Eric Ravussin

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. pmc Effect of short-term thyroxine administration on energy metabolism and mitochondrial efficiency in humans
    Darcy L Johannsen
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America
    PLoS ONE 7:e40837. 2012
  2. pmc Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss
    Leanne M Redman
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America
    PLoS ONE 4:e4377. 2009
  3. pmc Prevalence, awareness and control of diabetes in the Seychelles and relationship with excess body weight
    David Faeh
    University Institute for Social and Preventive Medicine IUMSP, Lausanne, Switzerland
    BMC Public Health 7:163. 2007
  4. ncbi request reprint Human genomics and obesity: finding appropriate drug targets
    E Ravussin
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Eur J Pharmacol 410:131-145. 2000
  5. ncbi request reprint Have we entered the brown adipose tissue renaissance?
    E Ravussin
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obes Rev 10:265-8. 2009
  6. pmc Ectopic lipid accumulation and reduced glucose tolerance in elderly adults are accompanied by altered skeletal muscle mitochondrial activity
    Darcy L Johannsen
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 97:242-50. 2012
  7. ncbi request reprint Lipids and insulin resistance: what we've learned at the Fourth International Smolenice Symposium
    E Ravussin
    Pennington Biomedical Research Center, Department of Health and Performance Enhancement, Baton Rouge, Louisiana 70808 4124, USA
    Ann N Y Acad Sci 967:576-80. 2002
  8. ncbi request reprint Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus
    Eric Ravussin
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Ann N Y Acad Sci 967:363-78. 2002
  9. pmc Cellular sensors of feast and famine
    Eric Ravussin
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808 4124, USA
    J Clin Invest 109:1537-40. 2002
  10. ncbi request reprint Physiology. A NEAT way to control weight?
    Eric Ravussin
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Science 307:530-1. 2005

Detail Information

Publications118 found, 100 shown here

  1. pmc Effect of short-term thyroxine administration on energy metabolism and mitochondrial efficiency in humans
    Darcy L Johannsen
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America
    PLoS ONE 7:e40837. 2012
    ..Our findings may be clinically relevant given the expanding application of T4 to treat non-thyroidal conditions such as obesity and weight loss...
  2. pmc Metabolic and behavioral compensations in response to caloric restriction: implications for the maintenance of weight loss
    Leanne M Redman
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America
    PLoS ONE 4:e4377. 2009
    ..Metabolic and behavioral adaptations to caloric restriction (CR) in free-living conditions have not yet been objectively measured...
  3. pmc Prevalence, awareness and control of diabetes in the Seychelles and relationship with excess body weight
    David Faeh
    University Institute for Social and Preventive Medicine IUMSP, Lausanne, Switzerland
    BMC Public Health 7:163. 2007
    ..We assessed the prevalence, awareness and control of diabetes (DM) in the Seychelles, a rapidly developing country in the African region. We also examined the relationship between body mass index, fasting serum insulin and DM...
  4. ncbi request reprint Human genomics and obesity: finding appropriate drug targets
    E Ravussin
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Eur J Pharmacol 410:131-145. 2000
    ....
  5. ncbi request reprint Have we entered the brown adipose tissue renaissance?
    E Ravussin
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obes Rev 10:265-8. 2009
    ..These recent discoveries should revamp our effort to target the molecular development of brown adipogenesis in the treatment of obesity...
  6. pmc Ectopic lipid accumulation and reduced glucose tolerance in elderly adults are accompanied by altered skeletal muscle mitochondrial activity
    Darcy L Johannsen
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 97:242-50. 2012
    ..Recent studies suggest that skeletal muscle mitochondrial activity may underlie some age-associated metabolic abnormalities...
  7. ncbi request reprint Lipids and insulin resistance: what we've learned at the Fourth International Smolenice Symposium
    E Ravussin
    Pennington Biomedical Research Center, Department of Health and Performance Enhancement, Baton Rouge, Louisiana 70808 4124, USA
    Ann N Y Acad Sci 967:576-80. 2002
    ..Highlights and issues of the conference are mentioned, as well as strategies for the future...
  8. ncbi request reprint Increased fat intake, impaired fat oxidation, and failure of fat cell proliferation result in ectopic fat storage, insulin resistance, and type 2 diabetes mellitus
    Eric Ravussin
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Ann N Y Acad Sci 967:363-78. 2002
    ..These two new paradigms provide a framework to advance our understanding of the pathophysiology of the insulin-resistance syndrome...
  9. pmc Cellular sensors of feast and famine
    Eric Ravussin
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808 4124, USA
    J Clin Invest 109:1537-40. 2002
  10. ncbi request reprint Physiology. A NEAT way to control weight?
    Eric Ravussin
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Science 307:530-1. 2005
  11. pmc Reduced oxygenation in human obese adipose tissue is associated with impaired insulin suppression of lipolysis
    Magdalena Pasarica
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 95:4052-5. 2010
    ..Adipose tissue in obese individuals is characterized by reduced capillary density and reduced oxygenation...
  12. doi request reprint Consistency of fat mass--fat-free mass relationship across ethnicity and sex groups
    Stephanie T Broyles
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Br J Nutr 105:1272-6. 2011
    ..In conclusion, results from our large, biethnic sample of men and women found a FM-FFM relationship very close to that originally described by Forbes, absent of significant variability by ethnicity or sex...
  13. doi request reprint Effect of calorie restriction on resting metabolic rate and spontaneous physical activity
    Corby K Martin
    Department of Health Psychology, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 15:2964-73. 2007
    ..Additionally, it is unknown if changes in SPA, measured in a respiratory chamber, reflect changes in free-living physical activity level (PAL)...
  14. pmc Metabolic flexibility in response to glucose is not impaired in people with type 2 diabetes after controlling for glucose disposal rate
    Jose E Galgani
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 57:841-5. 2008
    ....
  15. ncbi request reprint Determinants of sedentary 24-h energy expenditure: equations for energy prescription and adjustment in a respiratory chamber
    Yan Y Lam
    Pennington Biomedical Research Center, Baton Rouge, LA YYL, LMR, GAB, FLG, DJ, and ER, and Florida Hospital and Sanford Burnham Translational Research Institute, Orlando, FL SRS
    Am J Clin Nutr 99:834-42. 2014
    ..However, 24-h energy expenditure (24EE) predictions based on estimated resting metabolic rate and physical activity level are often inaccurate and imprecise...
  16. pmc Regulation of skeletal muscle oxidative capacity and insulin signaling by the mitochondrial rhomboid protease PARL
    Anthony E Civitarese
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Cell Metab 11:412-26. 2010
    ..We propose that lower PARL expression may contribute to the mitochondrial abnormalities seen in aging and T2DM...
  17. pmc Lorcaserin, a 5-HT(2C) receptor agonist, reduces body weight by decreasing energy intake without influencing energy expenditure
    Corby K Martin
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 96:837-45. 2011
    ..Lorcaserin, a selective 5-hydroxytryptamine (5-HT)(2C) receptor agonist, reduces body weight. It is unclear whether weight loss is due to reduced energy intake (EI) or also to enhanced energy expenditure (EE)...
  18. doi request reprint Ethnic-specific BMI and waist circumference thresholds
    Peter T Katzmarzyk
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 19:1272-8. 2011
    ..There are no apparent ethnic differences in men; however, in AA women the optimal BMI and WC values are ~3 kg/m2 and 5 cm higher than in white women...
  19. pmc Adipose tissue collagen VI in obesity
    Magdalena Pasarica
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 94:5155-62. 2009
    ..We hypothesized in humans that increased collagen VI alpha3-subunit (COL6A3) mRNA is associated with adipose tissue macrophage chemotaxis and inflammation and that weight gain is accompanied by changes in the expression of COL6A3...
  20. pmc Effect of calorie restriction with or without exercise on insulin sensitivity, beta-cell function, fat cell size, and ectopic lipid in overweight subjects
    D Enette Larson-Meyer
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Diabetes Care 29:1337-44. 2006
    ....
  21. doi request reprint Racial differences in abdominal depot-specific adiposity in white and African American adults
    Peter T Katzmarzyk
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808 4124, USA
    Am J Clin Nutr 91:7-15. 2010
    ..There is increasing interest in understanding racial differences in adiposity in specific body depots as a way to explain differential health risks associated with obesity...
  22. pmc Trunk versus extremity adiposity and cardiometabolic risk factors in white and African American adults
    Gang Hu
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Diabetes Care 34:1415-8. 2011
    ..To determine contributions of trunk and extremity adiposity to cardiometabolic risk factors (blood pressure, fasting blood glucose, HDL cholesterol, and triglycerides) among white and African American adults...
  23. pmc Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function
    D Enette Larson-Meyer
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 16:1355-62. 2008
    ....
  24. doi request reprint Impaired insulin sensitivity and elevated ectopic fat in healthy obese vs. nonobese prepubertal children
    Brian Bennett
    School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Obesity (Silver Spring) 20:371-5. 2012
    ..nonobese children prior to puberty. Excessive adiposity during early development appears concomitant with precursors of type 2 diabetes and the metabolic syndrome...
  25. pmc Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    JAMA 295:1539-48. 2006
    ..Whether prolonged calorie restriction affects biomarkers of longevity or markers of oxidative stress, or reduces metabolic rate beyond that expected from reduced metabolic mass, has not been investigated in humans...
  26. pmc Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
    Anthony E Civitarese
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America
    PLoS Med 4:e76. 2007
    ..However, the mechanism responsible for this adaptation are poorly understood...
  27. pmc Calorie restriction and bone health in young, overweight individuals
    Leanne M Redman
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Arch Intern Med 168:1859-66. 2008
    ..Calorie restriction (CR) is promoted to increase longevity, yet this regimen could lead to bone loss and fracture and therefore affect quality of life...
  28. ncbi request reprint Empirical evaluation of the ability to learn a calorie counting system and estimate portion size and food intake
    Corby K Martin
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Br J Nutr 98:439-44. 2007
    ..It is concluded that people can learn the HMR Calorie System and improve the accuracy of portion size and food intake estimates. The PACE is a useful assessment tool to test if participants learn a calorie counting system...
  29. ncbi request reprint Differential effect of weight loss on adipocyte size subfractions in patients with type 2 diabetes
    Magdalena Pasarica
    Human Physiology, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 17:1976-8. 2009
    ..These data provide support for the measures of adipocyte size distribution in concert with in vitro adipokine secretion and lipolysis in future studies...
  30. ncbi request reprint Glucose ingestion during exercise blunts exercise-induced gene expression of skeletal muscle fat oxidative genes
    Anthony E Civitarese
    Dept of Human Physiology, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 289:E1023-9. 2005
    ..05). In conclusion, glucose ingestion during exercise decreases the expression of genes involved in lipid metabolism rather than increasing genes involved in carbohydrate metabolism...
  31. doi request reprint The relationship of waist circumference and BMI to visceral, subcutaneous, and total body fat: sex and race differences
    Sarah M Camhi
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 19:402-8. 2011
    ..Sex differences, and in some instances race differences, in the relationships between anthropometry and fat-specific depots demonstrate that these characteristics need to be considered when predicting adiposity from WC or BMI...
  32. doi request reprint Urinary C-peptide excretion: a novel alternate measure of insulin sensitivity in physiological conditions
    Jose E Galgani
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 18:1852-7. 2010
    ..60; P < 0.01). In nondiabetic subjects, two novel estimates of IS--daily urinary C-peptide urinary excretion and glycolytic rate during an oral glucose tolerance test --were related to IS by a clamp...
  33. pmc Caloric restriction with or without exercise: the fitness versus fatness debate
    D Enette Larson-Meyer
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Med Sci Sports Exerc 42:152-9. 2010
    ..There is a debate over the independent effects of aerobic fitness and body fatness on mortality and disease risks...
  34. pmc Energy requirements in nonobese men and women: results from CALERIE
    Leanne M Redman
    Pennington Biomedical Research Center, Baton Rouge, LA LMR, CKM, and ER the Duke Clinical Research Institute and Duke University Medical Center, Durham, NC WEK and MB the USDA Jean Mayer Human Nutrition Research Center on Aging at Tufts University, Boston, MA SKD and SB Roberts the Department of Medicine, Washington University School of Medicine, St Louis, MO SB Racette and LF the Department of Medicine, Salerno University Medical School, Salerno, Italy LF CEINGE Biotecnologie Avanzate, Napoli, Italy LF and the USDA Agricultural Research Service, Children s Nutrition Research Center, Department of Pediatrics, Baylor College of Medicine, Houston, TX WWW
    Am J Clin Nutr 99:71-8. 2014
    ..The energy intake necessary to maintain weight and body composition is called the energy requirement for weight maintenance and can be determined by using the doubly labeled water (DLW) method...
  35. pmc Low macrophage accumulation in skeletal muscle of obese type 2 diabetics and elderly subjects
    Charmaine S Tam
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Obesity (Silver Spring) 20:1530-3. 2012
    ..In conclusion, we found little evidence of macrophage accumulation in skeletal muscle in obese T2D subjects or in elderly individuals. A 9-month exercise program was not associated with a decrease in macrophage content...
  36. pmc Leptin replacement prevents weight loss-induced metabolic adaptation in congenital leptin-deficient patients
    Jose E Galgani
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 95:851-5. 2010
    ..005) and higher than the reference population (P = 0.0001). Conclusion: In congenital leptin-deficient subjects, leptin replacement prevented the decrease in energy expenditure and fat oxidation often observed after weight loss...
  37. pmc Examination of cognitive function during six months of calorie restriction: results of a randomized controlled trial
    Corby K Martin
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Rejuvenation Res 10:179-90. 2007
    ..It is unclear if calorie restriction/dieting contributes to cognitive impairment. During this randomized controlled trial, the effect of 6 months of calorie restriction on cognitive functioning was tested...
  38. ncbi request reprint Alternate-day fasting in nonobese subjects: effects on body weight, body composition, and energy metabolism
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 81:69-73. 2005
    ..Prolonged dietary restriction increases the life span in rodents. Some evidence suggests that alternate-day fasting may also prolong the life span...
  39. pmc Lower total adipocyte number but no evidence for small adipocyte depletion in patients with type 2 diabetes
    Magdalena Pasarica
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Diabetes Care 32:900-2. 2009
    ..We hypothesized that, compared with obese subjects, patients with type 2 diabetes have a lower total adipocyte number with fewer small adipocytes...
  40. pmc Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy
    Eric Ravussin
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 17:1736-43. 2009
    ..These results support further development of pramlintide/metreleptin as a novel, integrated neurohormonal approach to obesity pharmacotherapy...
  41. pmc Effect of calorie restriction with or without exercise on body composition and fat distribution
    Leanne M Redman
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 92:865-72. 2007
    ..There is debate over the independent and combined effects of dieting and increased physical activity on improving metabolic risk factors (body composition and fat distribution)...
  42. pmc The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance
    Bolormaa Vandanmagsar
    Laboratory of Neuroendocrine Immunology, Louisiana State University, Baton Rouge, Louisiana, USA
    Nat Med 17:179-88. 2011
    ..Collectively, these data establish that the Nlrp3 inflammasome senses obesity-associated danger signals and contributes to obesity-induced inflammation and insulin resistance...
  43. pmc Defining insulin resistance from hyperinsulinemic-euglycemic clamps
    Charmaine S Tam
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Diabetes Care 35:1605-10. 2012
    ..e., insulin sensitivity...
  44. ncbi request reprint The role of physical activity in maintaining a reduced weight
    Darcy L Johannsen
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Curr Atheroscler Rep 9:463-71. 2007
    ..Only then will rigorous activity recommendations be easier to implement...
  45. doi request reprint No effect of caloric restriction on salivary cortisol levels in overweight men and women
    Charmaine S Tam
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808 The Charles Perkins Centre and School of Biological Sciences, University of Sydney, NSW, Australia
    Metabolism 63:194-8. 2014
    ..The objective was to test the hypothesis that 24 weeks of moderate caloric restriction (CR) (25%) by diet or diet and aerobic exercise would alter morning and diurnal salivary cortisol levels...
  46. pmc Aging, resting metabolic rate, and oxidative damage: results from the Louisiana Healthy Aging Study
    Madlyn I Frisard
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    J Gerontol A Biol Sci Med Sci 62:752-9. 2007
    ..The current study was designed to test whether nonagenarians have a relatively low metabolic rate and whether it is associated with low levels of oxidative stress relative to age...
  47. pmc Validation study of energy expenditure and intake during calorie restriction using doubly labeled water and changes in body composition
    Lilian De Jonge
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Am J Clin Nutr 85:73-9. 2007
    ..Clinical trials involving calorie restriction (CR) require an assessment of adherence to a prescribed CR with the use of an objective measure of energy intake (EI)...
  48. pmc Physical activity in aging: comparison among young, aged, and nonagenarian individuals
    Darcy L Johannsen
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    J Appl Physiol (1985) 105:495-501. 2008
    ..Interestingly, PA was similar between young volunteers and those who were in their 60s and 70s, likely due to the sedentary nature of our society, particularly in young adults...
  49. pmc Potential role of increased matrix metalloproteinase-2 (MMP2) transcription in impaired adipogenesis in type 2 diabetes mellitus
    Severine G Dubois
    Health and Performance Enhancement Division, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Biochem Biophys Res Commun 367:725-8. 2008
    ..32, p=0.03). We conclude that early steps of adipogenesis may be impaired in T2DM independently of obesity due, in part, to an upregulation of the MMP2 transcription...
  50. doi request reprint Effect of capsinoids on energy metabolism in human subjects
    Jose E Galgani
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Br J Nutr 103:38-42. 2010
    ..Longer exposure and higher capsinoids doses may be required to cause meaningful acute effects on energy metabolism...
  51. pmc Measurement of dietary restraint: validity tests of four questionnaires
    Donald A Williamson
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Appetite 48:183-92. 2007
    ..These findings suggest that, of the four questionnaires tested, the EI Restraint Scale was the most valid measure of the intent to diet and actual caloric restriction...
  52. pmc Effect of caloric restriction with and without exercise on metabolic intermediates in nonobese men and women
    Leanne M Redman
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 96:E312-21. 2011
    ....
  53. ncbi request reprint Diet, energy metabolism and mitochondrial biogenesis
    Anthony E Civitarese
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Curr Opin Clin Nutr Metab Care 10:679-87. 2007
    ..This review highlights some recent findings regarding nutritional and endocrine regulators of mitochondrial mass and function and their association with insulin resistance...
  54. ncbi request reprint Calorie restriction and aging: review of the literature and implications for studies in humans
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 78:361-9. 2003
    ..Future studies in nonobese humans should focus on the effects of prolonged CR on metabolic rate, on neuroendocrine adaptations, on diverse biomarkers of aging, and on predictors of chronic age-related diseases...
  55. ncbi request reprint Glucose tolerance and skeletal muscle gene expression in response to alternate day fasting
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obes Res 13:574-81. 2005
    ..The aim of this study was to examine the effects of 3 weeks of alternate day fasting on glucose tolerance and skeletal muscle expression of genes involved in fatty acid transport/oxidation, mitochondrial biogenesis, and stress response...
  56. pmc The effect of caloric restriction interventions on growth hormone secretion in nonobese men and women
    Leanne M Redman
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Aging Cell 9:32-9. 2010
    ..05) and LCD (19 +/- 4%, P < 0.001). A 25% CR diet for 6 months does not change GH, GH secretion or IGF-1 in nonobese men and women...
  57. ncbi request reprint Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice
    Zhanguo Gao
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 292:E84-91. 2007
    ..This study suggests that loss of PKCtheta reduces energy expenditure and increases the risk of dietary obesity and insulin resistance in mice...
  58. pmc Effect of caloric restriction in non-obese humans on physiological, psychological and behavioral outcomes
    Leanne M Redman
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Physiol Behav 94:643-8. 2008
    ....
  59. pmc Decreased expression of adipogenic genes in obese subjects with type 2 diabetes
    Severine G Dubois
    Health and Performance Enhancement Division, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 14:1543-52. 2006
    ..The inability of the adipose tissue to recruit new fat cells may cause ectopic fat deposition and insulin resistance...
  60. ncbi request reprint Lack of an effect of a novel beta3-adrenoceptor agonist, TAK-677, on energy metabolism in obese individuals: a double-blind, placebo-controlled randomized study
    Leanne M Redman
    Pennington Biomedical Research Center, Louisiana 70808, USA
    J Clin Endocrinol Metab 92:527-31. 2007
    ..Our objective was to test the safety and metabolic effects of a novel beta(3)-adrenoreceptor agonist (TAK-677) in humans...
  61. pmc The association between flow-mediated dilation and physical function in older men
    Michael A Welsch
    Louisiana State University, Baton Rouge, LA, USA
    Med Sci Sports Exerc 40:1237-43. 2008
    ..The probability that an individual is able to live independently decreases sharply below the threshold score of 57 units on the physical functional performance (PFP-10) test...
  62. doi request reprint Is caloric restriction associated with development of eating-disorder symptoms? Results from the CALERIE trial
    Donald A Williamson
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Health Psychol 27:S32-42. 2008
    ..This study tested a secondary hypothesis of the CALERIE trial (Heilbronn et al., 2006) that a 12-month period of intentional dietary restriction would be associated with an increase in eating disorder symptoms...
  63. pmc The fall in leptin concentration is a major determinant of the metabolic adaptation induced by caloric restriction independently of the changes in leptin circadian rhythms
    Virgile Lecoultre
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 96:E1512-6. 2011
    ....
  64. ncbi request reprint Energy restriction and aging
    Julie V Smith
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Curr Opin Clin Nutr Metab Care 7:615-22. 2004
    ....
  65. pmc Impact of 6-month caloric restriction on autonomic nervous system activity in healthy, overweight, individuals
    Lilian De Jonge
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 18:414-6. 2010
    ..HR and SNS index increased and PNS index decreased in response to the meal in all intervention groups. The results therefore suggest that weight loss improved SNS/PNS balance especially when CR is combined with exercise...
  66. pmc Role of adiponectin in human skeletal muscle bioenergetics
    Anthony E Civitarese
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Cell Metab 4:75-87. 2006
    ..Our findings define a skeletal muscle pathway by which adiponectin increases mitochondrial number and function and exerts antidiabetic effects...
  67. doi request reprint Resveratrol vs. calorie restriction: data from rodents to humans
    Yan Y Lam
    John S McIlhenny Skeletal Muscle Physiology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, United States
    Exp Gerontol 48:1018-24. 2013
    ..Future studies which characterize the bioavailability and efficacy of resveratrol supplementation are critical to provide evidence for its long-term health benefits. ..
  68. pmc Caloric restriction in humans: impact on physiological, psychological, and behavioral outcomes
    Leanne M Redman
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Antioxid Redox Signal 14:275-87. 2011
    ..With the incremental expansion of research endeavors in the area of energy or caloric restriction, data on the effects of CR in animal models and human subjects are becoming more accessible...
  69. pmc Aerobic exercise in women with polycystic ovary syndrome improves ovarian morphology independent of changes in body composition
    Leanne M Redman
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Fertil Steril 95:2696-9. 2011
    ....
  70. pmc Metabolic flexibility and insulin resistance
    Jose E Galgani
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Am J Physiol Endocrinol Metab 295:E1009-17. 2008
    ..We propose to study metabolic flexibility in response to high-fat diets in individuals having contrasting degree of insulin sensitivity and/or mitochondrial characteristics...
  71. doi request reprint Adiposity and comorbidities: favorable impact of caloric restriction
    Eric Ravussin
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Nestle Nutr Workshop Ser Pediatr Program 63:135-46; discussion 147-50, 259-68. 2009
    ....
  72. pmc Physical activity level and physical functionality in nonagenarians compared to individuals aged 60-74 years
    Madlyn I Frisard
    Pennington Biomedical Research Center, and Louisiana State University, Baton Rouge, LA 70808, USA
    J Gerontol A Biol Sci Med Sci 62:783-8. 2007
    ..The loss of independence is thought to be partially due to a decrease in physical activity. However, in populations, accurate measurement of physical activity is challenging and may not provide information on functional impairment...
  73. pmc Effect of dihydrocapsiate on resting metabolic rate in humans
    Jose E Galgani
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 92:1089-93. 2010
    ..Dihydrocapsiate is a capsinoid found in chili peppers. Dihydrocapsiate is similar to capsaicin, which is known for its thermogenic properties...
  74. ncbi request reprint Energy metabolism and oxidative stress: impact on the metabolic syndrome and the aging process
    Madlyn Frisard
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Endocrine 29:27-32. 2006
    ..However, other factors, such as mitochondrial function, may be important in the production of free radicals and the subsequent effect on aging and disease states...
  75. pmc Ghrelin and peptide YY in postpartum lactating and nonlactating women
    D Enette Larson-Meyer
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Am J Clin Nutr 91:366-72. 2010
    ..Ghrelin and peptide YY (PYY) are gut hormones involved in appetite regulation and energy homeostasis and are biological neuroendocrine signals that potentially affect body weight and adiposity...
  76. pmc Mitochondrial energetics and insulin resistance
    Anthony E Civitarese
    Skeletal Muscle Metabolism Laboratory, Human Physiology, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Endocrinology 149:950-4. 2008
    ....
  77. ncbi request reprint Genetic and physiological factors in obesity
    Steven R Smith
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    J La State Med Soc 157:S12-8. 2005
    ..As we better understand the environmental, genetic, physiological, and behavioral aspects of obesity, we will undoubtedly develop better strategies and therapies for obesity...
  78. doi request reprint Spontaneous physical activity: relationship between fidgeting and body weight control
    Darcy L Johannsen
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Curr Opin Endocrinol Diabetes Obes 15:409-15. 2008
    ..To discuss the potential importance of spontaneous physical activity in regulating body weight and outline possible reasons for the large interindividual variance in spontaneous physical activity...
  79. ncbi request reprint Role of ghrelin polymorphisms in obesity based on three different studies
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    Obes Res 10:782-91. 2002
    ..Associations between preproghrelin DNA variants and obesity-related phenotypes were studied in 3004 subjects from the Québec Family Study (QFS), the HERITAGE Family Study (HERITAGE), and the Swedish Obese Subjects (SOS) Study...
  80. ncbi request reprint Mutations in the adiponectin gene in lean and obese subjects from the Swedish obese subjects cohort
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808 4124, USA
    Metabolism 52:881-4. 2003
    ..In conclusion, adiponectin DNA sequence variations might play a role in the complications of morbid obesity and should be further investigated...
  81. ncbi request reprint The role of mitochondria in health and disease
    Darcy L Johannsen
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Curr Opin Pharmacol 9:780-6. 2009
    ..These inconsistent findings have promoted ongoing investigation into mitochondrial function to determine whether impaired function is a cause or consequence of metabolic disorders...
  82. doi request reprint The presence and role of brown fat in adult humans
    Eric Ravussin
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Curr Diab Rep 10:90-2. 2010
    ..Whether BAT can be up regulated in adult humans remain to be shown? Furthermore, the potential role of BAT in the regulation of energy balance needs to be investigated in response to overfeeding...
  83. ncbi request reprint Loss of taste responds to high-dose biotin treatment
    Frank L Greenway
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    J Am Coll Nutr 30:178-81. 2011
    ..We saw 2 patients who lost their sense of taste, which was restored by pharmacologic doses of biotin. The key objective is to describe the 2 case reports and suggest a potential treatment for unexplained loss of taste...
  84. pmc Endocrine alterations in response to calorie restriction in humans
    Leanne M Redman
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, United States
    Mol Cell Endocrinol 299:129-36. 2009
    ....
  85. doi request reprint The implication of brown adipose tissue for humans
    Eric Ravussin
    Human Physiology, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Annu Rev Nutr 31:33-47. 2011
    ..In this review, we discuss the physiological relevance of brown adipose tissue on thermogenesis and its potential usefulness on body weight control in humans...
  86. ncbi request reprint Emerging paradigms for understanding fatness and diabetes risk
    Steven R Smith
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Curr Diab Rep 2:223-30. 2002
    ..Recent data do not entirely support this hypothesis. As such, two new paradigms have emerged that may explain the established links between adiposity and disease...
  87. ncbi request reprint Microanalysis of eating behavior of three leptin deficient adults treated with leptin therapy
    Donald A Williamson
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Appetite 45:75-80. 2005
    ..These results are discussed in the context of the scientific literature pertaining to leptin and its effects on appetite and obesity...
  88. pmc Calorie restriction extends life span--but which calories?
    Leonie K Heilbronn
    Health and Performance Enhancement Division, Pennington Biomedical Research Centre, Baton Rouge, Louisiana, USA
    PLoS Med 2:e231. 2005
  89. pmc Regional variation in adipogenesis and IGF regulatory proteins in the fetal baboon
    Yourka D Tchoukalova
    Pennington Biomedical Research Center, Department of Human Physiology, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Biochem Biophys Res Commun 380:679-83. 2009
    ..05); all variables were intermediate in femoral preadipocytes. The regional variation of the adipogenesis and the IGF regulatory pathway set the stage for differential responsiveness of fat depots to external signals...
  90. pmc Effect of dietary fat on serum and intramyocellular lipids and running performance
    D Enette Larson-Meyer
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Med Sci Sports Exerc 40:892-902. 2008
    ..This study evaluated whether lowering IMCL stores via 3-d consumption of very-low-fat (LFAT) diet impairs endurance performance relative to a moderate-fat diet (MFAT), and whether such a diet unfavorably alters lipid profiles...
  91. ncbi request reprint Failure of fat cell proliferation, mitochondrial function and fat oxidation results in ectopic fat storage, insulin resistance and type II diabetes mellitus
    L Heilbronn
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Int J Obes Relat Metab Disord 28:S12-21. 2004
    ..This hypothesis proposes that increased adiposity, particularly in the visceral depots, leads to increased free-fatty acid flux and inhibition of insulin-action via Randle's effect in insulin-sensitive tissues...
  92. ncbi request reprint The insulin-sensitizing role of the fat derived hormone adiponectin
    L K Heilbronn
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Curr Pharm Des 9:1411-8. 2003
    ....
  93. pmc Energy metabolism, fuel selection and body weight regulation
    J Galgani
    Human Physiology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 32:S109-19. 2008
    ..The concept of metabolic flexibility and its impact on body weight regulation is also presented...
  94. ncbi request reprint [Determinants and control of energy expenditure]
    E Ravussin
    Pennington Biomedical Research Center, 6400 Perkins Road Baton Rouge, LA 70804 4124, USA
    Ann Endocrinol (Paris) 63:96-105. 2002
    ..New discoveries should provide information on obesity susceptibility genes and increase the chances of developing new anti-obesity treatments...
  95. ncbi request reprint Relationship between serum resistin concentrations and insulin resistance in nonobese, obese, and obese diabetic subjects
    L K Heilbronn
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 89:1844-8. 2004
    ....
  96. ncbi request reprint Plasma ghrelin concentration and energy balance: overfeeding and negative energy balance studies in twins
    E Ravussin
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    J Clin Endocrinol Metab 86:4547-51. 2001
    ..However, studies in free-living individuals are needed to clarify this question...
  97. ncbi request reprint Mutations in the preproghrelin/ghrelin gene associated with obesity in humans
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    J Clin Endocrinol Metab 86:3996-9. 2001
    ..In conclusion, the data provide evidence that a low frequency sequence variation in the ghrelin gene could play a role in the etiology of obesity...
  98. ncbi request reprint A rare mutation in AgRP, +79G>A, affects promoter activity
    M A Sözen
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Eur J Clin Nutr 61:809-12. 2007
    ....
  99. ncbi request reprint Adiponectin receptors gene expression and insulin sensitivity in non-diabetic Mexican Americans with or without a family history of Type 2 diabetes
    A E Civitarese
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Diabetologia 47:816-20. 2004
    ..The aim of this study was to determine for the first time whether skeletal muscle AdipoR1 and/or AdipoR2 gene expression levels are associated with insulin resistance...
  100. pmc Adipogenic human adenovirus Ad-36 induces commitment, differentiation, and lipid accumulation in human adipose-derived stem cells
    Magdalena Pasarica
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Stem Cells 26:969-78. 2008
    ..Thus, Ad-36 has the potential to induce adipogenesis in hASC, which may contribute to adiposity induced by the virus...

Research Grants16

  1. Metabolic Adaptation After 2 Years of Caloric Restriction in Non-Obese Humans
    Eric Ravussin; Fiscal Year: 2010
    ..Both low body temperature and low oxidative stress are predictive of longer life. ..
  2. Fat Cell Size, Overfeeding & Ectopic Fat
    Eric Ravussin; Fiscal Year: 2010
    ..We hypothesize that individuals with both a poor potential for adipose tissue expansion and an impaired function of muscle mitochondria will have the most deterioration of insulin sensitivity after 8 weeks of overfeeding. ..
  3. Fat Cell Size, Muscle Lipid Infiltration and Insulin Re*
    Eric Ravussin; Fiscal Year: 2003
    ..Gene expression will also be measured in Type 2 diabetics after one year of intensive lifestyle changes. ..
  4. Metabolic Adaptation After 2 Years of Caloric Restriction in Non-Obese Humans
    Eric Ravussin; Fiscal Year: 2009
    ..Both low body temperature and low oxidative stress are predictive of longer life. ..
  5. Fat Cell Size, Muscle Lipid Infiltration and Insulin Re*
    Eric Ravussin; Fiscal Year: 2005
    ..Gene expression will also be measured in Type 2 diabetics after one year of intensive lifestyle changes. ..
  6. Fat Cell Size, Overfeeding & Ectopic Fat
    Eric Ravussin; Fiscal Year: 2009
    ..We hypothesize that individuals with both a poor potential for adipose tissue expansion and an impaired function of muscle mitochondria will have the most deterioration of insulin sensitivity after 8 weeks of overfeeding. ..
  7. Metabolic Adaptations to Two Year Caloric Restriction
    Eric Ravussin; Fiscal Year: 2007
    ..5. Improves the quality of life and metabolic fitness. A multidisciplinary team, including physiologists, behavioral psychologists, endocrinologists, molecular biologi and geneticists will conduct this study. ..
  8. Fat Cell Size, Overfeeding & Ectopic Fat
    Eric Ravussin; Fiscal Year: 2007
    ..We hypothesize that individuals with both a poor potential for adipose tissue expansion and an impaired function of muscle mitochondria will have the most deterioration of insulin sensitivity after 8 weeks of overfeeding. ..
  9. Fat Cell Size, Muscle Lipid Infiltration and Insulin Re*
    Eric Ravussin; Fiscal Year: 2004
    ..Gene expression will also be measured in Type 2 diabetics after one year of intensive lifestyle changes. ..
  10. Fat Cell Size, Muscle Lipid Infiltration and Insulin Re*
    Eric Ravussin; Fiscal Year: 2002
    ..Gene expression will also be measured in Type 2 diabetics after one year of intensive lifestyle changes. ..
  11. Fat Cell Size, Muscle Lipid and Insulin Resistance
    Eric Ravussin; Fiscal Year: 2001
    ..Gene expression will also be measured in Type 2 diabetics after one year of intensive lifestyle changes. ..