T Rankinen

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. ncbi request reprint G protein beta 3 polymorphism and hemodynamic and body composition phenotypes in the HERITAGE Family Study
    Tuomo Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 8:151-7. 2002
  2. pmc Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808 4124, USA
    J Appl Physiol (1985) 112:892-7. 2012
  3. ncbi request reprint The human gene map for performance and health-related fitness phenotypes: the 2003 update
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 36:1451-69. 2004
  4. pmc CREB1 is a strong genetic predictor of the variation in exercise heart rate response to regular exercise: the HERITAGE Family Study
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808 4124, USA
    Circ Cardiovasc Genet 3:294-9. 2010
  5. ncbi request reprint Genetics of food intake and eating behavior phenotypes in humans
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Annu Rev Nutr 26:413-34. 2006
  6. doi request reprint Advances in exercise, fitness, and performance genomics
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 42:835-46. 2010
  7. pmc Gene-physical activity interactions: overview of human studies
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 16:S47-50. 2008
  8. pmc FTO genotype is associated with exercise training-induced changes in body composition
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 18:322-6. 2010
  9. ncbi request reprint Invited commentary: Physical activity, mortality, and genetics
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Epidemiol 166:260-2. 2007
  10. pmc A major haplotype block at the rho-associated kinase 2 locus is associated with a lower risk of hypertension in a recessive manner: the HYPGENE study
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Hypertens Res 31:1651-7. 2008

Research Grants

  1. HYPGENE-GENETICS FITNESS OBESITY & RISK OF HYPERTENSION
    Tuomo Rankinen; Fiscal Year: 2004
  2. HYPGENE-GENETICS FITNESS OBESITY & RISK OF HYPERTENSION
    Tuomo Rankinen; Fiscal Year: 2005
  3. HYPGENE-GENETICS FITNESS OBESITY & RISK OF HYPERTENSION
    Tuomo Rankinen; Fiscal Year: 2006
  4. HYPGENE-GENETICS FITNESS OBESITY & RISK OF HYPERTENSION
    Tuomo Rankinen; Fiscal Year: 2007
  5. HERITAGE FAMILY STUDY, PHASE 4
    Tuomo Rankinen; Fiscal Year: 2009
  6. HERITAGE FAMILY STUDY, PHASE 4
    Tuomo Rankinen; Fiscal Year: 2010

Collaborators

Detail Information

Publications109 found, 100 shown here

  1. ncbi request reprint G protein beta 3 polymorphism and hemodynamic and body composition phenotypes in the HERITAGE Family Study
    Tuomo Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 8:151-7. 2002
    ..The GNB3 genotype may play a minor role in HR and body fatness regulation in blacks and in responsiveness of resting BP to endurance training in black women...
  2. pmc Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808 4124, USA
    J Appl Physiol (1985) 112:892-7. 2012
    ..Our results indicate that SNPs in nine genes related to cardiomyocyte and neuronal functions, as well as cardiac memory formation, fully account for the heritability of the submaximal heart rate training response...
  3. ncbi request reprint The human gene map for performance and health-related fitness phenotypes: the 2003 update
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 36:1451-69. 2004
    ..Moreover, there are 15 mitochondrial genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes...
  4. pmc CREB1 is a strong genetic predictor of the variation in exercise heart rate response to regular exercise: the HERITAGE Family Study
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808 4124, USA
    Circ Cardiovasc Genet 3:294-9. 2010
    ..A genome-wide linkage scan identified a quantitative trait locus for exercise training-induced changes in submaximal exercise (50 W) heart rate (DeltaHR50) on chromosome 2q33.3-q34 in the HERITAGE Family Study (n=472)...
  5. ncbi request reprint Genetics of food intake and eating behavior phenotypes in humans
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Annu Rev Nutr 26:413-34. 2006
    ..Understanding the relative contribution of global genetic variation and of DNA sequence variants in specific genes is important in the effort to influence dietary habits in a healthier direction...
  6. doi request reprint Advances in exercise, fitness, and performance genomics
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 42:835-46. 2010
    ..We conclude from this first installment that exercise scientists need to prioritize high-quality research designs and that replication studies with large sample sizes are urgently needed...
  7. pmc Gene-physical activity interactions: overview of human studies
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 16:S47-50. 2008
    ..Progress is likely to come when studies will be designed to truly address gene-exercise or physical activity interaction issues and with sample sizes that will provide adequate statistical power...
  8. pmc FTO genotype is associated with exercise training-induced changes in body composition
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 18:322-6. 2010
    ..Resistance to exercise-induced reduction in total adiposity may represent one mechanism by which the FTO A allele promotes overweight and obesity...
  9. ncbi request reprint Invited commentary: Physical activity, mortality, and genetics
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Epidemiol 166:260-2. 2007
    ....
  10. pmc A major haplotype block at the rho-associated kinase 2 locus is associated with a lower risk of hypertension in a recessive manner: the HYPGENE study
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Hypertens Res 31:1651-7. 2008
    ..Identification of functional mutation(s) could thus help in the development of ROCK2-specific treatments...
  11. ncbi request reprint Genome-wide linkage scan for exercise stroke volume and cardiac output in the HERITAGE Family Study
    Tuomo Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 10:57-62. 2002
    ..3, 3q13.3, 12q13.2) and one for baseline SV50 and Q50 (10p14). All these chromosomal regions include several potential candidate genes and therefore warrant further studies in the HERITAGE cohort and other studies...
  12. ncbi request reprint Titin is a candidate gene for stroke volume response to endurance training: the HERITAGE Family Study
    Tuomo Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 15:27-33. 2003
    ..Since TTN is the largest gene in the human genome, the challenge is to identify the DNA sequence variants contributing to the interindividual differences in cardiac adaptation to endurance training...
  13. ncbi request reprint Effect of endothelin 1 genotype on blood pressure is dependent on physical activity or fitness levels
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Hypertension 50:1120-5. 2007
    ..Our study provides an illustrative example of how physical activity and fitness level modifies the associations between a candidate gene and outcome phenotype...
  14. ncbi request reprint Cardiorespiratory fitness, BMI, and risk of hypertension: the HYPGENE study
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 39:1687-92. 2007
    ..Genetic factors contribute significantly to the interindividual differences in endurance training-induced changes in BP. However, similar data on the genotype-by-fitness interactions on the risk of hypertension are scarce...
  15. ncbi request reprint Genome scans for human nutritional traits: what have we learned?
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Nutrition 20:9-13. 2004
  16. ncbi request reprint NOS3 Glu298Asp genotype and blood pressure response to endurance training: the HERITAGE family study
    T Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA, USA
    Hypertension 36:885-9. 2000
    ....
  17. ncbi request reprint Genomic scan for exercise blood pressure in the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study
    T Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808 4124, USA
    Hypertension 38:30-7. 2001
    ..All the detected chromosomal regions include several potential candidate genes and therefore warrant further studies in the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) cohort and other studies...
  18. ncbi request reprint Relationship between lipid peroxidation and plasma fibrinogen in middle-aged men
    T Rankinen
    Kuopio Research Institute of Exercise Medicine and Department of Physiology, University of Kuopio, Finland
    Thromb Res 99:453-9. 2000
    ..6%, 9.7%, 5.5%, and 2.3%, respectively. WHR, serum triglycerides, and age did not enter the model. These data suggest that increased lipid peroxidation is associated with elevated plasma fibrinogen level in middle-aged men...
  19. ncbi request reprint The Na(+)-K(+)-ATPase alpha2 gene and trainability of cardiorespiratory endurance: the HERITAGE family study
    T Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    J Appl Physiol (1985) 88:346-51. 2000
    ..017). These data suggest that genetic variation at the Na(+)-K(+)-ATPase alpha2 locus influences the trainability of VO(2 max) in sedentary Caucasian subjects...
  20. ncbi request reprint Genomic scan for maximal oxygen uptake and its response to training in the HERITAGE Family Study
    C Bouchard
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    J Appl Physiol (1985) 88:551-9. 2000
    ..These chromosomal regions harbor many genes that may qualify as candidate genes for these quantitative traits. They should be investigated in this and other cohorts...
  21. ncbi request reprint Variations in the four and a half LIM domains 1 gene (FHL1) are associated with fasting insulin and insulin sensitivity responses to regular exercise
    M Teran-Garcia
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Diabetologia 50:1858-66. 2007
    ....
  22. ncbi request reprint Interactions among the beta2- and beta3- adrenergic receptor genes and total body fat and abdominal fat level in the HERITAGE Family Study
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes Relat Metab Disord 27:389-93. 2003
    ....
  23. ncbi request reprint The agouti-related protein and body fatness in humans
    G Argyropoulos
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Int J Obes Relat Metab Disord 27:276-80. 2003
    ....
  24. ncbi request reprint Age, body mass index, race and other determinants of steroid hormone variability: the HERITAGE Family Study
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Eur J Endocrinol 145:1-9. 2001
    ..Sample sizes varied from 676 to 750 per hormone. Incremental regression methods were used to examine the contributions of the variables to steroid hormone variability...
  25. ncbi request reprint Is adiposity at normal body weight relevant for cardiovascular disease risk?
    S Tanaka
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Int J Obes Relat Metab Disord 26:176-83. 2002
    ..To examine the relation between adiposity and risk factors for cardiovascular disease (CVD) in normal weight (NW) individuals...
  26. doi request reprint Measured maximal heart rates compared to commonly used age-based prediction equations in the Heritage Family Study
    M A Sarzynski
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, 70808
    Am J Hum Biol 25:695-701. 2013
    ..The purpose of this study was to examine how well two commonly used age-based prediction equations for maximal heart rate (HRmax ) estimate the actual HRmax measured in Black and White adults from the HERITAGE Family Study...
  27. ncbi request reprint The human gene map for performance and health-related fitness phenotypes
    T Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808-4124, USA
    Med Sci Sports Exerc 33:855-67. 2001
    ..A yearly update of this human gene map will be published...
  28. ncbi request reprint Associations between cardiorespiratory responses to exercise and the C34T AMPD1 gene polymorphism in the HERITAGE Family Study
    J Rico-Sanz
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808, USA
    Physiol Genomics 14:161-6. 2003
    ..Furthermore, the training response of ventilatory phenotypes during maximal exercise is more limited in TT...
  29. ncbi request reprint Polymorphisms in the leptin and leptin receptor genes in relation to resting metabolic rate and respiratory quotient in the Québec Family Study
    R J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 30:183-90. 2006
    ..Leptin (LEP) is an endocrine hormone that participates in many metabolic pathways, including those associated with the central regulation of energy homeostasis...
  30. ncbi request reprint Genome-wide linkage scan for submaximal exercise heart rate in the HERITAGE family study
    Nadine Spielmann
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Am J Physiol Heart Circ Physiol 293:H3366-71. 2007
    ..The most promising regions for fine mapping in the HERITAGE Family Study were found on 2q33 for HR50 training response in whites, on 10q25-26 for baseline HR60 in blacks, and on 18q21-22 for both baseline HR50 and DeltaHR60 in whites...
  31. ncbi request reprint Quantitative trait loci for maximal exercise capacity phenotypes and their responses to training in the HERITAGE Family Study
    J Rico-Sanz
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808, USA
    Physiol Genomics 16:256-60. 2004
    ..These chromosomal regions harbor several candidate genes that deserve further investigation...
  32. ncbi request reprint A quantitative trait locus on 7q31 for the changes in plasma insulin in response to exercise training: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Diabetes 52:1583-7. 2003
    ..The present findings may be important in identifying individuals at increased risk of developing type 2 diabetes and who are most likely to benefit from a physically active lifestyle...
  33. ncbi request reprint Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Obes Res 13:829-34. 2005
    ..Gene-gene interactions between the PTPN1 and leptin receptor genes contributed to the phenotypic variability of insulin sensitivity. The PTPN1 Pro387Leu variant was associated with lower glucose tolerance...
  34. pmc Functional dimorphism of two hAgRP promoter SNPs in linkage disequilibrium
    F Bai
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Med Genet 41:350-3. 2004
    ..The region encompassing the -38C>T SNP had approximately 1000-fold higher activity than the region encompassing the -3019G>A SNP, potentially determining the net functional effect between these two SNPs...
  35. ncbi request reprint Physical activity, fibrinogen plasma level and gene polymorphisms in postmenopausal women
    R Rauramaa
    Kuopio Research Institute of Exercise Medicine and Department of Physiology, University of Kuopio, Finland
    Thromb Haemost 78:840-4. 1997
    ..001) compared to the physically less active subjects. These results suggest that, in postmenopausal women, the relation between physical activity and plasma fibrinogen is modulated by genetic variation in the alpha-fibrinogen gene...
  36. ncbi request reprint Quantitative trait locus on chromosome 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Physiol Genomics 27:103-7. 2006
    ..The present findings may be useful in the ongoing effort to search for genes contributing to inflammation and to identify individuals at an increased risk of chronic inflammatory diseases...
  37. ncbi request reprint Role of ghrelin polymorphisms in obesity based on three different studies
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    Obes Res 10:782-91. 2002
    ..Associations between preproghrelin DNA variants and obesity-related phenotypes were studied in 3004 subjects from the Québec Family Study (QFS), the HERITAGE Family Study (HERITAGE), and the Swedish Obese Subjects (SOS) Study...
  38. ncbi request reprint Melanocortin-4 receptor gene and physical activity in the Québec Family Study
    R J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 29:420-8. 2005
    ..Physical inactivity is a risk factor for numerous chronic diseases. Low compliance with interventions to increase activity suggests involvement of biological systems...
  39. ncbi request reprint A 12-year follow-up study of treated obese children in Japan
    K Togashi
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Int J Obes Relat Metab Disord 26:770-7. 2002
    ....
  40. ncbi request reprint A dopamine D2 receptor gene polymorphism and physical activity in two family studies
    Riitta L Simonen
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Physiol Behav 78:751-7. 2003
    ..09, P=.023) and 27-33% lower work index (F=6.23, P=.004) than the CC homozygotes and CT heterozygotes. The results suggest that DNA sequence variation in the DRD2 gene is associated with physical activity levels among White women...
  41. ncbi request reprint Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: the HERITAGE Family Study
    Margarita Teran-Garcia
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 54:2251-5. 2005
    ..The benefits from an exercise program on Si are likely to be substantial in the general population given the high frequency of the LIPC -514C allele, particularly in whites...
  42. ncbi request reprint The human gene map for performance and health-related fitness phenotypes: the 2005 update
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 38:1863-88. 2006
    ....
  43. pmc SNP-by-fitness and SNP-by-BMI interactions from seven candidate genes and incident hypertension after 20 years of follow-up: the CARDIA Fitness Study
    M A Sarzynski
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    J Hum Hypertens 25:509-18. 2011
    ..We found that SNPs in these candidate genes did not modify the association between baseline fitness or BMI and risk of hypertension in CARDIA participants...
  44. ncbi request reprint Genetics and blood pressure response to exercise, and its interactions with adiposity
    T Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808 4124, USA
    Prev Cardiol 5:138-44. 2002
    ..The current knowledge regarding the role of genetic factors in the modification of blood pressure responses to endurance training will be summarized and discussed...
  45. ncbi request reprint A genome-wide linkage scan for dietary energy and nutrient intakes: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family Study
    Agron Collaku
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Am J Clin Nutr 79:881-6. 2004
    ..A poor diet is a risk factor for chronic diseases such as obesity, cardiovascular disease, hypertension, and some cancers. Twin and family studies suggest that genetic factors potentially influence energy and nutrient intakes...
  46. ncbi request reprint Effect of regular exercise on homocysteine concentrations: the HERITAGE Family Study
    Tomohiro Okura
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Eur J Appl Physiol 98:394-401. 2006
    ..Men exhibit racial differences for tHcy responses to exercise training. Regular aerobic exercise has favorable effects on individuals with hyperhomocysteinemia, but tHcy slightly increased in individuals within the normal range...
  47. ncbi request reprint Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Quebec Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 85:26-34. 2007
    ..Despite adiponectin's presumed role in fatty acid oxidation and energy homeostasis, little is known about the effect of gene variants on substrate oxidation, energy expenditure, and adiposity-related phenotypes...
  48. ncbi request reprint Resting metabolic rate and respiratory quotient: results from a genome-wide scan in the Quebec Family Study
    Peter Jacobson
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 84:1527-33. 2006
    ....
  49. ncbi request reprint Adiponectin polymorphisms, adiposity and insulin metabolism: HERITAGE family study and Oulu diabetic study
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge 70808 4124, USA
    Ann Med 37:141-50. 2005
    ..Adiponectin is an adipocytokine with lowered blood levels in obesity and Type 2 diabetes mellitus. We sought to define the specific effects of different alleles of the gene encoding adiponectin...
  50. doi request reprint Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases
    M A Sarzynski
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Int J Obes (Lond) 35:676-83. 2011
    ..To test whether DNA sequence variation in 11 obesity genes is associated with maximum weight loss and weight regain over 6 years of follow-up in bariatric surgery patients of the Swedish obese subjects (SOS) intervention study...
  51. ncbi request reprint Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort
    Peter Jacobson
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 87:4442-6. 2002
    ..In conclusion, our results do not support the prevailing notion that sequence variation in the melanocortin 4 receptor gene is a frequent cause of human obesity...
  52. ncbi request reprint CETP genotypes and HDL-cholesterol phenotypes in the HERITAGE Family Study
    Nadine Spielmann
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 31:25-31. 2007
    ..The CETP and APOE genotypes account for up to 9% of the variance in HDL-c phenotypes in the HERITAGE Family Study...
  53. ncbi request reprint Association of lipin 1 gene polymorphisms with measures of energy and glucose metabolism
    Ruth J F Loos
    Pennington Biomedical Research Center, Human Genomics Laboratory, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 15:2723-32. 2007
    ..Lpin1 was identified as the mutated gene in the fatty liver dystrophy mouse, which exhibits lipin deficiency and features of human lipodystrophy...
  54. ncbi request reprint Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 82:1097-101. 2005
    ..Exogenous administration of AGRP in rodents predisposes to high fat and high sugar intakes...
  55. pmc KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise
    George Argyropoulos
    Energy Balance Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Physiol Genomics 36:79-88. 2009
    ..Furthermore, training-induced changes in submaximal exercise stroke volume may be due to mitochondrial function and variation in KIF5B expression as determined by functional SNPs in its promoter...
  56. ncbi request reprint Genome-wide linkage scan for physical activity levels in the Quebec Family study
    Riitta L Simonen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 35:1355-9. 2003
    ..Four physical activity level phenotypes were used...
  57. pmc FTO genotype and the weight loss benefits of moderate intensity exercise
    Jonathan A Mitchell
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 18:641-3. 2010
    ....
  58. ncbi request reprint Individual differences in response to regular physical activity
    C Bouchard
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 33:S446-51; discussion S452-3. 2001
    ..The purpose of this review was to address the question of interindividual variation in responsiveness to regular exercise training and to define the contributions of age, sex, race, and pretraining phenotype level to this variability...
  59. doi request reprint Genes, exercise, growth, and the sedentary, obese child
    Margarita Teran-Garcia
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Appl Physiol (1985) 105:988-1001. 2008
    ....
  60. ncbi request reprint Familial resemblance for muscle phenotypes in the HERITAGE Family Study
    Jesus Rico-Sanz
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 35:1360-6. 2003
    ..We hypothesized that skeletal muscle histological and biochemical phenotypes aggregate within families...
  61. ncbi request reprint Calcium intake is associated with adiposity in Black and White men and White women of the HERITAGE Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    J Nutr 134:1772-8. 2004
    ..04). No significant associations were found in Black women. Low Ca(2+) intake may be associated with higher adiposity, particularly in men and White women...
  62. ncbi request reprint The human gene map for performance and health-related fitness phenotypes: the 2001 update
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 34:1219-33. 2002
    ..Finally, 13 sequence variants in mitochondrial DNA have been shown to influence relevant fitness and performance phenotypes...
  63. ncbi request reprint Genome-wide linkage scan for the metabolic syndrome in the HERITAGE Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 88:5935-43. 2003
    ..Some of these chromosomal regions harbor promising potential candidate genes...
  64. ncbi request reprint The TNF-alpha G-308A polymorphism is associated with C-reactive protein levels: the HERITAGE Family Study
    Hanna Maaria Lakka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808 4124, USA
    Vascul Pharmacol 44:377-83. 2006
    ..Pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), stimulate the release of C-reactive protein (CRP). We investigated the association between the TNF-alpha G-308A polymorphism and plasma CRP levels...
  65. ncbi request reprint Physical exercise and blood pressure with reference to the angiotensinogen M235T polymorphism
    Rainer Rauramaa
    Kuopio Research Institute of Exercise Medicine and Department of Physiology, University of Kuopio, 70100 Kuopio, Finland
    Physiol Genomics 10:71-7. 2002
    ..026 and 0.024 for net effects), respectively. Regular moderate intensity exercise attenuates aging-related increase in systolic BP and decreases diastolic BP among the M homozygotes of the AGT gene M235T polymorphism...
  66. ncbi request reprint Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study
    Timo A Lakka
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808 4124, USA
    Diabetes 53:1603-8. 2004
    ..Similar interaction was observed in blacks (P = 0.046). Variations in the LEP and LEPR genes are associated with the magnitude of the effects of regular exercise on glucose homeostasis in nondiabetic individuals...
  67. pmc Profiles of sedentary behavior in children and adolescents: the US National Health and Nutrition Examination Survey, 2001-2006
    Susan B Sisson
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Int J Pediatr Obes 4:353-9. 2009
    ..To describe the prevalence of time spent in sedentary behaviors (e.g., TV/video and computer use) among youth in the US...
  68. ncbi request reprint The human obesity gene map: the 2003 update
    Eric E Snyder
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    Obes Res 12:369-439. 2004
    ..Overall, more than 430 genes, markers, and chromosomal regions have been associated or linked with human obesity phenotypes. The electronic version of the map with links to useful sites can be found at http://obesitygene.pbrc.edu...
  69. ncbi request reprint The human obesity gene map: the 2001 update
    Tuomo Rankinen
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    Obes Res 10:196-243. 2002
    ..Likewise, the number of negative studies, which are only partially reviewed here, is also on the rise...
  70. ncbi request reprint A polymorphism in the human agouti-related protein is associated with late-onset obesity
    George Argyropoulos
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 87:4198-202. 2002
    ..The c.199G-->A polymorphism in hAGRP could, therefore, play a role in the development of human obesity in an age-dependent fashion...
  71. ncbi request reprint MC4R marker associated with stature in children and young adults: a longitudinal study
    Nicola Santoro
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808 4124, USA
    J Pediatr Endocrinol Metab 18:859-63. 2005
    ..These results suggest that DNA sequence variation in the MC4R locus may contribute to the gain in body height from childhood to adulthood...
  72. pmc Genomic predictors of the maximal O₂ uptake response to standardized exercise training programs
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Appl Physiol (1985) 110:1160-70. 2011
    ..These genomic predictors of the response of Vo(2max) to regular exercise provide new targets for the study of the biology of fitness and its adaptation to regular exercise. Large-scale replication studies are warranted...
  73. ncbi request reprint Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Eur Heart J 26:2018-25. 2005
    ..To study the effect of exercise training on plasma C-reactive protein, a marker of inflammation...
  74. ncbi request reprint Peroxisome proliferator-activated receptor-delta polymorphisms are associated with physical performance and plasma lipids: the HERITAGE Family Study
    Arto J Hautala
    Pennington Biomedical Research Center, Human Genomics Laboratory, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Am J Physiol Heart Circ Physiol 292:H2498-505. 2007
    ..DNA sequence variation in the PPARdelta locus is a potential modifier of changes in cardiorespiratory fitness and plasma HDL-C in healthy individuals in response to regular exercise...
  75. pmc Leisure time sedentary behavior, occupational/domestic physical activity, and metabolic syndrome in U.S. men and women
    Susan B Sisson
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Metab Syndr Relat Disord 7:529-36. 2009
    ....
  76. ncbi request reprint Endurance training-induced changes in insulin sensitivity and gene expression
    Margarita Teran-Garcia
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 288:E1168-78. 2005
    ..Further study of these novel candidate genes should provide a better understanding of molecular mechanisms involved in the improvement in insulin sensitivity in response to regular exercise...
  77. pmc Functional identification of the promoter of SLC4A5, a gene associated with cardiovascular and metabolic phenotypes in the HERITAGE Family Study
    Adrian M Stütz
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, USA
    Eur J Hum Genet 17:1481-9. 2009
    ..Summarizing, the observed associations with resting and submaximal-exercise cardiovascular and metabolic traits in the HERITAGE Family Study are likely due to neither variation in the promoter nor known coding SNPs of SLC4A5...
  78. ncbi request reprint Gene-diet interactions on body weight changes
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Am Diet Assoc 105:S29-34. 2005
    ..This growing body of research may help in the development of antiobesity treatments and perhaps genetic tests to predict the risk for obesity...
  79. ncbi request reprint Heart rate recovery after maximal exercise is associated with acetylcholine receptor M2 (CHRM2) gene polymorphism
    Arto J Hautala
    Pennington Biomedical Research Center, Human Genomics Laboratory, Louisiana State University System, Baton Rouge, Louisiana, USA
    Am J Physiol Heart Circ Physiol 291:H459-66. 2006
    ..025) and after endurance training (P = 0.005). These data suggest that DNA sequence variation at the CHRM2 locus is a potential modifier of HR recovery in the sedentary state and after short-term endurance training in healthy individuals...
  80. ncbi request reprint A genome-wide linkage scan for steroids and SHBG levels in black and white families: the HERITAGE Family Study
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisianan State University, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 87:3708-20. 2002
    ..3. Several genes encoding enzymes of the steroid biosynthesis pathways but also other potential candidate genes were located in the vicinity of the genomic regions showing evidence of linkage in this genomic scan...
  81. ncbi request reprint Skeletal muscle characteristics predict body fat gain in response to overfeeding in never-obese young men
    Guang Sun
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Metabolism 51:451-6. 2002
    ..43 to 0.53, and account for 18% to 28% of the variance in the response to overfeeding. The results suggest that an elevated skeletal muscle oxidative capacity plays a protective role in the response to long-term positive energy balance...
  82. ncbi request reprint The human obesity gene map: the 2005 update
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Obesity (Silver Spring) 14:529-644. 2006
    ..The obesity gene map shows putative loci on all chromosomes except Y. The electronic version of the map with links to useful publications and relevant sites can be found at http://obesitygene.pbrc.edu...
  83. pmc Template to improve glycemic control without reducing adiposity or dietary fat
    R Krishnapuram
    Infections and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State Univ System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 300:E779-89. 2011
    ..This metabolic engineering by Ad36 appears relevant to humans for developing more practical and effective antidiabetic approaches...
  84. ncbi request reprint Familial aggregation of physical activity levels in the Québec Family Study
    Riita L Simonen
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 34:1137-42. 2002
    ..Familial aggregation of physical activity phenotypes was investigated in 696 subjects from 200 families of the Quebec Family Study. The mean age of offspring and parents was 27 and 53 yr, respectively...
  85. ncbi request reprint Effects of aerobic physical exercise on inflammation and atherosclerosis in men: the DNASCO Study: a six-year randomized, controlled trial
    Rainer Rauramaa
    Kuopio Research Institute of Exercise Medicine, University of Kuopio, and Kuopio University Hospital, Kuopio, Finland
    Ann Intern Med 140:1007-14. 2004
    ..Although regular physical activity is recommended for prevention of cardiovascular diseases, no data are available on its antiatherosclerotic effects in the general population...
  86. pmc The alpha 2-adrenergic receptor gene and body fat content and distribution: the HERITAGE Family Study
    Christophe Garenc
    Division of Kinesiology, Department of Preventive Medicine, Laval University, Ste Foy, Quebec, Canada
    Mol Med 8:88-94. 2002
    ..A C-1291G polymorphism is located in the alpha2-adrenergic receptor gene (ADRA2A) but no association with body fat accumulation has been reported yet...
  87. ncbi request reprint A genomewide linkage scan for abdominal subcutaneous and visceral fat in black and white families: The HERITAGE Family Study
    Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 51:848-55. 2002
    ..Additional work in an independent sample is needed to verify the linkages for baseline AVF as well as the response measures...
  88. ncbi request reprint Leptin levels, leptin receptor gene polymorphisms, and energy metabolism in women
    Machteld Wauters
    Department of Diabetology, Metabolism and Clinical Nutrition, University Hospital Antwerp, Belgium
    Obes Res 10:394-400. 2002
    ..We evaluated whether leptin levels and polymorphisms in the leptin receptor (LEPR) gene were associated with energy expenditure phenotypes...
  89. ncbi request reprint Menopause, estrogen, and training effects on exercise hemodynamics: the HERITAGE study
    John S Green
    Department of Health and Kinesiology, Texas A and M University, College Station, TX 77843 4243, USA
    Med Sci Sports Exerc 34:74-82. 2002
    ..To investigate the influences of menopause, hormone replacement, and endurance exercise training on cardiovascular hemodynamics and oxygen uptake parameters during exercise in women...
  90. ncbi request reprint Pleiotropic QTL on chromosome 12q23-q24 influences triglyceride and high-density lipoprotein cholesterol levels: the HERITAGE family study
    Mary E Feitosa
    Division of Statistical Genomics in the Center for Genome Sciences, Washington University School of Medicine, Saint Louis, MO, USA
    Hum Biol 78:317-27. 2006
    ..Further investigation should confirm whether IGF1 or another nearby gene is responsible for the concomitant variation in TG and HDL-C levels...
  91. ncbi request reprint Genomewide linkage scan of resting blood pressure: HERITAGE Family Study. Health, Risk Factors, Exercise Training, and Genetics
    Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hypertension 39:1037-43. 2002
    ....
  92. ncbi request reprint Major gene effects on exercise ventilatory threshold: the HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Appl Physiol (1985) 93:1000-6. 2002
    ....
  93. ncbi request reprint Association between a beta2-adrenergic receptor polymorphism and elite endurance performance
    Bernd Wolfarth
    Department of Preventive and Rehabilitative Sports Medicine, Technical University Munich, 80809, Munich, Germany
    Metabolism 56:1649-51. 2007
    ..In conclusion, we found suggestive evidence that the Arg16Gly polymorphism in the gene encoding for the beta(2)-adrenergic receptor may associate with endurance performance status in white men...
  94. ncbi request reprint The human obesity gene map: the 2004 update
    Louis Perusse
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada
    Obes Res 13:381-490. 2005
    ..The electronic version of the map with links to useful publications and genomic and other relevant sites can be found at http://obesitygene.pbrc.edu...
  95. ncbi request reprint Effects of exercise training on glucose homeostasis: the HERITAGE Family Study
    Normand G Boule
    Division of Kinesiology, Laval University, Sainte Foy, Quebec, Canada
    Diabetes Care 28:108-14. 2005
    ..To determine the effect of a 20-week endurance training program in healthy, previously sedentary participants on measures derived from an intravenous glucose tolerance test (i.v.GTT)...
  96. ncbi request reprint The human gene map for performance and health-related fitness phenotypes: the 2004 update
    Bernd Wolfarth
    Department of Preventive and Rehabilitative Sports Medicine, Technical University Munich, Munich, Germany
    Med Sci Sports Exerc 37:881-903. 2005
    ..But exercise science and sports medicine is generally lagging behind in terms of utilizing the advances in genetic and genomic technologies...
  97. ncbi request reprint Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3
    Liisa Koivukoski
    Department of Endocrinology, Malmo University Hospital, Lund University, SE 205 02 Malmo, Sweden
    Hum Mol Genet 13:2325-32. 2004
    ..We conclude that modest or non-significant linkage on chromosomes 3p14.1-q12.3 and 2p12-q22.1 in each individual study translates into genome-wide significant or highly suggestive linkages to HT and DBP in our GSMA analysis...
  98. ncbi request reprint Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity: the HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Campus Box 8067, 660 S Euclid, St Louis, MO 63110 1093, USA
    Atherosclerosis 185:426-32. 2006
    ..Polymorphisms in the APOE gene, and possibly LIPE gene, appear to be strong candidates for the source of this pleiotropic QTL...
  99. ncbi request reprint Evidence of QTLs on chromosomes 13q and 14q for triglycerides before and after 20 weeks of exercise training: the HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, Campus Box 8067 Washington University School of Medicine, 660 S Euclid, Saint Louis, MO 63110 1093, USA
    Atherosclerosis 182:349-60. 2005
    ..It is interesting that the strongest signals were found for the LDL-TG and HDL-TG subfractions, given their particular relationships with the atherogenic lipid profile including dense LDL and HDL particles...
  100. ncbi request reprint Evidence of QTLs on chromosomes 1q42 and 8q24 for LDL-cholesterol and apoB levels in the HERITAGE family study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO, USA
    J Lipid Res 46:281-6. 2005
    ..As there are no known strong candidate genes in these regions for lipids, follow-up studies to determine the source of those signals are needed...
  101. ncbi request reprint Fitness alters the associations of BMI and waist circumference with total and abdominal fat
    Ian Janssen
    Department of Community Health and Epidemiology, Division of Endocrinology and Metabolism, Queen s University, Kingston, Ontario, Canada
    Obes Res 12:525-37. 2004
    ....

Research Grants7

  1. HYPGENE-GENETICS FITNESS OBESITY & RISK OF HYPERTENSION
    Tuomo Rankinen; Fiscal Year: 2004
    ..These data could ultimately lead to more efficient use of physical activity and body weight control in the primary and secondary prevention of hypertension. ..
  2. HYPGENE-GENETICS FITNESS OBESITY & RISK OF HYPERTENSION
    Tuomo Rankinen; Fiscal Year: 2005
    ..These data could ultimately lead to more efficient use of physical activity and body weight control in the primary and secondary prevention of hypertension. ..
  3. HYPGENE-GENETICS FITNESS OBESITY & RISK OF HYPERTENSION
    Tuomo Rankinen; Fiscal Year: 2006
    ..These data could ultimately lead to more efficient use of physical activity and body weight control in the primary and secondary prevention of hypertension. ..
  4. HYPGENE-GENETICS FITNESS OBESITY & RISK OF HYPERTENSION
    Tuomo Rankinen; Fiscal Year: 2007
    ..These data could ultimately lead to more efficient use of physical activity and body weight control in the primary and secondary prevention of hypertension. ..
  5. HERITAGE FAMILY STUDY, PHASE 4
    Tuomo Rankinen; Fiscal Year: 2009
    ..abstract_text> ..
  6. HERITAGE FAMILY STUDY, PHASE 4
    Tuomo Rankinen; Fiscal Year: 2010
    ..abstract_text> ..