S R Smith

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. ncbi request reprint The effects of triiodothyronine on bone metabolism in healthy ambulatory men
    Steven R Smith
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Thyroid 13:357-64. 2003
  2. ncbi request reprint Concurrent physical activity increases fat oxidation during the shift to a high-fat diet
    S R Smith
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 72:131-8. 2000
  3. ncbi request reprint Fat and carbohydrate balances during adaptation to a high-fat
    S R Smith
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 71:450-7. 2000
  4. ncbi request reprint A paradigm of experimentally induced mild hyperthyroidism: effects on nitrogen balance, body composition, and energy expenditure in healthy young men
    J C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    J Clin Endocrinol Metab 82:765-70. 1997
  5. ncbi request reprint Ethnic differences in dietary intakes, physical activity, and energy expenditure in middle-aged, premenopausal women: the Healthy Transitions Study
    J C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 74:90-5. 2001
  6. doi request reprint Effect of a 3-day high-fat feeding period on carbohydrate balance and ad libitum energy intake in humans
    J E Galgani
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 34:886-91. 2010
  7. ncbi request reprint Prediction of energy expenditure in a whole body indirect calorimeter at both low and high levels of physical activity
    L de Jonge
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Int J Obes Relat Metab Disord 25:929-34. 2001
  8. ncbi request reprint Low-dose T(3) improves the bed rest model of simulated weightlessness in men and women
    J C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Am J Physiol 277:E370-9. 1999
  9. ncbi request reprint Peripheral administration of human corticotropin-releasing hormone: a novel method to increase energy expenditure and fat oxidation in man
    S R Smith
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 86:1991-8. 2001
  10. ncbi request reprint Relationship of dietary fat and serum cholesterol ester and phospholipid fatty acids to markers of insulin resistance in men and women with a range of glucose tolerance
    J C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808-4124, USA
    Metabolism 50:86-92. 2001

Collaborators

Detail Information

Publications88

  1. ncbi request reprint The effects of triiodothyronine on bone metabolism in healthy ambulatory men
    Steven R Smith
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Thyroid 13:357-64. 2003
    ..4% (p = 0.08). Bone mineral density showed no change. We conclude that T(3) accelerates bone turnover and that bone formation does not increase acutely to prevent bone loss...
  2. ncbi request reprint Concurrent physical activity increases fat oxidation during the shift to a high-fat diet
    S R Smith
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 72:131-8. 2000
    ..We hypothesized that concurrent physical activity would accelerate fat oxidation during an isoenergetic high-fat diet...
  3. ncbi request reprint Fat and carbohydrate balances during adaptation to a high-fat
    S R Smith
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 71:450-7. 2000
    ..Failure to compensate for the positive fat balance that occurs during the shift to a high-fat, low-carbohydrate diet by increasing energy expenditure or by decreasing food intake may result in the gain of fat mass...
  4. ncbi request reprint A paradigm of experimentally induced mild hyperthyroidism: effects on nitrogen balance, body composition, and energy expenditure in healthy young men
    J C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    J Clin Endocrinol Metab 82:765-70. 1997
    ..We conclude that although healthy men are able to adapt to mild hyperthyroidism in terms of nitrogen balance, they exhibit significant and persistent changes in fat and fat-free mass as well as energy balance...
  5. ncbi request reprint Ethnic differences in dietary intakes, physical activity, and energy expenditure in middle-aged, premenopausal women: the Healthy Transitions Study
    J C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 74:90-5. 2001
    ..Menopause is a time of increased risk of obesity in women. The effect of menopause in African American women, in whom obesity is already highly prevalent, is unknown...
  6. doi request reprint Effect of a 3-day high-fat feeding period on carbohydrate balance and ad libitum energy intake in humans
    J E Galgani
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 34:886-91. 2010
    ..We assessed the effect of an isoenergetic switch from a 49%-carbohydrate to 50%-fat diet on nutrient balance and ad libitum food intake. We hypothesized that carbohydrate balance would be inversely related to ad libitum energy intake...
  7. ncbi request reprint Prediction of energy expenditure in a whole body indirect calorimeter at both low and high levels of physical activity
    L de Jonge
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Int J Obes Relat Metab Disord 25:929-34. 2001
    ..The objective of this study was to develop a method for predicting an individual's 24 h EE in a room calorimeter at both low (1.4xRMR) and high (1.8xRMR) levels of physical activity...
  8. ncbi request reprint Low-dose T(3) improves the bed rest model of simulated weightlessness in men and women
    J C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Am J Physiol 277:E370-9. 1999
    ..In conclusion, addition of low-dose T(3) to the bed rest model of muscle unloading improves the ground-based simulation of spaceflight and unmasks several important gender differences...
  9. ncbi request reprint Peripheral administration of human corticotropin-releasing hormone: a novel method to increase energy expenditure and fat oxidation in man
    S R Smith
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 86:1991-8. 2001
    ..Peripheral CRH administration offers a novel strategy to increase energy expenditure...
  10. ncbi request reprint Relationship of dietary fat and serum cholesterol ester and phospholipid fatty acids to markers of insulin resistance in men and women with a range of glucose tolerance
    J C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808-4124, USA
    Metabolism 50:86-92. 2001
    ..Furthermore, enhancement of dihomo-gamma-linolenic and myristic acids in serum CE and PL, presumably markers for dietary intake, predicted insulin resistance...
  11. ncbi request reprint Effect of pioglitazone on body composition and bone density in subjects with prediabetes in the ACT NOW trial
    G A Bray
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Diabetes Obes Metab 15:931-7. 2013
    ....
  12. pmc Effect of diet composition on energy expenditure during weight loss: the POUNDS LOST Study
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 36:448-55. 2012
    ..Hypothesis: We tested the hypothesis that macronutrient composition of the diet might affect the partitioning of energy expenditure during weight loss...
  13. pmc Subtyping obesity with microarrays: implications for the diagnosis and treatment of obesity
    S Wang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 33:481-9. 2009
    ..We aimed to separate obese subjects into distinct subgroups using microarray technology to identify gene expression-based subgroups to predict weight loss...
  14. pmc Increased visceral fat and decreased energy expenditure during the menopausal transition
    J C Lovejoy
    Department of Molecular Endocrinology, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 32:949-58. 2008
    ..We hypothesized that total fat and abdominal body fat would increase at menopause due to decreased energy expenditure (EE) and declining estrogen, respectively...
  15. ncbi request reprint Testosterone administration preserves protein balance but not muscle strength during 28 days of bed rest
    J J Zachwieja
    Exercise and Nutrition Program and Inpatient Clinical Trials Unit, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    J Clin Endocrinol Metab 84:207-12. 1999
    ..These results suggest that in the absence of daily ambulatory activity, T administration will not increase or, in the case of this bed rest model, preserve muscle strength...
  16. ncbi request reprint Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity
    S R Smith
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Metabolism 50:425-35. 2001
    ..375). These data suggest that total body fat is a major contributor to the metabolic sequelae of obesity, with specific fat depots, VAT, and DSAT also making significant contributions...
  17. pmc Effect of valproic acid on body weight, food intake, physical activity and hormones: results of a randomized controlled trial
    C K Martin
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    J Psychopharmacol 23:814-25. 2009
    ..Research testing VPA on short-term (1 week) EI, metabolism, and substrate partitioning is warranted...
  18. ncbi request reprint Pharmaceutical cost savings of treating obesity with weight loss medications
    F L Greenway
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Obes Res 7:523-31. 1999
    ....
  19. ncbi request reprint Consumption of a controlled low-fat diet containing olestra for 9 months improves health risk factors in conjunction with weight loss in obese men: the Ole' Study
    J C Lovejoy
    Pennington Biomedical Research Center, Baton Rouge, LA70808, USA
    Int J Obes Relat Metab Disord 27:1242-9. 2003
    ..To compare the effects of a standard American diet, a traditional low-fat diet, and a low-fat diet containing the fat substitute olestra on risk factors for heart disease and diabetes...
  20. ncbi request reprint Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects
    L K Heilbronn
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 89:1844-8. 2004
    ....
  21. ncbi request reprint Plasma myostatin-immunoreactive protein is increased after prolonged bed rest with low-dose T3 administration
    J J Zachwieja
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Gravit Physiol 6:11-5. 1999
    ..01) than measured at baseline. These data support the idea that myostatin regulates muscle growth in humans and that it may be a novel target for interventions aiming to reduce space flight induced muscle atrophy...
  22. pmc Pioglitazone treatment in type 2 diabetes mellitus when combined with portion control diet modifies the metabolic syndrome
    A K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Diabetes Obes Metab 11:330-7. 2009
    ..Treatment with thiazolidinediones (TZDs) produces weight gain...
  23. ncbi request reprint Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus
    L Heilbronn
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Int J Obes Relat Metab Disord 28:S12-21. 2004
    ..This hypothesis proposes that increased adiposity, particularly in the visceral depots, leads to increased free-fatty acid flux and inhibition of insulin-action via Randle's effect in insulin-sensitive tissues...
  24. ncbi request reprint Reliability and validity of a macronutrient self-selection paradigm and a food preference questionnaire
    P J Geiselman
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808 4124, USA
    Physiol Behav 63:919-28. 1998
    ..In addition, this paradigm detected a large range of sugar and total caloric intake. It is anticipated that the use of these laboratory tools can enhance our understanding of the relationship between dietary fat intake and obesity...
  25. ncbi request reprint Chamber for indirect calorimetry with accurate measurement and time discrimination of metabolic plateaus of over 20 min
    T Nguyen
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Med Biol Eng Comput 41:572-8. 2003
    ..81 min (-1) and 0.01 min). The successful integration of the algorithm into the Pennington chambers allows for traditional 24 h energy expenditure measurements and various metabolic experiments requiring rapid responses...
  26. ncbi request reprint A rare mutation in AgRP, +79G>A, affects promoter activity
    M A Sözen
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Eur J Clin Nutr 61:809-12. 2007
    ....
  27. pmc Assessment of EchoMRI-AH versus dual-energy X-ray absorptiometry to measure human body composition
    J E Galgani
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 35:1241-6. 2011
    ..We compared EchoMRI-AH and dual-energy X-ray absorptiometry (DXA) (Hologic QDR-4500A) for estimating fat mass in 301 volunteers...
  28. ncbi request reprint Voluntary wheel running decreases adipose tissue mass and expression of leptin mRNA in Osborne-Mendel rats
    J J Zachwieja
    Exercise and Nutrition Program, Pennington Biomedical Research Center at Louisiana State University, Baton Rouge 70808, USA
    Diabetes 46:1159-66. 1997
    ..e., reduced expression and secretion of protein) can occur independently of changes in whole-body insulin sensitivity and susceptibility to diet-induced obesity...
  29. ncbi request reprint The insulin-sensitizing role of the fat derived hormone adiponectin
    L K Heilbronn
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Curr Pharm Des 9:1411-8. 2003
    ....
  30. ncbi request reprint The future of obesity research
    F L Greenway
    Outpatient Clinic, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Nutrition 16:976-82. 2000
    ..Due to the availability of molecular approaches, obesity treatment is expected to advance faster than chronic disease research of the past...
  31. doi request reprint Combination therapy with naltrexone and bupropion for obesity reduces total and visceral adiposity
    S R Smith
    Translational Research Institute for Metabolism and Diabetes, Florida Hospital Burnham Institute, Winter Park, FL 32789, USA
    Diabetes Obes Metab 15:863-6. 2013
    ..Reductions in body fat and VAT mass with naltrexone/bupropion were proportional with weight loss. Weight loss with naltrexone/bupropion was not associated with a greater relative reduction in lean mass than placebo or the monotherapies. ..
  32. ncbi request reprint A leptin dose-response study in obese (ob/ob) and lean (+/?) mice
    R B Harris
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Endocrinology 139:8-19. 1998
    ..This study shows enhanced leptin sensitivity in ob/ob mice and suggests that increased temperature and sympathetic activity are indirect responses to high concentrations of protein...
  33. pmc Expression profile of mRNAs encoding core circadian regulatory proteins in human subcutaneous adipose tissue: correlation with age and body mass index
    X Wu
    Stem Cell Biology Laboratory, Molecular Endocrinology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 33:971-7. 2009
    ..This study set out to examine the expression of CCRP mRNAs in human subcutaneous adipose tissues...
  34. ncbi request reprint Effect of growth hormone on body composition and visceral adiposity in middle-aged men with visceral obesity
    Magdalena Pasarica
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 92:4265-70. 2007
    ..GH replacement in GH-deficient adults results in an improvement in metabolic status. GH might also decrease visceral adiposity in obese adults that are not GH deficient...
  35. ncbi request reprint Hormonal responses to a fast-food meal compared with nutritionally comparable meals of different composition
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Ann Nutr Metab 51:163-71. 2007
    ..Fast food is consumed in large quantities each day. Whether there are differences in the acute metabolic response to these meals as compared to 'healthy' meals with similar composition is unknown...
  36. ncbi request reprint Pramlintide treatment reduces 24-h caloric intake and meal sizes and improves control of eating in obese subjects: a 6-wk translational research study
    Steven R Smith
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Am J Physiol Endocrinol Metab 293:E620-7. 2007
    ....
  37. ncbi request reprint Adipose tissue distribution in relation to insulin resistance in type 2 diabetes mellitus
    Koichiro Azuma
    Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 15213, USA
    Am J Physiol Endocrinol Metab 293:E435-42. 2007
    ..In summary, T2DM, compared with similarly obese nondiabetic men and women, is associated with less leg FM and greater trunk FM and hepatic fat...
  38. ncbi request reprint The effect of beta-adrenergic and peroxisome proliferator-activated receptor-gamma stimulation on target genes related to lipid metabolism in human subcutaneous adipose tissue
    Iwona Bogacka
    Molecular Endocrinology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes Care 30:1179-86. 2007
    ....
  39. pmc Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
    Anthony E Civitarese
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America
    PLoS Med 4:e76. 2007
    ..However, the mechanism responsible for this adaptation are poorly understood...
  40. ncbi request reprint Family history of diabetes links impaired substrate switching and reduced mitochondrial content in skeletal muscle
    Barbara Ukropcova
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Diabetes 56:720-7. 2007
    ....
  41. pmc Effect of calorie restriction with or without exercise on body composition and fat distribution
    Leanne M Redman
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 92:865-72. 2007
    ..There is debate over the independent and combined effects of dieting and increased physical activity on improving metabolic risk factors (body composition and fat distribution)...
  42. pmc Unsupervised clustering of gene expression data points at hypoxia as possible trigger for metabolic syndrome
    Andrey Ptitsyn
    Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA
    BMC Genomics 7:318. 2006
    ..Classification of large volumes of data produced in a microarray experiment allows for the extraction of important clues as to the nature of a disease...
  43. pmc Calorie restriction and bone health in young, overweight individuals
    Leanne M Redman
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Arch Intern Med 168:1859-66. 2008
    ..Calorie restriction (CR) is promoted to increase longevity, yet this regimen could lead to bone loss and fracture and therefore affect quality of life...
  44. pmc Adipose tissue lipin-1 expression is correlated with peroxisome proliferator-activated receptor alpha gene expression and insulin sensitivity in healthy young men
    Jimmy Donkor
    University of California, Department of Human Genetics, 6506A Gonda, 695 Charles E Young Drive South, Los Angeles, California 90095, USA
    J Clin Endocrinol Metab 93:233-9. 2008
    ..Lipin-1 functions in adipocyte triglyceride biosynthesis and in the regulation of gene expression, both of which may influence metabolic homeostasis...
  45. pmc Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function
    D Enette Larson-Meyer
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 16:1355-62. 2008
    ....
  46. pmc Effect of dietary fat on serum and intramyocellular lipids and running performance
    D Enette Larson-Meyer
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Med Sci Sports Exerc 40:892-902. 2008
    ..This study evaluated whether lowering IMCL stores via 3-d consumption of very-low-fat (LFAT) diet impairs endurance performance relative to a moderate-fat diet (MFAT), and whether such a diet unfavorably alters lipid profiles...
  47. pmc Metabolic flexibility in response to glucose is not impaired in people with type 2 diabetes after controlling for glucose disposal rate
    Jose E Galgani
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 57:841-5. 2008
    ....
  48. ncbi request reprint Increased fat accumulation in liver may link insulin resistance with subcutaneous abdominal adipocyte enlargement, visceral adiposity, and hypoadiponectinemia in obese individuals
    Juraj Koska
    Obesity and Diabetes Clinical Research Section, NIDDK NIH DHHS, Phoenix, AZ 85016, USA
    Am J Clin Nutr 87:295-302. 2008
    ....
  49. doi request reprint Effect of calorie restriction on resting metabolic rate and spontaneous physical activity
    Corby K Martin
    Department of Health Psychology, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 15:2964-73. 2007
    ..Additionally, it is unknown if changes in SPA, measured in a respiratory chamber, reflect changes in free-living physical activity level (PAL)...
  50. pmc Potential role of increased matrix metalloproteinase-2 (MMP2) transcription in impaired adipogenesis in type 2 diabetes mellitus
    Severine G Dubois
    Health and Performance Enhancement Division, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Biochem Biophys Res Commun 367:725-8. 2008
    ..32, p=0.03). We conclude that early steps of adipogenesis may be impaired in T2DM independently of obesity due, in part, to an upregulation of the MMP2 transcription...
  51. ncbi request reprint Diet, energy metabolism and mitochondrial biogenesis
    Anthony E Civitarese
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Curr Opin Clin Nutr Metab Care 10:679-87. 2007
    ..This review highlights some recent findings regarding nutritional and endocrine regulators of mitochondrial mass and function and their association with insulin resistance...
  52. pmc Role of adiponectin and inflammation in insulin resistance of Mc3r and Mc4r knockout mice
    James L Trevaskis
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisana 70808, USA
    Obesity (Silver Spring) 15:2664-72. 2007
    ..To investigate the involvement of hypoadiponectinemia and inflammation in coupling obesity to insulin resistance in melanocortin-3 receptor and melanocortin-4 receptor knockout (KO) mice (Mc3/4rKO)...
  53. ncbi request reprint Determinants of intramyocellular triglyceride turnover: implications for insulin sensitivity
    Cedric Moro
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 294:E203-13. 2008
    ..Further studies are clearly required to better understand the relationship between the rate of turnover of IMTG and the accumulation of lipotoxic intermediates in the pathophysiology of insulin resistance...
  54. ncbi request reprint Lack of an effect of a novel beta3-adrenoceptor agonist, TAK-677, on energy metabolism in obese individuals: a double-blind, placebo-controlled randomized study
    Leanne M Redman
    Pennington Biomedical Research Center, Louisiana 70808, USA
    J Clin Endocrinol Metab 92:527-31. 2007
    ..Our objective was to test the safety and metabolic effects of a novel beta(3)-adrenoreceptor agonist (TAK-677) in humans...
  55. ncbi request reprint High-fat/low-carbohydrate diets regulate glucose metabolism via a long-term transcriptional loop
    Lauren M Sparks
    Department of Biological Sciences, Louisiana State University and Agricultural and Mechanical College, Baton Rouge, LA, USA
    Metabolism 55:1457-63. 2006
    ..Combined, these results suggest a mechanism whereby HF/LCD regulates the genes necessary for glucose utilization and storage vis-á-vis transcriptional control...
  56. ncbi request reprint Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 81:69-73. 2005
    ..Prolonged dietary restriction increases the life span in rodents. Some evidence suggests that alternate-day fasting may also prolong the life span...
  57. ncbi request reprint Effect of pioglitazone on body composition and energy expenditure: a randomized controlled trial
    Steven R Smith
    Department of Molecular Endocrinology, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Metabolism 54:24-32. 2005
    ..Some, but not all, studies demonstrate reductions in visceral adipose tissue. Changes in body weight are the result of changes in energy intake, energy expenditure, or both...
  58. ncbi request reprint Metabolic syndrome targets
    Steven R Smith
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Curr Drug Targets CNS Neurol Disord 3:431-9. 2004
    ..The advantages and pitfalls of these targets will be discussed with an eye towards the relevant literature...
  59. ncbi request reprint Effect of a dietary herbal supplement containing caffeine and ephedra on weight, metabolic rate, and body composition
    Frank L Greenway
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Obes Res 12:1152-7. 2004
    ..To evaluate the effect of a dietary supplement containing herbal caffeine (70 mg/dose) and ephedra (24 mg/dose; C&E) on metabolic rate, weight loss, body composition, and safety parameters...
  60. ncbi request reprint The effect of pioglitazone on peroxisome proliferator-activated receptor-gamma target genes related to lipid storage in vivo
    Iwona Bogacka
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Diabetes Care 27:1660-7. 2004
    ..The aim of this study was to define the effect of pioglitazone on the expression of genes related to carbohydrate and lipid metabolism in subcutaneous fat obtained from type 2 diabetic patients...
  61. ncbi request reprint Agouti expression in human adipose tissue: functional consequences and increased expression in type 2 diabetes
    Steven R Smith
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Diabetes 52:2914-22. 2003
    ..The influence of MCR signaling on adipogenesis combined with the well-established role of MCR signaling in the hypothalamus suggest that adipogenesis is coordinately regulated with food intake and energy expenditure...
  62. ncbi request reprint Effects of tyrosine, phentermine, caffeine D-amphetamine, and placebo on cognitive and motor performance deficits during sleep deprivation
    Richard A Magill
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Nutr Neurosci 6:237-46. 2003
    ..As a naturally occurring amino acid, and thus amenable to nutritional strategies, tyrosine may deserve further testing...
  63. ncbi request reprint A comparison of tyrosine against placebo, phentermine, caffeine, and D-amphetamine during sleep deprivation
    William F Waters
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Nutr Neurosci 6:221-35. 2003
    ..Tyrosine (when compared to placebo) had no effect on any sleep related measure, but it did stimulate prolactin release...
  64. ncbi request reprint Emerging paradigms for understanding fatness and diabetes risk
    Steven R Smith
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Curr Diab Rep 2:223-30. 2002
    ..Recent data do not entirely support this hypothesis. As such, two new paradigms have emerged that may explain the established links between adiposity and disease...
  65. ncbi request reprint Human mesenchymal stem cells as an in vitro model for human adipogenesis
    Lenka Janderová
    Pennington Biomedical Research Center 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Obes Res 11:65-74. 2003
    ....
  66. ncbi request reprint A 9-mo randomized clinical trial comparing fat-substituted and fat-reduced diets in healthy obese men: the Ole Study
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 76:928-34. 2002
    ..Dietary fat has been implicated as a risk factor for cardiovascular disease and obesity...
  67. ncbi request reprint The influence of different fats and fatty acids on obesity, insulin resistance and inflammation
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Nutr 132:2488-91. 2002
    ..One important conclusion from this review is that both total fat and individual fatty acids have to be considered when reaching conclusions about dietary fat and obesity...
  68. ncbi request reprint Effects of diets enriched in saturated (palmitic), monounsaturated (oleic), or trans (elaidic) fatty acids on insulin sensitivity and substrate oxidation in healthy adults
    Jennifer C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Diabetes Care 25:1283-8. 2002
    ..Diets high in total and saturated fat are associated with insulin resistance. This study examined the effects of feeding monounsaturated, saturated, and trans fatty acids on insulin action in healthy adults...
  69. ncbi request reprint Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus
    Eric Ravussin
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Ann N Y Acad Sci 967:363-78. 2002
    ..These two new paradigms provide a framework to advance our understanding of the pathophysiology of the insulin-resistance syndrome...
  70. ncbi request reprint Genetic and physiological factors in obesity
    Steven R Smith
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    J La State Med Soc 157:S12-8. 2005
    ..As we better understand the environmental, genetic, physiological, and behavioral aspects of obesity, we will undoubtedly develop better strategies and therapies for obesity...
  71. ncbi request reprint Glucose tolerance and skeletal muscle gene expression in response to alternate day fasting
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obes Res 13:574-81. 2005
    ..The aim of this study was to examine the effects of 3 weeks of alternate day fasting on glucose tolerance and skeletal muscle expression of genes involved in fatty acid transport/oxidation, mitochondrial biogenesis, and stress response...
  72. pmc Decreased expression of adipogenic genes in obese subjects with type 2 diabetes
    Severine G Dubois
    Health and Performance Enhancement Division, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 14:1543-52. 2006
    ..The inability of the adipose tissue to recruit new fat cells may cause ectopic fat deposition and insulin resistance...
  73. ncbi request reprint Importance of diagnosing and treating the metabolic syndrome in reducing cardiovascular risk
    Steven R Smith
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 14:128S-134S. 2006
    ..Further research is needed to define the etiology of the metabolic syndrome...
  74. ncbi request reprint Free fatty acids and atherosclerosis--guilty or innocent?
    Steven R Smith
    J Clin Endocrinol Metab 91:2506-8. 2006
  75. pmc Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects
    D Enette Larson-Meyer
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Diabetes Care 29:1337-44. 2006
    ....
  76. pmc Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    JAMA 295:1539-48. 2006
    ..Whether prolonged calorie restriction affects biomarkers of longevity or markers of oxidative stress, or reduces metabolic rate beyond that expected from reduced metabolic mass, has not been investigated in humans...
  77. pmc Muscle-associated triglyceride measured by computed tomography and magnetic resonance spectroscopy
    D Enette Larson-Meyer
    Department of Family and Consumer Sciences Human Nutrition, Department 3354, College of Agriculture, 1000 East University Avenue, Laramie, WY 82071, USA
    Obesity (Silver Spring) 14:73-87. 2006
    ..Little is known, however, about the cross-correlation between these techniques and their test-retest reliability...
  78. ncbi request reprint Energy restriction lowers the expression of genes linked to inflammation, the cytoskeleton, the extracellular matrix, and angiogenesis in mouse adipose tissue
    Yoshikazu Higami
    Department of Pathology and Gerontology, Nagasaki University Graduate School of Biomedical Science, Nagasaki 852 8523, Japan
    J Nutr 136:343-52. 2006
    ..These alterations may play an important role in the protection against WAT-derived inflammation and in lifespan extension by LER...
  79. ncbi request reprint The Hurricane Katrina aftermath and its impact on diabetes care: observations from "ground zero": lessons in disaster preparedness of people with diabetes
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, Louisiana 70808, USA
    Diabetes Care 29:158-60. 2006
  80. pmc Combining beta-adrenergic and peroxisome proliferator-activated receptor gamma stimulation improves lipoprotein composition in healthy moderately obese subjects
    Thomas A Hughes
    Health Science Center, Department of Medicine, University of Tennessee, Memphis, TN 38163, USA
    Metabolism 55:26-34. 2006
    ..Because LpA-I appears to be the most efficient mediator of reverse-cholesterol transport and a major negative risk factor for cardiovascular disease, this combination therapy may provide very effective treatment of atherosclerosis...
  81. ncbi request reprint Comparison of the acute response to meals enriched with cis- or trans-fatty acids on glucose and lipids in overweight individuals with differing FABP2 genotypes
    Michael Lefevre
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Metabolism 54:1652-8. 2005
    ....
  82. ncbi request reprint Structural and functional consequences of mitochondrial biogenesis in human adipocytes in vitro
    Iwona Bogacka
    Pennington Biomedical Research Center, Department of Molecular Endocrinology, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 90:6650-6. 2005
    ..The aim of the study was to explore pathways affecting mitochondrial biogenesis and fatty acid oxidation (FAO) in human white adipocytes...
  83. pmc Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor
    Barbara Ukropcova
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Clin Invest 115:1934-41. 2005
    ..The interindividual variability in metabolic phenotypes was preserved in human myotubes separated from their neuroendocrine environment, which supports the hypothesis that metabolic switching is an intrinsic property of skeletal muscle...
  84. ncbi request reprint A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle
    Lauren M Sparks
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Diabetes 54:1926-33. 2005
    ..These changes mimic those observed in diabetes and insulin resistance and, if sustained, may result in mitochondrial dysfunction in the prediabetic/insulin-resistant state...
  85. ncbi request reprint Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo
    Iwona Bogacka
    Molecular Endocrinology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA, USA
    Diabetes 54:1392-9. 2005
    ..Finally, the increased mitochondrial copy number and the higher expression of genes involved in fatty acid oxidation in human adipocytes may contribute to the hypolipidemic effects of pioglitazone...
  86. ncbi request reprint Triglyceride concentrations and endotoxemia
    Jennifer Rood
    Am J Clin Nutr 88:248-9; author reply 249-50. 2008
  87. ncbi request reprint Neuropsychological and emotional changes during simulated microgravity: effects of triiodothyronine alendronate, and testosterone
    Wm Drew Gouvier
    Department of Psychology, Louisiana State University, Baton Rouge, LA 70803, USA
    Arch Clin Neuropsychol 19:153-63. 2004
    ..Resultant data were subjected to repeated measures, between groups analysis of variance testing for all 82 neurocognitive and psychological test measures...
  88. ncbi request reprint Exploring the validity of the comprehensive trail making test
    Steven R Smith
    Department of Counselling, Clinical, and School Psychology, University of California, Santa Barbara, CA 93106 9490, USA
    Clin Neuropsychol 22:507-18. 2008
    ..Overall, although further research is needed, results tentatively suggest that the CTMT may be a useful addition to a multifaceted neuropsychological test battery...