Alok Gupta

Summary

Affiliation: Pennington Biomedical R esearch Center, Louisiana State University System
Location: Baton Rouge, USA
Publications:
Galgani JE, Johannsen NM, Bajpeyi S, Costford SR, Zhang Z, Gupta AK, Ravussin E. Role of skeletal muscle mitochondrial density on exercise-stimulated lipid oxidation. Obesity (Silver Spring). 2012 Jul;20(7):1387-93. doi: 10.1038/oby.2011.166. Epub 2011 Jun 16. PubMed PMID: .
Related citations
2: Gupta AK, Ravussin E, Johannsen DL, Stull AJ, Cefalu WT, Johnson WD. Endothelial Dysfunction: An Early Cardiovascular Risk Marker in Asymptomatic Obese Individuals with Prediabetes. British Journal of Medicine & Medical Research. 2012 June ; 2(3):413-423.
3: Rahman M, Ford CE, Cutler JA, Davis BR, Piller LB, Whelton PK, Wright JT Jr, Barzilay JI, Brown CD, Colon PJ Sr, Fine LJ, Grimm RH Jr, Gupta AK, Baimbridge C, Haywood LJ, Henriquez MA, Ilamaythi E, Oparil S, Preston R; ALLHAT Collaborative Research Group. Long-term renal and cardiovascular outcomes in Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) participants by baseline estimated GFR. Clin J Am Soc Nephrol. 2012 Jun;7(6):989-1002. Epub 2012 Apr 5. PubMed PMID: ; PubMed Central PMCID: PMC3362309.
Related citations
4: Gupta AK, Brashear MM, Johnson WD. Low vitamin D levels, prediabetes and prehypertension in healthy African American adults. Nutr Metab Cardiovasc Dis. 2012 Apr 9. [Epub ahead of print] PubMed PMID: .
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5: Barzilay JI, Davis BR, Pressel SL, Cutler JA, Einhorn PT, Black HR, Cushman WC, Ford CE, Margolis KL, Moloo J, Oparil S, Piller LB, Simmons DL, Sweeney ME, Whelton PK, Wong ND, Wright JT Jr; ALLHAT Collaborative Research Group. Long-term effects of incident diabetes mellitus on cardiovascular outcomes in people treated for hypertension: the ALLHAT Diabetes Extension Study. Circ Cardiovasc Qual Outcomes. 2012 Mar 1;5(2):153-62. Epub 2012 Mar 6. PubMed PMID: ; PubMed Central PMCID: PMC3359874.
Related citations
6: Greenway F, Liu Z, Yu Y, Gupta A. A clinical trial testing the safety and efficacy of a standardized Eucommia ulmoides Oliver bark extract to treat hypertension. Altern Med Rev. 2011 Dec;16(4):338-47. PubMed PMID: .
Related citations
7: Hendricks EJ, Greenway FL, Westman EC, Gupta AK. Blood pressure and heart rate effects, weight loss and maintenance during long-term phentermine pharmacotherapy for obesity. Obesity (Silver Spring). 2011 Dec;19(12):2351-60. doi: 10.1038/oby.2011.94. Epub 2011 Apr 28. PubMed PMID: .
Related citations
8: Kumarasamy S, Gopalakrishnan K, Kim DH, Abraham NG, Johnson WD, Joe B, Gupta AK. Dysglycemia induces abnormal circadian blood pressure variability. Cardiovasc Diabetol. 2011 Nov 22;10:104. PubMed PMID: ; PubMed Central PMCID: PMC3247849.
Free full textRelated citations
9: Johnson WD, Brashear MM, Gupta AK, Rood JC, Ryan DH. Incremental weight loss improves cardiometabolic risk in extremely obese adults. Am J Med. 2011 Oct;124(10):931-8. PubMed PMID: .
Related citations
10: Dubuisson O, Dhurandhar EJ, Krishnapuram R, Kirk-Ballard H, Gupta AK, Hegde V, Floyd E, Gimble JM, Dhurandhar NV. PPARgamma-independent increase in glucose uptake and adiponectin abundance in fat cells. Endocrinology. 2011 Oct;152(10):3648-60. Epub 2011 Jul 26. PubMed PMID: ; PubMed Central PMCID: PMC3176641.
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11: Krishnapuram R, Dhurandhar EJ, Dubuisson O, Kirk-Ballard H, Bajpeyi S, Butte N, Sothern MS, Larsen-Meyer E, Chalew S, Bennett B, Gupta AK, Greenway FL, Johnson W, Brashear M, Reinhart G, Rankinen T, Bouchard C, Cefalu WT, Ye J, Javier R, Zuberi A, Dhurandhar NV. Template to improve glycemic control without reducing adiposity or dietary fat. Am J Physiol Endocrinol Metab. 2011 May;300(5):E779-89. Epub 2011 Jan 25. PubMed PMID: ; PubMed Central PMCID: PMC3093976.
Free full textCited in PMCRelated citations
12: Gupta AK, Brashear MM, Johnson WD. Coexisting prehypertension and prediabetes in healthy adults: a pathway for accelerated cardiovascular events. Hypertens Res. 2011 Apr;34(4):456-61. Epub 2011 Jan 13. PubMed PMID: .
Cited in PMCRelated citations
13: Bajpeyi S, Pasarica M, Moro C, Conley K, Jubrias S, Sereda O, Burk DH, Zhang Z, Gupta A, Kjems L, Smith SR. Skeletal muscle mitochondrial capacity and insulin resistance in type 2 diabetes. J Clin Endocrinol Metab. 2011 Apr;96(4):1160-8. Epub 2011 Feb 9. PubMed PMID: ; PubMed Central PMCID: PMC3070252.
Free full textCited in PMCRelated citations
14: Gupta AK, Brashear MM, Johnson WD. Prediabetes and prehypertension in healthy adults are associated with low vitamin D levels. Diabetes Care. 2011 Mar;34(3):658-60. Epub 2011 Jan 31. PubMed PMID: ; PubMed Central PMCID: PMC3041202.
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15: Singh RB, Fedacko J, Pella D, Macejova Z, Ghosh S, de Amit K, Begom R, Tumbis ZA, Haque M, Vajpeyee SK, de Meester F, Sergey C, Agarwalo R, Muthusamy VV; Five City Study Group, Gupta AK. Prevalence and risk factors for prehypertension and hypertension in five Indian cities. Acta Cardiol. 2011 Feb;66(1):29-37. PubMed PMID: .
Cited in PMCRelated citations
16: Rochon J, Bales CW, Ravussin E, Redman LM, Holloszy JO, Racette SB, Roberts SB, Das SK, Romashkan S, Galan KM, Hadley EC, Kraus WE; CALERIE Study Group. Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy. J Gerontol A Biol Sci Med Sci. 2011 Jan;66(1):97-108. Epub 2010 Oct 5. PubMed PMID: ; PubMed Central PMCID: PMC3032519.
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17: Gupta AK, Cornelissen G, Greenway FL, Dhoopati V, Halberg F, Johnson WD. Abnormalities in circadian blood pressure variability and endothelial function: pragmatic markers for adverse cardiometabolic profiles in asymptomatic obese adults. Cardiovasc Diabetol. 2010 Sep 24;9:58. PubMed PMID: ; PubMed Central PMCID: PMC2955642.
Free full textCited in PMCRelated citations
18: Gupta AK, Bray GA, Greenway FL, Martin CK, Johnson WD, Smith SR. Pioglitazone, but not metformin, reduces liver fat in Type-2 diabetes mellitus independent of weight changes. J Diabetes Complications. 2010 Sep-Oct;24(5):289-96. Epub 2009 Jul 4. PubMed PMID: ; PubMed Central PMCID: PMC2891296.
Free full textCited in PMCRelated citations
19: Gupta AK, McGlone M, Greenway FL, Johnson WD. Prehypertension in disease-free adults: a marker for an adverse cardiometabolic risk profile. Hypertens Res. 2010 Sep;33(9):905-10. Epub 2010 Jun 10. PubMed PMID: .
Cited in PMCRelated citations
20: Gupta AK, Johnson WD. Prediabetes and prehypertension in disease free obese adults correlate with an exacerbated systemic proinflammatory milieu. J Inflamm (Lond). 2010 Jul 26;7:36. PubMed PMID: ; PubMed Central PMCID: PMC2920244.
Free full textCited in PMCRelated citations
21: Martin CK, Gupta AK, Smith SR, Greenway FL, Han H, Bray GA. Effect of pioglitazone on energy intake and ghrelin in diabetic patients. Diabetes Care. 2010 Apr;33(4):742-4. Epub 2010 Jan 12. PubMed PMID: ; PubMed Central PMCID: PMC2845018.
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22: Ryan DH, Johnson WD, Myers VH, Prather TL, McGlone MM, Rood J, Brantley PJ, Bray GA, Gupta AK, Broussard AP, Barootes BG, Elkins BL, Gaudin DE, Savory RL, Brock RD, Datz G, Pothakamuri SR, McKnight GT, Stenlof K, Sj

Publications

  1. pmc Prediabetes and prehypertension in healthy adults are associated with low vitamin D levels
    Alok K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes Care 34:658-60. 2011
  2. doi Coexisting prehypertension and prediabetes in healthy adults: a pathway for accelerated cardiovascular events
    Alok K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Hypertens Res 34:456-61. 2011
  3. pmc Template to improve glycemic control without reducing adiposity or dietary fat
    R Krishnapuram
    Infections and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State Univ System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 300:E779-89. 2011
  4. ncbi A clinical trial testing the safety and efficacy of a standardized Eucommia ulmoides Oliver bark extract to treat hypertension
    Frank Greenway
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Altern Med Rev 16:338-47. 2011
  5. pmc Skeletal muscle mitochondrial capacity and insulin resistance in type 2 diabetes
    Sudip Bajpeyi
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 96:1160-8. 2011
  6. ncbi Prevalence and risk factors for prehypertension and hypertension in five Indian cities
    Ram B Singh
    Hamberg Hospital and Research Institute, Moradabad, India
    Acta Cardiol 66:29-37. 2011
  7. doi Blood pressure and heart rate effects, weight loss and maintenance during long-term phentermine pharmacotherapy for obesity
    Ed J Hendricks
    The Center for Weight Management, Roseville, California, USA
    Obesity (Silver Spring) 19:2351-60. 2011
  8. doi Role of skeletal muscle mitochondrial density on exercise-stimulated lipid oxidation
    Jose E Galgani
    Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile
    Obesity (Silver Spring) 20:1387-93. 2012
  9. pmc PPARgamma-independent increase in glucose uptake and adiponectin abundance in fat cells
    Olga Dubuisson
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Endocrinology 152:3648-60. 2011
  10. doi Incremental weight loss improves cardiometabolic risk in extremely obese adults
    William D Johnson
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Am J Med 124:931-8. 2011

Detail Information

Publications28

  1. pmc Prediabetes and prehypertension in healthy adults are associated with low vitamin D levels
    Alok K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes Care 34:658-60. 2011
    ..To determine whether modest elevations of fasting serum glucose (FSG) and resting blood pressure (BP) in healthy adults are associated with differential serum vitamin D concentrations...
  2. doi Coexisting prehypertension and prediabetes in healthy adults: a pathway for accelerated cardiovascular events
    Alok K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Hypertens Res 34:456-61. 2011
    ..High prevalence of Co-PreHTN+PreDM in healthy US adults, a strong correlate for dysregulated cardiometabolic risk factors, highlights a plausible accelerated pathway for early cardiovascular events...
  3. pmc Template to improve glycemic control without reducing adiposity or dietary fat
    R Krishnapuram
    Infections and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State Univ System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 300:E779-89. 2011
    ..This metabolic engineering by Ad36 appears relevant to humans for developing more practical and effective antidiabetic approaches...
  4. ncbi A clinical trial testing the safety and efficacy of a standardized Eucommia ulmoides Oliver bark extract to treat hypertension
    Frank Greenway
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Altern Med Rev 16:338-47. 2011
    ..A tea made from Eucommia ulmoides leaves and bark is part of the Japanese diet. Eucommia is an herbal medicine that, by increasing nitric oxide, reduced blood pressure (BP) in rats and humans in an uncontrolled clinical trial...
  5. pmc Skeletal muscle mitochondrial capacity and insulin resistance in type 2 diabetes
    Sudip Bajpeyi
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 96:1160-8. 2011
    ..The objective of this study was to determine the role of maximum mitochondrial capacity on the variation in insulin sensitivity within a population of patients with type 2 diabetes mellitus (T2DM)...
  6. ncbi Prevalence and risk factors for prehypertension and hypertension in five Indian cities
    Ram B Singh
    Hamberg Hospital and Research Institute, Moradabad, India
    Acta Cardiol 66:29-37. 2011
    ..There are few studies detailing the prevalence of prehypertension and hypertension in India...
  7. doi Blood pressure and heart rate effects, weight loss and maintenance during long-term phentermine pharmacotherapy for obesity
    Ed J Hendricks
    The Center for Weight Management, Roseville, California, USA
    Obesity (Silver Spring) 19:2351-60. 2011
    ....
  8. doi Role of skeletal muscle mitochondrial density on exercise-stimulated lipid oxidation
    Jose E Galgani
    Department of Nutrition, Faculty of Medicine, University of Chile, Santiago, Chile
    Obesity (Silver Spring) 20:1387-93. 2012
    ..Twenty-four-hour lipid oxidation and its relationship with mitochondrial density need to be assessed...
  9. pmc PPARgamma-independent increase in glucose uptake and adiponectin abundance in fat cells
    Olga Dubuisson
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Endocrinology 152:3648-60. 2011
    ..In conclusion, Ad36 provides a novel template to metabolically remodel human adipose tissue to enhance glycemic control without the concomitant increase in adiposity or PPARĪ³ induction associated with TZD actions...
  10. doi Incremental weight loss improves cardiometabolic risk in extremely obese adults
    William D Johnson
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Am J Med 124:931-8. 2011
    ....
  11. pmc Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy
    James Rochon
    Duke Clinical Research Institute, PO Box 17969, Durham, NC 27715, USA
    J Gerontol A Biol Sci Med Sci 66:97-108. 2011
    ..This article presents the design and implementation of this study...
  12. pmc Abnormalities in circadian blood pressure variability and endothelial function: pragmatic markers for adverse cardiometabolic profiles in asymptomatic obese adults
    Alok K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Cardiovasc Diabetol 9:58. 2010
    ..Cardiovascular disease (CVD) risk, although perceived to be high, is often difficult to demonstrate in disease free (healthy) obese adults...
  13. doi Low vitamin D levels, prediabetes and prehypertension in healthy African American adults
    A K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Nutr Metab Cardiovasc Dis 22:877-82. 2012
    ..We hypothesized that despite overall lower serum vitamin D concentrations in AA, an increase in the prevalence for PreDM and PreHTN would be seen in those with low vitamin D levels...
  14. pmc Long-term renal and cardiovascular outcomes in Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) participants by baseline estimated GFR
    Mahboob Rahman
    Division of Nephrology and Hypertension, Case Western Reserve University, University Hospitals Case Medical Center, USA
    Clin J Am Soc Nephrol 7:989-1002. 2012
    ....
  15. pmc Long-term effects of incident diabetes mellitus on cardiovascular outcomes in people treated for hypertension: the ALLHAT Diabetes Extension Study
    Joshua I Barzilay
    Kaiser Permanente of Georgia and Emory University School of Medicine, Atlanta, GA
    Circ Cardiovasc Qual Outcomes 5:153-62. 2012
    ....
  16. pmc Pioglitazone, but not metformin, reduces liver fat in Type-2 diabetes mellitus independent of weight changes
    Alok K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    J Diabetes Complications 24:289-96. 2010
    ..Pioglitazone (Pio) treatment induces weight gain in Type 2 diabetes mellitus (T2DM), which could worsen hepatic lipid accumulation, and alter adiponectin and high-sensitivity C-reactive protein (hs-CRP)...
  17. pmc Effect of pioglitazone on energy intake and ghrelin in diabetic patients
    Corby K Martin
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Diabetes Care 33:742-4. 2010
    ..To measure ghrelin and energy intake in the laboratory after pioglitazone treatment...
  18. doi Prehypertension in disease-free adults: a marker for an adverse cardiometabolic risk profile
    Alok K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Hypertens Res 33:905-10. 2010
    ..Clinical care designed to prevent progression from PreHTN to HTN (JNC 7 recommendation) may attenuate risk...
  19. pmc Prediabetes and prehypertension in disease free obese adults correlate with an exacerbated systemic proinflammatory milieu
    Alok K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    J Inflamm (Lond) 7:36. 2010
    ..This cascade of events in some measure explains the susceptibility of obese adults for co-morbid conditions like diabetes mellitus and hypertension...
  20. pmc Dysglycemia induces abnormal circadian blood pressure variability
    Sivarajan Kumarasamy
    Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH 43614, USA
    Cardiovasc Diabetol 10:104. 2011
    ..Prediabetes (PreDM) in asymptomatic adults is associated with abnormal circadian blood pressure variability (abnormal CBPV)...
  21. doi Nonsurgical weight loss for extreme obesity in primary care settings: results of the Louisiana Obese Subjects Study
    Donna H Ryan
    Pennington Biomedical Research Center of Louisiana State University System, Baton Rouge, LA 70808, USA
    Arch Intern Med 170:146-54. 2010
    ....
  22. ncbi An assay to measure angiogenesis in human fat tissue
    Frank L Greenway
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Obes Surg 17:510-5. 2007
    ..Inhibition of angiogenesis reverses rodent obesity. A validated assay in human fat tissue is needed to study the role of angiogenesis in human obesity...
  23. ncbi Using intranasal lidocaine to reduce food intake
    F L Greenway
    Outpatient Clinic Unit, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 31:858-63. 2007
    ..Develop a dose-response curve for the effect of intranasal lidocaine on food intake...
  24. pmc Prediabetes is associated with abnormal circadian blood pressure variability
    A K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    J Hum Hypertens 22:627-33. 2008
    ..001). ACV detected with 7-day ABPM may account for the enhanced CVD risk in prediabetes. These findings provide a basis for larger-scale studies to assess the predictive value of 7-day ABPM over the long term...
  25. doi Rational design of a combination medication for the treatment of obesity
    Frank L Greenway
    1Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 17:30-9. 2009
    ..This novel treatment approach (BUP+NAL) holds promise for the treatment of obesity.\..
  26. pmc Cardiovascular risk escalation with caloric excess: a prospective demonstration of the mechanics in healthy adults
    Alok K Gupta
    Clinical Research, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Cardiovasc Diabetol 12:23. 2013
    ..The link between weight gain and cardiovascular risk characterized with circadian blood pressure variability [CBPV] and endothelial function [EF] is unexplored...
  27. doi Predisease conditions and serum vitamin D levels in healthy Mexican American adults
    Alok K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Postgrad Med 124:136-42. 2012
    ..To elucidate the relationship between low circulating serum vitamin D levels and predisease conditions (ie, prediabetes and prehypertension) in healthy Mexican American adults...
  28. pmc Pioglitazone treatment in type 2 diabetes mellitus when combined with portion control diet modifies the metabolic syndrome
    A K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Diabetes Obes Metab 11:330-7. 2009
    ..Treatment with thiazolidinediones (TZDs) produces weight gain...