CLAUDIA T KAPPEN

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. ncbi request reprint Gene expression in teratogenic exposures: A new approach to understanding individual risk
    Claudia Kappen
    Department of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, United States Electronic address
    Reprod Toxicol 45:94-104. 2014
  2. pmc Expression of cartilage developmental genes in Hoxc8- and Hoxd4-transgenic mice
    Claudia Kruger
    Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 5:e8978. 2010
  3. pmc Transgenic studies on homeobox genes in nervous system development: spina bifida in Isl1 transgenic mice
    Claudia Kappen
    Department of Developmental Biology, Pennington Biomedical Research Center Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70810, USA
    Transgenic Res 22:343-58. 2013
  4. pmc Maternal diet modulates placenta growth and gene expression in a mouse model of diabetic pregnancy
    Claudia Kappen
    Department of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States of America
    PLoS ONE 7:e38445. 2012
  5. pmc Maternal diabetes alters transcriptional programs in the developing embryo
    Gabriela Pavlinkova
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198 5455, USA
    BMC Genomics 10:274. 2009
  6. ncbi request reprint Molecular basis for skeletal variation: insights from developmental genetic studies in mice
    C Kappen
    Center for Human Molecular Genetics, Munroe Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Birth Defects Res B Dev Reprod Toxicol 80:425-50. 2007
  7. pmc Identification of regulatory elements in the Isl1 gene locus
    Claudia Kappen
    Pennington Biomedical Research Center, Baton Rouge, LA 71010, USA
    Int J Dev Biol 53:935-46. 2009
  8. pmc Maternal diet modulates the risk for neural tube defects in a mouse model of diabetic pregnancy
    Claudia Kappen
    Department of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Reprod Toxicol 31:41-9. 2011

Research Grants

  1. FOLATE AND HOX GENES IN CRANIOFACIAL DEVELOPMENT
    Claudia Kappen; Fiscal Year: 2003
  2. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    CLAUDIA T KAPPEN; Fiscal Year: 2010
  3. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    Claudia Kappen; Fiscal Year: 2000
  4. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    Claudia Kappen; Fiscal Year: 2007
  5. Genetic dissection of skeletal patterning
    Claudia Kappen; Fiscal Year: 2006
  6. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    Claudia Kappen; Fiscal Year: 2007
  7. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    Claudia Kappen; Fiscal Year: 2005
  8. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    Claudia Kappen; Fiscal Year: 2006
  9. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    Claudia Kappen; Fiscal Year: 2005
  10. Genome-wide discovery of beta cell gene control elements
    Claudia Kappen; Fiscal Year: 2004

Collaborators

  • Claudia Kruger
  • Gabriela Pavlinkova
  • J Michael Salbaum

Detail Information

Publications8

  1. ncbi request reprint Gene expression in teratogenic exposures: A new approach to understanding individual risk
    Claudia Kappen
    Department of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, United States Electronic address
    Reprod Toxicol 45:94-104. 2014
    ..We propose that focus on the variation between exposed individuals could help to discover factors that may play a causative role for abnormal developmental processes that occur with incomplete penetrance. ..
  2. pmc Expression of cartilage developmental genes in Hoxc8- and Hoxd4-transgenic mice
    Claudia Kruger
    Department of Genetics, Cell Biology, and Anatomy, University of Nebraska Medical Center, Omaha, Nebraska, United States of America
    PLoS ONE 5:e8978. 2010
    ....
  3. pmc Transgenic studies on homeobox genes in nervous system development: spina bifida in Isl1 transgenic mice
    Claudia Kappen
    Department of Developmental Biology, Pennington Biomedical Research Center Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70810, USA
    Transgenic Res 22:343-58. 2013
    ....
  4. pmc Maternal diet modulates placenta growth and gene expression in a mouse model of diabetic pregnancy
    Claudia Kappen
    Department of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States of America
    PLoS ONE 7:e38445. 2012
    ..These results implicate maternal diet as an important factor in pregnancy complications and suggest that the early phases of placenta development could be a critical time window for developmental origins of adult disease...
  5. pmc Maternal diabetes alters transcriptional programs in the developing embryo
    Gabriela Pavlinkova
    Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198 5455, USA
    BMC Genomics 10:274. 2009
    ..We here report results from gene expression profiling of exposed embryos from a mouse diabetes model...
  6. ncbi request reprint Molecular basis for skeletal variation: insights from developmental genetic studies in mice
    C Kappen
    Center for Human Molecular Genetics, Munroe Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA
    Birth Defects Res B Dev Reprod Toxicol 80:425-50. 2007
    ..Environmental agents that induce variations, such as teratogens, likely interact with the molecular pathways that regulate skeletal development...
  7. pmc Identification of regulatory elements in the Isl1 gene locus
    Claudia Kappen
    Pennington Biomedical Research Center, Baton Rouge, LA 71010, USA
    Int J Dev Biol 53:935-46. 2009
    ..Embryonic Isl1 expression in several tissues of mesodermal origin is driven by a specific enhancer that is located 3-6kb downstream of the gene...
  8. pmc Maternal diet modulates the risk for neural tube defects in a mouse model of diabetic pregnancy
    Claudia Kappen
    Department of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Reprod Toxicol 31:41-9. 2011
    ....

Research Grants15

  1. FOLATE AND HOX GENES IN CRANIOFACIAL DEVELOPMENT
    Claudia Kappen; Fiscal Year: 2003
    ..Knowledge about the interactions of genes with environmental factors will be important for designing therapeutic strategies and preventive measures against craniofacial defects. ..
  2. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    CLAUDIA T KAPPEN; Fiscal Year: 2010
    ..These experiments will generate new and comprehensive insights into the function of pancreatic transcription factors and their pathogenic potential in metabolic disease and fetal development. ..
  3. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    Claudia Kappen; Fiscal Year: 2000
    ..Finally, the regulation of Isl-1 will be investigated using deletion analysis of the Isl-1 promoter. It is hoped that understanding the effects of Isl-1 overexpression will lead to new reagents to study diabetic embryopathy. ..
  4. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    Claudia Kappen; Fiscal Year: 2007
    ..These experiments will generate new and comprehensive insights into the function of pancreatic transcription factors and their pathogenic potential in metabolic disease and fetal development. ..
  5. Genetic dissection of skeletal patterning
    Claudia Kappen; Fiscal Year: 2006
    ..The identification of modifier loci that act on skeletal patterning will reveal new molecular mechanisms in skeletal development and has important implications for the evolution of vertebrate body plans. ..
  6. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    Claudia Kappen; Fiscal Year: 2007
    ..These experiments will generate new and comprehensive insights into the function of pancreatic transcription factors and their pathogenic potential in metabolic disease and fetal development. ..
  7. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    Claudia Kappen; Fiscal Year: 2005
    ..These experiments will generate new and comprehensive insights into the function of pancreatic transcription factors and their pathogenic potential in metabolic disease and fetal development. ..
  8. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    Claudia Kappen; Fiscal Year: 2006
    ..These experiments will generate new and comprehensive insights into the function of pancreatic transcription factors and their pathogenic potential in metabolic disease and fetal development. ..
  9. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    Claudia Kappen; Fiscal Year: 2005
    ..These experiments will generate new and comprehensive insights into the function of pancreatic transcription factors and their pathogenic potential in metabolic disease and fetal development. ..
  10. Genome-wide discovery of beta cell gene control elements
    Claudia Kappen; Fiscal Year: 2004
    ..Together, our studies will show how speck gene expression is achieved in beta cells and provide a framework to integrate gene transcription and beta cell biology. ..
  11. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    Claudia Kappen; Fiscal Year: 2004
    ..These experiments will generate new and comprehensive insights into the function of pancreatic transcription factors and their pathogenic potential in metabolic disease and fetal development. ..
  12. Genome-wide discovery of beta cell gene control elements
    Claudia Kappen; Fiscal Year: 2003
    ..Together, our studies will show how speck gene expression is achieved in beta cells and provide a framework to integrate gene transcription and beta cell biology. ..
  13. Genome-wide discovery of beta cell gene control elements
    Claudia Kappen; Fiscal Year: 2002
    ..Together, our studies will show how speck gene expression is achieved in beta cells and provide a framework to integrate gene transcription and beta cell biology. ..
  14. MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHY
    Claudia Kappen; Fiscal Year: 1999
    ..Finally, the regulation of Isl-1 will be investigated using deletion analysis of the Isl-1 promoter. It is hoped that understanding the effects of Isl-1 overexpression will lead to new reagents to study diabetic embryopathy. ..