P C Appelbaum

Summary

Affiliation: Pennsylvania State University
Country: USA

Publications

  1. pmc Inducible clindamycin resistance and molecular epidemiologic trends of pediatric community-acquired methicillin-resistant Staphylococcus aureus in Dallas, Texas
    Susana Chavez-Bueno
    University of Texas Southwestern Medical Center of Dallas, and Children s Medical Center of Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9063, USA
    Antimicrob Agents Chemother 49:2283-8. 2005
  2. ncbi request reprint The emergence of vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus
    P C Appelbaum
    Hershey Medical Center, Hershey, Pennsylvania, USA
    Clin Microbiol Infect 12:16-23. 2006
  3. pmc Antipneumococcal activity of DW-224a, a new quinolone, compared to those of eight other agents
    Klaudia Kosowska-Shick
    Department of Pathology, Hershey Medical Center, PA 17033, USA
    Antimicrob Agents Chemother 50:2064-71. 2006
  4. ncbi request reprint Genetic characterization of erythromycin- and methicillin-resistant community-acquired Staphylococcus aureus isolated from children in Texas
    Tatiana Bogdanovich
    Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA
    Diagn Microbiol Infect Dis 59:231-3. 2007
  5. pmc Polymorphism, genetic exchange and intragenic recombination of the aureolysin gene among Staphylococcus aureus strains
    Artur J Sabat
    National Medicines Institute, 00 725 Warsaw, Poland
    BMC Microbiol 8:129. 2008
  6. pmc Antipneumococcal activity of LBM415, a new peptide deformylase inhibitor, compared with those of other agents
    Lois M Ednie
    Department of Pathology, Penn State Hershey Medical Center, 500 University Dr, H160, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 48:4027-32. 2004
  7. ncbi request reprint Activity of the new quinolone WCK 771 against pneumococci
    P C Appelbaum
    Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA
    Clin Microbiol Infect 11:9-14. 2005
  8. ncbi request reprint MRSA--the tip of the iceberg
    P C Appelbaum
    Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033 0850, USA
    Clin Microbiol Infect 12:3-10. 2006
  9. pmc Postantibiotic effect of ceftobiprole against 12 Gram-positive organisms
    G A Pankuch
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 50:3956-8. 2006
  10. ncbi request reprint Resistance among Streptococcus pneumoniae: Implications for drug selection
    Peter C Appelbaum
    Departments of Pathology and Clinical Microbiology, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA
    Clin Infect Dis 34:1613-20. 2002

Detail Information

Publications113 found, 100 shown here

  1. pmc Inducible clindamycin resistance and molecular epidemiologic trends of pediatric community-acquired methicillin-resistant Staphylococcus aureus in Dallas, Texas
    Susana Chavez-Bueno
    University of Texas Southwestern Medical Center of Dallas, and Children s Medical Center of Dallas, 5323 Harry Hines Boulevard, Dallas, Texas 75390 9063, USA
    Antimicrob Agents Chemother 49:2283-8. 2005
    ..001). The phenotype of strains was associated with their sequence type. Our results demonstrate a clonal shift in CA-MRSA in Dallas children from 1999 to 2002...
  2. ncbi request reprint The emergence of vancomycin-intermediate and vancomycin-resistant Staphylococcus aureus
    P C Appelbaum
    Hershey Medical Center, Hershey, Pennsylvania, USA
    Clin Microbiol Infect 12:16-23. 2006
    ..The treatment options available for these infections are now severely compromised and thus new classes of antimicrobial agents effective against MRSA, VISA and VRSA are urgently required...
  3. pmc Antipneumococcal activity of DW-224a, a new quinolone, compared to those of eight other agents
    Klaudia Kosowska-Shick
    Department of Pathology, Hershey Medical Center, PA 17033, USA
    Antimicrob Agents Chemother 50:2064-71. 2006
    ..Azithromycin selected resistant clones in three of the five parents tested. Amoxicillin-clavulanate and cefuroxime did not yield resistant clones after 50 days...
  4. ncbi request reprint Genetic characterization of erythromycin- and methicillin-resistant community-acquired Staphylococcus aureus isolated from children in Texas
    Tatiana Bogdanovich
    Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA
    Diagn Microbiol Infect Dis 59:231-3. 2007
    ..PVL(-)/SCC type II/agr type II strains, although rare, were consistently present in the community throughout the study period...
  5. pmc Polymorphism, genetic exchange and intragenic recombination of the aureolysin gene among Staphylococcus aureus strains
    Artur J Sabat
    National Medicines Institute, 00 725 Warsaw, Poland
    BMC Microbiol 8:129. 2008
    ..aureus population. Therefore, an epidemiologically and genetically diverse collection of S. aureus strains was used to determine the range of aureolysin (aur) gene polymorphism...
  6. pmc Antipneumococcal activity of LBM415, a new peptide deformylase inhibitor, compared with those of other agents
    Lois M Ednie
    Department of Pathology, Penn State Hershey Medical Center, 500 University Dr, H160, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 48:4027-32. 2004
    ..Gatifloxacin and moxifloxacin were the most active quinolones tested, while the MICs of the beta-lactams rose with those of penicillin G. LBM415 at two times the MIC was bactericidal (99.9% killing) against six strains after 24 h...
  7. ncbi request reprint Activity of the new quinolone WCK 771 against pneumococci
    P C Appelbaum
    Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA
    Clin Microbiol Infect 11:9-14. 2005
    ..Overall, WCK 771 was potent both in vivo and in vitro against quinolone-susceptible, but not quinolone-resistant, S. pneumoniae, regardless of penicillin susceptibility...
  8. ncbi request reprint MRSA--the tip of the iceberg
    P C Appelbaum
    Pennsylvania State College of Medicine, Hershey, Pennsylvania 17033 0850, USA
    Clin Microbiol Infect 12:3-10. 2006
    ..Ceftobiprole is refractory to the development of endogenous resistance both in vitro and in vivo. The additional activity of ceftobiprole against MRSA strains makes it a potentially important addition to currently available agents...
  9. pmc Postantibiotic effect of ceftobiprole against 12 Gram-positive organisms
    G A Pankuch
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 50:3956-8. 2006
    ..4 to 3.1 h, 0 to 1.8 h, and 0 to 0.9 h, respectively. The PA-SMEs (0.4 times the MIC) for pneumococci, staphylococci, and enterococci were 4.8 to >10.3 h, 1.5 to 9.6 h, and 3.8 to >10.7 h, respectively...
  10. ncbi request reprint Resistance among Streptococcus pneumoniae: Implications for drug selection
    Peter C Appelbaum
    Departments of Pathology and Clinical Microbiology, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey, PA, 17033, USA
    Clin Infect Dis 34:1613-20. 2002
    ..Efforts should be made to prevent pneumococcal infections in high-risk patients through vaccination...
  11. pmc Incidence and characteristics of vancomycin nonsusceptible strains of methicillin-resistant Staphylococcus aureus at Hershey Medical Center
    Klaudia Kosowska-Shick
    Department of Pathology H160, Hershey Medical Center, P O Box 850, Hershey, PA 17033
    Antimicrob Agents Chemother 52:4510-3. 2008
    ..Repeat testing showed a false-positivity rate of only 15 of the original 87 isolates by plate screening...
  12. ncbi request reprint Reduced glycopeptide susceptibility in methicillin-resistant Staphylococcus aureus (MRSA)
    Peter C Appelbaum
    Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Int J Antimicrob Agents 30:398-408. 2007
    ..Rapid identification of patients harbouring VRSA, VISA or hVISA as well as prompt isolation and adherence to infection control protocols are paramount in controlling the dissemination of these pathogens...
  13. pmc Capability of 11 antipneumococcal antibiotics to select for resistance by multistep and single-step methodologies
    Catherine L Clark
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 51:4196-201. 2007
    ..Tigecycline also yielded a low frequency of resistance in single-step tests compared to all beta-lactams, macrolides/ketolides, and quinolones tested...
  14. ncbi request reprint Microbiology of antibiotic resistance in Staphylococcus aureus
    Peter C Appelbaum
    Division of Clinical Pathology, Penn State College of Medicine, and Clinical Microbiology, Penn State Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Clin Infect Dis 45:S165-70. 2007
    ..Vancomycin nonsusceptibility in S. aureus is on the increase, further complicating therapy...
  15. ncbi request reprint Vancomycin resistance in Staphylococcus aureus
    Peter C Appelbaum
    Department of Pathology, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Clin Lab Med 24:381-402. 2004
    ..These developments are of great concern, and every effort should be made to prevent further development and spread of vancomycin resistance in staphylococci...
  16. pmc Antistaphylococcal activity of DX-619, a new des-F(6)-quinolone, compared to those of other agents
    Tatiana Bogdanovich
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 49:3325-33. 2005
    ..DX-619 has potent in vitro activity against staphylococci, including methicillin-, ciprofloxacin-, and vancomycin-resistant strains...
  17. ncbi request reprint Recently approved and investigational antibiotics for treatment of severe infections caused by Gram-positive bacteria
    Peter C Appelbaum
    Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA
    Curr Opin Microbiol 8:510-7. 2005
    ..Misuse of potent new agents will, however, result in the inevitable development of resistance to these agents; responsible use of potent new agents is required to prevent continuation of this vicious cycle...
  18. ncbi request reprint Antimicrobial selection for community-acquired lower respiratory tract infections in the 21st century: a review of gemifloxacin
    P C Appelbaum
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Int J Antimicrob Agents 23:533-46. 2004
    ..The improved potency, broad spectrum of activity and proven clinical and bacteriological efficacy and safety profile should make it a useful agent in the 21st century battle against community-acquired LRTIs...
  19. ncbi request reprint Single- and multi-step resistance selection study of gemifloxacin compared with trovafloxacin, ciprofloxacin, gatifloxacin and moxifloxacin in Streptococcus pneumoniae
    K Nagai
    Department of Pathology (Clinical Microbiology, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    J Antimicrob Chemother 48:365-74. 2001
    ..All quinolones tested selected for resistance; judicious use and proper dosing will be necessary to avoid resistance selection of newer broad-spectrum fluoroquinolones...
  20. ncbi request reprint Susceptibility of 170 penicillin-susceptible and penicillin-resistant pneumococci to six oral cephalosporins, four quinolones, desacetylcefotaxime, Ro 23-9424 and RP 67829
    S K Spangler
    Department of Pathology Clinical Microbiology, Hershey Medical Center, Hershey, PA 17033
    J Antimicrob Chemother 31:273-80. 1993
    ..125 mg/L [S], 0.25 mg/L [I], 0.5 mg/L [R]). The results indicated that several newly introduced and experimental antimicrobials have potential for the treatment of infections caused by resistant strains of S. pneumoniae...
  21. pmc Activities of a new fluoroketolide, HMR 3787, and its (des)-fluor derivative RU 64399 compared to those of telithromycin, erythromycin A, azithromycin, clarithromycin, and clindamycin against macrolide-susceptible or -resistant Streptococcus pneumoniae an
    K Nagai
    Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 45:3242-5. 2001
    ..Telithromycin and RU 64399 were equally active against macrolide-susceptible (MICs, 0.008 to 0.06 microg/ml) and -resistant S. pyogenes isolates, but HMR 3787 had lower MICs for ermB strains...
  22. ncbi request reprint Activity of telithromycin compared with seven other agents against 1039 Streptococcus pyogenes pediatric isolates from ten centers in central and eastern Europe
    B Bozdogan
    Department of Pathology, Hershey Medical Center, 500 University Dr, Hershey, PA 17033, USA
    Clin Microbiol Infect 9:741-5. 2003
    ..3%) or to a mef(A)-encoded efflux pump (25.7%). One strain had alterations of both 23S rRNA (A2058G Escherichia coli numbering) and ribosomal protein L22 (G95D)...
  23. pmc Susceptibilities of Streptococcus pneumoniae and Haemophilus influenzae to 10 oral antimicrobial agents based on pharmacodynamic parameters: 1997 U.S. Surveillance study
    M R Jacobs
    Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA
    Antimicrob Agents Chemother 43:1901-8. 1999
    ..With the continuing rise in resistance, judicious use of oral antimicrobial agents is necessary in all age groups...
  24. pmc Postantibiotic effects of daptomycin against 14 staphylococcal and pneumococcal clinical isolates
    G A Pankuch
    Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 47:3012-4. 2003
    ..5 h. The mean pneumococcal PAEs were 1.7 h, ranging between 1.0 and 2.5 h. The staphylococcal and pneumococcal postantibiotic sub-MIC effects at 0.4 times the MIC ranged from 3.0 to >12.0 h and 1.9 to >12.0 h, respectively...
  25. ncbi request reprint Microbiological and pharmacodynamic considerations in the treatment of infection due to antimicrobial-resistant Streptococcus pneumoniae
    P C Appelbaum
    Department of Pathology, Milton S Hershey Medical Center, Hershey, PA 17033, USA
    Clin Infect Dis 31:S29-34. 2000
    ..Prudent use of all antimicrobials is essential to decrease the emergence of strains resistant to these agents...
  26. pmc Postantibiotic effects of garenoxacin (BMS-284756) against 12 gram-positive or -negative organisms
    G A Pankuch
    Department of Pathology, Hershey Medical Center, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 47:1140-2. 2003
    ..9 to 1.6 h. The mean PA-SMEs (0.4 times the MIC) for pneumococci, staphylococci, and enterococci were 3.0 to >10 h, 1.8 to >10.7 h, and 5.8 h, respectively, while those for E. coli and P. aeruginosa were 7.6 and 4.4 h, respectively...
  27. ncbi request reprint Single- and multistep selection study of the antipneumococcal activity of BMS-284756 compared to ciprofloxacin, levofloxacin, trovafloxacin and moxifloxacin
    C L Clark
    Department of Pathology, Hershey Medical Center, PO Box 850, 500 University Drive, Hershey, PA 17033, USA
    Clin Microbiol Infect 8:373-80. 2002
    ..Although all quinolones selected, to a greater or lesser degree, for resistant clones with mutations usually in parC or gyrA, BMS-284756 tended to select for resistant clones at a lower rate than other quinolones studied...
  28. ncbi request reprint Activity of telithromycin and seven other agents against 1034 pediatric Streptococcus pneumoniae isolates from ten central and eastern European centers
    B Bozdogan
    Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Clin Microbiol Infect 9:653-61. 2003
    ....
  29. ncbi request reprint Telithromycin post-antibiotic and post-antibiotic sub-MIC effects for 10 Gram-positive cocci
    Michael R Jacobs
    Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland, 11100 Euclid Ave, Cleveland, OH 44106, USA
    J Antimicrob Chemother 52:809-12. 2003
    ....
  30. pmc In vitro activity of the new quinolone WCK 771 against staphylococci
    Michael R Jacobs
    Department of Pathology, Case Western Reserve University, Cleveland, OH, USA
    Antimicrob Agents Chemother 48:3338-42. 2004
    ..Overall, WCK 771 was the most potent quinolone tested against the staphylococci tested, regardless of quinolone susceptibility...
  31. ncbi request reprint Evaluation of PCR primers to screen for Streptococcus pneumoniae isolates and beta-lactam resistance, and to detect common macrolide resistance determinants
    K Nagai
    Department of Pathology Clinical Microbiology, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    J Antimicrob Chemother 48:915-8. 2001
    ..All isolates were positive for lytA. The primers were useful for screening for Streptococcus pneumoniae and beta-lactam resistance, and for detection of common macrolide resistance determinants...
  32. ncbi request reprint Time-kill study of the activity of trovafloxacin compared with ciprofloxacin, sparfloxacin, metronidazole, cefoxitin, piperacillin and piperacillin/tazobactam against six anaerobes
    S K Spangler
    Department of Pathology Clinical Microbiology, Hershey Medical Center, PA 17033, USA
    J Antimicrob Chemother 39:23-7. 1997
    ..125-64/0.125-64; piperacillin/tazobactam, 0.06-2/0.125-8. Bacteriostatic levels were within two dilutions of broth MICs. By this time-kill method, trovafloxacin had the lowest bacteriostatic concentrations of all compounds tested...
  33. pmc Antianaerobe activity of RBX 7644 (ranbezolid), a new oxazolidinone, compared with those of eight other agents
    Lois M Ednie
    Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 47:1143-7. 2003
    ..125 and 1; clindamycin, 0.25 and 8; metronidazole, 1 and 4; gatifloxacin, 0.5 and 4; and moxifloxacin, 0.5 and 2, respectively. Ranbezolid had very good in vitro activity against both gram-negative and -positive anaerobes...
  34. ncbi request reprint Activity of five quinolones, three macrolides and telithromycin against 12 Haemophilus influenzae strains with different resistance phenotypes
    G A Pankuch
    Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA
    Clin Microbiol Infect 11:1040-4. 2005
    ..0-8.0 mg/L), except for two strains without efflux systems (0.0125-0.5 mg/L) and two with efflux systems and ribosomal protein mutations (> 64.0 mg/L), and were bactericidal against eight to ten strains tested at 2 x MIC after 24 h...
  35. ncbi request reprint Pneumococcal conjugate vaccine serotypes of Streptococcus pneumoniae isolates and the antimicrobial susceptibility of such isolates in children with otitis media
    M L Joloba
    Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland, Cleveland, OH 44106, USA
    Clin Infect Dis 33:1489-94. 2001
    ....
  36. ncbi request reprint Bacterial resistance in the new millennium. Its impact on antibiotic selection for respiratory tract infections
    P C Appelbaum
    Pennsylvania State University Collegeof Medicine, Hershey Medical Center, Hershey, PA 17033, USA
    Postgrad Med 108:5-16. 2000
    ..Clearly, reassessment of current prescribing practices is critical if antibiotic efficacy is to be preserved and the risk for selection of resistance minimized in the new millennium...
  37. pmc Comparative study of the mutant prevention concentrations of moxifloxacin, levofloxacin, and gemifloxacin against pneumococci
    Kim Credito
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 54:673-7. 2010
    ..001), thus representing a lower selective pressure for proliferation of resistant mutants. Only moxifloxacin gave a 50% MPC (MPC50) value (1 microg/ml) within the susceptible range...
  38. pmc Susceptibilities to telithromycin and six other agents and prevalence of macrolide resistance due to L4 ribosomal protein mutation among 992 Pneumococci from 10 central and Eastern European countries
    Kensuke Nagai
    Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 46:371-7. 2002
    ..Telithromycin at < or =0.5 microg/ml was active against 99.8% of S. pneumoniae isolates tested and may be useful for the treatment of respiratory tract infections caused by macrolide-resistant S. pneumoniae isolates...
  39. pmc Activities of ceftobiprole, a novel broad-spectrum cephalosporin, against Haemophilus influenzae and Moraxella catarrhalis
    Tatiana Bogdanovich
    Department of Pathology, Hershey Medical Center, PA 17033, USA
    Antimicrob Agents Chemother 50:2050-7. 2006
    ..influenzae or M. catarrhalis clones with elevated ceftobiprole MICs is quite low...
  40. pmc Antipneumococcal activities of two novel macrolides, GW 773546 and GW 708408, compared with those of erythromycin, azithromycin, clarithromycin, clindamycin, and telithromycin
    Vlatka Matic
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 48:4103-12. 2004
    ..5 x 10(-7) for GW 773546, GW 708408, and telithromycin for macrolide-susceptible strains and 1.1 x 10(-7) to >4.3 x 10(-3) for resistant strains. The postantibiotic effects of GW 773546, GW 708408, and telithromycin were 2.4 to 9.8 h...
  41. ncbi request reprint Single and multi-step resistance selection study in Streptococcus pneumoniae comparing ceftriaxone with levofloxacin, gatifloxacin and moxifloxacin
    Frederick A Browne
    Department of Medicine, Hershey Medical Center, 500 University Drive, PA 17033, USA
    Int J Antimicrob Agents 20:93-9. 2002
    ..This in vitro mutation study demonstrates a clear distinction between the low frequency of development of resistance with ceftriaxone exposure as opposed to the high frequency with quinolone exposure...
  42. ncbi request reprint Susceptibility of 310 nonfermentative gram-negative bacteria to aztreonam, carumonam, ciprofloxacin, ofloxacin and fleroxacin
    P C Appelbaum
    Department of Pathology Clinical Microbiology, Hershey Medical Center, PA
    Chemotherapy 34:40-5. 1988
    ..The broad-spectrum activity of the 3 quinolones suggests potential use in therapy of infections caused by nonfermenters; monobactams should be reserved for infections caused by P. aeruginosa and possibly Acinetobacter spp...
  43. pmc Postantibiotic effect of ceftaroline against gram-positive organisms
    G A Pankuch
    Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 53:4537-9. 2009
    ..4 times the MIC) were 2.5 to 6.7 h, 2.9 to >0.0 h, and 7.9 to >10.3 h, respectively. The PA-SMEs were longer than the PAEs, suggesting that sub-MIC levels extend the PAE of ceftaroline against gram-positive cocci...
  44. pmc Affinity of ceftaroline and other beta-lactams for penicillin-binding proteins from Staphylococcus aureus and Streptococcus pneumoniae
    K Kosowska-Shick
    Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 54:1670-7. 2010
    ..aureus (IC(50), 0.01 to 1 microg/ml) with up to 256-fold-higher affinity than those of other agents. Ceftaroline demonstrated very good PBP affinity against all S. aureus and S. pneumoniae strains tested, including resistant isolates...
  45. pmc Antistaphylococcal activity of LBM415, a new peptide deformylase inhibitor, compared with those of other agents
    Kim Credito
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 48:4033-6. 2004
    ..All strains were also susceptible to vancomycin, linezolid, ranbezolid, daptomycin, oritavancin, and quinupristin-dalfopristin. LBM415 at the MIC was bacteriostatic after 24 h...
  46. pmc Activities of two novel macrolides, GW 773546 and GW 708408, compared with those of telithromycin, erythromycin, azithromycin, and clarithromycin against Haemophilus influenzae
    Klaudia Kosowska
    Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 48:4113-9. 2004
    ..6 to 6.9 h), and 6.4 h (range, 3.8 to 9.7 h), respectively. The results of in vitro studies obtained with both novel macrolides were similar to those obtained with telithromycin and better than those obtained with older macrolides...
  47. ncbi request reprint Activity of nine oral agents against gram-positive and gram-negative bacteria encountered in community-acquired infections: use of pharmacokinetic/pharmacodynamic breakpoints in the comparative assessment of beta-lactam and macrolide antimicrobial agents
    Mihaela Peric
    Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Clin Ther 25:169-77. 2003
    ....
  48. pmc Antistaphylococcal activity of dalbavancin, an experimental glycopeptide
    Gengrong Lin
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 49:770-2. 2005
    ..For all strains, MICs of vancomycin, linezolid, ranbezolid, oritavancin, daptomycin, and quinupristin-dalfopristin were </=4.0 microg/ml. Dalbavancin was bactericidal at four times the MIC against all six strains tested...
  49. pmc Activity of LBM415 compared to those of 11 other agents against Haemophilus species
    Tatiana Bogdanovich
    Hershey Medical Center, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 50:2323-9. 2006
    ..No mutations in deformylase (def) and formyltransferase (fmt) genes were detected in any of the LBM415-resistant mutants...
  50. ncbi request reprint Antibacterial susceptibility of a vancomycin-resistant Staphylococcus aureus strain isolated at the Hershey Medical Center
    Bulent Bozdogan
    Departments of Pathology and Medicine, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    J Antimicrob Chemother 52:864-8. 2003
    ....
  51. ncbi request reprint Susceptibility of 1100 Streptococcus pneumoniae strains isolated in 1997 from seven Latin American and Caribbean countries. Laser Study Group
    M R Jacobs
    Department of Pathology, Case Western Reserve University and University Hospitals of Cleveland, OH 44106, USA
    Int J Antimicrob Agents 16:17-24. 2000
    ..pneumoniae in Latin American and Caribbean countries, continued surveillance efforts are necessary in order to guide clinical empiric treatment and provide for judicious use of antimicrobial agents...
  52. pmc Postantibiotic effect of tigecycline against 14 gram-positive organisms
    G A Pankuch
    Department of Pathology, Hershey Medical Center, PA 17033, USA
    Antimicrob Agents Chemother 53:782-4. 2009
    ..1 to 5.0, 1.9 to 2.1, 1.7 to 1.8, 1.0 to 1.7, and 0.7 to 3 h, respectively. The PA-SMEs (four times the MIC) ranged from 6.7 to >11 h for gram-positive organisms and from 2.3 to >11.3 h for gram-negative organisms...
  53. pmc Effects of an efflux mechanism and ribosomal mutations on macrolide susceptibility of Haemophilus influenzae clinical isolates
    Mihaela Peric
    Department of Pathology, Hershey Medical Center, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 47:1017-22. 2003
    ..3%) due to one or several ribosomal mutations. Occasional hypersusceptible strains (1.8%) were found and had no macrolide resistance mechanisms and appeared to be the only truly macrolide-susceptible variants of H. influenzae...
  54. ncbi request reprint Bactericidal activity of daptomycin against Streptococcus pneumoniae compared with eight other antimicrobials
    Glenn A Pankuch
    Department of Pathology, Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA
    J Antimicrob Chemother 51:443-6. 2003
    ..0 mg/L. Time-kill assays with eight strains demonstrated that daptomycin (2 x MIC) was bactericidal in seven of eight strains tested at 24 h, with >90% killing at 1 h...
  55. pmc Susceptibility to telithromycin in 1,011 Streptococcus pyogenes isolates from 10 central and Eastern European countries
    Kensuke Nagai
    Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 46:546-9. 2002
    ..3% of strains. Erm(A) [subclass erm(TR)] was most commonly encountered (60.5%), followed by mef(A) (23.4%) and erm(B) (14.5%). At <0.5 microg/ml, telithromycin was active against 98.5% of the strains tested...
  56. pmc Antipneumococcal and antistaphylococcal activities of ranbezolid (RBX 7644), a new oxazolidinone, compared to those of other agents
    Dianne B Hoellman
    Department of Pathology, Hershey Medical Center, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 47:1148-50. 2003
    ..Ranbezolid was bacteriostatic against pneumococci. Ranbezolid MICs were similar to or lower than those of linezolid. Vancomycin and quinupristin-dalfopristin were also very active...
  57. pmc Effect of efflux on telithromycin and macrolide susceptibility in Haemophilus influenzae
    Tatiana Bogdanovich
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 50:893-8. 2006
    ..From these results we conclude that telithromycin efflux with or without additional ribosomal alterations is present in all H. influenzae strains, except for those for which the telithromycin MICs were very low...
  58. pmc Postantibiotic effect of DX-619 against 16 gram-positive organisms
    G A Pankuch
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 49:3963-5. 2005
    ..7 to 5.0 h, 0.7 to 1.8 h, and 1.2 to 6.5 h, respectively. The PA-SME ranges (0.4x MIC) for pneumococci, staphylococci, and enterococci were 5.2 to >8.6 h, 2.1 to 8.3 h, and 4.9 to >10.0 h, respectively...
  59. pmc Postantibiotic effects of telavancin against 16 gram-positive organisms
    G A Pankuch
    Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 53:1275-7. 2009
    ..7 to >10.7 h, >10.7 to >11.0 h, and >10 to >10.8 h, respectively. The extended PAE of telavancin, together with its long elimination half-life in humans, supports once-daily dosing for this investigational drug...
  60. ncbi request reprint Development of macrolide resistance by ribosomal protein L4 mutation in Streptococcus pyogenes during miocamycin treatment of an eight-year-old Greek child with tonsillopharyngitis
    B Bozdogan
    Department of Pathology, Hershey Medical Center, Hershey, PA, USA
    Clin Microbiol Infect 9:966-9. 2003
    ..The initial isolate was macrolide-susceptible, but the isolates after the treatment were resistant to 14 and 15-membered macrolides and had two amino acid (65WR66) deletions in ribosomal protein L4...
  61. ncbi request reprint Activity of cefditoren against respiratory pathogens
    Catherine L Clark
    Departments of Pathology Clinical Microbiology, Hershey Medical Center, Hershey, PA 17033, USA
    J Antimicrob Chemother 50:33-41. 2002
    ..Single-step mutation studies showed that cefditoren, at the MIC, had the lowest frequency of spontaneous mutants compared with other drugs...
  62. pmc In vitro capability of faropenem to select for resistant mutants of Streptococcus pneumoniae and Haemophilus influenzae
    Klaudia Kosowska-Shick
    Department of Pathology, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 52:748-52. 2008
    ..Faropenem also yielded low rates of spontaneous mutations against all organisms of both species. By comparison, resistant clones were obtained with macrolides, ketolides, and quinolones...
  63. pmc In vitro activity of DC-159a, a new broad-spectrum fluoroquinolone, compared with that of other agents against drug-susceptible and -resistant pneumococci
    Catherine Clark
    Department of Pathology, Clinical Microbiology, Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 52:77-84. 2008
    ..Multistep resistance selection studies showed that even after 50 consecutive subcultures of 10 strains in the presence of sub-MICs, DC-159a produced only two mutants with maximum MICs of 1 microg/ml...
  64. pmc In vitro selection of resistance in Haemophilus influenzae by amoxicillin-clavulanate, cefpodoxime, cefprozil, azithromycin, and clarithromycin
    Catherine Clark
    Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 46:2956-62. 2002
    ..influenzae did not rise more than fourfold, in contrast to cefprozil, azithromycin, and clarithromycin, whose MICs rose to variable degrees...
  65. pmc Activity of DX-619 compared to other agents against viridans group streptococci, Streptococcus bovis, and Cardiobacterium hominis
    Klaudia Kosowska-Shick
    Hershey Medical Center, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 50:4191-4. 2006
    ..008 and 16 microg/ml. Azithromycin resistance was found in most species, while most were telithromycin susceptible. Glycopeptides and linezolid were active against viridans group strains but inactive against C. hominis...
  66. pmc Antistreptococcal activity of AR-709 compared to that of other agents
    Kathy Smith
    Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 52:2279-82. 2008
    ..Furthermore, AR-709 was active against strains that were both susceptible and resistant to trimethoprim-sulfamethoxazole...
  67. pmc Multistep resistance selection and postantibiotic-effect studies of the antipneumococcal activity of LBM415 compared to other agents
    Klaudia Kosowska-Shick
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 51:770-3. 2007
    ..MIC increases correlated with changes mostly in the 70GXGXAAXQ77 motif in peptide deformylase. The postantibiotic effect of LBM415 ranged from 0.3 to 1.4 h...
  68. pmc Derivatives of a vancomycin-resistant Staphylococcus aureus strain isolated at Hershey Medical Center
    Bulent Bozdogan
    Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 48:4762-5. 2004
    ..However induction with vancomycin increased glycopeptide MICs and stabilized the resistance...
  69. pmc Activity of telavancin against staphylococci and enterococci determined by MIC and resistance selection studies
    Klaudia Kosowska-Shick
    Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 53:4217-24. 2009
    ..Single-step mutation frequencies for telavancin (<4.0 x 10(-11) to <2.9 x 10(-10) at 2x MIC) were lower than the spontaneous mutation frequencies obtained with the comparators...
  70. pmc Effects of amino acid alterations in penicillin-binding proteins (PBPs) 1a, 2b, and 2x on PBP affinities of penicillin, ampicillin, amoxicillin, cefditoren, cefuroxime, cefprozil, and cefaclor in 18 clinical isolates of penicillin-susceptible, -intermedia
    Kensuke Nagai
    Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania, USA
    Antimicrob Agents Chemother 46:1273-80. 2002
    ..Overall, the MICs for and PBP affinities of the strains correlated with the changes found in the PBP active binding sites...
  71. ncbi request reprint Inability of L22 ribosomal protein alteration to increase macrolide MICs in the absence of efflux mechanism in Haemophilus influenzae HMC-S
    Mihaela Peric
    Department of Pathology, Hershey Medical Center, Mail code H083, 500 University Dr, Hershey, PA 17033, USA
    J Antimicrob Chemother 54:393-400. 2004
    ..Haemophilus influenzae HMC-C with high-level macrolide resistance after multi-step selection by clarithromycin reverted spontaneously and became hypersusceptible to macrolides...
  72. pmc Antistaphylococcal activity of CB-181963 (CAB-175), an experimental parenteral cephalosporin
    Dianne B Hoellman
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 48:4037-9. 2004
    ..Most methicillin-resistant strains were levofloxacin resistant. CB-181963 was bactericidal against all six methicillin-resistant strains at four times the MIC after 24 h...
  73. pmc Antistaphylococcal activity of CG400549, a new experimental FabI inhibitor, compared with that of other agents
    Tatiana Bogdanovich
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 51:4191-5. 2007
    ..Single-passage selection testing showed low resistance frequencies with CG400549, but multistep analysis showed that CG400549 yielded resistant mutants after 14 to 17 days in all strains tested...
  74. pmc In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms
    Pamela McGhee
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 54:230-8. 2010
    ..CEM-101 had low MICs as well as low potential for the selection of resistant mutants, independent of bacterial species or resistance phenotypes in pneumococci and S. pyogenes...
  75. ncbi request reprint The fluoroquinolone antibacterials: past, present and future perspectives
    P C Appelbaum
    Department of Pathology, Hershey Medical Center, PA 17033, USA
    Int J Antimicrob Agents 16:5-15. 2000
    ....
  76. pmc Multistep resistance development studies of ceftaroline in gram-positive and -negative bacteria
    Catherine Clark
    Department of Pathology, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 55:2344-51. 2011
    ..The parental ceftaroline MIC for the one K. pneumoniae extended-spectrum β-lactamase-negative isolate tested was 0.5 μg/ml and did not change after 50 daily passages...
  77. pmc Activity of ACHN-490 tested alone and in combination with other agents against Pseudomonas aeruginosa
    Glenn A Pankuch
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 55:2463-5. 2011
    ..Combinations of ACHN-490 with cefepime, doripenem, imipenem, or piperacillin-tazobactam yielded synergies in ≥70% and ≥80% of strains at 6 and 12 h, respectively, and in ≥68% at 24 h...
  78. doi request reprint Molecular and epidemiologic characteristics of linezolid-resistant coagulase-negative staphylococci at a tertiary care hospital
    Klaudia Kosowska-Shick
    Department of Pathology, Penn State Hershey Medical Center, Hershey, PA 17033, USA
    Diagn Microbiol Infect Dis 68:34-9. 2010
    ..The increase in linezolid-resistant coagulase-negative staphylococci correlated with nosocomial transmission of selected mutated strains in patients who had received linezolid...
  79. pmc Mutant prevention concentrations of four carbapenems against gram-negative rods
    Kim Credito
    Hershey Medical Center, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 54:2692-5. 2010
    ..aeruginosa the MPC/MIC ratios were 4 to > or =16. The MPC/MIC ratios for beta-lactamase-positive K. pneumoniae and E. coli isolates were much higher (range, 4 to >16 microg/ml) than those for ss-lactamase-negative strains...
  80. pmc Resistance selection studies comparing the activity of razupenem (PTZ601) to vancomycin and linezolid against eight methicillin-resistant and two methicillin-susceptible Staphylococcus aureus strains
    Catherine Clark
    Department of Pathology, Hershey Medical Center, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 53:3118-21. 2009
    ..016 to 2 microg/ml (parents) to 0.125 to 8 microg/ml (with clones stable after 10 drug-free subcultures). Single-step mutant selection frequencies were similarly low for razupenem and comparators...
  81. pmc Incidence, epidemiology, and characteristics of quinolone-nonsusceptible Streptococcus pneumoniae in Croatia
    Glenn A Pankuch
    Department of Pathology, Hershey Medical Center, PO Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 46:2671-5. 2002
    ..The remaining 14 strains were more heterogeneous and had mutations only in parC and/or parE, and the MICs of quinolones were lower for these strains...
  82. pmc Activity of levofloxacin alone and in combination with a DnaK inhibitor against gram-negative rods, including levofloxacin-resistant strains
    Kim Credito
    Department of Pathology, Hershey Medical Center, PA 17033, USA
    Antimicrob Agents Chemother 53:814-7. 2009
    ..Fourteen of these 34 organisms were quinolone resistant (levofloxacin MICs of > or =4 microg/ml)...
  83. pmc In vitro activity of fusidic acid (CEM-102, sodium fusidate) against Staphylococcus aureus isolates from cystic fibrosis patients and its effect on the activities of tobramycin and amikacin against Pseudomonas aeruginosa and Burkholderia cepacia
    Pamela McGhee
    Department of Pathology, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 55:2417-9. 2011
    ..5 μg/ml with 91 to 97% protein binding) against all MRSA strains. No antagonism was observed; synergy occurred for one MRSA strain treated with fusidic acid plus tobramycin...
  84. pmc Characterization of a daptomycin-nonsusceptible vancomycin-intermediate Staphylococcus aureus strain in a patient with endocarditis
    Kathleen Julian
    Penn State Milton S Hershey Medical Center, Room C6833, BMR Bldg, Mailcode H036, 500 University Dr, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 51:3445-8. 2007
    ..The daptomycin-nonsusceptible VISA's cell wall demonstrated a reduction in muramic acid O-acetylation, a phenotypic parameter not previously reported for VISA; some isolates also contained a single point mutation in the mprF gene...
  85. pmc Single- and multistep resistance selection studies on the activity of retapamulin compared to other agents against Staphylococcus aureus and Streptococcus pyogenes
    Klaudia Kosowska-Shick
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 50:765-9. 2006
    ..Retapamulin has a low potential for resistance selection in S. pyogenes, with a slow and gradual propensity for resistance development in S. aureus...
  86. pmc Antipneumococcal activity of DK-507k, a new quinolone, compared with the activities of 10 other agents
    Frederick A Browne
    Department of Medicine, Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 47:3815-24. 2003
    ..Exposure to DK-507k and sitafloxacin resulted in mutations, mostly in gyrA...
  87. pmc Activity of retapamulin against Streptococcus pyogenes and Staphylococcus aureus evaluated by agar dilution, microdilution, E-test, and disk diffusion methodologies
    Glenn A Pankuch
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 50:1727-30. 2006
    ..aureus (including methicillin-resistant and vancomycin-nonsusceptible strains) are inhibited by very low concentrations of retapamulin and that all four testing methods are satisfactory for use for susceptibility testing...
  88. ncbi request reprint Macrolide resistance in Streptococci and Haemophilus influenzae
    Bulent Bozdogan
    Department of Pathology, Hershey Medical Center, 500 University Drive, Pennsylvania State University, Hershey, PA 17033, USA
    Clin Lab Med 24:455-75. 2004
    ..This article analyses macrolide-resistance mechanisms and their worldwide distributions in S pneumoniae, S pyogenes, and H influenzae...
  89. ncbi request reprint The Alexander Project 1998-2000: susceptibility of pathogens isolated from community-acquired respiratory tract infection to commonly used antimicrobial agents
    Michael R Jacobs
    Department of Pathology, Case Western Reserve University of Cleveland, 11100 Euclid Ave, Cleveland, OH 44106, USA
    J Antimicrob Chemother 52:229-46. 2003
    ..The Alexander Project is a continuing surveillance study, begun in 1992, examining the susceptibility of pathogens involved in adult community-acquired respiratory tract infections (CARTI) to a range of antimicrobial agents...
  90. pmc Antistaphylococcal activity of ceftobiprole, a new broad-spectrum cephalosporin
    Tatiana Bogdanovich
    Department of Pathology, Hershey Medical Center, PA 17033, USA
    Antimicrob Agents Chemother 49:4210-9. 2005
    ..Single-passage selections showed very low frequencies of resistance to ceftobiprole irrespective of genotype or phenotype; the maximal ceftobiprole MIC of recovered clones was 8 mug/ml...
  91. ncbi request reprint Macrolide resistance in Streptococcus pneumoniae: clonality and mechanisms of resistance in 24 countries
    Bulent Bozdogan
    Department of Pathology, Hershey Medical Center, 500 University Dr, Hershey, PA 17033, USA
    Curr Drug Targets Infect Disord 4:169-76. 2004
    ..Common clones were observed between Europe, Asia, and America. Overall, while serotypes/serogroups of macrolide resistant isolates were limited, multiple PFGE and MLST types were found, with clustering of common clones within countries...
  92. ncbi request reprint Are cephalosporins appropriate for the treatment of acute otitis media in this era of increasing antimicrobial resistance among common respiratory tract pathogens?
    Peter C Appelbaum
    Division of Clinical Pathology, Medical Director, Clinical Microbiology, Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Clin Pediatr (Phila) 44:95-107. 2005
  93. ncbi request reprint Vancomycin-resistant Staphylococcus aureus in the absence of vancomycin exposure
    Cynthia J Whitener
    The Penn State Milton S Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Clin Infect Dis 38:1049-55. 2004
    ..For clinical and public health reasons, it is essential that microbiology laboratories adequately test for vancomycin-resistance in S. aureus...
  94. ncbi request reprint In vitro anti-anaerobic activity of the cephalosporin derivative RWJ 54428, compared to seven other compounds
    D B Hoellman
    Department of Pathology, Hershey Medical Center, PO Box 850, PA 17033, USA
    Clin Microbiol Infect 8:814-22. 2002
    ..125 mg/L and MIC90s of 1.0 mg/L). Piperacillin-tazobactam, clindamycin and metronidazole were active against most strains, and ceftriaxone was active mainly against beta-lactamase-negative organisms...
  95. pmc Antistaphylococcal activity of dihydrophthalazine antifolates, a family of novel antibacterial drugs
    Catherine Clark
    Department of Pathology, Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 53:1353-61. 2009
    ....
  96. pmc Activity of daptomycin alone and in combination with rifampin and gentamicin against Staphylococcus aureus assessed by time-kill methodology
    Kim Credito
    Department of Pathology, Hershey Medical Center, P O Box 850, Hershey, PA 17033, USA
    Antimicrob Agents Chemother 51:1504-7. 2007
    ..Daptomycin combined with rifampin yielded synergy in one vancomycin-intermediate S. aureus strain only, and virtually all synergy occurred between daptomycin and gentamicin...
  97. pmc Activities of HMR 3787 and RU 64399 compared with those of four other agents against Haemophilus influenzae and Haemophilus parainfluenzae
    Bulent Bozdogan
    Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 47:405-7. 2003
    ..Time-kill studies of 12 strains showed that HMR 3787, RU 64399, and telithromycin were bactericidal against all strains after 24 h at two times the MIC...
  98. ncbi request reprint Antipneumococcal activity of AZD2563, a new oxazolidinone, compared with nine other agents
    Mihaela Peric
    Departments of Pathology, Hershey Medical Center, 500 University Drive, Hershey, PA 17033, USA
    J Antimicrob Chemother 50:95-100. 2002
    ..Erythromycin was bactericidal against all 10 strains with MICs < or= 8 mg/L at 4 x MIC after 24 h...
  99. ncbi request reprint Vascular prosthetic infection with Staphylococcus epidermidis: experimental study of pathogenesis and therapy
    L F Martin
    Department of Surgery, Milton S Hershey Medical Center, Pennsylvania State University College of Medicine, Hershey 17033
    J Vasc Surg 9:464-71. 1989
    ..The administration of perioperative antibiotics reduced but did not abolish these effects of bacterial contamination of prosthetic vascular grafts...
  100. pmc Time-kill activity of the streptogramin NXL 103 against Gram-positive and -negative bacteria
    Glenn A Pankuch
    Hershey Medical Center, Hershey, Pennsylvania 17033, USA
    Antimicrob Agents Chemother 55:1787-91. 2011
    ..After the exposure of one strain of each species to NXL 103 for 10 daily subcultures, the MICs remained within ± 1 dilution...
  101. pmc Antistaphylococcal activity of WCK 771, a tricyclic fluoroquinolone, in animal infection models
    Mahesh V Patel
    Wockhardt Research Centre, Aurangabad, India
    Antimicrob Agents Chemother 48:4754-61. 2004
    ..These studies have demonstrated the effectiveness of WCK 771, administered orally and parenterally, for the treatment of diverse staphylococcal infections in mice, including those caused by quinolone-resistant strains...