IRINA OBROSOVA

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. pmc High-fat diet-induced neuropathy of prediabetes and obesity: effect of PMI-5011, an ethanolic extract of Artemisia dracunculus L
    Pierre Watcho
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Mediators Inflamm 2010:268547. 2010
  2. pmc Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis
    Sergey Lupachyk
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Mol Med 29:989-98. 2012
  3. pmc Metanx alleviates multiple manifestations of peripheral neuropathy and increases intraepidermal nerve fiber density in Zucker diabetic fatty rats
    Hanna Shevalye
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 61:2126-33. 2012
  4. pmc Prediabetic nephropathy as an early consequence of the high-calorie/high-fat diet: relation to oxidative stress
    Hanna Shevalye
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Endocrinology 153:1152-61. 2012
  5. pmc Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, Louisiana 70808, USA
    Diabetes 54:3435-41. 2005
  6. pmc Poly(Adenosine 5'-diphosphate-ribose) polymerase inhibition counteracts multiple manifestations of experimental type 1 diabetic nephropathy
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Endocrinology 150:5273-83. 2009
  7. doi Diabetic painful and insensate neuropathy: pathogenesis and potential treatments
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Neurotherapeutics 6:638-47. 2009
  8. pmc PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Free Radic Biol Med 44:972-81. 2008
  9. pmc Early diabetes-induced biochemical changes in the retina: comparison of rat and mouse models
    I G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Diabetologia 49:2525-33. 2006
  10. ncbi Peroxynitrite and cardiomyocyte cell death: an evolving story. A commentary on "Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivo"
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Free Radic Biol Med 41:866-8. 2006

Research Grants

  1. 12/15-Lipoxygenase and Diabetic Neuropathy
    IRINA OBROSOVA; Fiscal Year: 2009
  2. 12/15-Lipoxygenase and Diabetic Neuropathy
    IRINA OBROSOVA; Fiscal Year: 2009
  3. Role of poly(ADP-ribosyl)ation in diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2003
  4. Na+/H+-exchanger-1 and Diabetic Neuropathy
    Irina G Obrosova; Fiscal Year: 2010
  5. Peroxynitrite, protein nitration and advanced diabetic neuropathy
    Irina G Obrosova; Fiscal Year: 2010
  6. Na+/H+-exchanger-1 and Diabetic Neuropathy
    IRINA OBROSOVA; Fiscal Year: 2009
  7. 12/15-Lipoxygenase and Diabetic Neuropathy
    IRINA OBROSOVA; Fiscal Year: 2007
  8. Peroxynitrite decomposition catalyst:diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2006
  9. Poly(ADP-ribose) polymerase in diabetic nephropathy
    IRINA OBROSOVA; Fiscal Year: 2006
  10. 12/15-Lipoxygenase and Diabetic Neuropathy
    Irina G Obrosova; Fiscal Year: 2010

Collaborators

Detail Information

Publications47

  1. pmc High-fat diet-induced neuropathy of prediabetes and obesity: effect of PMI-5011, an ethanolic extract of Artemisia dracunculus L
    Pierre Watcho
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Mediators Inflamm 2010:268547. 2010
    ..PMI-5011, a safe and nontoxic botanical extract, may find use in treatment of neuropathic changes at the earliest stage of disease...
  2. pmc Na+/H+-exchanger-1 inhibition counteracts diabetic cataract formation and retinal oxidative-nitrative stress and apoptosis
    Sergey Lupachyk
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Mol Med 29:989-98. 2012
    ..In conclusion, NHE-1 contributes to diabetic cataract formation, and retinal oxidative-nitrative stress and apoptosis. The findings identify a new therapeutic target for diabetic ocular complications...
  3. pmc Metanx alleviates multiple manifestations of peripheral neuropathy and increases intraepidermal nerve fiber density in Zucker diabetic fatty rats
    Hanna Shevalye
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 61:2126-33. 2012
    ..Clinical studies are needed to determine if Metanx finds use in management of diabetic peripheral neuropathy...
  4. pmc Prediabetic nephropathy as an early consequence of the high-calorie/high-fat diet: relation to oxidative stress
    Hanna Shevalye
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Endocrinology 153:1152-61. 2012
    ....
  5. pmc Oxidative-nitrosative stress and poly(ADP-ribose) polymerase (PARP) activation in experimental diabetic neuropathy: the relation is revisited
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, Louisiana 70808, USA
    Diabetes 54:3435-41. 2005
    ..The relations between oxidative-nitrosative stress and PARP activation in diabetes are bi- rather than unidirectional, and PARP activation cannot only result from but also lead to free radical and oxidant generation...
  6. pmc Poly(Adenosine 5'-diphosphate-ribose) polymerase inhibition counteracts multiple manifestations of experimental type 1 diabetic nephropathy
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Endocrinology 150:5273-83. 2009
    ..These findings provide rationale for development and further studies of PARP inhibitors and PARP inhibitor-containing combination therapies...
  7. doi Diabetic painful and insensate neuropathy: pathogenesis and potential treatments
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Neurotherapeutics 6:638-47. 2009
    ..This review describes recent achievements in studying the pathogenesis of diabetic neuropathic pain and sensory disorders in diabetic animal models and developing potential pathogenetic treatments...
  8. pmc PARP inhibition or gene deficiency counteracts intraepidermal nerve fiber loss and neuropathic pain in advanced diabetic neuropathy
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Free Radic Biol Med 44:972-81. 2008
    ..The results support a rationale for the development of potent and low-toxicity PARP inhibitors and PARP inhibitor-containing combination therapies...
  9. pmc Early diabetes-induced biochemical changes in the retina: comparison of rat and mouse models
    I G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Diabetologia 49:2525-33. 2006
    ..The present study compared retinal biochemical changes in rats and mice with similar (6-week) durations of streptozotocin-induced diabetes...
  10. ncbi Peroxynitrite and cardiomyocyte cell death: an evolving story. A commentary on "Peroxynitrite is a major trigger of cardiomyocyte apoptosis in vitro and in vivo"
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Free Radic Biol Med 41:866-8. 2006
  11. doi Diabetes and the peripheral nerve
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Biochim Biophys Acta 1792:931-40. 2009
    ....
  12. ncbi High-fat diet induced neuropathy of pre-diabetes and obesity: effects of "healthy" diet and aldose reductase inhibition
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 56:2598-608. 2007
    ..This study evaluated neuropathic changes and their amenability to dietary and pharmacological interventions in mice fed a high-fat diet (HFD), a model of pre-diabetes and alimentary obesity...
  13. ncbi Role of nitrosative stress in early neuropathy and vascular dysfunction in streptozotocin-diabetic rats
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 293:E1645-55. 2007
    ..The findings reveal the important role of nitrosative stress in early neuropathy and vasculopathy and provide the rationale for further studies of peroxynitrite decomposition catalysts in long-term diabetic models...
  14. pmc Aldose reductase inhibition counteracts oxidative-nitrosative stress and poly(ADP-ribose) polymerase activation in tissue sites for diabetes complications
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 54:234-42. 2005
    ..These findings reveal the new beneficial properties of fidarestat, thus further justifying the ongoing clinical trials of this specific, potent, and low-toxic ARI...
  15. ncbi Role for poly(ADP-ribose) polymerase activation in diabetic nephropathy, neuropathy and retinopathy
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
    Curr Vasc Pharmacol 3:267-83. 2005
    ..This review describes recent studies addressing the role for poly(ADP-ribose) polymerase activation in diabetic nephropathy, neuropathy and retinopathy...
  16. ncbi Diabetic cataracts: mechanisms and management
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Diabetes Metab Res Rev 26:172-80. 2010
    ..An improved understanding of pathogenetic mechanisms, together with finding effective therapeutic agents, remain highest priority for diabetic cataract-related research and pharmaceutical development...
  17. pmc Evaluation of the aldose reductase inhibitor fidarestat on ischemia-reperfusion injury in rat retina
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Mol Med 26:135-42. 2010
    ..The results identify AR as an important therapeutic target for diseases involving IR injury, and provide the rationale for development of fidarestat and other AR inhibitors...
  18. ncbi Role for nitrosative stress in diabetic neuropathy: evidence from studies with a peroxynitrite decomposition catalyst
    Irina G Obrosova
    Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA
    FASEB J 19:401-3. 2005
    ..This provides the rationale for development of agents counteracting peroxynitrite formation and promoting peroxynitrite decomposition, and their evaluation in DN...
  19. ncbi Aldose reductase / polyol inhibitors for diabetic retinopathy
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
    Curr Pharm Biotechnol 12:373-85. 2011
    ..A detailed analysis of clinical diabetic retinopathy trials of aldose reductase inhibitors is also provided...
  20. pmc Different roles of 12/15-lipoxygenase in diabetic large and small fiber peripheral and autonomic neuropathies
    Irina G Obrosova
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Pathol 177:1436-47. 2010
    ..This should be considered in the selection of endpoints for future clinical trials of 12/15-lipoxygenase inhibitors...
  21. ncbi Aldose reductase inhibitor fidarestat prevents retinal oxidative stress and vascular endothelial growth factor overexpression in streptozotocin-diabetic rats
    Irina G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Room 5570, Ann Arbor, MI 48109 0678, USA
    Diabetes 52:864-71. 2003
    ..In conclusion, increased AR activity contributes to retinal oxidative stress and VEGF protein overexpression in early diabetes. The findings justify the rationale for evaluation of fidarestat on diabetic retinopathy...
  22. doi Poly(ADP-ribose)polymerase inhibition counteracts cataract formation and early retinal changes in streptozotocin-diabetic rats
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Invest Ophthalmol Vis Sci 50:1778-90. 2009
    ..This study evaluated the role for poly(ADP-ribose) polymerase (PARP) in diabetes-induced cataractogenesis and early retinal changes...
  23. ncbi Nitrosative stress and peripheral diabetic neuropathy in leptin-deficient (ob/ob) mice
    Igor Vareniuk
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Exp Neurol 205:425-36. 2007
    ..Peroxynitrite decomposition catalysts alleviate Type 2 diabetes-associated sensory nerve dysfunction, likely by mechanism(s) not involving arrest of degenerative changes or enhanced regeneration of small sensory nerve fibers...
  24. pmc Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy
    Olga Ilnytska
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 55:1686-94. 2006
    ..In conclusion, PARP activation contributes to early diabetic sensory neuropathy by mechanisms that may include oxidative stress but not neuronal apoptosis...
  25. pmc Aldose reductase inhibitor fidarestat counteracts diabetes-associated cataract formation, retinal oxidative-nitrosative stress, glial activation, and apoptosis
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Mol Med 21:667-76. 2008
    ....
  26. ncbi Role of poly(ADP-ribose) polymerase activation in diabetic neuropathy
    Irina G Obrosova
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Diabetes 53:711-20. 2004
    ..Thus, the current work identifies PARP activation as an important mechanism in diabetic neuropathy and provides the first evidence for the potential therapeutic value of PARP inhibitors in this devastating complication of diabetes...
  27. pmc A peroxynitrite decomposition catalyst counteracts sensory neuropathy in streptozotocin-diabetic mice
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Eur J Pharmacol 569:48-58. 2007
    ..In conclusion, nitrosative stress plays an important role in sensory neuropathy associated with Type 1 diabetes. The findings provide rationale for further studies of peroxynitrite decomposition catalysts in a long-term diabetic model...
  28. ncbi Taurine replacement attenuates hyperalgesia and abnormal calcium signaling in sensory neurons of STZ-D rats
    Fei Li
    Department of Internal Medicine, Michigan Diabetes Research and Training Center, University of Michigan, Ann Arbor Veterans Administration Hospitals, Ann Arbor, Michigan, USA
    Am J Physiol Endocrinol Metab 288:E29-36. 2005
    ..These data indicate that taurine is important in the regulation of neuronal Ca2+ signaling and that taurine deficiency may predispose one to nerve hyperexcitability and pain, complicating diabetes...
  29. pmc Evaluation of the peroxynitrite decomposition catalyst Fe(III) tetra-mesitylporphyrin octasulfonate on peripheral neuropathy in a mouse model of type 1 diabetes
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Mol Med 20:783-92. 2007
    ..The findings provide rationale for development of potent peroxynitrite decomposition catalysts for the treatment of diabetic neuropathy...
  30. doi Poly(ADP-ribose) polymerase (PARP) inhibition counteracts multiple manifestations of kidney disease in long-term streptozotocin-diabetic rat model
    Hanna Shevalye
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, United States
    Biochem Pharmacol 79:1007-14. 2010
    ..These findings provide rationale for development and further studies of PARP inhibitors and PARP inhibitor-containing combination therapies, for prevention and treatment of diabetic nephropathy...
  31. ncbi An aldose reductase inhibitor reverses early diabetes-induced changes in peripheral nerve function, metabolism, and antioxidative defense
    Irina G Obrosova
    Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan 48109 0354, USA
    FASEB J 16:123-5. 2002
    ..In conclusion, treatment with adequate doses of ARIs (that is, doses that completely inhibit increased sorbitol pathway activity) is an effective approach for reversal of, at least, early diabetic neuropathy...
  32. ncbi Poly(ADP-ribose) polymerase inhibitors counteract diabetes- and hypoxia-induced retinal vascular endothelial growth factor overexpression
    Irina G Obrosova
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI, USA
    Int J Mol Med 14:55-64. 2004
    ..The results justify studies of PARP inhibitors in models of retinopathy of prematurity and diabetic retinopathy...
  33. pmc Aldose reductase inhibition counteracts nitrosative stress and poly(ADP-ribose) polymerase activation in diabetic rat kidney and high-glucose-exposed human mesangial cells
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
    Free Radic Biol Med 40:1454-65. 2006
    ..These findings reveal new beneficial properties of the AR inhibitor F and provide the rationale for detailed studies of F on diabetic nephropathy...
  34. ncbi The leptin-deficient (ob/ob) mouse: a new animal model of peripheral neuropathy of type 2 diabetes and obesity
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 55:3335-43. 2006
    ..The results support the role for increased aldose reductase activity in functional and structural changes of PDN in type 2 diabetes...
  35. ncbi Low-dose poly(ADP-ribose) polymerase inhibitor-containing combination therapies reverse early peripheral diabetic neuropathy
    Fei Li
    Department of Internal Medicine, University of Michigan, Ann Arbor, USA
    Diabetes 54:1514-22. 2005
    ..In conclusion, low-dose PARP inhibitor-containing combination therapies may constitute a new approach for treatment of PDN...
  36. pmc New therapeutic and biomarker discovery for peripheral diabetic neuropathy: PARP inhibitor, nitrotyrosine, and tumor necrosis factor-{alpha}
    Viktor R Drel
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Endocrinology 151:2547-55. 2010
    ....
  37. doi Poly(ADP-ribose) polymerase-1 (PARP-1) gene deficiency alleviates diabetic kidney disease
    Hanna Shevalye
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Biochim Biophys Acta 1802:1020-7. 2010
    ..In conclusion, PARP-1-/- gene deficiency alleviates although does not completely prevent diabetic kidney disease...
  38. pmc Peripheral neuropathy in mice with neuronal nitric oxide synthase gene deficiency
    Igor Vareniuk
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Mol Med 23:571-80. 2009
    ..nNOS gene deficiency does not protect from development of nerve conduction deficit, sensory neuropathy and intraepidermal nerve fiber loss...
  39. ncbi Early oxidative stress in the diabetic kidney: effect of DL-alpha-lipoic acid
    Irina G Obrosova
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, MI 48109, USA
    Free Radic Biol Med 34:186-95. 2003
    ..controls, and these activities, except glutathione peroxidase, were decreased by DL-alpha-lipoic acid. In conclusion, enhanced oxidative stress is present in rat renal cortex in early diabetes, and is prevented by DL-alpha-lipoic acid...
  40. ncbi How does glucose generate oxidative stress in peripheral nerve?
    Irina G Obrosova
    Department of Internal Medicine, Division of Endocrinology and Metabolism, University of Michigan Medical Center, Ann Arbor, Michigan 48109, USA
    Int Rev Neurobiol 50:3-35. 2002
    ..Growing evidence indicates that AR has a key role in oxidative stress in the peripheral nerve and contributes to superoxide production by the vascular endothelium. The potential mechanisms of this phenonmenon are discussed...
  41. ncbi Taurine reverses neurological and neurovascular deficits in Zucker diabetic fatty rats
    Fei Li
    Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA
    Neurobiol Dis 22:669-76. 2006
    ..An 84% deficit of dorsal root ganglion neuron calcitonin gene-related peptide in D rats was prevented by taurine. In summary, the antioxidant taurine reverses neurological and neurovascular deficits in experimental type 2 diabetes...
  42. ncbi Increased sorbitol pathway activity generates oxidative stress in tissue sites for diabetic complications
    Irina G Obrosova
    Divison of Nutrition and Chronic Disease, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Antioxid Redox Signal 7:1543-52. 2005
    ....
  43. ncbi Increased JNK phosphorylation and oxidative stress in response to increased glucose flux through increased GLUT1 expression in rat retinal endothelial cells
    Jie Zhou
    Departments of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48109, USA
    Invest Ophthalmol Vis Sci 46:3403-10. 2005
    ..To investigate whether increased glucose flux through increased glucose transporter1 (GLUT1) expression results in increased oxidative stress and increased c-jun N-terminal kinase (JNK) phosphorylation...
  44. ncbi Update on the pathogenesis of diabetic neuropathy
    Irina G Obrosova
    University of Michigan, Division of Endocrinology and Metabolism, Department of Internal Medicine, University of Michigan Medical Center, 1150 West Medical Center Drive, MSRB II, Room 5570, Ann Arbor, MI 48109 0678, USA
    Curr Diab Rep 3:439-45. 2003
    ..Further studies are needed to understand the role of other signaling pathways as well as interactions among previously discovered mechanisms in the pathogenesis of PDN...
  45. pmc Role of nitrosative stress and peroxynitrite in the pathogenesis of diabetic complications. Emerging new therapeutical strategies
    Pal Pacher
    Laboratory of Physiologic Studies, National Institutes of Health, NIAAA, Bethesda, MD 20892 9413, USA
    Curr Med Chem 12:267-75. 2005
    ....
  46. ncbi Thioredoxin interacting protein is increased in sensory neurons in experimental diabetes
    Sally A Price
    Faculty of Life Sciences, Stopford Building, University of Manchester, 3 613 4 Stopford Building, Oxford Road, Manchester M13 9PT, UK
    Brain Res 1116:206-14. 2006
    ..These results indicate another mechanism by which diabetes may cause oxidative damage in peripheral nerve, and may represent a novel target for therapeutic intervention...
  47. ncbi Diabetes-induced overexpression of endothelin-1 and endothelin receptors in the rat renal cortex is mediated via poly(ADP-ribose) polymerase activation
    Alexander G Minchenko
    Department of Anesthesiology, Thomas Jefferson University, Philadelphia, Pennsylvania, USA
    FASEB J 17:1514-6. 2003
    ..PARP inhibitors could provide a novel therapeutic approach for diabetic complications including nephropathy, and other diseases that involve the endothelin system...

Research Grants12

  1. 12/15-Lipoxygenase and Diabetic Neuropathy
    IRINA OBROSOVA; Fiscal Year: 2009
    ..The findings will generate new information on the role for 12/15-LO in PDN of Type 1 and Type 2 diabetes, and may provide rationale for development of 12/15-LO inhibitors for its prevention and treatment. ..
  2. 12/15-Lipoxygenase and Diabetic Neuropathy
    IRINA OBROSOVA; Fiscal Year: 2009
    ..The findings will generate new information on the role for 12/15-LO in PDN of Type 1 and Type 2 diabetes, and may provide rationale for development of 12/15-LO inhibitors for its prevention and treatment. ..
  3. Role of poly(ADP-ribosyl)ation in diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2003
    ..The studies are of direct relevance to the pathogenesis of PDN and may provide the rationale for development of PARS inhibitors for its prevention and treatment. ..
  4. Na+/H+-exchanger-1 and Diabetic Neuropathy
    Irina G Obrosova; Fiscal Year: 2010
    ....
  5. Peroxynitrite, protein nitration and advanced diabetic neuropathy
    Irina G Obrosova; Fiscal Year: 2010
    ..They may also lead to identification of a new biomarker(s) of PDN with diagnostic and prognostic value. ..
  6. Na+/H+-exchanger-1 and Diabetic Neuropathy
    IRINA OBROSOVA; Fiscal Year: 2009
    ....
  7. 12/15-Lipoxygenase and Diabetic Neuropathy
    IRINA OBROSOVA; Fiscal Year: 2007
    ..The findings will generate new information on the role for 12/15-LO in PDN of Type 1 and Type 2 diabetes, and may provide rationale for development of 12/15-LO inhibitors for its prevention and treatment. ..
  8. Peroxynitrite decomposition catalyst:diabetic neuropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  9. Poly(ADP-ribose) polymerase in diabetic nephropathy
    IRINA OBROSOVA; Fiscal Year: 2006
    ..abstract_text> ..
  10. 12/15-Lipoxygenase and Diabetic Neuropathy
    Irina G Obrosova; Fiscal Year: 2010
    ..The findings will generate new information on the role for 12/15-LO in PDN of Type 1 and Type 2 diabetes, and may provide rationale for development of 12/15-LO inhibitors for its prevention and treatment. ..