MICHAEL AXTELLSummaryAffiliation: Pennsylvania State University Country: USA Publications
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Publications
Classification and Comparison of Small RNAs from PlantsMichael J Axtell
Department of Biology and Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania 16802 email
Annu Rev Plant Biol 64:137-59. 2013..Tertiary subdivisions can be identified within many of the secondary classifications as well. Comparisons between the different classes of plant small RNAs help to illuminate key goals for future research...
Vive la différence: biogenesis and evolution of microRNAs in plants and animalsMichael J Axtell
Department of Biology, The Pennsylvania State University, 208 Mueller Laboratory, University Park, PA 16802, USA
Genome Biol 12:221. 2011..MicroRNAs are pervasive in both plants and animals, but many aspects of their biogenesis, function and evolution differ. We reveal how these differences contribute to characteristic features of microRNA evolution in the two kingdoms...- Common functions for diverse small RNAs of land plantsMichael J Axtell
Department of Biology and Huck Institutes of the Life Sciences, Pensylvania State University, University Park, PA 16802, USA
Plant Cell 19:1750-69. 2007..Diverse, lineage-specific, small RNAs can therefore perform common biological functions in plants... - Evolution of microRNAs and their targets: are all microRNAs biologically relevant?Michael J Axtell
Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
Biochim Biophys Acta 1779:725-34. 2008..However, this ever-changing cast of transient miRNAs could provide a reservoir of potentially useful miRNAs from which new regulatory interactions sometimes are selected... 
A two-hit trigger for siRNA biogenesis in plantsMichael J Axtell
Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
Cell 127:565-77. 2006..Therefore, two "hits,"--often, but not always, two cleavage events--constitute a conserved trigger for siRNA biogenesis, a finding with implications for recognition and silencing of aberrant RNA...- Arabidopsis lyrata small RNAs: transient MIRNA and small interfering RNA loci within the Arabidopsis genusZhaorong Ma
Integrative Biosciences PhD Program in Bioinformatics and Genomics, Huck Institutes of the Life Sciences, Pensylvania State University, University Park, Pensylvania 16802, USA
Plant Cell 22:1090-103. 2010..thaliana. Altogether, our findings indicate that many MIRNAs and most p4-siRNA hot spots are rapidly changing and evolutionarily transient within the Arabidopsis genus... - Physcomitrella patens DCL3 is required for 22-24 nt siRNA accumulation, suppression of retrotransposon-derived transcripts, and normal developmentSung Hyun Cho
Department of Biology, Pennsylvania State University, University Park, PA, USA
PLoS Genet 4:e1000314. 2008..patens. We conclude that intergenic/repeat-derived siRNAs are indeed a broadly conserved, distinct class of small regulatory RNAs within land plants... - Endogenous siRNA and miRNA targets identified by sequencing of the Arabidopsis degradomeCharles Addo-Quaye
Department of Computer Science and Engineering, Pennsylvania State University, University Park, PA 16802, USA
Curr Biol 18:758-62. 2008..This empirical method is broadly applicable to the discovery and quantification of cleaved targets of small RNAs without a priori predictions... - Evolution of plant microRNAs and their targetsMichael J Axtell
Department of Biology and Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA
Trends Plant Sci 13:343-9. 2008..These data have provided a coherent set of hypotheses explaining the birth, selection and death of miRNAs in land plants... - Sliced microRNA targets and precise loop-first processing of MIR319 hairpins revealed by analysis of the Physcomitrella patens degradomeCharles Addo-Quaye
Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA
RNA 15:2112-21. 2009..MIR319 is thus a conserved exception to the general rule of loop-last processing of MIRNA hairpins. Loop-first MIR319 processing may contribute to the high efficacy of a widely used MIR319-based strategy for aMIRNA production in plants... - RNA secondary structural determinants of miRNA precursor processing in ArabidopsisLiang Song
The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA
Curr Biol 20:37-41. 2010.... - CleaveLand: a pipeline for using degradome data to find cleaved small RNA targetsCharles Addo-Quaye
Department of Computer Science and Engineering and Department of Biology, Pennsylvania State University, University Park, PA 16802, USA
Bioinformatics 25:130-1. 2009..AVAILABILITY: The code and documentation for CleaveLand is freely available under a GNU license at http://www.bio.psu.edu/people/faculty/Axtell/AxtellLab/Software.html.. - A method to discover phased siRNA lociMichael J Axtell
Department of Biology, Pennsylvania State University, University Park, PA, USA
Methods Mol Biol 592:59-70. 2010..Top ranked loci are candidates for further computational and biological analyses... - Large-scale sequencing reveals 21U-RNAs and additional microRNAs and endogenous siRNAs in C. elegansJ Graham Ruby
Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, MA 02142, USA
Cell 127:1193-207. 2006..The motif is conserved in other nematodes, presumably because of its importance for producing these diverse, autonomously expressed, small RNAs (dasRNAs)... - Antiquity of microRNAs and their targets in land plantsMichael J Axtell
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142, USA
Plant Cell 17:1658-73. 2005..Therefore, several individual miRNA regulatory circuits have ancient origins and have remained intact throughout the evolution and diversification of plants... - Initiation of RPS2-specified disease resistance in Arabidopsis is coupled to the AvrRpt2-directed elimination of RIN4Michael J Axtell
Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, CA 94720, USA
Cell 112:369-77. 2003..Therefore, we suggest that RPS2 initiates signaling based upon perception of RIN4 disappearance rather than direct recognition of AvrRpt2... - Genetic and molecular evidence that the Pseudomonas syringae type III effector protein AvrRpt2 is a cysteine proteaseMichael J Axtell
University of California, Berkeley, Department of Plant and Microbial Biology, 111 Koshland Hall, Berkeley, CA 94720, USA
Mol Microbiol 49:1537-46. 2003..These data indicate that AvrRpt2 is most likely a sequence divergent cysteine protease whose activity is required for elimination of RIN4 during infection... - NPK1, an MEKK1-like mitogen-activated protein kinase kinase kinase, regulates innate immunity and development in plantsHailing Jin
Department of Plant and Microbial Biology, University of California, Berkeley, 94720, USA
Dev Cell 3:291-7. 2002..Our results provide evidence that NPK1 functions in the regulation of N-, Bs2-, and Rx-mediated resistance responses and may play a role in one or more MAPK cascades, regulating multiple cellular processes...
Research Grants
- Functional and Evolutionary Genomics of Ancient Small RNAsMichael J Axtell; Fiscal Year: 2010..This project will reveal basic mechanisms of microRNA-mediated gene control by defining the roles of ancient microRNAs in readily studied model organisms. ..
- Functional and Evolutionary Genomics of Ancient Small RNAsMICHAEL AXTELL; Fiscal Year: 2009..This project will reveal basic mechanisms of microRNA-mediated gene control by defining the roles of ancient microRNAs in readily studied model organisms. ..