Research Topics
Genomes and Genes | Jeffrey M GimbleSummaryAffiliation: Pennington Biomedical Research Center Country: USA Publications
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Publications
Circadian clocks are resounding in peripheral tissuesAndrey A Ptitsyn
Experimental Obesity Laboratory, Louisiana State University Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
PLoS Comput Biol 2:e16. 2006..We conclude that greater attention should be given to the potential influence of circadian mechanisms on any biological pathway related to metabolism and obesity...
The relationship between adipose tissue and bone metabolismJeffrey M Gimble
Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Clin Biochem 45:874-9. 2012..The authors have set out to evaluate the literature relevant to the dynamic regulation of adipogenesis and osteogenesis...- Human adipose-derived cells: an update on the transition to clinical translationJeffrey M Gimble
Center for Stem Cell Research and Regenerative Medicine, Department of Pharmacology, Tulane University Health Science Center, New Orleans, LA 70112, USA
Regen Med 7:225-35. 2012..This review focuses on the literature of the past 2 years in order to assess the status of clinical and preclinical studies on adipose-derived cell therapies for regenerative medicine... - Prospective influences of circadian clocks in adipose tissue and metabolismJeffrey M Gimble
Stem Cell Biology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Nat Rev Endocrinol 7:98-107. 2011..Thus, circadian mechanisms represent a novel putative target for therapy in patients with metabolic diseases... 
Adipose tissue as a stem cell source for musculoskeletal regenerationJeffrey M Gimble
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
Front Biosci (Schol Ed) 3:69-81. 2011..We discuss the utility of ASCs for musculo-skeletal tissue repair and some of the technologies that can be implemented to unlock the full regenerative potential of these highly valuable cells...- Playing with bone and fatJeffrey M Gimble
Stem Cell Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
J Cell Biochem 98:251-66. 2006..In this review, we focus on the recent literature exploring the mechanisms underlying these differentiation events and discuss their implications relevant to osteoporosis and regenerative medicine... - Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cellsJeffrey M Gimble
Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Stem Cell Res Ther 1:19. 2010..Future directions and challenges facing the field are discussed and evaluated... - Fat circadian biologyJeffrey M Gimble
Pennington Biomedical Research Center, Louisiana State Univ, Stem Cell Biology Laboratory, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
J Appl Physiol 107:1629-37. 2009..It will be important to integrate circadian mechanisms and networks into future descriptions of adipose tissue physiology... - Adipose-derived stem cells for regenerative medicineJeffrey M Gimble
Stem Cell Biology Laboratory and Clinical Nutrition Research Unit, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Circ Res 100:1249-60. 2007..The isolation, characterization, and preclinical and clinical application of adipose-derived stem cells (ASCs) are reviewed in this article... - Delta sleep-inducing peptide and glucocorticoid-induced leucine zipper: potential links between circadian mechanisms and obesity?J M Gimble
Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Obes Rev 10:46-51. 2009..Together, these observations suggest that GILZ is an attractive candidate for future studies evaluating the role of circadian mechanisms in adipose tissue physiology and pathology... - The 4th dimension and adult stem cells: Can timing be everything?Jeffrey M Gimble
Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
J Cell Biochem 107:569-78. 2009.... - Circadian biology and sleep: missing links in obesity and metabolism?J M Gimble
Pennington Biomedical Research Center, Stem Cell Biology Laboratory, Baton Rouge, LA 70808, USA
Obes Rev 10:1-5. 2009..Furthermore, we hope to spark the interest and attention of the next generation of scientists who will tackle the questions presented by the changing interface between technology, lifestyle and biological rhythms... - Bone and fat: old questions, new insightsJeffrey M Gimble
Pennington Biomedical Research Center, LSU, 6400 Perkins Rd, Baton Rouge, LA, 70808, USA
Endocrine 23:183-8. 2004..Particular attention is given to the multipotent adult stem cell populations that reside within bone and fat. These adult stem cells have critical importance to the emerging field of tissue engineering and regenerative medicine... - Circadian rhythms in adipose tissue: an updateJeffrey M Gimble
Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Curr Opin Clin Nutr Metab Care 14:554-61. 2011..This review highlights recent in-vitro and in-vivo findings from murine, human and model organism studies... - Differentiation potential of adipose derived adult stem (ADAS) cellsJeffrey M Gimble
Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
Curr Top Dev Biol 58:137-60. 2003 - Concise review: Adipose-derived stromal vascular fraction cells and stem cells: let's not get lost in translationJeffrey M Gimble
Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
Stem Cells 29:749-54. 2011..This transparency will accelerate the standardization and reproducibility of adipose-derived cell therapies with respect to their efficacy and safety... - Circadian mechanisms in murine and human bone marrow mesenchymal stem cells following dexamethasone exposureXiying Wu
Stem Cell Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
Bone 42:861-70. 2008..We conclude that human and murine BMSCs represent a valid in vitro model for the analysis of circadian mechanisms in bone metabolism and stem cell biology... - Characterization of equine adipose tissue-derived stromal cells: adipogenic and osteogenic capacity and comparison with bone marrow-derived mesenchymal stromal cellsMartin A Vidal
Equine Health Studies Program, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
Vet Surg 36:613-22. 2007..To characterize equine adipose tissue-derived stromal cell (ASC) frequency and growth characteristics and assess of their adipogenic and osteogenic differentiation potential... - Induction of circadian gene expression in human subcutaneous adipose-derived stem cellsXiying Wu
Stem Cell Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
Obesity (Silver Spring) 15:2560-70. 2007..This study tests the hypothesis that human subcutaneous adipose-derived stem cells (ASCs) provide an in vitro model in which to monitor the activity of the core circadian transcriptional apparatus... - Culture effects of epidermal growth factor (EGF) and basic fibroblast growth factor (bFGF) on cryopreserved human adipose-derived stromal/stem cell proliferation and adipogenesisTeddi L Hebert
Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
J Tissue Eng Regen Med 3:553-61. 2009..These findings indicate that bFGF and EGF can be used as culture supplements to optimize the proliferative capacity of cryopreserved human ASCs and their adipogenic differentiation potential... - Isolation of murine adipose-derived stem cellsGang Yu
Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
Methods Mol Biol 702:29-36. 2011..Herein, we describe methods for the isolation, expansion, and long-term storage of murine adipose-derived stem cells along with a protocol for inducing adipogenesis in this cell population... - Yield and characterization of subcutaneous human adipose-derived stem cells by flow cytometric and adipogenic mRNA analyzesGang Yu
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
Cytotherapy 12:538-46. 2010..This study reports our recent experience of isolating and immunophenotypically characterizing ASC from >60 human patients with a mean age of 43.6 and body mass index (BMI) of 27... - The effect of storage time on adipose-derived stem cell recovery from human lipoaspiratesPedro P Carvalho
Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Cells Tissues Organs 194:494-500. 2011..These findings should be considered in the future development of standard operating procedures for cGMP processing of clinical-grade human ASCs... - Circadian oscillation of gene expression in murine calvarial boneSanjin Zvonic
Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge 70808, USA
J Bone Miner Res 22:357-65. 2007..Thus, circadian mechanisms may directly modulate oxidative phosphorylation and multiple metabolic pathways in bone homeostasis... - Characterization of peripheral circadian clocks in adipose tissuesSanjin Zvonic
Stem Cell Laboratory, Louisiana State University, Pennington Biomedical Research Center, Baton Rouge, LA, USA
Diabetes 55:962-70. 2006.... - Adipogenic differentiation of adipose-derived stem cellsGang Yu
Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
Methods Mol Biol 702:193-200. 2011..The current chapter describes methods to induce adipogenesis and to quantify this differentiation process in vitro... - Cell growth characteristics, differentiation frequency, and immunophenotype of adult ear mesenchymal stem cellsJaroslaw Staszkiewicz
Regenerative Biology Laboratory, Louisiana State University System, Baton Rouge, Louisiana, Department of Animal Physiology, University of Warmia and Mazury, Olsztyn, Poland
Stem Cells Dev 19:83-92. 2010..Further studies will be necessary to determine their utility for tissue engineering and regenerative medical applications... - Comparison of chondrogenic potential in equine mesenchymal stromal cells derived from adipose tissue and bone marrowMartin A Vidal
Equine Health Studies Program, Laboratory for Equine and Comparative Orthopedic Research, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA, USA
Vet Surg 37:713-24. 2008..To compare the chondrogenic potential of adult equine mesenchymal stem cells derived from bone marrow (MSCs) or adipose tissue (ASCs)... - Use of animal protein-free products for passaging adherent human adipose-derived stromal/stem cellsPedro P Carvalho
Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
Cytotherapy 13:594-7. 2011..ASC harvested with each trypsin product were comparable... - Secretome of primary cultures of human adipose-derived stem cells: modulation of serpins by adipogenesisSanjin Zvonic
Stem Cell Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Mol Cell Proteomics 6:18-28. 2007..These findings, together with the recent identification of vaspin, suggest that the serpin protein family warrants further proteomics investigation with respect to the etiology of obesity and type 2 diabetes... - Cellular response of adipose derived passage-4 adult stem cells to freezing stressRam V Devireddy
Bioengineering Laboratory, Department of Mechanical Engineering, Louisiana State University, Baton Rouge, LA, USA
J Biomech Eng 127:1081-6. 2005..And finally, the simulation results were analyzed to predict the optimal rates of freezing P4 adipose derived cells in the presence and absence of CPAs... - Isolation of human adipose-derived stem cells from lipoaspiratesGang Yu
Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
Methods Mol Biol 702:17-27. 2011..We present a large-scale procedure suitable for processing >100-ml volumes of lipoaspirate tissue specimens by collagenase digestion and a related procedure suitable for processing adipose tissue aspirates without digestion... - Proteome of human subcutaneous adipose tissue stromal vascular fraction cells versus mature adipocytes based on DIGEIndu Kheterpal
Proteomics and Metabolomics Core Facility, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, Louisiana 70808, United States
J Proteome Res 10:1519-27. 2011..The proteins identified may have value as biomarkers for monitoring the physiology and pathology of cell populations within subcutaneous adipose depots... - Cryopreservation characteristics of adipose-derived stem cells: maintenance of differentiation potential and viabilityBrian C Goh
Stem Cell Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
J Tissue Eng Regen Med 1:322-4. 2007..We found that the post-thaw viability was a function of storage concentration and that an optimal viability was observed for a concentration of 0.5 x 10(6) cells/ml cryopreservation medium... - Diet-induced obesity in stem cell antigen-1 KO miceJaroslaw Staszkiewicz
Regenerative Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
Stem Cells Dev 21:249-59. 2012..Thus, the Sca-1-deficient mice may provide a useful model for metabolic studies... - Impaired expansion and multipotentiality of adult stromal cells in a rat chronic alcohol abuse modelNan K Huff
Department of Veterinary Clinical Sciences, Laboratory for Equine and Comparative Orthopedic Research, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA
Alcohol 45:393-402. 2011..Maintenance of the effects through multiple cell passages in vitro suggests cells may be permanently compromised... - Effect of various freezing parameters on the immediate post-thaw membrane integrity of adipose tissue derived adult stem cellsSreedhar Thirumala
Bioengineering Laboratory, Department of Mechanical Engineering, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA
Biotechnol Prog 21:1511-24. 2005..These observed results will be used as a basis to further develop freezing storage protocols of ADAS cells... - Differentiation of adipose stem cellsBruce A Bunnell
Department of Pharmacology, Center for Gene Therapy, Division of Gene Therapy, Tulane National Primate Research Center, Covington, LA, USA
Methods Mol Biol 456:155-71. 2008.... - Evaluation of polyvinylpyrrolidone as a cryoprotectant for adipose tissue-derived adult stem cellsSreedhar Thirumala
Department of Mechanical Engineering, Louisiana State University, Baton Rouge, LA 70808, USA
Tissue Eng Part C Methods 16:783-92. 2010..Our results suggest that after thawing, ASC viability and adipogenic and osteogenic differentiation abilities can be maintained even when ASCs are frozen in the absence of serum but with 10% PVP in DMEM... - In vitro expansion and differentiation of fresh and revitalized adult canine bone marrow-derived and adipose tissue-derived stromal cellsNakia D Spencer
Laboratory for Equine and Comparative Orthopedic Research, Louisiana State University, School of Veterinary Medicine, Skip Bertman Drive, Baton Rouge, LA 70803, USA
Vet J 191:231-9. 2012..Protein was significantly greater in P3 versus P6 ASC chondrogenic pellets. Based on these findings, fresh and revitalized canine ASCs are viable alternatives to BMSCs for stromal cell applications... - Permutation test for periodicity in short time series dataAndrey A Ptitsyn
Experimental Obesity Laboratory, Louisiana State University Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
BMC Bioinformatics 7:S10. 2006..The data produced in these experiments carries a high degree of stochastic variation, obscuring the periodic pattern and a limited number of replicates, typically covering not more than two complete periods of oscillation... - The melanocortin-3 receptor is required for entrainment to meal intakeGregory M Sutton
Neuropeptides Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
J Neurosci 28:12946-55. 2008..In summary, Mc3r are required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for normal regulation of cortical clock function... - Evaluation of methylcellulose and dimethyl sulfoxide as the cryoprotectants in a serum-free freezing media for cryopreservation of adipose-derived adult stem cellsSreedhar Thirumala
Bioengineering Laboratory, Department of Mechanical Engineering, Louisiana State University, Baton Rouge, Louisiana 70803, USA
Stem Cells Dev 19:513-22. 2010..Our results suggest that post-thaw ASC viability, adipogenic and osteogenic differentiability can be maintained even when they are frozen in the absence of serum but with a minimal concentration of 2% DMSO in DMEM... - Isolation of human adipose-derived stem cells from biopsies and liposuction specimensSeverine G Dubois
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Methods Mol Biol 449:69-79. 2008..5 g. Although we have focused on the isolation of ASCs from human adipose tissue, the procedure can be applied to adipose tissues from other species with minimal modifications... - Cytokine profile of human adipose-derived stem cells: expression of angiogenic, hematopoietic, and pro-inflammatory factorsGail E Kilroy
Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
J Cell Physiol 212:702-9. 2007..We conclude that the ASCs display cytokine secretory properties similar to those reported for bone marrow-derived mesenchymal stem cells (MSCs)... - Cell growth characteristics and differentiation frequency of adherent equine bone marrow-derived mesenchymal stromal cells: adipogenic and osteogenic capacityMartin A Vidal
Equine Health Studies Program, Department of Veterinary Clinical Sciences, School of Veterinary Medicine and the Stem Cell Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
Vet Surg 35:601-10. 2006..To characterize equine bone marrow (BM)-derived mesenchymal stem cell (MSC) growth characteristics and frequency as well as their adipogenic and osteogenic differentiation potential... - Effects of prolyl hydroxylase inhibitors on adipogenesis and hypoxia inducible factor 1 alpha levels under normoxic conditionsZ Elizabeth Floyd
Stem Cell Laboratory and Clinical Nutrition Research Unit, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
J Cell Biochem 101:1545-57. 2007..1 expression or HIF-1alpha protein levels, suggesting that hydroxylation-independent mechanisms are involved in regulating HIF-1alpha expression in adipocytes under aerobic conditions... - Cryopreservation of stromal vascular fraction of adipose tissue in a serum-free freezing mediumSreedhar Thirumala
Department of Mechanical Engineering, Louisiana State University, Baton Rouge, LA, USA
J Tissue Eng Regen Med 4:224-32. 2010..Our results suggest that post-thaw SVF cell viability and adipogenic and osteogenic differentiability can be maintained even when they are frozen in the absence of serum and DMSO but with 10% PVP in DMEM... - Mesenchymal stromal cells: past, present, and futureNakia D Spencer
Laboratory for Equine and Comparative Orthopedic Research, Louisiana State University, School of Veterinary Medicine, Veterinary Clinical Sciences, Baton Rouge, LA 70803, USA
Vet Surg 40:129-39. 2011..Positive results from a number of recent investigations support the use of adult mesenchymal stromal cells for clinical application. This review article provides a brief overview of past, present, and future stromal cell technology... - Analysis of circadian pattern reveals tissue-specific alternative transcription in leptin signaling pathwayAndrey A Ptitsyn
Experimental Obesity Laboratory, Louisiana State University Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
BMC Bioinformatics 8:S15. 2007..It has been previously reported that most mammalian genes display a circadian oscillation in their baseline expression. Consequently, the phase and amplitude of each component of a signal transduction cascade has downstream consequences... - Circadian rhythms and the regulation of metabolic tissue function and energy homeostasisSanjin Zvonic
Stem Cell Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
Obesity (Silver Spring) 15:539-43. 2007..In this discussion, we present the hypothesis that circadian dysfunction may be involved in the pathogenesis of obesity, type 2 diabetes, and the metabolic syndrome... - Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistanceHyunwon Yang
Laboratory of Neuroendocrine Immunology, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
J Immunol 185:1836-45. 2010..Development of future long-term T cell depletion protocols specific to visceral fat may represent an additional strategy to manage obesity-associated comorbidities... - Adipose-derived stromal/stem cells (ASC) in regenerative medicine: pharmaceutical applicationsJeffrey M Gimble
Stem Cell Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Curr Pharm Des 17:332-9. 2011..With appropriate commercial development and in vivo validation, ASC and SVF cells will have a significant therapeutic impact in the future... - Biological aging alters circadian mechanisms in murine adipose tissue depotsGregory M Sutton
Protein Deficiency and Developmental Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA, 70808, USA
Age (Dordr) 35:533-47. 2013.... - Effect of intrastriatal mesenchymal stromal cell injection on progression of a murine model of Krabbe diseaseShawna E Wicks
Nutritional Neuroscience and Aging, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
Behav Brain Res 225:415-25. 2011..Validation of rotarod and automated gait analysis for detection of subtle differences in disease progression is important for early stage efforts to develop treatments for juvenile disorders... - Food entrainment of circadian gene expression altered in PPARalpha-/- brown fat and heartBrian C Goh
Stem Cell Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Biochem Biophys Res Commun 360:828-33. 2007..Likewise, PPARalpha responsive genes in the livers of PPARalpha null mice exhibited a significantly prolonged phase shift relative to control mice. These findings confirm and extend recent observations in the literature... - Mesenchymal lineage stem cells have pronounced anti-inflammatory effects in the twitcher mouse model of Krabbe's diseaseCynthia B Ripoll
Division of Regenerative Medicine, Tulane National Primate Research Center, Tulane University School of Medicine, New Orleans, LA 70112, USA
Stem Cells 29:67-77. 2011.... - Acceleration of spinal fusion using syngeneic and allogeneic adult adipose derived stem cells in a rat modelMandi J Lopez
Laboratory for Equine and Comparative Orthopedic Research, Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Skip Bertman Drive, Louisiana State University, Baton Rouge, Louisiana 70803, USA
J Orthop Res 27:366-73. 2009..3 +/- 0.85%; allogeneic = 23.5 +/- 2.33%) versus scaffold alone (46.8 +/- 11.8%) 4 weeks after surgery. Results of this study support syngeneic and allogeneic ASC acceleration of posterior lumbar spinal fusion in a rat model... - Proteomic analysis of primary cultures of human adipose-derived stem cells: modulation by AdipogenesisJames P Delany
Stable Isotope Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
Mol Cell Proteomics 4:731-40. 2005..These findings suggest that the heat shock protein family proteome warrants further investigation with respect to the etiology of obesity and type 2 diabetes... - PPARgamma-independent increase in glucose uptake and adiponectin abundance in fat cellsOlga Dubuisson
Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
Endocrinology 152:3648-60. 2011..In conclusion, Ad36 provides a novel template to metabolically remodel human adipose tissue to enhance glycemic control without the concomitant increase in adiposity or PPARγ induction associated with TZD actions... - IFATS collection: Stem cell antigen-1-positive ear mesenchymal stem cells display enhanced adipogenic potentialJaroslaw Staszkiewicz
Regenerative Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
Stem Cells 26:2666-73. 2008..The data presented here suggest that Sca-1 is a biomarker for EMSC with the potential to become functionally active adipocytes. Disclosure of potential conflicts of interest is found at the end of this article... - Metabolism: what causes the gut's circadian instincts?Jeffrey M Gimble
Stem Cell Biology, Louisiana State University System, Baton Rouge, LA 70808, USA
Curr Biol 21:R624-6. 2011..What mechanisms control circadian rhythms in the gastrointestinal tract and how does this impact nutrient metabolism? The deadenylase and leucine zipper protein Nocturnin is now shown to play a central role... - The epigenetics of adult (somatic) stem cellsKenneth J Eilertsen
Epigenetics and Nuclear Reprogramming Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Crit Rev Eukaryot Gene Expr 18:189-206. 2008..The role of these epigenetic mechanisms in manipulating adult stem cells is followed by a discussion of the challenges and opportunities facing this emerging field... - An improved method for isolation of RNA from boneLauren E Carter
Ubiquitin Biology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
BMC Biotechnol 12:5. 2012.... - Transport phenomena during freezing of adipose tissue derived adult stem cellsSreedhar Thirumala
Department of Mechanical Engineering, Bioengineering Laboratory, Louisiana State University, Baton Rouge, Louisiana 70803, USA
Biotechnol Bioeng 92:372-83. 2005..And finally, the simulation results were analyzed to predict the optimal rates of freezing adipose derived cells in the presence and absence of CPAs... - Prospecting for adipose progenitor cell biomarkers: biopanning for gold with in vivo phage displayJeffrey M Gimble
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Cell Stem Cell 9:1-2. 2011..Their use of phage display biopanning in vivo identified an isoform of the extracellular matrix protein decorin as a receptor for the adipokine resistin... - Structural and functional consequences of mitochondrial biogenesis in human adipocytes in vitroIwona Bogacka
Pennington Biomedical Research Center, Department of Molecular Endocrinology, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
J Clin Endocrinol Metab 90:6650-6. 2005..The aim of the study was to explore pathways affecting mitochondrial biogenesis and fatty acid oxidation (FAO) in human white adipocytes... - Adipose tissue-derived therapeuticsJeffrey M Gimble
Artecel Sciences, Inc, Brightleaf Square, 905 West Main Street, Box 44, Suite 25 B, Durham, NC 27701, USA
Expert Opin Biol Ther 3:705-13. 2003..Based on the promising findings from adipose-derived and other adult stem cells to date, it is likely that future studies will address these challenges... - Adipose-derived adult stem cells for cartilage tissue engineeringFarshid Guilak
Departments of Surgery and Biomedical Engineering, Duke University Medical Center, Durham, NC 27710, USA
Biorheology 41:389-99. 2004..Overall, ADAS cells show significant promise for the development of functional tissue replacements for various tissues of the musculoskeletal system... - Chondrogenic differentiation of adipose-derived adult stem cells in agarose, alginate, and gelatin scaffoldsHani A Awad
Department of Surgery, Division of Orthopaedic Surgery, Duke University Medical Center, Durham, NC 27710, USA
Biomaterials 25:3211-22. 2004.... - Effects of transforming growth factor beta1 and dexamethasone on the growth and chondrogenic differentiation of adipose-derived stromal cellsHani A Awad
Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Tissue Eng 9:1301-12. 2003..The addition of dexamethasone appeared to amplify protein synthesis but had suppressive effects on proteoglycan synthesis and accumulation... - Controlling the balance between osteoblastogenesis and adipogenesis and the consequent therapeutic implicationsMark E Nuttall
Centocor, 200 Great Malvern Parkway, Malvern, PA 19355, USA
Curr Opin Pharmacol 4:290-4. 2004..These pathways provide exciting future pharmacological targets with which to enhance bone formation and therefore reduce the risk of fracture... - Engineering adipose-like tissue in vitro and in vivo utilizing human bone marrow and adipose-derived mesenchymal stem cells with silk fibroin 3D scaffoldsJoshua R Mauney
Department of Biomedical Engineering, Tufts University, 4 Colby Street, Medford, MA 02155, USA
Biomaterials 28:5280-90. 2007.... - Neurogenic differentiation of murine and human adipose-derived stromal cellsKristine M Safford
Department of Surgery, Division of Pediatric Surgery, Box 3815, Duke University Medical Center, Durham, NC 27710, USA
Biochem Biophys Res Commun 294:371-9. 2002..Pretreatment with EGF and basic FGF augmented the neuronal differentiation of huADAS cells. The neuronal differentiation of stromal cells from adipose tissue has broad biological and clinical implications... - Human adipose-derived adult stem cells produce osteoid in vivoKevin C Hicok
Artecel Sciences, Durham, North Carolina, USA
Tissue Eng 10:371-80. 2004..In summary, the data demonstrate the ability of ADAS cells to form osteoid matrix in vivo. Because of their abundance and accessibility, ADAS cells may prove to be a novel cell therapeutic for bone repair and regeneration... - Influence of oxygen on the proliferation and metabolism of adipose derived adult stem cellsDavid W Wang
Department of Surgery, Division of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina, USA
J Cell Physiol 204:184-91. 2005.... - Clonal analysis of the differentiation potential of human adipose-derived adult stem cellsFarshid Guilak
Orthopaedic Research Laboratories, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
J Cell Physiol 206:229-37. 2006..However, it is important to exercise caution in interpreting these results until they are validated using functional in vivo assays... - Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivoGeoffrey R Erickson
Department of Surgery, Orthopaedic Research Laboratories, Duke University Medical Center, Durham, North Carolina 27710, USA
Biochem Biophys Res Commun 290:763-9. 2002.... - Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markersJames B Mitchell
Cognate Therapeutics, Inc, Baltimore, MD, USA
Stem Cells 24:376-85. 2006.... - The immunogenicity of human adipose-derived cells: temporal changes in vitroKevin McIntosh
Cognate Therapeutics, Inc, Baltimore, Maryland, USA
Stem Cells 24:1246-53. 2006..Indeed, late passage ASCs actually suppressed the MLR response. Although these results support the feasibility of allogeneic human ASC transplantation, confirmatory in vivo animal studies will be required... - Gene expression profiling reveals a regulatory role for ROR alpha and ROR gamma in phase I and phase II metabolismHong Soon Kang
Cell Biology Section, National Institutes of Health, Research Triangle Park, North Carolina 27709, USA
Physiol Genomics 31:281-94. 2007.... - Mechanical signals as regulators of stem cell fateBradley T Estes
Department of Surgery, Division of Orthopaedic Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA
Curr Top Dev Biol 60:91-126. 2004..A further understanding of the biomechanical and biochemical pathways involved in mechanical signal transduction by stem cells will hopefully provide new insight for the improvement of stem-cell based therapies... - Human Proteinpedia enables sharing of human protein dataSuresh Mathivanan
Nat Biotechnol 26:164-7. 2008 - Digital signal processing reveals circadian baseline oscillation in majority of mammalian genesAndrey A Ptitsyn
Department of Microbiology, Immunology and Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Fort Collins, Colorado, United States of America
PLoS Comput Biol 3:e120. 2007..Changes in gene expression caused by mutations or regulation of environmental factors (such as photic stimuli or feeding) should be considered in the context of changes in the amplitude and phase of genetic oscillations...
Research Grants
- USE OF ADIPOSE-DERIVED PREADIPOCYTES IN BONE DISOREDERSJeffrey Gimble; Fiscal Year: 2002..This has commercial application to orthopedic and periodontal surgical treatments of joint replacement, fracture repair, and bone resorption secondary to tooth decay...
- Spinal Fusion Using Adipose Derived Adult Stem CellsJeffrey Gimble; Fiscal Year: 2005..The availability of "off the shelf ADAS cells for clinical orthopedic procedures will have a significant commercial and therapeutic impact. ..
- CIRCADIAN MECHANISMS REGULATING OSTEOGENESISJeffrey Gimble; Fiscal Year: 2005..Findings from this innovative proposal have clinical implications regarding the optimal timing for daily medication regimens in bone diseases and for elective orthopedic and orthodontic procedures. ..