Zhong Q Wang

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. ncbi Oral chromium picolinate improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4 translocation in obese, hyperinsulinemic (JCR-LA corpulent) rats
    William T Cefalu
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA
    J Nutr 132:1107-14. 2002
  2. pmc Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice
    Zhong Q Wang
    Nutrition and Diabetes Research Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Nanomedicine 7:2999-3012. 2012
  3. pmc Gene expression profile in human skeletal muscle cells infected with human adenovirus type 36
    Zhong Q Wang
    Nutrition and Diabetes Research Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    J Med Virol 84:1254-66. 2012
  4. pmc Human adenovirus 36 decreases fatty acid oxidation and increases de novo lipogenesis in primary cultured human skeletal muscle cells by promoting Cidec/FSP27 expression
    Z Q Wang
    Diabetes and Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 34:1355-64. 2010
  5. pmc Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice
    Zhong Q Wang
    Center for the Study of Botanicals and Metabolic Syndrome, Pennington Biomedical Research Center, LSU System, Baton Rouge, LA 70808, USA
    J Nutr Biochem 22:1064-73. 2011
  6. pmc Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat diet
    Zhong Q Wang
    Pennington Biomedical Research Center, Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 56:1635-42. 2007
  7. pmc Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus
    William T Cefalu
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 59:755-62. 2010
  8. pmc An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-A(y) mice
    Zhong Q Wang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    J Nutr Biochem 22:71-8. 2011
  9. pmc Modulation of skeletal muscle insulin signaling with chronic caloric restriction in cynomolgus monkeys
    Zhong Q Wang
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Diabetes 58:1488-98. 2009
  10. pmc Bioactives of Artemisia dracunculus L enhance cellular insulin signaling in primary human skeletal muscle culture
    Zhong Q Wang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S58-64. 2008

Collaborators

Detail Information

Publications30

  1. ncbi Oral chromium picolinate improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4 translocation in obese, hyperinsulinemic (JCR-LA corpulent) rats
    William T Cefalu
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA
    J Nutr 132:1107-14. 2002
    ..Thus, CrPic supplementation enhances insulin sensitivity and glucose disappearance, and improves lipids in male obese hyperinsulinemic JCR:LA-corpulent rats...
  2. pmc Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice
    Zhong Q Wang
    Nutrition and Diabetes Research Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Nanomedicine 7:2999-3012. 2012
    ..To compare the effects of dietary fibers on hepatic cellular signaling in mice...
  3. pmc Gene expression profile in human skeletal muscle cells infected with human adenovirus type 36
    Zhong Q Wang
    Nutrition and Diabetes Research Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    J Med Virol 84:1254-66. 2012
    ..However, it remains to be investigated if HAdV-36 infection could lead to oncogenesis...
  4. pmc Human adenovirus 36 decreases fatty acid oxidation and increases de novo lipogenesis in primary cultured human skeletal muscle cells by promoting Cidec/FSP27 expression
    Z Q Wang
    Diabetes and Nutrition Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 34:1355-64. 2010
    ..However, the underlying molecular mechanism of Ad-36 inducing obesity remains unknown. We sought to investigate the effect of Ad-36 infection on Cidec, AMPK pathway and lipid metabolism in primary cultured human skeletal muscle cells...
  5. pmc Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice
    Zhong Q Wang
    Center for the Study of Botanicals and Metabolic Syndrome, Pennington Biomedical Research Center, LSU System, Baton Rouge, LA 70808, USA
    J Nutr Biochem 22:1064-73. 2011
    ..Nutritional supplementation with this extract, if validated for human studies, may offer an adjunctive therapy for diabetes...
  6. pmc Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat diet
    Zhong Q Wang
    Pennington Biomedical Research Center, Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 56:1635-42. 2007
    ....
  7. pmc Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus
    William T Cefalu
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 59:755-62. 2010
    ..Thus, modulation of lipid metabolism by Cr in peripheral tissues may represent a novel mechanism of action...
  8. pmc An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-A(y) mice
    Zhong Q Wang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    J Nutr Biochem 22:71-8. 2011
    ..PMI 5011 may modulate skeletal muscle protein degradation and phosphatase activity as a possible mode of action...
  9. pmc Modulation of skeletal muscle insulin signaling with chronic caloric restriction in cynomolgus monkeys
    Zhong Q Wang
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Diabetes 58:1488-98. 2009
    ..We sought to examine insulin receptor signaling and transcriptional alterations in skeletal muscle of nonhuman primates subjected to CR over a 4-year period...
  10. pmc Bioactives of Artemisia dracunculus L enhance cellular insulin signaling in primary human skeletal muscle culture
    Zhong Q Wang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S58-64. 2008
    ....
  11. pmc An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes
    Heather Kirk-Ballard
    Ubiquitin Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    PLoS ONE 8:e57112. 2013
    ....
  12. pmc Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway
    Zhong Q Wang
    Nutrition and Diabetes Research Laboratory, Pennington Biomedical Research Center, LSU System, Baton Rouge, LA 70808, USA
    Metabolism 62:1239-49. 2013
    ..In this regard, we sought to evaluate the effects of extracts of Artemisia santolinaefolia (SANT) and Artemisia scoparia (SCO) on hepatic lipid deposition and cellular signaling in a diet-induced obesity (DIO) animal model...
  13. pmc Human adenovirus type 36 enhances glucose uptake in diabetic and nondiabetic human skeletal muscle cells independent of insulin signaling
    Zhong Q Wang
    Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 57:1805-13. 2008
    ..Human adenovirus type 36 (Ad-36) increases adiposity but improves insulin sensitivity in experimentally infected animals. We determined the ability of Ad-36 to increase glucose uptake by human primary skeletal muscle (HSKM) cells...
  14. pmc Proteomic analysis reveals cellular pathways regulating carbohydrate metabolism that are modulated in primary human skeletal muscle culture due to treatment with bioactives from Artemisia dracunculus L
    Peter Scherp
    Protein Structural Biology, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    J Proteomics 75:3199-210. 2012
    ..These findings provide a molecular mechanism by which a botanical extract improves insulin stimulated glucose uptake, transport and metabolism at the cellular level resulting in enhanced whole body insulin sensitivity...
  15. pmc Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet
    Laura K Stewart
    Division of Experimental Obesity, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Metabolism 57:S39-46. 2008
    ..However, quercetin at the levels provided was effective in reducing circulating markers of inflammation observed in animals on an HF diet at 8W...
  16. pmc Phenotype of subjects with type 2 diabetes mellitus may determine clinical response to chromium supplementation
    Zhong Q Wang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 56:1652-5. 2007
    ..4038) (P = .0004). Subject phenotype appears to be very important when assessing the clinical response to Cr because baseline insulin sensitivity was found to account for nearly 40% of the variance in the clinical response to Cr...
  17. pmc Bioactives of Artemisia dracunculus L. mitigate the role of ceramides in attenuating insulin signaling in rat skeletal muscle cells
    Diana N Obanda
    Botanical Research Center, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 61:597-605. 2012
    ..PMI 5011 attenuates the reduction in insulin signaling induced by ceramide accumulation, but the mechanism of improved insulin signaling is independent of ceramide formation...
  18. ncbi Regulation of insulin action by an extract of Artemisia dracunculus L. in primary human skeletal muscle culture: a proteomics approach
    Indu Kheterpal
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Phytother Res 24:1278-84. 2010
    ..These data demonstrate that a well characterized botanical extract of Artemisia dracunculus L. significantly modulates proteins involved in regulating inflammatory pathways, particularly the NFkappaB complex system...
  19. pmc Skeletal muscle protein tyrosine phosphatase 1B regulates insulin sensitivity in African Americans
    April J Stull
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 61:1415-22. 2012
    ..These data show that skeletal muscle PTP1B gene expression is increased in African American subjects with T2DM, is negatively associated with whole-body insulin sensitivity, and contributes to modulation of insulin signaling...
  20. ncbi Chromium picolinate enhances skeletal muscle cellular insulin signaling in vivo in obese, insulin-resistant JCR:LA-cp rats
    Zhong Q Wang
    Pennington Biomedical Research Center, Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, LA, USA
    J Nutr 136:415-20. 2006
    ..Our data suggest that chromium supplementation of obese, insulin-resistant rats may improve insulin action by enhancing intracellular signaling...
  21. pmc An ethanolic extract of Artemisia dracunculus L. regulates gene expression of ubiquitin-proteasome system enzymes in skeletal muscle: Potential role in the treatment of sarcopenic obesity
    Heather Kirk-Ballard
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Nutrition 30:S21-5. 2014
    ..The aim of this study was to examine the effect of PMI 5011 on the ubiquitin-proteasome system, a central regulator of muscle protein degradation...
  22. doi Current concepts about chromium supplementation in type 2 diabetes and insulin resistance
    Zhong Q Wang
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Curr Diab Rep 10:145-51. 2010
    ....
  23. pmc Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol
    Z Elizabeth Floyd
    Ubiquitin Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S32-8. 2008
    ..These results indicate that the resveratrol-mediated effects in adipocytes involve regulation of PPARgamma expression and transcriptional activity along with decreased responsiveness to insulin...
  24. pmc Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, Louisiana 70808, USA
    Diabetes 54:3435-41. 2005
    ..The relations between oxidative-nitrosative stress and PARP activation in diabetes are bi- rather than unidirectional, and PARP activation cannot only result from but also lead to free radical and oxidant generation...
  25. pmc Bitter melon extract attenuating hepatic steatosis may be mediated by FGF21 and AMPK/Sirt1 signaling in mice
    Yongmei Yu
    Nutrition and Diabetes Research Laboratory, Pennington Biomedical Research Center, LSU System Baton Rouge, LA 70808
    Sci Rep 3:3142. 2013
    ..We, for the first time, demonstrated that BM extract attenuated hepatic steatosis in mice by enhancing hepatic FGF21 and AMPK/Sirt1 signaling. ..
  26. ncbi Caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): metabolic, physiologic, and atherosclerotic measures from a 4-year intervention trial
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    J Gerontol A Biol Sci Med Sci 59:1007-14. 2004
    ..Thus, further studies are needed to determine if improved insulin sensitivity might decrease arterial inflammation and improve endothelial function, despite no changes in atherosclerosis extent...
  27. ncbi Efficacy of dietary supplementation with botanicals on carbohydrate metabolism in humans
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Endocr Metab Immune Disord Drug Targets 8:78-81. 2008
    ..Thus, well defined randomized clinical trials are warranted in this area...
  28. ncbi Clinical research observations with use of exubera in patients with type 1 and 2 diabetes
    William T Cefalu
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Diabetes Technol Ther 9:S28-40. 2007
  29. ncbi Botanicals and the metabolic syndrome
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 87:481S-7S. 2008
    ..With the completion of our research, we anticipate a better understanding of the cellular mechanisms by which insulin resistance develops and the role of botanicals in modulating the progression to metabolic syndrome...
  30. ncbi Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes
    Julie Martin
    Division of Endocrinology and Metabolism, University of Vermont, Burlington, USA
    Diabetes Care 29:1826-32. 2006
    ..We sought to determine the effect of CrPic on insulin sensitivity, glycemic control, and body composition in subjects with type 2 diabetes...