Michael Lefevre

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. ncbi request reprint Comparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile: studies in the fasting and postprandial states
    Lars Berglund
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Clin Nutr 86:1611-20. 2007
  2. ncbi request reprint Individual variability in cardiovascular disease risk factor responses to low-fat and low-saturated-fat diets in men: body mass index, adiposity, and insulin resistance predict changes in LDL cholesterol
    Michael Lefevre
    Division of Functional Foods Research, Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Am J Clin Nutr 82:957-63; quiz 1145-6. 2005
  3. ncbi request reprint Comparison of the acute response to meals enriched with cis- or trans-fatty acids on glucose and lipids in overweight individuals with differing FABP2 genotypes
    Michael Lefevre
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Metabolism 54:1652-8. 2005
  4. ncbi request reprint Dietary fatty acids, hemostasis, and cardiovascular disease risk
    Michael Lefevre
    Division of Functional Foods Research, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    J Am Diet Assoc 104:410-9; quiz 492. 2004
  5. ncbi request reprint Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes
    Zhanguo Gao
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Mol Endocrinol 18:2024-34. 2004
  6. ncbi request reprint A 9-mo randomized clinical trial comparing fat-substituted and fat-reduced diets in healthy obese men: the Ole Study
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 76:928-34. 2002
  7. pmc Butyrate improves insulin sensitivity and increases energy expenditure in mice
    Zhanguo Gao
    Antioxidant and Gene Regulation Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Diabetes 58:1509-17. 2009
  8. ncbi request reprint Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice
    Zhanguo Gao
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 292:E84-91. 2007
  9. ncbi request reprint Secretome of primary cultures of human adipose-derived stem cells: modulation of serpins by adipogenesis
    Sanjin Zvonic
    Stem Cell Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Mol Cell Proteomics 6:18-28. 2007
  10. pmc Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function
    D Enette Larson-Meyer
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 16:1355-62. 2008

Research Grants

Detail Information

Publications24

  1. ncbi request reprint Comparison of monounsaturated fat with carbohydrates as a replacement for saturated fat in subjects with a high metabolic risk profile: studies in the fasting and postprandial states
    Lars Berglund
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Am J Clin Nutr 86:1611-20. 2007
    ..In subjects with a high prevalence of metabolic risk abnormalities, the preferred replacement for saturated fat is unresolved...
  2. ncbi request reprint Individual variability in cardiovascular disease risk factor responses to low-fat and low-saturated-fat diets in men: body mass index, adiposity, and insulin resistance predict changes in LDL cholesterol
    Michael Lefevre
    Division of Functional Foods Research, Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Am J Clin Nutr 82:957-63; quiz 1145-6. 2005
    ..Although reductions in total and saturated fat consumption are recommended to reduce the risk of cardiovascular disease, individual variability in plasma lipid responses exists...
  3. ncbi request reprint Comparison of the acute response to meals enriched with cis- or trans-fatty acids on glucose and lipids in overweight individuals with differing FABP2 genotypes
    Michael Lefevre
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Metabolism 54:1652-8. 2005
    ....
  4. ncbi request reprint Dietary fatty acids, hemostasis, and cardiovascular disease risk
    Michael Lefevre
    Division of Functional Foods Research, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    J Am Diet Assoc 104:410-9; quiz 492. 2004
    ..An array of dietary strategies that target multiple CVD risk factors could have a greater impact on CVD than a single risk factor intervention strategy...
  5. ncbi request reprint Inhibition of insulin sensitivity by free fatty acids requires activation of multiple serine kinases in 3T3-L1 adipocytes
    Zhanguo Gao
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Mol Endocrinol 18:2024-34. 2004
    ....
  6. ncbi request reprint A 9-mo randomized clinical trial comparing fat-substituted and fat-reduced diets in healthy obese men: the Ole Study
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 76:928-34. 2002
    ..Dietary fat has been implicated as a risk factor for cardiovascular disease and obesity...
  7. pmc Butyrate improves insulin sensitivity and increases energy expenditure in mice
    Zhanguo Gao
    Antioxidant and Gene Regulation Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Diabetes 58:1509-17. 2009
    ..We examined the role of butyric acid, a short-chain fatty acid formed by fermentation in the large intestine, in the regulation of insulin sensitivity in mice fed a high-fat diet...
  8. ncbi request reprint Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice
    Zhanguo Gao
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 292:E84-91. 2007
    ..This study suggests that loss of PKCtheta reduces energy expenditure and increases the risk of dietary obesity and insulin resistance in mice...
  9. ncbi request reprint Secretome of primary cultures of human adipose-derived stem cells: modulation of serpins by adipogenesis
    Sanjin Zvonic
    Stem Cell Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Mol Cell Proteomics 6:18-28. 2007
    ..These findings, together with the recent identification of vaspin, suggest that the serpin protein family warrants further proteomics investigation with respect to the etiology of obesity and type 2 diabetes...
  10. pmc Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function
    D Enette Larson-Meyer
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 16:1355-62. 2008
    ....
  11. ncbi request reprint Effects of diets enriched in saturated (palmitic), monounsaturated (oleic), or trans (elaidic) fatty acids on insulin sensitivity and substrate oxidation in healthy adults
    Jennifer C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Diabetes Care 25:1283-8. 2002
    ..Diets high in total and saturated fat are associated with insulin resistance. This study examined the effects of feeding monounsaturated, saturated, and trans fatty acids on insulin action in healthy adults...
  12. ncbi request reprint The influence of different fats and fatty acids on obesity, insulin resistance and inflammation
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Nutr 132:2488-91. 2002
    ..One important conclusion from this review is that both total fat and individual fatty acids have to be considered when reaching conclusions about dietary fat and obesity...
  13. ncbi request reprint Effect of diets enriched in almonds on insulin action and serum lipids in adults with normal glucose tolerance or type 2 diabetes
    Jennifer C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Am J Clin Nutr 76:1000-6. 2002
    ..Nuts appear to have cardiovascular benefits but their effect in diabetic patients is unclear...
  14. pmc Calorie restriction and bone health in young, overweight individuals
    Leanne M Redman
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Arch Intern Med 168:1859-66. 2008
    ..Calorie restriction (CR) is promoted to increase longevity, yet this regimen could lead to bone loss and fracture and therefore affect quality of life...
  15. pmc The effect of caloric restriction interventions on growth hormone secretion in nonobese men and women
    Leanne M Redman
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Aging Cell 9:32-9. 2010
    ..05) and LCD (19 +/- 4%, P < 0.001). A 25% CR diet for 6 months does not change GH, GH secretion or IGF-1 in nonobese men and women...
  16. pmc Dose effects of dietary phytosterols on cholesterol metabolism: a controlled feeding study
    Susan B Racette
    Washington University School of Medicine, St Louis, MO, and the Pennington Biomedical Research Center, Baton Rouge, LA 63108, USA
    Am J Clin Nutr 91:32-8. 2010
    ..Phytosterol supplementation of 2 g/d is recommended by the National Cholesterol Education Program to reduce LDL cholesterol. However, the effects of different intakes of phytosterol on cholesterol metabolism are uncertain...
  17. ncbi request reprint Rice bran oil, not fiber, lowers cholesterol in humans
    Marlene M Most
    Division of Functional Foods Research, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 81:64-8. 2005
    ..The cholesterol-lowering abilities of rice bran's fiber and oil apart from its fatty acid composition remain unclear...
  18. ncbi request reprint Proteomic analysis of primary cultures of human adipose-derived stem cells: modulation by Adipogenesis
    James P Delany
    Stable Isotope Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Mol Cell Proteomics 4:731-40. 2005
    ..These findings suggest that the heat shock protein family proteome warrants further investigation with respect to the etiology of obesity and type 2 diabetes...
  19. ncbi request reprint The association of homocysteine and related factors to brachial artery diameter and flow-mediated dilation
    Joanie B Wilson
    Department of Kinesiology, Louisiana State University, Baton Rouge, LA 70802, USA
    Metabolism 56:641-8. 2007
    ..Finally, the data suggest that the effect of homocysteine on vascular reactivity is in part a consequence of its influence on baseline brachial artery diameter...
  20. ncbi request reprint Botanicals and the metabolic syndrome
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 87:481S-7S. 2008
    ..With the completion of our research, we anticipate a better understanding of the cellular mechanisms by which insulin resistance develops and the role of botanicals in modulating the progression to metabolic syndrome...
  21. ncbi request reprint Serine phosphorylation of insulin receptor substrate 1 by inhibitor kappa B kinase complex
    Zhanguo Gao
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    J Biol Chem 277:48115-21. 2002
    ....
  22. pmc Gene expression microarray analysis of the effects of grape anthocyanins in mice: a test of a hypothesis-generating paradigm
    Michael Lefevre
    Center for Advanced Nutrition, Utah State University, Logan, UT 84322 4715, USA
    Metabolism 57:S52-7. 2008
    ..From these data, 3 hypotheses were developed for future investigation...
  23. ncbi request reprint Summary of American Heart Association Diet and Lifestyle Recommendations revision 2006
    Alice H Lichtenstein
    Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA 02111, USA
    Arterioscler Thromb Vasc Biol 26:2186-91. 2006
  24. ncbi request reprint Diet and lifestyle recommendations revision 2006: a scientific statement from the American Heart Association Nutrition Committee
    Alice H Lichtenstein
    Circulation 114:82-96. 2006
    ..By adhering to these diet and lifestyle recommendations, Americans can substantially reduce their risk of developing cardiovascular disease, which remains the leading cause of morbidity and mortality in the United States...

Research Grants1

  1. Diet, genetics, and CVD risk factor response in Blacks
    Michael Lefevre; Fiscal Year: 2006
    ..This information will guide the design of future dietary and lifestyle interventions to combat CVD. ..