
  6. ncbi request reprint Effectiveness and strategies of iron supplementation during pregnancy
    J L Beard
    Nutrition Department, The Pennsylvania State University, University Park 16802, USA
    Am J Clin Nutr 71:1288S-94S. 2000
    ..Currently, no single approach may be universally acceptable, although a moderate iron dosage protocol will likely provide the most benefit to those who require supplemental iron...
  7. ncbi request reprint Iron deficiency alters H- and L-ferritin expression in rat brain
    J Han
    Department of Nutrition, The Pennsylvania State University, University Park 16802, USA
    Cell Mol Biol (Noisy-le-grand) 46:517-28. 2000
    ..These data indicate that ferritin H and L subunits within the brain respond differently to iron status and suggest post transcription regulation as a key event...
  8. ncbi request reprint Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brain
    E A Malecki
    Department of Pediatrics, College of Medicine, The Pennsylvania State University, Hershey, PA 17033, USA
    J Neurol Sci 170:112-8. 1999
    ..Additionally, these data suggest that endogenous synthesis of Tf is necessary for Fe transport from the choroid plexus...
  9. ncbi request reprint Resistance training affects iron status in older men and women
    L E Murray-Kolb
    Department of Nutrition, The Pennsylvania State University, University Park, PA 16802, USA
    Int J Sport Nutr Exerc Metab 11:287-98. 2001
    ..030). CONCLUSIONS: With resistance training, iron status of older men and women changes in a sex specific way...
  10. ncbi request reprint Iron deficiency decreases dopamine D1 and D2 receptors in rat brain
    K M Erikson
    Department of Nutrition, Graduate Program in Nutrition, The Pennsylvania State University, S-126 Henderson Building, University Park, PA 16802, USA
    Pharmacol Biochem Behav 69:409-18. 2001
    ..Importantly, the impact of ID on dopamine was more pronounced in males than females, demonstrating sex-related different sensitivities to nutrient deprivation...
  11. ncbi request reprint Iron biology in immune function, muscle metabolism and neuronal functioning
    J L Beard
    Nutrition Department, College of Human Development, The Pennsylvania State State University, University Park, PA 16802, USA
    J Nutr 131:568S-579S; discussion 580S. 2001
    ....
  12. ncbi request reprint A genetic developmental model of iron deficiency: biological aspects
    A C Morse
    Department of Biobehavioral Health, College of Health and Human Development, Pennsylvania State University, University Park 16802, USA
    Proc Soc Exp Biol Med 220:147-52. 1999
    ..Future studies should continue to examine the contributions of both genetics and sex to the development of iron deficiency...
  13. ncbi request reprint New insights into the mechanism and actions of growth hormone (GH) in poultry
    R Vasilatos-Younken
    Department of Poultry Science, The Pennsylvania State University, University Park 16802, USA
    Domest Anim Endocrinol 17:181-90. 1999
    ..Based upon these studies, it is now evident that GH does in fact have significant effects in poultry, but metabolic responses may confound the anabolic potential of the hormone...
  14. ncbi request reprint Transferrin response in normal and iron-deficient mice heterozygotic for hypotransferrinemia; effects on iron and manganese accumulation
    E A Malecki
    Department of Pediatrics, College of Medicine, Pennsylvania State University, Hershey 17033, USA
    Biometals 11:265-76. 1998
    ..Furthermore, we observed no differences in tissue distribution of 54Mn despite the differences in circulating Tf concentrations and body iron stores; this suggests that there are non-Tf dependent mechanisms for Mn transport...
  15. ncbi request reprint Iron deficiency anemia and steady-state work performance at high altitude
    J L Beard
    Nutrition Program, Pennsylvania State University, University Park 16802
    J Appl Physiol 64:1878-84. 1988
    ..In conclusion, O2 transport during exercise at high altitude seems unaffected by the Hb concentrations as low as the 10th percentile of the population mean.(ABSTRACT TRUNCATED AT 250 WORDS)..
  16. ncbi request reprint Iron levels in human retina: sex difference and increase with age
    Paul Hahn
    The F M Kirby Center for Molecular Ophthalmology, University of Pennsylvania, Philadelphia, USA
    Neuroreport 17:1803-6. 2006
    ..We found that retinal iron increases with age, similar to serum ferritin levels. Women had more retinal iron than men at all ages, suggesting that there may be gender-specific influences on iron regulation...
  17. ncbi request reprint Regulation of the profile of iron-management proteins in brain microvasculature
    Joseph R Burdo
    Department of Neural and Behavioral Sciences, Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033, USA
    J Cereb Blood Flow Metab 24:67-74. 2004
    ..The results also indicate that brain iron status dictates the response of the microvascular protein profile to systemic iron manipulation...
  18. ncbi request reprint Recent evidence from human and animal studies regarding iron status and infant development
    John Beard
    Department of Nutritional Sciences, Pennsylvania State University, University Park, PA 16802, USA
    J Nutr 137:524S-530S. 2007
    ..These cross-species studies indicate a vulnerable period in early development that may result in long-lasting damage...
  19. pmc Gestational and lactational iron deficiency alters the developing striatal metabolome and associated behaviors in young rats
    Kay L Ward
    Department of Pediatrics, University of Minnesota, Minneapolis, MN, USA
    J Nutr 137:1043-9. 2007
    ..These novel data imply that alterations in the metabolite profile of the striatum likely influence later neural functioning in early iron deficiency...
  20. ncbi request reprint Dietary iron intakes and elevated iron stores in the elderly: is it time to abandon the set-point hypothesis of regulation of iron absorption?
    John Beard
    Am J Clin Nutr 76:1189-90. 2002
  21. pmc Long-lasting neural and behavioral effects of iron deficiency in infancy
    Betsy Lozoff
    Center for Human Growth and Development and the Department of Pediatrics and Communicable Diseases, University of Michigan, Ann Arbor 48109, USA
    Nutr Rev 64:S34-43; discussion S72-91. 2006
    ..Research in animal models points to mechanisms for such long-lasting effects. Potential mechanisms relate to effects of iron deficiency during brain development on neurometabolism, myelination, and neurotransmitter function...
  22. ncbi request reprint Correlation of proton transverse relaxation rates (R2) with iron concentrations in postmortem brain tissue from alzheimer's disease patients
    Michael J House
    School of Physics, University of Western Australia, Perth, Australia
    Magn Reson Med 57:172-80. 2007
    ..High-field MRI may therefore be a useful research tool for assessing brain iron changes associated with AD...
  23. pmc Iron status of inner-city African-American infants
    Betsy Lozoff
    Center for Human Growth and Development, University of Michigan, Ann Arbor, Michigan 48109, USA
    Am J Hematol 82:112-21. 2007
    ..Functional indicators of poor iron status in young infants are urgently needed...
  24. pmc Cohort profile: the 45 and up study
    Emily Banks
    Sax Institute, Sydney, Australia
    Int J Epidemiol 37:941-7. 2008
  25. ncbi request reprint Subcellular localization of iron regulatory proteins to Golgi and ER membranes
    Stephanie M Patton
    Department of Neurosurgery, G M Leader Family Laboratory for Alzheimer s Disease Research, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA
    J Cell Sci 118:4365-73. 2005
    ..As a result of this study we propose a novel model for intracellular distribution of IRPs and identify differences between the two iron regulatory proteins...
  26. ncbi request reprint Thy1 expression in the brain is affected by iron and is decreased in Restless Legs Syndrome
    Xinsheng Wang
    Department of Neural and Behavioral Science H109, Penn State College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    J Neurol Sci 220:59-66. 2004
    ....
  27. pmc Health impacts of pesticide exposure in a cohort of outdoor workers
    John Beard
    Southern Cross Institute of Health Research, Southern Cross University, Lismore, New South Wales, Australia
    Environ Health Perspect 111:724-30. 2003
    ..Diabetes was reported more commonly by subjects reporting occupational use of herbicides. These findings lend weight to other studies suggesting an association between adverse health effects and exposure to pesticides...
  28. ncbi request reprint Hemochromatosis protein (HFE) and tumor necrosis factor receptor 2 (TNFR2) influence tissue iron levels: elements of a common gut pathway?
    Paul N Meyer
    H107, Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, 500 University Drive, Hershey, PA 17033, USA
    Blood Cells Mol Dis 29:274-85. 2002
    ..These data suggest that HFE and TNFR2 may contribute to a common pathway of the iron stores regulator insuring the controlled efflux of gut iron...
  29. ncbi request reprint Mouse brains deficient in H-ferritin have normal iron concentration but a protein profile of iron deficiency and increased evidence of oxidative stress
    Khristy Thompson
    Department of Neuroscience and Anatomy, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania, USA
    J Neurosci Res 71:46-63. 2003
    ..These results suggest that this mouse may be a model to determine the role of iron mismanagement in neurodegenerative disorders and for testing antioxidant therapeutic strategies...
  30. ncbi request reprint Substance use disorders in an Australian community survey
    Maree Teesson
    National Drug and Alcohol Research Centre, University of New South Wales, Australia
    Drug Alcohol Rev 21:275-80. 2002
    ..A third (33%) of those people with an alcohol use disorder and 42% of those with a drug use disorder had consulted a health professional in the past 12 months for their substance use disorder...
  31. pmc Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD
    Majda Hadziahmetovic
    FM Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, University of Pennsylvania, Philadelphia, Pennsylvania, USA
    Invest Ophthalmol Vis Sci 49:2728-36. 2008
    ..In this study, the location and timing of iron accumulation, the rate and reproducibility of retinal degeneration, and the roles of oxidative stress and complement activation were determined...