Research Topics
Genomes and Genes
| Avery AugustSummaryAffiliation: Pennsylvania State University Country: USA Publications
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Detail Information
Publications
Enhanced development of CD4+ gammadelta T cells in the absence of Itk results in elevated IgE productionQian Qi
Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA
Blood 114:564-71. 2009..In addition, our data indicate that the elevated IgE observed in Itk-deficient mice is due in part to the enhanced development of CD4(+) gammadelta T cells in the absence of Itk...
Reduced airway hyperresponsiveness and tracheal responses during allergic asthma in mice lacking tyrosine kinase inducible T-cell kinaseTanna J Ferrara
Physiology Graduate Program and Department of Chemical Engineering, Pennsylvania State University, University Park 16802, USA
J Allergy Clin Immunol 117:780-6. 2006....- Differential sensitivity to Itk kinase signals for T helper 2 cytokine production and chemokine-mediated migrationNisebita Sahu
Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA 16802, USA
J Immunol 180:3833-8. 2008..Manipulation of Itk's activity can thus provide a new strategy to treat allergic asthma by differentially affecting migration of T cells into the lungs, leaving Th2 responses intact... - Elevated non-specific immunity and normal Listeria clearance in young and old vitamin D receptor knockout miceDanny Bruce
Department of Veterinary and Biomedical Science, Center for Immunology and Infectious Disease, Pennsylvania State University, University Park, PA 16802, USA
Int Immunol 21:113-22. 2009..The increased antibody and cytokine responses in the old VDR KO mice are consistent with the increased susceptibility of these mice to autoimmunity... - Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthmaElizabeth Rose Walsh
Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA
J Exp Med 205:1285-92. 2008..These studies indicate that on the C57BL/6 background, eosinophils are integral to the development of airway allergic responses by modulating chemokine and/or cytokine production in the lung, leading to T cell recruitment... - A role for the Tec family kinase ITK in regulating SEB-induced interleukin-2 production in vivo via c-jun phosphorylationMelanie J Ragin
Center for Molecular Immunology and Infectious Disease, Department of Veterinary Science, The Pennsylvania State University, University Park, PA 16802, USA
BMC Immunol 6:19. 2005..In order to determine if ITK represents such a target, mice lacking ITK were analyzed for their response to SEB exposure... - Structural requirements for the inhibition of calcium mobilization and mast cell activation by the pyrazole derivative BTP2Mankit Law
Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Int J Biochem Cell Biol 43:1228-39. 2011..We conclude that BTP2 and related compounds may be potent modulators of mast cell responses and potentially useful for the treatment of symptoms of allergic inflammation... - Combinatorial signals from CD28 differentially regulate human immunodeficiency virus transcription in T cellsMalini Natarajan
Intercollege Graduate Degree Program in Immunology and Infectious Disease, Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Biol Chem 285:17338-47. 2010..Our studies reveal that CD28 regulates HIV-1 provirus transcription through a complex interplay of positive and negative signals that may be manipulated to control HIV-1 transcription and replication... - Naive and innate memory phenotype CD4+ T cells have different requirements for active Itk for their developmentJianfang Hu
Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
J Immunol 180:6544-52. 2008..Our data also suggest that CD4(+)CD62L(low)CD44(high) memory phenotype T cells have innate immune function... - Vitamin D receptor expression by the lung micro-environment is required for maximal induction of lung inflammationAnja Wittke
Department of Veterinary and Biomedical Science, The Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA 16802, USA
Arch Biochem Biophys 460:306-13. 2007.... - Selective expression rather than specific function of Txk and Itk regulate Th1 and Th2 responsesNisebita Sahu
Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA
J Immunol 181:6125-31. 2008..These results suggest that Txk is not a specific regulator of Th1 responses. Importantly, they suggest that Itk and Txk exert their effects on Th cell differentiation/function at the level of expression... - Nutrients, nuclear receptors, inflammation, immunity lipids, PPAR, and allergic asthmaAvery August
Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, 16802, USA
J Nutr 136:695-9. 2006..In vitro, T cells from ciglitazone-treated mice secreted significantly less IL-4 and IFN-gamma in response to restimulation. These data suggest that PPARgamma agonists may be useful for the treatment of allergic asthma... - Differential roles of IL-2-inducible T cell kinase-mediated TCR signals in tissue-specific localization and maintenance of skin intraepithelial T cellsMingcan Xia
Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, Pennsylvania State University, University Park, PA 16802, USA
J Immunol 184:6807-14. 2010..These findings provide insights into molecular mechanisms underlying differential requirements of TCR signaling in peripheral localization and maintenance of the tissue-specific T cells... - A unique role for ITK in survival of invariant NKT cells associated with the p53-dependent pathway in miceQian Qi
Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA 16801, USA
J Immunol 188:3611-9. 2012..Our results suggest that TXK plays an overlapping role with ITK in iNKT cell development and function but that ITK also has a unique function in the survival of iNKT cells, likely via a p53-dependent pathway... 
Computational and experimental analysis reveals a requirement for eosinophil-derived IL-13 for the development of allergic airway responses in C57BL/6 miceElizabeth R Walsh
Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, Center for Molecular Immunology and Infectious Disease, University Park, PA 16802, USA
J Immunol 186:2936-49. 2011..These experiments suggest that eosinophils and T cells have an interdependent relationship, centered on IL-13, which regulates T cell recruitment to the lung and development of allergic asthma...- The Tec family kinase, IL-2-inducible T cell kinase, differentially controls mast cell responsesArchana S Iyer
Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802, USA
J Immunol 180:7869-77. 2008..Our results also suggest that Itk differentially modulates mast cell degranulation and cytokine production in part by regulating expression and activation of NFAT proteins in these cells... - Memory phenotype CD8+ T cells with innate function selectively develop in the absence of active ItkJianfang Hu
Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Eur J Immunol 37:2892-9. 2007..These results indicate that active signals from Tec kinases regulate the development of memory-like CD8(+) T cells with innate function... - Differential regulation of cytokine production by CD1d-restricted NKT cells in response to superantigen staphylococcal enterotoxin B exposureMelanie J Ragin
Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, 115 Henning Building, University Park, PA 16803, USA
Infect Immun 74:282-8. 2006..These data suggest that NKT cells may regulate the nature of the cytokine response to exposure to the superantigen SEB and may act as regulatory T cells during exposure to this superantigen... - A kinase independent function for Tec kinase ITK in regulating antigen receptor induced serum response factor activationShengli Hao
Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, 115 Henning Building, University Park, 16802, USA
FEBS Lett 580:2691-7. 2006.... - Interleukin-2-inducible T cell kinase (Itk) network edge dependence for the maturation of iNKT cellQian Qi
Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Biol Chem 286:138-46. 2011.... - Vitamin D receptor-deficient mice fail to develop experimental allergic asthmaAnja Wittke
Department of Nutrition, Immunology Research Laboratory, Pennsylvania State University, University Park 16802, USA
J Immunol 173:3432-6. 2004..However, VDR-deficient mice failed to develop experimental allergic asthma, suggesting an important role for the vitamin D endocrine system in the generation of Th2-driven inflammation in the lung... - Itk derived signals regulate the expression of Th-POK and controls the development of CD4 T cellsJianfang Hu
Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, Center for Molecular Immunology and Infectious Disease, University Park, Pennsylvania, United States of America
PLoS ONE 5:e8891. 2010..Our data also suggest that the lower level of TCR signaling that occurs with a low affinity TCR in the absence of Itk can redirect some MHC class II restricted CD4(+) T cell to class II-restricted CD8(+) innate memory phenotype T cells... - Eosinophils and allergic airway disease: there is more to the storyElizabeth R Walsh
Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Trends Immunol 31:39-44. 2010..These findings are changing the way that eosinophil function in disease is perceived, and represent a shift in the dogma of allergic disease development... - Chemico-genetic identification of drebrin as a regulator of calcium responsesJason C Mercer
Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Science, The Pennsylvania State University, University Park, PA 16802, USA
Int J Biochem Cell Biol 42:337-45. 2010..The identification of drebrin as a mediator of this process should provide new insight into the interaction between actin rearrangement and store-operated channel mediated calcium influx... - Keeping the (kinase) party going: SLP-76 and ITK dance to the beatQian Qi
Center for Molecular Immunology and Infectious Disease, Immunology and Infectious Disease Graduate Program, and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
Sci STKE 2007:pe39. 2007..This suggests that SLP-76 acts as more than a neutral adaptor in mediating T cell activation; SLP-76 also directly influences the kinase activity of ITK, allowing ITK to phosphorylate PLC-gamma1... - Activation of the N-terminally truncated form of the Stk receptor tyrosine kinase Sf-Stk by Friend virus-encoded gp55 is mediated by cysteine residues in the ecotropic domain of gp55 and the extracellular domain of Sf-StkShihan He
Pathobiology Graduate Program, The Pennsylvania State University, University Park, Pennsylvania 16802 3500, USA
J Virol 84:2223-35. 2010.... - Regulation of CXC chemokine receptor 4-mediated migration by the Tec family tyrosine kinase ITKAngela M Fischer
Department of Veterinary Science, Pathobiology Graduate Program, Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Biol Chem 279:29816-20. 2004..Our data suggest that ITK may regulate the ability of CXCR4 to induce T cell migration... - Peroxisome proliferator-activated receptor gamma ligands attenuate immunological symptoms of experimental allergic asthmaCynthia Mueller
Department of Veterinary Science, The Pennsylvania State University, University Park, PA 16802, USA
Arch Biochem Biophys 418:186-96. 2003..T cells from these ciglitazone treated mice also produced less IFNgamma, IL-4, and IL-2 upon rechallenge in vitro with the model allergen. Our results suggest that ligands for PPARgamma may be effective treatments for asthmatic patients... - Absence of Tec family kinases interleukin-2 inducible T cell kinase (Itk) and Bruton's tyrosine kinase (Btk) severely impairs Fc epsilonRI-dependent mast cell responsesArchana S Iyer
Center for Molecular Immunology and Infectious Disease and Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Biol Chem 286:9503-13. 2011..Network analysis suggests that although they may share substrates, Itk plays both positive and negative roles, while Btk primarily plays a positive role in mast cell FcεRI-induced cytokine secretion... - The Src kinase Lck facilitates assembly of HIV-1 at the plasma membraneAmy B Strasner
Intergrated Bioscience Program in Immunobiology, Huck Institute of the Life Sciences, Pennsylvania State University, University Park, PA 16802, USA
J Immunol 181:3706-13. 2008..Furthermore, HIV-1 Gag directly interacted with the Lck unique domain in the context of infected cells. These results indicate that Lck plays a key role in targeting HIV-1 Gag to the plasma membrane in T cells... - Attenuation of immunological symptoms of allergic asthma in mice lacking the tyrosine kinase ITKCynthia Mueller
Immunology Research Laboratories and Department of Veterinary Science, Pennsylvania State University, University Park, PA 16802, USA
J Immunol 170:5056-63. 2003..Our results suggest that the tyrosine kinase ITK preferentially regulates the secretion of the T(H)2 cytokines IL-5 and IL-13 and may be an attractive target for antiasthmatic drugs... - ITK inhibitors in inflammation and immune-mediated disordersNisebita Sahu
Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA 16802, USA
Curr Top Med Chem 9:690-703. 2009..We discuss here the possibilities and pitfalls of targeting ITK for inflammatory disorders... - The Tec family kinase Itk exists as a folded monomer in vivoQian Qi
Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Biol Chem 284:29882-92. 2009..Zn2+ coordinating residues in the Tec Homology domain, not the proline-rich region, are critical for this intramolecular interaction. These data have implications for our understanding of Tec family kinase structure... - The Tec family of tyrosine kinases in T cells, amplifiers of T cell receptor signalsAvery August
Immunology Research Laboratories and Department of Veterinary Science, The Pennsylvania State University, 115 Henning Building, University Park, PA 16802, USA
Int J Biochem Cell Biol 34:1184-9. 2002..Recent evidence suggests that these kinases may not activate unique pathways, but instead serve as amplifiers for the upstream kinases Lck and Zap-70. This review will discuss the evidence for this view... - A Polymerase mechanism-based strategy for viral attenuation and vaccine developmentSpencer A Weeks
Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Biol Chem 287:31618-22. 2012..Given the conservation of this residue in all viral polymerases, this study suggests that a universal, mechanism-based strategy may exist for viral attenuation and vaccine development... - Akt plays a critical role in replication of nonsegmented negative-stranded RNA virusesMinghao Sun
Center of Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, Pennsylvania State University, 115 Henning Bldg, University Park, PA 16802, USA
J Virol 82:105-14. 2008..The finding that Akt plays a critical role in replication of NNSV will lead to a better understanding of how these viruses replicate, as well as novel strategies to treat infectious diseases caused by NNSVs... - Endocytic delivery of vancomycin mediated by a synthetic cell surface receptor: rescue of bacterially infected Mammalian cells and tissue targeting in vivoSiwarutt Boonyarattanakalin
Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, USA
J Am Chem Soc 129:268-9. 2007 - p38 MAP kinase is necessary for melanoma-mediated regulation of VE-cadherin disassemblyPayal Khanna
Dept of Bioengineering, Penn State Univ, Univ Park, PA 16802, USA
Am J Physiol Cell Physiol 298:C1140-50. 2010..These findings indicate that p38 MAP kinase proteins regulate VE-cadherin junction disassembly, facilitating melanoma migration across endothelial cells... - IL-2-inducible T-cell kinase (ITK) finds another (dance) partner...TFII-IAvery August
Center for Molecular Immunology and Infectious Disease, Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, PA 16802, USA
Eur J Immunol 39:2354-7. 2009..A paper in this issue of the European Journal of Immunology extends our knowledge on the subject by showing that ITK interacts with the transcriptional regulator TFII-I. The implications of this finding are discussed... - Actin depolymerization transduces the strength of B-cell receptor stimulationShengli Hao
Immunology Research Laboratories, Department of Veterinary Science, The Pennsylvania State University, University Park, PA 16802, USA
Mol Biol Cell 16:2275-84. 2005..Furthermore actin depolymerization by itself induces altered lipid raft clustering and ERK activation, suggesting that F-actin may play a role in separating lipid rafts and in setting the threshold for cellular activation... - Tec family kinases: Itk signaling and the development of NKT αβ and γδ T cellsQian Qi
Department of Veterinary and Biomedical Sciences, Center for Molecular Immunology and Infectious Disease, The Pennsylvania State University, University Park, PA, USA
FEBS J 278:1970-9. 2011..We discuss how these cells take what could be the same signaling pathway regulated by Itk, and interpret it to give different outcomes with regards to development and function... - Tec kinase Itk forms membrane clusters specifically in the vicinity of recruiting receptorsQian Qi
Center for Molecular Immunology and Infectious Disease, and Department of Veterinary and Biomedical Sciences, The Pennsylvania State University, University Park, PA 16802, USA
J Biol Chem 281:38529-34. 2006..Our results indicate that Itk forms dimers in the membrane and that receptors that recruit Itk do so to specific membrane regions... - Modulation of tracheal smooth muscle responses in inducible T-cell kinase knockout miceTanna J Ferrara
Intercollege Graduate Program in Physiology, Pennsylvania State University, University Park, PA 16802, USA
Pulm Pharmacol Ther 17:301-8. 2004..Taken together, these results suggest that the presence of ITK may play a modulating role in the pharmacomechanical as well as in the electromechanical coupling of airway smooth muscle contraction... - Natural killer T cells: rapid responders controlling immunity and diseaseJason C Mercer
Immunology Research Laboratories and Department of Veterinary Science, The Pennsylvania State University, 115 Henning Building, University Park, PA 16802, USA
Int J Biochem Cell Biol 37:1337-43. 2005..They may also play both protective and harmful roles in the progression of certain autoimmune diseases, such as diabetes, lupus, atherosclerosis, and allergen-induced asthma... - CD28-dependent HIV-1 transcription is associated with Vav, Rac, and NF-kappa B activationJulie A Cook
Graduate Program in Biochemistry, Microbiology, and Molecular Biology, The Department of Biochemistry, Pennsylvania State University, University Park, 16802, USA
J Biol Chem 278:35812-8. 2003..These studies show that signaling events initiated by tyrosine 200 of CD28 are required for efficient expression of HIV-1 transcription in activated T cells... - The proline rich region of the Tec homology domain of ITK regulates its activityShengli Hao
Immunology Research Laboratories and Department of Veterinary Science, The Pennsylvania State University, 115 Henning Building, University Park, PA 16802, USA
FEBS Lett 525:53-8. 2002..These results suggest that the proline rich region within the Tec homology domain of ITK regulates its basal activity and its response to Src family kinase signals... - Differential regulation of NFAT and SRF by the B cell receptor via a PLCgamma-Ca(2+)-dependent pathwayShengli Hao
Immunology Research Laboratories, Cell and Developmental Biology Graduate Program, The Pennsylvania State University, University Park, PA 16802, USA
EMBO J 22:4166-77. 2003..These data suggest that combinatorial assembly of signaling pathways emanating from the BCR differentially regulate NFAT and SRF, to activate gene expression... - Recruitment of phosphatidylinositol 3-kinase to CD28 inhibits HIV transcription by a Tat-dependent mechanismJulie A Cook
Graduate Program, Department of Biochemistry, Pennsylvania State University, University Park, PA 16802, USA
J Immunol 169:254-60. 2002..These studies demonstrate that PI3K negatively impacts HIV-1 transcription and that Tat activity is sensitive to T cell signaling events...