Jianping Ye

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. pmc Regulation of energy metabolism by inflammation: a feedback response in obesity and calorie restriction
    Jianping Ye
    Pennington Biomedical Research Center, Louisiana State University System, LA 70808, USA
    Aging (Albany NY) 2:361-8. 2010
  2. pmc Mechanisms of insulin resistance in obesity
    Jianping Ye
    Antioxidant and Gene Regulation Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Front Med 7:14-24. 2013
  3. pmc Inflammation during obesity is not all bad: evidence from animal and human studies
    Jianping Ye
    Antioxidant and Gene Regulation Laboratory, Pennington Biomedical Research Center, Louisiana State Univ System, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 304:E466-77. 2013
  4. ncbi request reprint Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice
    Zhanguo Gao
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 292:E84-91. 2007
  5. pmc Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation
    Jin Zhang
    Antioxidant and Gene Regulation Laboratory, Pennington Biomedical Research Center, Antioxidant and Gene Regulation, Baton Rouge, Louisiana 70808, USA
    Endocrinology 152:1829-38. 2011
  6. ncbi request reprint Role of insulin in the pathogenesis of free fatty acid-induced insulin resistance in skeletal muscle
    Jianping Ye
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Endocr Metab Immune Disord Drug Targets 7:65-74. 2007
  7. ncbi request reprint Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    Jianping Ye
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 293:E1118-28. 2007
  8. ncbi request reprint Insulin resistance: central and peripheral mechanisms. The 2007 Stock Conference Report
    J Ye
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Obes Rev 9:30-4. 2008
  9. pmc Regulation of PPARgamma function by TNF-alpha
    Jianping Ye
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Biochem Biophys Res Commun 374:405-8. 2008
  10. pmc Adipose tissue vascularization: its role in chronic inflammation
    Jianping Ye
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Curr Diab Rep 11:203-10. 2011

Collaborators

Detail Information

Publications63

  1. pmc Regulation of energy metabolism by inflammation: a feedback response in obesity and calorie restriction
    Jianping Ye
    Pennington Biomedical Research Center, Louisiana State University System, LA 70808, USA
    Aging (Albany NY) 2:361-8. 2010
    ..Inflammation is a mechanism for energy balance in the body. Inflammation resistance will lead to obesity. We will review the recent literature in support of the viewpoints...
  2. pmc Mechanisms of insulin resistance in obesity
    Jianping Ye
    Antioxidant and Gene Regulation Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Front Med 7:14-24. 2013
    ..This new concept provides a unifying cellular and molecular mechanism of insulin resistance in obesity, which may apply to insulin resistance in aging and lipodystrophy...
  3. pmc Inflammation during obesity is not all bad: evidence from animal and human studies
    Jianping Ye
    Antioxidant and Gene Regulation Laboratory, Pennington Biomedical Research Center, Louisiana State Univ System, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 304:E466-77. 2013
    ..Thus, the positive effects of proinflammatory events should be considered in evaluating the impact of inflammation in obesity and type 2 diabetes...
  4. ncbi request reprint Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice
    Zhanguo Gao
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 292:E84-91. 2007
    ..This study suggests that loss of PKCtheta reduces energy expenditure and increases the risk of dietary obesity and insulin resistance in mice...
  5. pmc Inhibition of glyceroneogenesis by histone deacetylase 3 contributes to lipodystrophy in mice with adipose tissue inflammation
    Jin Zhang
    Antioxidant and Gene Regulation Laboratory, Pennington Biomedical Research Center, Antioxidant and Gene Regulation, Baton Rouge, Louisiana 70808, USA
    Endocrinology 152:1829-38. 2011
    ..These results suggest that HDAC3 mediates NF-κB activity to repress Pepck transcription. This mechanism is responsible for inhibition of glyceroneogenesis in adipocytes, which contributes to lipodystrophy in the aP2-p65 Tg mice...
  6. ncbi request reprint Role of insulin in the pathogenesis of free fatty acid-induced insulin resistance in skeletal muscle
    Jianping Ye
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Endocr Metab Immune Disord Drug Targets 7:65-74. 2007
    ..According to this hypothesis, prevention of increased beta-cell response to glucose may be a potential approach for early intervention of metabolic syndrome...
  7. ncbi request reprint Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    Jianping Ye
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 293:E1118-28. 2007
    ..These data suggest a potential role of hypoxia in the induction of chronic inflammation and inhibition of adiponectin in the adipose tissue in obesity...
  8. ncbi request reprint Insulin resistance: central and peripheral mechanisms. The 2007 Stock Conference Report
    J Ye
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Obes Rev 9:30-4. 2008
    ..The 2007 Stock Conference focused on the role of fatty acids and other lipid signals in initiating insulin resistance and the consequences of central insulin resistance to the regulation of energy balance and peripheral metabolism...
  9. pmc Regulation of PPARgamma function by TNF-alpha
    Jianping Ye
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Biochem Biophys Res Commun 374:405-8. 2008
    ..IKK acts through at least two mechanisms: inhibition of PPARgamma expression and activation of PPARgamma corepressor. In this review article, literature is reviewed with a focus on the mechanisms of PPARgamma inhibition by TNF-alpha...
  10. pmc Adipose tissue vascularization: its role in chronic inflammation
    Jianping Ye
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Curr Diab Rep 11:203-10. 2011
    ..At the late stage, it causes adipose tissue dysfunction for insulin resistance. These points suggest that in obesity, adipose tissue vascularization controls chronic inflammation and influences systemic insulin sensitivity...
  11. pmc Lack of SIRT1 (Mammalian Sirtuin 1) activity leads to liver steatosis in the SIRT1+/- mice: a role of lipid mobilization and inflammation
    Fen Xu
    6400 Perkins Road, Baton Rouge, Louisiana 70808 or Jianping Weng, The Third Affiliated Hospital, Sun Yat Sen University, Guangzhou 510630, China
    Endocrinology 151:2504-14. 2010
    ..The inflammation may contribute to the pathogenesis of hepatic steatosis as well. A reduction in lipid mobilization may contribute to the hepatic steatosis and low energy expenditure...
  12. pmc Regulation of stem cell differentiation in adipose tissue by chronic inflammation
    Jianping Ye
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Clin Exp Pharmacol Physiol 38:872-8. 2011
    ..However, this activity of inflammation remains to be established in adipose tissue. The present article reviews the literature in support of this conclusion...
  13. ncbi request reprint Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes
    Zhanguo Gao
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Mol Endocrinol 18:2024-34. 2004
    ....
  14. pmc Butyrate improves insulin sensitivity and increases energy expenditure in mice
    Zhanguo Gao
    Antioxidant and Gene Regulation Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Diabetes 58:1509-17. 2009
    ..We examined the role of butyric acid, a short-chain fatty acid formed by fermentation in the large intestine, in the regulation of insulin sensitivity in mice fed a high-fat diet...
  15. pmc Uncoupling of inflammation and insulin resistance by NF-kappaB in transgenic mice through elevated energy expenditure
    Tianyi Tang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 285:4637-44. 2010
    ..The energy expenditure may lead to disassociation of inflammation with insulin resistance. The study indicates that inflammation may prevent insulin resistance by eliminating lipid accumulation...
  16. pmc Shilianhua extract inhibits GSK-3beta and promotes glucose metabolism
    Jun Yin
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 296:E1275-80. 2009
    ..We conclude that the F100 may be a bioactive component in the SLH plant. It promotes glucose metabolism in vitro and in vivo. Inhibition of GSK-3beta and NF-kappaB may be the potential mechanism...
  17. pmc Inactivation of NF-kappaB p50 leads to insulin sensitization in liver through post-translational inhibition of p70S6K
    Zhanguo Gao
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 284:18368-76. 2009
    ..The S6K1 reduction may contribute to insulin sensitivity in p50-KO mice. This study suggests that hepatic S6K1 may be a drug target in the treatment of insulin resistance...
  18. pmc Role of hypoxia in obesity-induced disorders of glucose and lipid metabolism in adipose tissue
    Jun Yin
    Pennington Biomedical Research Center, Louisiana State Univ System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 296:E333-42. 2009
    ..Necrosis and apoptosis were induced by hypoxia in 3T3-L1 adipocytes. These data suggest that ATH may promote FFA release and inhibit glucose uptake in adipocytes by inhibition of the insulin-signaling pathway and induction of cell death...
  19. pmc Regulation of HIF-1{alpha} activity in adipose tissue by obesity-associated factors: adipogenesis, insulin, and hypoxia
    Qing He
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 300:E877-85. 2011
    ..Adipose tissue HIF-1α activity is influenced by multiple signals, including adipogenesis, insulin, and hypoxia in obesity. The transcriptional activity of HIF-1α is inhibited by HDAC3-SMRT corepressor in the VEGF gene promoter...
  20. pmc S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-(alpha) signaling through IKK2
    Jin Zhang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 283:35375-82. 2008
    ..We present a new mechanism for TNF-alpha to induce insulin resistance that involves activation of S6K by an IKK2-dependent pathway. S6K directly phosphorylates IRS-1 on multiple serine residues to inhibit insulin signaling...
  21. ncbi request reprint Impaired coordination of nutrient intake and substrate oxidation in melanocortin-4 receptor knockout mice
    Diana C Albarado
    Pennington Biomedical Research Center Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Endocrinology 145:243-52. 2004
    ..This observation suggests that changes in liver secondary to triglyceride accumulation lead to hyperinsulinemia and increased hepatic FAS expression in Mc4r-/- mice...
  22. pmc GLP-1 receptor signaling is not required for reduced body weight after RYGB in rodents
    Jianping Ye
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana
    Am J Physiol Regul Integr Comp Physiol 306:R352-62. 2014
    ..It is likely that the beneficial effects of bariatric surgeries are expressed through complex mechanisms that require combination approaches for their identification. ..
  23. pmc Berberine improves glucose metabolism through induction of glycolysis
    Jun Yin
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 294:E148-56. 2008
    ..Berberine-induced AMPK activation is likely a consequence of mitochondria inhibition that increases the AMP/ATP ratio...
  24. pmc Angiogenic deficiency and adipose tissue dysfunction are associated with macrophage malfunction in SIRT1-/- mice
    Fen Xu
    Department of Endocrinology, The Third Affiliated Hospital of Sun Yat Sen University, Guangzhou 510630, China
    Endocrinology 153:1706-16. 2012
    ..The study supports the concept that inflammation regulates angiogenesis in the adipose tissue...
  25. pmc Macrophage infiltration into adipose tissue may promote angiogenesis for adipose tissue remodeling in obesity
    Can Pang
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 295:E313-22. 2008
    ..Although the PDGF level is elevated in adipose tissue, its activity in angiogenesis is dependent on the availability of sufficient endothelial cells. The study suggests a new function of macrophages in the adipose tissue in obesity...
  26. pmc Effect of Shilianhua extract and its fractions on body weight of obese mice
    Jun Yin
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S47-51. 2008
    ..The weight reduction observed with the over-the-counter SLH tablet in the pilot studies may be secondary to other components in the tablet, but not from the SLH extract...
  27. pmc Regulation of nuclear translocation of HDAC3 by IkappaBalpha is required for tumor necrosis factor inhibition of peroxisome proliferator-activated receptor gamma function
    Zhanguo Gao
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
    J Biol Chem 281:4540-7. 2006
    ..Rather, these results suggest that IkappaBalpha-dependent nuclear translocation of HDAC3 is responsible for PPARgamma inhibition by TNF-alpha...
  28. pmc Coactivators and corepressors of NF-kappaB in IkappaB alpha gene promoter
    Zhanguo Gao
    Pennington Biomedical Research Center, Louisiana State University Systems, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 280:21091-8. 2005
    ..This model may represent a mechanism for integration of extracellular signals into a precise control of gene transcription...
  29. pmc Human adenovirus type 36 enhances glucose uptake in diabetic and nondiabetic human skeletal muscle cells independent of insulin signaling
    Zhong Q Wang
    Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 57:1805-13. 2008
    ..Human adenovirus type 36 (Ad-36) increases adiposity but improves insulin sensitivity in experimentally infected animals. We determined the ability of Ad-36 to increase glucose uptake by human primary skeletal muscle (HSKM) cells...
  30. pmc Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity
    Zhanguo Gao
    Antioxidant and Gene Regulation Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 286:22227-34. 2011
    ..JNK2 exhibits an opposite activity in the regulation of SIRT1 degradation. The JNK1-SIRT1 pathway provides a new molecular mechanism for the pathogenesis of hepatic steatosis in obesity...
  31. ncbi request reprint Aspirin inhibits serine phosphorylation of insulin receptor substrate 1 in tumor necrosis factor-treated cells through targeting multiple serine kinases
    Zhanguo Gao
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    J Biol Chem 278:24944-50. 2003
    ..We conclude that aspirin may enhance insulin sensitivity by protecting IRS proteins from serine phosphorylation catalyzed by multiple kinases...
  32. pmc Reversible hyperphagia and obesity in rats with gastric bypass by central MC3/4R blockade
    Michael B Mumphrey
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, 70808, USA
    Obesity (Silver Spring) 22:1847-53. 2014
    ..To test the commonly held assumption that gastric bypass surgery lowers body weight because it limits the ability to eat large amounts of food...
  33. pmc Regulation of hepatocyte growth factor expression by NF-κB and PPARγ in adipose tissue
    Jun Yin
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana
    Am J Physiol Endocrinol Metab 306:E929-36. 2014
    ..Both Hgf and Vegf are induced by hypoxia. The study provides a molecular mechanism for the difference of inflammation and hypoxia in the regulation of angiogenic factors...
  34. pmc Phosphorylation and degradation of S6K1 (p70S6K1) in response to persistent JNK1 Activation
    Jin Zhang
    Antioxidant and Gene Regulation Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Biochim Biophys Acta 1832:1980-8. 2013
    ..These data suggest that S6K is phosphorylated by JNK1 and the phosphorylation makes S6K protein unstable in the absence of IKK2 activation. This study provides a mechanism for regulation of S6K protein stability. ..
  35. ncbi request reprint Nuclear corepressor is required for inhibition of phosphoenolpyruvate carboxykinase expression by tumor necrosis factor-alpha
    Jinhua Yan
    Department of Endocrinology, The First Affiliated Hospital, Sun Yat Sen University, Guangzhou 510080, China
    Mol Endocrinol 21:1630-41. 2007
    ..These data suggest a novel activity of nuclear corepressor in the regulation of PEPCK expression by TNF-alpha...
  36. pmc In vivo adipogenesis in rats measured by cell kinetics in adipocytes and plastic-adherent stroma-vascular cells in response to high-fat diet and thiazolidinedione
    Yourka D Tchoukalova
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 61:137-44. 2012
    ..We conclude that f(aSV) and f(AD) are reliable indices of in vivo adipogenesis. The proposed method represents a valuable tool for studying the effect of interventions (drugs, diets, and exercise) on in vivo adipogenesis...
  37. pmc Regulation of 11β-HSD1 expression during adipose tissue expansion by hypoxia through different activities of NF-κB and HIF-1α
    Jong Han Lee
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 304:E1035-41. 2013
    ..This study suggests that NF-κB may mediate the inflammatory cytokine signal to upregulate 11β-HSD1 expression...
  38. pmc Aging is associated with hypoxia and oxidative stress in adipose tissue: implications for adipose function
    Le Zhang
    Pennington Biomedical Research Center LSU System, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 301:E599-607. 2011
    ....
  39. pmc Development and verification of a mouse model for Roux-en-Y gastric bypass surgery with a small gastric pouch
    Zheng Hao
    Antioxidant and Gene Regulation Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    PLoS ONE 8:e52922. 2013
    ..This model will be useful for studying molecular mechanisms involved in the beneficial effects of RYGB on body weight and glucose homeostasis...
  40. pmc Traditional chinese medicine in treatment of metabolic syndrome
    Jun Yin
    Pennington Biomedical Research Center, Louisana State University System, Baton Rouge, LA 70808, USA
    Endocr Metab Immune Disord Drug Targets 8:99-111. 2008
    ....
  41. pmc Inhibition of transcriptional activity of c-JUN by SIRT1
    Zhanguo Gao
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Biochem Biophys Res Commun 376:793-6. 2008
    ..Glucose-induced MMP9 expression was also inhibited by SIRT1 in response to Resveratrol. These data consistently suggest that SIRT1 directly inhibits the transcriptional activity of AP-1 by targeting c-JUN...
  42. pmc E4orf1 improves lipid and glucose metabolism in hepatocytes: a template to improve steatosis & hyperglycemia
    Emily J Dhurandhar
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, United States of America
    PLoS ONE 7:e47813. 2012
    ..Elucidating the underlying molecular mechanism may help develop therapeutic approaches for treating diabetes or non-alcoholic fatty liver disease(NAFLD)...
  43. pmc Hypoxia-inducible factor 1 activation from adipose protein 2-cre mediated knockout of von Hippel-Lindau gene leads to embryonic lethality
    Jin Zhang
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Clin Exp Pharmacol Physiol 39:145-50. 2012
    ..Central and peripheral haemorrhages are responsible for the embryonic lethality in the homozygous knockout mice...
  44. pmc Efficacy of berberine in patients with type 2 diabetes mellitus
    Jun Yin
    Department of Endocrinology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China
    Metabolism 57:712-7. 2008
    ..Functional liver or kidney damages were not observed for all patients. In conclusion, this pilot study indicates that berberine is a potent oral hypoglycemic agent with beneficial effects on lipid metabolism...
  45. pmc Template to improve glycemic control without reducing adiposity or dietary fat
    R Krishnapuram
    Infections and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State Univ System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 300:E779-89. 2011
    ..This metabolic engineering by Ad36 appears relevant to humans for developing more practical and effective antidiabetic approaches...
  46. ncbi request reprint Botanicals and the metabolic syndrome
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 87:481S-7S. 2008
    ..With the completion of our research, we anticipate a better understanding of the cellular mechanisms by which insulin resistance develops and the role of botanicals in modulating the progression to metabolic syndrome...
  47. ncbi request reprint Inhibition of TNF-alpha gene expression and bioactivity by site-specific transcription factor-binding oligonucleotides
    Jianping Ye
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Am J Physiol Lung Cell Mol Physiol 284:L386-94. 2003
    ..This gene inhibition approach may be used as a research tool or as potential therapeutic modality for diseases with etiology dependent on aberrant gene expression...
  48. pmc Amino acids inhibit Agrp gene expression via an mTOR-dependent mechanism
    Christopher D Morrison
    Neurobehavior Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 293:E165-71. 2007
    ..01). Taken together, these observations indicate that amino acids can act within the brain to inhibit food intake and that a direct, mTOR-dependent inhibition of Agrp gene expression may contribute to this effect...
  49. pmc Regulation of insulin degrading enzyme activity by obesity-associated factors and pioglitazone in liver of diet-induced obese mice
    Xiuqing Wei
    Department of Digestive Disease, Third Affiliated Hospital, Sun Yet Sen University, Guangzhou, China Antioxidant and Gene Regulation Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States of America
    PLoS ONE 9:e95399. 2014
    ..The results suggest that IDE activity is regulated in liver by multiple factors in obesity and pioglitazone may induce IDE activity in the control of T2D. ..
  50. doi request reprint Resistant starch from high amylose maize (HAM-RS2) and dietary butyrate reduce abdominal fat by a different apparent mechanism
    Kirk Vidrine
    School of Human Ecology, Louisiana State University Agricultural Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 22:344-8. 2014
    ..RS treatment is associated with increased gut hormones peptide YY (PYY) and glucagon-like peptide 1 (GLP-1), but it is not known if SB increases these hormones...
  51. ncbi request reprint Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex
    Zhanguo Gao
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    J Biol Chem 277:48115-21. 2002
    ....
  52. ncbi request reprint Efficacy of dietary supplementation with botanicals on carbohydrate metabolism in humans
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Endocr Metab Immune Disord Drug Targets 8:78-81. 2008
    ..Thus, well defined randomized clinical trials are warranted in this area...
  53. doi request reprint Resistant starch, fermented resistant starch, and short-chain fatty acids reduce intestinal fat deposition in Caenorhabditis elegans
    Jolene Zheng
    Veterinary Science Department, LSU AgCenter, Louisiana StateUniversity, Baton Rouge, Louisiana 70803, USA
    J Agric Food Chem 58:4744-8. 2010
    ..001). The reduced intestinal fat deposition suggests reduced food intake or increased energy expenditure. C. elegans is a practical animal model to screen for bioactive compounds that may prevent or treat obesity...
  54. pmc Emerging role of adipose tissue hypoxia in obesity and insulin resistance
    J Ye
    Gene Regulation Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Int J Obes (Lond) 33:54-66. 2009
    ..In this review article, literatures are reviewed to summarize the evidence and possible cellular mechanisms of ATH. The directions and road blocks in the future studies are analyzed...
  55. ncbi request reprint Reciprocal modulation of Toll-like receptor-4 signaling pathways involving MyD88 and phosphatidylinositol 3-kinase/AKT by saturated and polyunsaturated fatty acids
    Joo Y Lee
    Western Human Nutrition Research Center, Agricultural Research Service, United States Department of Agriculture, Davis, California 95616, USA
    J Biol Chem 278:37041-51. 2003
    ....
  56. pmc p85alpha acts as a novel signal transducer for mediation of cellular apoptotic response to UV radiation
    Lun Song
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Mol Cell Biol 27:2713-31. 2007
    ....
  57. ncbi request reprint Botanical treatments for diabetes and obesity
    Jianping Ye
    Endocr Metab Immune Disord Drug Targets 8:77. 2008
  58. ncbi request reprint Inhibition of nuclear factor kappaB by phenolic antioxidants: interplay between antioxidant signaling and inflammatory cytokine expression
    Qiang Ma
    Receptor Biology Laboratory, Toxicology and Molecular Biology Branch, Health Effects Laboratory Division, National Institute for Occupational Safety and Health Centers for Disease Control and Prevention, Morgantown, WV 26505, USA
    Mol Pharmacol 64:211-9. 2003
    ....
  59. ncbi request reprint The regulation of the expression of inducible nitric oxide synthase by Src-family tyrosine kinases mediated through MyD88-independent signaling pathways of Toll-like receptor 4
    Joo Y Lee
    Department of Nutrition, University of California Davis, ARS, Western Human Nutrition Research Center, Meyer Hall, 95616, USA
    Biochem Pharmacol 70:1231-40. 2005
    ..These results provide new insight in understanding the role of STKs in TLR4 signaling pathways and inflammatory target gene expression...
  60. ncbi request reprint Induction or suppression of expression of cytochrome C oxidase subunit II by heregulin beta 1 in human mammary epithelial cells is dependent on the levels of ErbB2 expression
    Yanbo Sun
    Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Morgantown, West Virginia 26506 9177, USA
    J Cell Physiol 192:225-33. 2002
    ..This is the first report demonstrating that the expression of mitochondria-encoded COXII is HRG-responsive. The levels of ErbB2 expression are decisive for the diverse biological activities of HRG...
  61. ncbi request reprint Time course of pulmonary response of rats to inhalation of crystalline silica: NF-kappa B activation, inflammation, cytokine production, and damage
    Dale W Porter
    National Institute for Occupational Safety and Health, Health Effects Laboratory Division, Morgantown, West Virginia 26505, USA
    Inhal Toxicol 14:349-67. 2002
    ..This suggests that NF-kappa B activation in BAL cells may play an important role in the initiation and progression of silica-induced pulmonary inflammation, cellular damage, and fibrosis...
  62. ncbi request reprint Differential requirement of signal pathways for benzo[a]pyrene (B[a]P)-induced nitric oxide synthase (iNOS) in rat esophageal epithelial cells
    Jingyuan Chen
    Nelson Institute of Environmental Medicine, New York University School of Medicine, 57 Old Forge Road, Tuxedo, NY 10987, USA
    Carcinogenesis 26:1035-43. 2005
    ..In view of the potential role of iNOS in the development of esophageal SCC in humans, we speculate that the induction of iNOS by B[a]P may be one mechanism by which B[a]P could produce carcinogenic effects in the human esophagus...

Research Grants8

  1. Mechanism of IKK in FFA-associated Insulin Resistance
    Jianping Ye; Fiscal Year: 2004
    ..This model will benefit the development of new strategies for prevention and treatment of type 2 diabetes. ..
  2. Mechanism of IKK in FFA-associated Insulin Resistance
    Jianping Ye; Fiscal Year: 2005
    ..This model will benefit the development of new strategies for prevention and treatment of type 2 diabetes. ..
  3. Mechanism of IKK in FFA-associated Insulin Resistance
    Jianping Ye; Fiscal Year: 2006
    ..This model will benefit the development of new strategies for prevention and treatment of type 2 diabetes. ..
  4. Mechanism of IKK in FFA-associated Insulin Resistance
    Jianping Ye; Fiscal Year: 2007
    ..This model will benefit the development of new strategies for prevention and treatment of type 2 diabetes. ..
  5. Mechanism of IKK in FFA-associated Insulin Resistance
    Jianping Ye; Fiscal Year: 2009
    ..This model will benefit the development of new strategies for prevention and treatment of type 2 diabetes. ..
  6. Adipose Tissue Hypoxia and Inflammation in Obesity
    Jianping Ye; Fiscal Year: 2010
    ..In this study, we plan to identify the earlier biomarkers for diagnosis of the inflammation and insulin resistance in obese condition. ..
  7. Integration of IKK and JNK signals in Insulin Resistance
    Jianping Ye; Fiscal Year: 2010
    ..In this study, we will investigate the molecular mechanism by focusing on two molecules IKK2 and JNK1. The study will help us to understand the molecular mechanisms, and to identify new drug target for type 2 diabetes. ..