Avery August

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signaling
    Kathrin Kirsch
    Laboratory of Molecular Oncology, The Rockefeller University, NY, NY 10021, USA
    BMC Cell Biol 3:18. 2002
  2. ncbi request reprint The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals
    Avery August
    Immunology Research Laboratories and Department of Veterinary Science, The Pennsylvania State University, 115 Henning Building, University Park, PA 16802, USA
    Int J Biochem Cell Biol 34:1184-9. 2002
  3. pmc IL-2-inducible T-cell kinase (ITK) finds another (dance) partner...TFII-I
    Avery August
    Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, PA 16802, USA
    Eur J Immunol 39:2354-7. 2009
  4. pmc Differential sensitivity to Itk kinase signals for T helper 2 cytokine production and chemokine-mediated migration
    Nisebita Sahu
    Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 180:3833-8. 2008
  5. pmc Enhanced development of CD4+ gammadelta T cells in the absence of Itk results in elevated IgE production
    Qian Qi
    Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA
    Blood 114:564-71. 2009
  6. pmc A role for the Tec family kinase ITK in regulating SEB-induced interleukin-2 production in vivo via c-jun phosphorylation
    Melanie J Ragin
    Center for Molecular Immunology and Infectious Disease, Department of Veterinary Science, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Immunol 6:19. 2005
  7. pmc Elevated non-specific immunity and normal Listeria clearance in young and old vitamin D receptor knockout mice
    Danny Bruce
    Department of Veterinary and Biomedical Science, Center for Immunology and Infectious Disease, Pennsylvania State University, University Park, PA 16802, USA
    Int Immunol 21:113-22. 2009
  8. pmc Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells
    Mingcan Xia
    Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 184:6807-14. 2010
  9. pmc Combinatorial signals from CD28 differentially regulate human immunodeficiency virus transcription in T cells
    Malini Natarajan
    Intercollege Graduate Degree Program in Immunology and Infectious Disease, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 285:17338-47. 2010
  10. pmc Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma
    Elizabeth Rose Walsh
    Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA
    J Exp Med 205:1285-92. 2008

Collaborators

Detail Information

Publications53

  1. pmc A p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signaling
    Kathrin Kirsch
    Laboratory of Molecular Oncology, The Rockefeller University, NY, NY 10021, USA
    BMC Cell Biol 3:18. 2002
    ..To determine whether the substrate domain alone when tyrosine phosphorylated could signal, we have constructed a chimeric Cas molecule that is phosphorylated independently of upstream signals...
  2. ncbi request reprint The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signals
    Avery August
    Immunology Research Laboratories and Department of Veterinary Science, The Pennsylvania State University, 115 Henning Building, University Park, PA 16802, USA
    Int J Biochem Cell Biol 34:1184-9. 2002
    ..Recent evidence suggests that these kinases may not activate unique pathways, but instead serve as amplifiers for the upstream kinases Lck and Zap-70. This review will discuss the evidence for this view...
  3. pmc IL-2-inducible T-cell kinase (ITK) finds another (dance) partner...TFII-I
    Avery August
    Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, PA 16802, USA
    Eur J Immunol 39:2354-7. 2009
    ..A paper in this issue of the European Journal of Immunology extends our knowledge on the subject by showing that ITK interacts with the transcriptional regulator TFII-I. The implications of this finding are discussed...
  4. pmc Differential sensitivity to Itk kinase signals for T helper 2 cytokine production and chemokine-mediated migration
    Nisebita Sahu
    Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 180:3833-8. 2008
    ..Manipulation of Itk's activity can thus provide a new strategy to treat allergic asthma by differentially affecting migration of T cells into the lungs, leaving Th2 responses intact...
  5. pmc Enhanced development of CD4+ gammadelta T cells in the absence of Itk results in elevated IgE production
    Qian Qi
    Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA
    Blood 114:564-71. 2009
    ..In addition, our data indicate that the elevated IgE observed in Itk-deficient mice is due in part to the enhanced development of CD4(+) gammadelta T cells in the absence of Itk...
  6. pmc A role for the Tec family kinase ITK in regulating SEB-induced interleukin-2 production in vivo via c-jun phosphorylation
    Melanie J Ragin
    Center for Molecular Immunology and Infectious Disease, Department of Veterinary Science, The Pennsylvania State University, University Park, PA 16802, USA
    BMC Immunol 6:19. 2005
    ..In order to determine if ITK represents such a target, mice lacking ITK were analyzed for their response to SEB exposure...
  7. pmc Elevated non-specific immunity and normal Listeria clearance in young and old vitamin D receptor knockout mice
    Danny Bruce
    Department of Veterinary and Biomedical Science, Center for Immunology and Infectious Disease, Pennsylvania State University, University Park, PA 16802, USA
    Int Immunol 21:113-22. 2009
    ..The increased antibody and cytokine responses in the old VDR KO mice are consistent with the increased susceptibility of these mice to autoimmunity...
  8. pmc Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cells
    Mingcan Xia
    Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 184:6807-14. 2010
    ..These findings provide insights into molecular mechanisms underlying differential requirements of TCR signaling in peripheral localization and maintenance of the tissue-specific T cells...
  9. pmc Combinatorial signals from CD28 differentially regulate human immunodeficiency virus transcription in T cells
    Malini Natarajan
    Intercollege Graduate Degree Program in Immunology and Infectious Disease, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 285:17338-47. 2010
    ..Our studies reveal that CD28 regulates HIV-1 provirus transcription through a complex interplay of positive and negative signals that may be manipulated to control HIV-1 transcription and replication...
  10. pmc Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma
    Elizabeth Rose Walsh
    Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA
    J Exp Med 205:1285-92. 2008
    ..These studies indicate that on the C57BL/6 background, eosinophils are integral to the development of airway allergic responses by modulating chemokine and/or cytokine production in the lung, leading to T cell recruitment...
  11. pmc Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2
    Mankit Law
    Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Int J Biochem Cell Biol 43:1228-39. 2011
    ..We conclude that BTP2 and related compounds may be potent modulators of mast cell responses and potentially useful for the treatment of symptoms of allergic inflammation...
  12. pmc Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responses
    Nisebita Sahu
    Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 181:6125-31. 2008
    ..These results suggest that Txk is not a specific regulator of Th1 responses. Importantly, they suggest that Itk and Txk exert their effects on Th cell differentiation/function at the level of expression...
  13. ncbi request reprint Nutrients, nuclear receptors, inflammation, immunity lipids, PPAR, and allergic asthma
    Avery August
    Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, 16802, USA
    J Nutr 136:695-9. 2006
    ..In vitro, T cells from ciglitazone-treated mice secreted significantly less IL-4 and IFN-gamma in response to restimulation. These data suggest that PPARgamma agonists may be useful for the treatment of allergic asthma...
  14. pmc A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in mice
    Qian Qi
    Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA 16801, USA
    J Immunol 188:3611-9. 2012
    ..Our results suggest that TXK plays an overlapping role with ITK in iNKT cell development and function but that ITK also has a unique function in the survival of iNKT cells, likely via a p53-dependent pathway...
  15. pmc Chemico-genetic identification of drebrin as a regulator of calcium responses
    Jason C Mercer
    Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA 16802, USA
    Int J Biochem Cell Biol 42:337-45. 2010
    ..The identification of drebrin as a mediator of this process should provide new insight into the interaction between actin rearrangement and store-operated channel mediated calcium influx...
  16. doi request reprint Computational and experimental analysis reveals a requirement for eosinophil-derived IL-13 for the development of allergic airway responses in C57BL/6 mice
    Elizabeth R Walsh
    Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, Center for Molecular Immunology and Infectious Disease, University Park, PA 16802, USA
    J Immunol 186:2936-49. 2011
    ..These experiments suggest that eosinophils and T cells have an interdependent relationship, centered on IL-13, which regulates T cell recruitment to the lung and development of allergic asthma...
  17. pmc Naive and innate memory phenotype CD4+ T cells have different requirements for active Itk for their development
    Jianfang Hu
    Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 180:6544-52. 2008
    ..Our data also suggest that CD4(+)CD62L(low)CD44(high) memory phenotype T cells have innate immune function...
  18. pmc Modeling susceptibility versus resistance in allergic airway disease reveals regulation by Tec kinase Itk
    Nisebita Sahu
    Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania, United States of America
    PLoS ONE 5:e11348. 2010
    ..We suggest that the use of such approaches could clarify the behavior of various knockout mice in modeling allergic asthma...
  19. pmc Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active Itk
    Jianfang Hu
    Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Eur J Immunol 37:2892-9. 2007
    ..These results indicate that active signals from Tec kinases regulate the development of memory-like CD8(+) T cells with innate function...
  20. pmc The Tec family kinase, IL-2-inducible T cell kinase, differentially controls mast cell responses
    Archana S Iyer
    Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 180:7869-77. 2008
    ..Our results also suggest that Itk differentially modulates mast cell degranulation and cytokine production in part by regulating expression and activation of NFAT proteins in these cells...
  21. ncbi request reprint A kinase independent function for Tec kinase ITK in regulating antigen receptor induced serum response factor activation
    Shengli Hao
    Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, 115 Henning Building, University Park, 16802, USA
    FEBS Lett 580:2691-7. 2006
    ....
  22. pmc Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cell
    Qian Qi
    Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 286:138-46. 2011
    ....
  23. pmc Actin depolymerization transduces the strength of B-cell receptor stimulation
    Shengli Hao
    Immunology Research Laboratories, Department of Veterinary Science, The Pennsylvania State University, University Park, PA 16802, USA
    Mol Biol Cell 16:2275-84. 2005
    ..Furthermore actin depolymerization by itself induces altered lipid raft clustering and ERK activation, suggesting that F-actin may play a role in separating lipid rafts and in setting the threshold for cellular activation...
  24. pmc Differential regulation of cytokine production by CD1d-restricted NKT cells in response to superantigen staphylococcal enterotoxin B exposure
    Melanie J Ragin
    Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, 115 Henning Building, University Park, PA 16803, USA
    Infect Immun 74:282-8. 2006
    ..These data suggest that NKT cells may regulate the nature of the cytokine response to exposure to the superantigen SEB and may act as regulatory T cells during exposure to this superantigen...
  25. pmc Activation of the N-terminally truncated form of the Stk receptor tyrosine kinase Sf-Stk by Friend virus-encoded gp55 is mediated by cysteine residues in the ecotropic domain of gp55 and the extracellular domain of Sf-Stk
    Shihan He
    Pathobiology Graduate Program, The Pennsylvania State University, University Park, Pennsylvania 16802 3500, USA
    J Virol 84:2223-35. 2010
    ....
  26. pmc Keeping the (kinase) party going: SLP-76 and ITK dance to the beat
    Qian Qi
    Center for Molecular Immunology and Infectious Disease, Immunology and Infectious Disease Graduate Program, and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Sci STKE 2007:pe39. 2007
    ..This suggests that SLP-76 acts as more than a neutral adaptor in mediating T cell activation; SLP-76 also directly influences the kinase activity of ITK, allowing ITK to phosphorylate PLC-gamma1...
  27. ncbi request reprint Regulation of CXC chemokine receptor 4-mediated migration by the Tec family tyrosine kinase ITK
    Angela M Fischer
    Department of Veterinary Science, Pathobiology Graduate Program, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 279:29816-20. 2004
    ..Our data suggest that ITK may regulate the ability of CXCR4 to induce T cell migration...
  28. pmc Vitamin D receptor expression by the lung micro-environment is required for maximal induction of lung inflammation
    Anja Wittke
    Department of Veterinary and Biomedical Science, The Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA 16802, USA
    Arch Biochem Biophys 460:306-13. 2007
    ....
  29. pmc Eosinophils and allergic airway disease: there is more to the story
    Elizabeth R Walsh
    Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    Trends Immunol 31:39-44. 2010
    ..These findings are changing the way that eosinophil function in disease is perceived, and represent a shift in the dogma of allergic disease development...
  30. pmc Absence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependent mast cell responses
    Archana S Iyer
    Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 286:9503-13. 2011
    ..Network analysis suggests that although they may share substrates, Itk plays both positive and negative roles, while Btk primarily plays a positive role in mast cell FcεRI-induced cytokine secretion...
  31. pmc Itk derived signals regulate the expression of Th-POK and controls the development of CD4 T cells
    Jianfang Hu
    Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, Center for Molecular Immunology and Infectious Disease, University Park, Pennsylvania, United States of America
    PLoS ONE 5:e8891. 2010
    ..Our data also suggest that the lower level of TCR signaling that occurs with a low affinity TCR in the absence of Itk can redirect some MHC class II restricted CD4(+) T cell to class II-restricted CD8(+) innate memory phenotype T cells...
  32. ncbi request reprint Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthma
    Cynthia Mueller
    Department of Veterinary Science, The Pennsylvania State University, University Park, PA 16802, USA
    Arch Biochem Biophys 418:186-96. 2003
    ..T cells from these ciglitazone treated mice also produced less IFNgamma, IL-4, and IL-2 upon rechallenge in vitro with the model allergen. Our results suggest that ligands for PPARgamma may be effective treatments for asthmatic patients...
  33. pmc The Src kinase Lck facilitates assembly of HIV-1 at the plasma membrane
    Amy B Strasner
    Intergrated Bioscience Program in Immunobiology, Huck Institute of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 181:3706-13. 2008
    ..Furthermore, HIV-1 Gag directly interacted with the Lck unique domain in the context of infected cells. These results indicate that Lck plays a key role in targeting HIV-1 Gag to the plasma membrane in T cells...
  34. pmc The Tec family kinase Itk exists as a folded monomer in vivo
    Qian Qi
    Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 284:29882-92. 2009
    ..Zn2+ coordinating residues in the Tec Homology domain, not the proline-rich region, are critical for this intramolecular interaction. These data have implications for our understanding of Tec family kinase structure...
  35. ncbi request reprint Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptors
    Qian Qi
    Center for Molecular Immunology and Infectious Disease, and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
    J Biol Chem 281:38529-34. 2006
    ..Our results indicate that Itk forms dimers in the membrane and that receptors that recruit Itk do so to specific membrane regions...
  36. pmc Differential regulation of NFAT and SRF by the B cell receptor via a PLCgamma-Ca(2+)-dependent pathway
    Shengli Hao
    Immunology Research Laboratories, Cell and Developmental Biology Graduate Program, The Pennsylvania State University, University Park, PA 16802, USA
    EMBO J 22:4166-77. 2003
    ..These data suggest that combinatorial assembly of signaling pathways emanating from the BCR differentially regulate NFAT and SRF, to activate gene expression...
  37. pmc Endocytic delivery of vancomycin mediated by a synthetic cell surface receptor: rescue of bacterially infected Mammalian cells and tissue targeting in vivo
    Siwarutt Boonyarattanakalin
    Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Am Chem Soc 129:268-9. 2007
  38. pmc ITK inhibitors in inflammation and immune-mediated disorders
    Nisebita Sahu
    Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA 16802, USA
    Curr Top Med Chem 9:690-703. 2009
    ..We discuss here the possibilities and pitfalls of targeting ITK for inflammatory disorders...
  39. pmc A Polymerase mechanism-based strategy for viral attenuation and vaccine development
    Spencer A Weeks
    Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
    J Biol Chem 287:31618-22. 2012
    ..Given the conservation of this residue in all viral polymerases, this study suggests that a universal, mechanism-based strategy may exist for viral attenuation and vaccine development...
  40. pmc p38 MAP kinase is necessary for melanoma-mediated regulation of VE-cadherin disassembly
    Payal Khanna
    Dept of Bioengineering, Penn State Univ, Univ Park, PA 16802, USA
    Am J Physiol Cell Physiol 298:C1140-50. 2010
    ..These findings indicate that p38 MAP kinase proteins regulate VE-cadherin junction disassembly, facilitating melanoma migration across endothelial cells...
  41. pmc Akt plays a critical role in replication of nonsegmented negative-stranded RNA viruses
    Minghao Sun
    Center of Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, 115 Henning Bldg, University Park, PA 16802, USA
    J Virol 82:105-14. 2008
    ..The finding that Akt plays a critical role in replication of NNSV will lead to a better understanding of how these viruses replicate, as well as novel strategies to treat infectious diseases caused by NNSVs...
  42. doi request reprint Tec family kinases: Itk signaling and the development of NKT αβ and γδ T cells
    Qian Qi
    Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA, USA
    FEBS J 278:1970-9. 2011
    ..We discuss how these cells take what could be the same signaling pathway regulated by Itk, and interpret it to give different outcomes with regards to development and function...
  43. ncbi request reprint Modulation of tracheal smooth muscle responses in inducible T-cell kinase knockout mice
    Tanna J Ferrara
    Intercollege Graduate Program in Physiology, Pennsylvania State University, University Park, PA 16802, USA
    Pulm Pharmacol Ther 17:301-8. 2004
    ..Taken together, these results suggest that the presence of ITK may play a modulating role in the pharmacomechanical as well as in the electromechanical coupling of airway smooth muscle contraction...
  44. ncbi request reprint Natural killer T cells: rapid responders controlling immunity and disease
    Jason C Mercer
    Immunology Research Laboratories and Department of Veterinary Science, The Pennsylvania State University, 115 Henning Building, University Park, PA 16802, USA
    Int J Biochem Cell Biol 37:1337-43. 2005
    ..They may also play both protective and harmful roles in the progression of certain autoimmune diseases, such as diabetes, lupus, atherosclerosis, and allergen-induced asthma...
  45. ncbi request reprint CD28-dependent HIV-1 transcription is associated with Vav, Rac, and NF-kappa B activation
    Julie A Cook
    Graduate Program in Biochemistry, Microbiology, and Molecular Biology, The Department of Biochemistry, Pennsylvania State University, University Park, 16802, USA
    J Biol Chem 278:35812-8. 2003
    ..These studies show that signaling events initiated by tyrosine 200 of CD28 are required for efficient expression of HIV-1 transcription in activated T cells...
  46. ncbi request reprint hCMV IE Promoter is responsive to B cell receptor signaling in a Bruton's tyrosine kinase dependent manner: caution in their use as internal controls
    Shengli Hao
    Cell and Developmental Biology Option, Life Sciences Consortium and Immunology Research Laboratories, Department of Veterinary Science, The Pennsylvania State University, University Park, PA 16802, USA
    Anal Biochem 309:315-7. 2002
  47. ncbi request reprint The proline rich region of the Tec homology domain of ITK regulates its activity
    Shengli Hao
    Immunology Research Laboratories and Department of Veterinary Science, The Pennsylvania State University, 115 Henning Building, University Park, PA 16802, USA
    FEBS Lett 525:53-8. 2002
    ..These results suggest that the proline rich region within the Tec homology domain of ITK regulates its basal activity and its response to Src family kinase signals...
  48. ncbi request reprint Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase ITK
    Cynthia Mueller
    Immunology Research Laboratories and Department of Veterinary Science, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 170:5056-63. 2003
    ..Our results suggest that the tyrosine kinase ITK preferentially regulates the secretion of the T(H)2 cytokines IL-5 and IL-13 and may be an attractive target for antiasthmatic drugs...
  49. ncbi request reprint Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanism
    Julie A Cook
    Graduate Program, Department of Biochemistry, Pennsylvania State University, University Park, PA 16802, USA
    J Immunol 169:254-60. 2002
    ..These studies demonstrate that PI3K negatively impacts HIV-1 transcription and that Tat activity is sensitive to T cell signaling events...
  50. ncbi request reprint The role of eosinophils in allergic airway inflammation
    Elizabeth R Walsh
    Autoimmunity and Functional Genomics Section, Laboratory of Immunogenetics, National Institute of Allergy and Infectious Disease, National Institutes of Health, Rockville, Maryland 20852, USA
    Discov Med 9:357-62. 2010
    ..Finally, we discuss some ways in which these cells are being targeted in patients, and promising preclinical findings on novel targets for decreasing the number of these cells in patients with allergic asthma...
  51. ncbi request reprint Reduced airway hyperresponsiveness and tracheal responses during allergic asthma in mice lacking tyrosine kinase inducible T-cell kinase
    Tanna J Ferrara
    Physiology Graduate Program and Department of Chemical Engineering, Pennsylvania State University, University Park 16802, USA
    J Allergy Clin Immunol 117:780-6. 2006
    ....
  52. pmc Opposing roles of serine/threonine kinases MEKK1 and LOK in regulating the CD28 responsive element in T-cells
    Li Tao
    R W Johnson Pharmaceutical Research Institute, Drug Discovery Research, Raritan, NJ 08869, USA
    Biochem J 363:175-82. 2002
    ..These data suggest that MEKK1 and LOK may have opposing roles in regulating the CD28RE/AP1 element...
  53. ncbi request reprint Vitamin D receptor-deficient mice fail to develop experimental allergic asthma
    Anja Wittke
    Department of Nutrition, Immunology Research Laboratory, Pennsylvania State University, University Park 16802, USA
    J Immunol 173:3432-6. 2004
    ..However, VDR-deficient mice failed to develop experimental allergic asthma, suggesting an important role for the vitamin D endocrine system in the generation of Th2-driven inflammation in the lung...

Research Grants19

  1. Eosinophils and Allergic Airway Responses
    Avery August; Fiscal Year: 2009
    ....
  2. ITK Mast Cells and Allergic Airway Responses
    Avery August; Fiscal Year: 2007
    ....
  3. Eosinophils and Allergic Airway Responses
    Avery August; Fiscal Year: 2009
    ....
  4. Role of the Tyrosine Kinase ITK in Experimental Allergic Asthma
    Avery August; Fiscal Year: 2009
    ..PHS 398/2590 (Rev. 09/04, Reissued 4/2006) Page 10 Continuation Format Page ..
  5. Role of the Tyrosine Kinase ITK in Experimental Allergic Asthma
    Avery August; Fiscal Year: 2009
    ....
  6. Alcorn State University: Penn State University Bridges to the Doctorate Program
    Avery August; Fiscal Year: 2007
    ..This will have a significant impact on the increase in the pool of scientifically trained workers in the U.S. who can contribute to continued research and development. ..
  7. Tyrosine Kinase ITK in Experimental Allergic Asthma
    Avery August; Fiscal Year: 2007
    ..abstract_text> ..
  8. Tyrosine Kinase ITK in Experimental Allergic Asthma
    Avery August; Fiscal Year: 2006
    ..abstract_text> ..
  9. Tyrosine Kinase ITK in Experimental Allergic Asthma
    Avery August; Fiscal Year: 2003
    ..abstract_text> ..