Jun Yin

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. pmc Involvement of an alternatively spliced mitochondrial oxodicarboxylate carrier in adipogenesis in 3T3-L1 cells
    Masashi Niimi
    Otsuka Maryland Medicinal Laboratories, Inc, Rockville, Maryland, USA
    J Biomed Sci 16:92. 2009
  2. pmc Efficacy of berberine in patients with type 2 diabetes mellitus
    Jun Yin
    Department of Endocrinology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
    Metabolism 57:712-7. 2008
  3. pmc Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia
    Qing He
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 300:E877-85. 2011
  4. pmc Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation
    Fen Xu
    6400 Perkins Road, Baton Rouge, Louisiana 70808 or Jianping Weng, The Third Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, China
    Endocrinology 151:2504-14. 2010
  5. ncbi request reprint Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    Jianping Ye
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 293:E1118-28. 2007
  6. pmc Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in SIRT1-/- mice
    Fen Xu
    Department of Endocrinology, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou 510630, China
    Endocrinology 153:1706-16. 2012
  7. pmc Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis
    Xuan Xia
    Department of Endocrinology, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    PLoS ONE 6:e16556. 2011
  8. pmc Effect of Shilianhua extract and its fractions on body weight of obese mice
    Jun Yin
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S47-51. 2008
  9. pmc Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity
    Can Pang
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 295:E313-22. 2008
  10. pmc Berberine improves glucose metabolism through induction of glycolysis
    Jun Yin
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 294:E148-56. 2008

Collaborators

Detail Information

Publications16

  1. pmc Involvement of an alternatively spliced mitochondrial oxodicarboxylate carrier in adipogenesis in 3T3-L1 cells
    Masashi Niimi
    Otsuka Maryland Medicinal Laboratories, Inc, Rockville, Maryland, USA
    J Biomed Sci 16:92. 2009
    ..In order to identify genes critical for adipogenesis, we took a novel approach based on phenotype change of individual cell, to search for genes with regulatory roles in adipogenesis genome-wide in 3T3-L1 cells...
  2. pmc Efficacy of berberine in patients with type 2 diabetes mellitus
    Jun Yin
    Department of Endocrinology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
    Metabolism 57:712-7. 2008
    ..Functional liver or kidney damages were not observed for all patients. In conclusion, this pilot study indicates that berberine is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism...
  3. pmc Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia
    Qing He
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 300:E877-85. 2011
    ..Adipose tissue HIF-1α activity is influenced by multiple signals, including adipogenesis, insulin, and hypoxia in obesity. The transcriptional activity of HIF-1α is inhibited by HDAC3-SMRT corepressor in the VEGF gene promoter...
  4. pmc Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation
    Fen Xu
    6400 Perkins Road, Baton Rouge, Louisiana 70808 or Jianping Weng, The Third Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, China
    Endocrinology 151:2504-14. 2010
    ..The inflammation may contribute to the pathogenesis of hepatic steatosis as well. A reduction in lipid mobilization may contribute to the hepatic steatosis and low energy expenditure...
  5. ncbi request reprint Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    Jianping Ye
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 293:E1118-28. 2007
    ..These data suggest a potential role of hypoxia in the induction of chronic inflammation and inhibition of adiponectin in the adipose tissue in obesity...
  6. pmc Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in SIRT1-/- mice
    Fen Xu
    Department of Endocrinology, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou 510630, China
    Endocrinology 153:1706-16. 2012
    ..The study supports the concept that inflammation regulates angiogenesis in the adipose tissue...
  7. pmc Berberine improves glucose metabolism in diabetic rats by inhibition of hepatic gluconeogenesis
    Xuan Xia
    Department of Endocrinology, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou, China
    PLoS ONE 6:e16556. 2011
    ..This activity is not dependent on insulin action. The gluconeogenic inhibition is likely a result of mitochondria inhibition by BBR. The observation supports that BBR improves glucose metabolism through an insulin-independent pathway...
  8. pmc Effect of Shilianhua extract and its fractions on body weight of obese mice
    Jun Yin
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S47-51. 2008
    ..The weight reduction observed with the over-the-counter SLH tablet in the pilot studies may be secondary to other components in the tablet, but not from the SLH extract...
  9. pmc Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity
    Can Pang
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 295:E313-22. 2008
    ..Although the PDGF level is elevated in adipose tissue, its activity in angiogenesis is dependent on the availability of sufficient endothelial cells. The study suggests a new function of macrophages in the adipose tissue in obesity...
  10. pmc Berberine improves glucose metabolism through induction of glycolysis
    Jun Yin
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 294:E148-56. 2008
    ..Berberine-induced AMPK activation is likely a consequence of mitochondria inhibition that increases the AMP/ATP ratio...
  11. ncbi request reprint Effects of berberine on glucose metabolism in vitro
    Jun Yin
    Shanghai Institute of Endocrinology, Ruijin Hospital, Shanghai Second Medical University, Shanghai, China
    Metabolism 51:1439-43. 2002
    ..These observations suggest that berberine is able to exert a glucose-lowering effect in hepatocytes, which is insulin independent and similar to that of metformin, but has no effect on insulin secretion...
  12. pmc Traditional chinese medicine in treatment of metabolic syndrome
    Jun Yin
    Pennington Biomedical Research Center, Louisana State University System, Baton Rouge, LA 70808, USA
    Endocr Metab Immune Disord Drug Targets 8:99-111. 2008
    ....
  13. ncbi request reprint Hypoxia-enhanced expression of free deaminoneuraminic acid in human cancer cells
    Shinji Go
    Bioscience and Biotechnology Center, Nagoya University, Nagoya 464 8601, Japan
    Biochem Biophys Res Commun 357:537-42. 2007
    ..Kdn may thus be a target for diagnosis of cancers...
  14. ncbi request reprint Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells
    Jun Yin
    Department of Molecular Pathology, Aichi Cancer Center, Nagoya, Japan
    Cancer Res 66:2937-45. 2006
    ..As hypoxia is associated with diminished response to radiotherapy and chemotherapy, NeuGc-G(M2) is a potential therapeutic target for hypoxic cancer cells...
  15. ncbi request reprint Paraquat induces selective dopaminergic nigrostriatal degeneration in aging C57BL/6 mice
    Xia Li
    Department of Pharmacology, Shenyang Pharmaceutical University, Shenyang 110016, China
    Chin Med J (Engl) 118:1357-61. 2005
    ..Aging is an accepted risk factor for idiopathic Parkinson's disease. The aim of this study was to test the hypothesis that paraquat could induce PD-like nigrostriatal dopaminergic degeneration in aging C57BL/6 mice...
  16. ncbi request reprint A combination of soft-shell turtle powder and essential oil of a unicellular chorophyte prevents bone loss and decreased bone strength in ovariectomized rats
    Jun Yin
    Institute of Natural Medicine, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama 930 0194, Japan
    Biol Pharm Bull 28:275-9. 2005
    ..However, OHP alone showed no significant effects...