CLAUDIA T KAPPEN
Affiliation: Pennington Biomedical Research Center
- Transgenic studies on homeobox genes in nervous system development: spina bifida in Isl1 transgenic miceClaudia Kappen
Department of Developmental Biology, Pennington Biomedical Research Center Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70810, USA
Transgenic Res 22:343-58. 2013....
- Maternal diet modulates placenta growth and gene expression in a mouse model of diabetic pregnancyClaudia Kappen
Department of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States of America
PLoS ONE 7:e38445. 2012..These results implicate maternal diet as an important factor in pregnancy complications and suggest that the early phases of placenta development could be a critical time window for developmental origins of adult disease...
- Maternal diabetes alters transcriptional programs in the developing embryoGabriela Pavlinkova
Department of Genetics, Cell Biology and Anatomy, University of Nebraska Medical Center, Omaha, NE 68198 5455, USA
BMC Genomics 10:274. 2009..We here report results from gene expression profiling of exposed embryos from a mouse diabetes model...
- Molecular basis for skeletal variation: insights from developmental genetic studies in miceC Kappen
Center for Human Molecular Genetics, Munroe Meyer Institute, University of Nebraska Medical Center, Omaha, Nebraska, USA
Birth Defects Res B Dev Reprod Toxicol 80:425-50. 2007..Environmental agents that induce variations, such as teratogens, likely interact with the molecular pathways that regulate skeletal development...
- Identification of regulatory elements in the Isl1 gene locusClaudia Kappen
Pennington Biomedical Research Center, Baton Rouge, LA 71010, USA
Int J Dev Biol 53:935-46. 2009..Embryonic Isl1 expression in several tissues of mesodermal origin is driven by a specific enhancer that is located 3-6kb downstream of the gene...
- Maternal diet modulates the risk for neural tube defects in a mouse model of diabetic pregnancyClaudia Kappen
Department of Developmental Biology, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Reprod Toxicol 31:41-9. 2011....
- FOLATE AND HOX GENES IN CRANIOFACIAL DEVELOPMENTClaudia Kappen; Fiscal Year: 2003..Knowledge about the interactions of genes with environmental factors will be important for designing therapeutic strategies and preventive measures against craniofacial defects. ..
- MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHYCLAUDIA T KAPPEN; Fiscal Year: 2010..These experiments will generate new and comprehensive insights into the function of pancreatic transcription factors and their pathogenic potential in metabolic disease and fetal development. ..
- MOLECULAR MECHANISMS IN DIABETIC EMBRYOPATHYClaudia Kappen; Fiscal Year: 2000..Finally, the regulation of Isl-1 will be investigated using deletion analysis of the Isl-1 promoter. It is hoped that understanding the effects of Isl-1 overexpression will lead to new reagents to study diabetic embryopathy. ..
- Genetic dissection of skeletal patterningClaudia Kappen; Fiscal Year: 2006..The identification of modifier loci that act on skeletal patterning will reveal new molecular mechanisms in skeletal development and has important implications for the evolution of vertebrate body plans. ..
- Genome-wide discovery of beta cell gene control elementsClaudia Kappen; Fiscal Year: 2004..Together, our studies will show how speck gene expression is achieved in beta cells and provide a framework to integrate gene transcription and beta cell biology. ..