Brian M Barth

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate
    Brian M Barth
    Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States
    ACS Nano 7:2132-44. 2013
  2. pmc Ceramide kinase regulates TNFα-stimulated NADPH oxidase activity and eicosanoid biosynthesis in neuroblastoma cells
    Brian M Barth
    Department of Chemistry and Biochemistry, University of Alaska Fairbanks, 900 Yukon Drive, Fairbanks, AK 99775, USA
    Cell Signal 24:1126-33. 2012
  3. doi request reprint Targeted indocyanine-green-loaded calcium phosphosilicate nanoparticles for in vivo photodynamic therapy of leukemia
    Brian M Barth
    Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    ACS Nano 5:5325-37. 2011
  4. pmc Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance
    Brian M Barth
    Program in Biochemistry and Molecular Biology, Department of Chemistry and Biochemistry, University of Alaska Fairbanks, Fairbanks, AK, USA
    Cancer Biol Ther 10:1126-36. 2010
  5. ncbi request reprint Calcium phosphosilicate nanoparticles for imaging and photodynamic therapy of cancer
    Diana M Tacelosky
    Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Discov Med 13:275-85. 2012
  6. pmc Gaucher's disease and cancer: a sphingolipid perspective
    Brian M Barth
    Department of Pharmacology, Penn State College of Medicine, Hershey, PA, USA
    Crit Rev Oncog 18:221-34. 2013
  7. pmc Neutral sphingomyelinase activation precedes NADPH oxidase-dependent damage in neurons exposed to the proinflammatory cytokine tumor necrosis factor-α
    Brian M Barth
    Department of Pharmacology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, USA
    J Neurosci Res 90:229-42. 2012
  8. doi request reprint Nanoliposomal ceramide prevents in vivo growth of hepatocellular carcinoma
    Hephzibah Rani S Tagaram
    Departments of Pharmacology and of Cellular and Molecular Physiology, Hershey, PA 17033 0858, USA
    Gut 60:695-701. 2011
  9. pmc Exogenous ceramide-1-phosphate reduces lipopolysaccharide (LPS)-mediated cytokine expression
    Jody L Hankins
    Department of Pharmacology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 286:44357-66. 2011
  10. pmc Ceramide 1-phosphate mediates endothelial cell invasion via the annexin a2-p11 heterotetrameric protein complex
    Jody L Hankins
    Department of Pharmacology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 288:19726-38. 2013

Collaborators

  • Mark Kester
  • Jill P Smith
  • James H Adair
  • David F Claxton
  • Timothy M Ritty
  • Yixing Jiang
  • Samy A F Morad
  • Jody L Hankins
  • Gail L Matters
  • Todd E Fox
  • Diana M Tacelosky
  • Hephzibah Rani S Tagaram
  • Timothy K Cooper
  • Jiangang Liao
  • Evan L Gilius
  • Christopher O McGovern
  • Megan M Young
  • Jeremy K Haakenson
  • Katherine E Ward
  • Ushma A Doshi
  • Sam S Linton
  • Robert V Stahelin
  • Amy E Creecy
  • Sriram S Shanmugavelandy
  • Kellee A Unrath
  • James M Kaiser
  • Nicole A DiVittore
  • Diego Avella
  • Harriet C Isom
  • Kevin F Staveley-O'carroll
  • Eric T Kimchi

Detail Information

Publications14

  1. pmc PhotoImmunoNanoTherapy reveals an anticancer role for sphingosine kinase 2 and dihydrosphingosine-1-phosphate
    Brian M Barth
    Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, United States
    ACS Nano 7:2132-44. 2013
    ..These findings further defined a novel myeloid regulatory role for dihydrosphingosine-1-phosphate. PhotoImmunoNanoTherapy holds the potential to be a revolutionary treatment for cancers with inflammatory and immunosuppressive phenotypes...
  2. pmc Ceramide kinase regulates TNFα-stimulated NADPH oxidase activity and eicosanoid biosynthesis in neuroblastoma cells
    Brian M Barth
    Department of Chemistry and Biochemistry, University of Alaska Fairbanks, 900 Yukon Drive, Fairbanks, AK 99775, USA
    Cell Signal 24:1126-33. 2012
    ..This vital role of CerK in CNS inflammation could provide a novel therapeutic approach to intervene with the adverse consequences of a progressive CNS inflammation...
  3. doi request reprint Targeted indocyanine-green-loaded calcium phosphosilicate nanoparticles for in vivo photodynamic therapy of leukemia
    Brian M Barth
    Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    ACS Nano 5:5325-37. 2011
    ..Altogether, this study demonstrates that leukemia-targeted ICG-loaded CPSNPs offer the promise to effectively treat relapsing and multidrug-resistant leukemia and to improve the life of leukemia patients...
  4. pmc Inhibition of NADPH oxidase by glucosylceramide confers chemoresistance
    Brian M Barth
    Program in Biochemistry and Molecular Biology, Department of Chemistry and Biochemistry, University of Alaska Fairbanks, Fairbanks, AK, USA
    Cancer Biol Ther 10:1126-36. 2010
    ..Collectively, our findings indicated that pharmacological or molecular targeting of GCS, using non-toxic nanoliposome delivery systems, successfully augmented NOX activity, and improved the efficacy of known chemotherapeutic agents...
  5. ncbi request reprint Calcium phosphosilicate nanoparticles for imaging and photodynamic therapy of cancer
    Diana M Tacelosky
    Department of Pharmacology, The Pennsylvania State University College of Medicine, Hershey, Pennsylvania 17033, USA
    Discov Med 13:275-85. 2012
    ..We will also examine novel applications of CPSNPs and PDT for the treatment of leukemia to illustrate their potential utility in cancer therapeutics...
  6. pmc Gaucher's disease and cancer: a sphingolipid perspective
    Brian M Barth
    Department of Pharmacology, Penn State College of Medicine, Hershey, PA, USA
    Crit Rev Oncog 18:221-34. 2013
    ..Furthermore, this review proposes that the therapies used to treat Gaucher's disease, which augment ceramide accumulation, are likely not linked to correlations with cancer...
  7. pmc Neutral sphingomyelinase activation precedes NADPH oxidase-dependent damage in neurons exposed to the proinflammatory cytokine tumor necrosis factor-α
    Brian M Barth
    Department of Pharmacology, College of Medicine, Pennsylvania State University, Hershey, Pennsylvania, USA
    J Neurosci Res 90:229-42. 2012
    ....
  8. doi request reprint Nanoliposomal ceramide prevents in vivo growth of hepatocellular carcinoma
    Hephzibah Rani S Tagaram
    Departments of Pharmacology and of Cellular and Molecular Physiology, Hershey, PA 17033 0858, USA
    Gut 60:695-701. 2011
    ..The purpose of this study was to evaluate the efficacy of nanoliposomal C6-ceramide as an antineoplastic agent in an in vivo model of human HCC...
  9. pmc Exogenous ceramide-1-phosphate reduces lipopolysaccharide (LPS)-mediated cytokine expression
    Jody L Hankins
    Department of Pharmacology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 286:44357-66. 2011
    ..Taken together, these data demonstrate that C-1-P may function as an anti-inflammatory lipid mediator of immune response...
  10. pmc Ceramide 1-phosphate mediates endothelial cell invasion via the annexin a2-p11 heterotetrameric protein complex
    Jody L Hankins
    Department of Pharmacology, Penn State University College of Medicine, Hershey, Pennsylvania 17033, USA
    J Biol Chem 288:19726-38. 2013
    ..These results imply that extracellular C-1-P, acting through the extracellular annexin a2-p11 heterotetrameric protein, can mediate vascular endothelial cell invasion. ..
  11. doi request reprint The therapeutic potential of nanoscale sphingolipid technologies
    Jody L Hankins
    Department of Pharmacology, R130, Penn State University College of Medicine, Hershey, PA, 17033, USA
    Handb Exp Pharmacol 215:197-210. 2013
    ..We conclude with a discussion of the challenges associated with regulatory approval, scale-up, and development of these nanotechnology therapies for clinical applications...
  12. ncbi request reprint Ceramide-based therapeutics for the treatment of cancer
    Brian M Barth
    Department of Pharmacology, Pennsylvania State University College of Medicine, Hershey, 17033, USA
    Anticancer Agents Med Chem 11:911-9. 2011
    ..This review will discuss new therapeutic strategies designed specifically to modulate ceramide metabolism, as well as nanoscale delivery systems engineered to selectively deliver ceramide to cancerous cells and tissues...
  13. ncbi request reprint Cholecystokinin mediates progression and metastasis of pancreatic cancer associated with dietary fat
    Gail L Matters
    Department of Biochemistry and Molecular Biology, College of Medicine, The Pennsylvania State University, Hershey, PA, 17033, USA
    Dig Dis Sci 59:1180-91. 2014
    ..Obesity and dietary fat are associated with increased risk of several malignancies including pancreatic cancer. The incidence of pancreatic cancer is increased in countries that consume diets high in fat...
  14. pmc Proinflammatory cytokines provoke oxidative damage to actin in neuronal cells mediated by Rac1 and NADPH oxidase
    Brian M Barth
    Department of Chemistry and Biochemistry, University of Alaska Fairbanks, 900 Yukon Drive, REIC 194, Fairbanks, AK 99775, USA
    Mol Cell Neurosci 41:274-85. 2009
    ..Inhibition of NADPH oxidase activity or Rac1 abolished the adverse effects of cytokines. These findings suggest that oxidative damage to the neuronal actin cytoskeleton could represent a key step in CNS neurodegeneration...