NIKHIL DHURANDHAR

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. pmc Doxycycline-regulated 3T3-L1 preadipocyte cell line with inducible, stable expression of adenoviral E4orf1 gene: a cell model to study insulin-independent glucose disposal
    Rashmi Krishnapuram
    Infections and Obesity Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America
    PLoS ONE 8:e60651. 2013
  2. pmc E4orf1 improves lipid and glucose metabolism in hepatocytes: a template to improve steatosis & hyperglycemia
    Emily J Dhurandhar
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, United States of America
    PLoS ONE 7:e47813. 2012
  3. pmc E4orf1: a novel ligand that improves glucose disposal in cell culture
    Emily J Dhurandhar
    Infections and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States of America
    PLoS ONE 6:e23394. 2011
  4. doi request reprint Insulin sparing action of adenovirus 36 and its E4orf1 protein
    Nikhil V Dhurandhar
    Infections and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    J Diabetes Complications 27:191-9. 2013
  5. pmc Long-term changes in adiposity and glycemic control are associated with past adenovirus infection
    Wan Yu Lin
    Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    Diabetes Care 36:701-7. 2013
  6. pmc Seroprevalence of 13 common pathogens in a rapidly growing U.S. minority population: Mexican Americans from San Antonio, TX
    Rohina Rubicz
    Department of Genetics, Texas Biomedical Research Institute, PO Box 760549, San Antonio, TX 78245 0549, USA
    BMC Res Notes 4:433. 2011
  7. ncbi request reprint Human adenovirus Ad-36 induces adipogenesis via its E4 orf-1 gene
    P M Rogers
    Department of Infections and Obesity, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 32:397-406. 2008
  8. doi request reprint A framework for identification of infections that contribute to human obesity
    Nikhil V Dhurandhar
    Infection and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Lancet Infect Dis 11:963-9. 2011
  9. pmc Template to improve glycemic control without reducing adiposity or dietary fat
    R Krishnapuram
    Infections and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State Univ System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 300:E779-89. 2011
  10. pmc PPARgamma-independent increase in glucose uptake and adiponectin abundance in fat cells
    Olga Dubuisson
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Endocrinology 152:3648-60. 2011

Research Grants

Collaborators

  • C Bouchard
  • David B Allison
  • W T Cefalu
  • F L Greenway
  • A K Gupta
  • M S Sothern
  • T Rankinen
  • Anthony G Comuzzie
  • Jianping Ye
  • Zhong Q Wang
  • Eric Ravussin
  • K-L Catherine Jen
  • Juraj Koska
  • Jeffrey M Gimble
  • Olga Dubuisson
  • Emily J Dhurandhar
  • Rashmi Krishnapuram
  • Vijay Hegde
  • Magdalena Pasarica
  • Rohina Rubicz
  • Nazar Mashtalir
  • Wan Yu Lin
  • John Blangero
  • Charles T Leach
  • R Krishnapuram
  • Pamela M Rogers
  • P M Rogers
  • Nathan Markward
  • Minghuan Yu
  • Sharada D Vangipuram
  • Joanne E Curran
  • Nianjun Liu
  • Harald Goring
  • Rongya Tao
  • X Charlie Dong
  • O Dubuisson
  • Harald Hh Göring
  • S Bajpeyi
  • Heather Kirk-Ballard
  • Barry Grubbs
  • S Chalew
  • E Larsen-Meyer
  • A Zuberi
  • W Johnson
  • Robert Yolken
  • Elizabeth Floyd
  • Ellen Kraig
  • H Kirk-Ballard
  • N Butte
  • E J Dhurandhar
  • M Brashear
  • R Javier
  • G Reinhart
  • B Bennett
  • Emily J McAllister
  • G M Sutton
  • G Kilroy
  • Miloni A Rathod
  • Gail E Kilroy
  • S A Loiler
  • M K Shaw
  • Barbora de Courten
  • Scott Babin
  • E J McAllister
  • K A Fusinski
  • M Pasarica
  • N Mashtalir
  • T C Holland
  • Kumar Dasuri
  • M A Rathod
  • Paska Permana
  • Sheba MohanKumar
  • Puliyur S MohanKumar
  • Hui Mei Ou Yang
  • Andrew C Shin
  • Miloni Rathod
  • Thomas C Holland
  • Jonathan Sheele
  • Richard L Atkinson

Detail Information

Publications16

  1. pmc Doxycycline-regulated 3T3-L1 preadipocyte cell line with inducible, stable expression of adenoviral E4orf1 gene: a cell model to study insulin-independent glucose disposal
    Rashmi Krishnapuram
    Infections and Obesity Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America
    PLoS ONE 8:e60651. 2013
    ..This stable cell line offers a valuable resource to carefully study the novel signaling pathways E4orf1 uses to enhance cellular glucose disposal independent of insulin...
  2. pmc E4orf1 improves lipid and glucose metabolism in hepatocytes: a template to improve steatosis & hyperglycemia
    Emily J Dhurandhar
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, United States of America
    PLoS ONE 7:e47813. 2012
    ..Elucidating the underlying molecular mechanism may help develop therapeutic approaches for treating diabetes or non-alcoholic fatty liver disease(NAFLD)...
  3. pmc E4orf1: a novel ligand that improves glucose disposal in cell culture
    Emily J Dhurandhar
    Infections and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States of America
    PLoS ONE 6:e23394. 2011
    ..Thus, the highly attractive anti-hyperglycemic effect of Ad36 is mirrored by E4orf1 protein, which may offer a novel ligand to develop anti-hyperglycemic drugs...
  4. doi request reprint Insulin sparing action of adenovirus 36 and its E4orf1 protein
    Nikhil V Dhurandhar
    Infections and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    J Diabetes Complications 27:191-9. 2013
    ....
  5. pmc Long-term changes in adiposity and glycemic control are associated with past adenovirus infection
    Wan Yu Lin
    Institute of Epidemiology and Preventive Medicine, College of Public Health, National Taiwan University, Taipei, Taiwan
    Diabetes Care 36:701-7. 2013
    ..This study compared longitudinal observations in indices of adiposity (BMI and body fat percentage) and glycemic control (fasting glucose and insulin) in Ad36-infected versus uninfected adults...
  6. pmc Seroprevalence of 13 common pathogens in a rapidly growing U.S. minority population: Mexican Americans from San Antonio, TX
    Rohina Rubicz
    Department of Genetics, Texas Biomedical Research Institute, PO Box 760549, San Antonio, TX 78245 0549, USA
    BMC Res Notes 4:433. 2011
    ..abstract:..
  7. ncbi request reprint Human adenovirus Ad-36 induces adipogenesis via its E4 orf-1 gene
    P M Rogers
    Department of Infections and Obesity, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 32:397-406. 2008
    ..Therefore, we investigated the role of Ad-36 as a novel regulator of the adipogenic process...
  8. doi request reprint A framework for identification of infections that contribute to human obesity
    Nikhil V Dhurandhar
    Infection and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Lancet Infect Dis 11:963-9. 2011
    ..Clinicians should be aware of infectobesity (obesity of infectious origin), and its potential importance in effective obesity management...
  9. pmc Template to improve glycemic control without reducing adiposity or dietary fat
    R Krishnapuram
    Infections and Obesity Laboratory, Pennington Biomedical Research Center, Louisiana State Univ System, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 300:E779-89. 2011
    ..This metabolic engineering by Ad36 appears relevant to humans for developing more practical and effective antidiabetic approaches...
  10. pmc PPARgamma-independent increase in glucose uptake and adiponectin abundance in fat cells
    Olga Dubuisson
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Endocrinology 152:3648-60. 2011
    ..In conclusion, Ad36 provides a novel template to metabolically remodel human adipose tissue to enhance glycemic control without the concomitant increase in adiposity or PPARγ induction associated with TZD actions...
  11. pmc Metabolically favorable remodeling of human adipose tissue by human adenovirus type 36
    Pamela M Rogers
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 57:2321-31. 2008
    ..To exploit the potential of the viral proteins as a therapeutic target for treating insulin resistance, this study investigated the ability of Ad-36 to induce metabolically favorable changes in human adipose tissue...
  12. pmc Human adenovirus type 36 enhances glucose uptake in diabetic and nondiabetic human skeletal muscle cells independent of insulin signaling
    Zhong Q Wang
    Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 57:1805-13. 2008
    ..Human adenovirus type 36 (Ad-36) increases adiposity but improves insulin sensitivity in experimentally infected animals. We determined the ability of Ad-36 to increase glucose uptake by human primary skeletal muscle (HSKM) cells...
  13. pmc Adipogenic human adenovirus Ad-36 induces commitment, differentiation, and lipid accumulation in human adipose-derived stem cells
    Magdalena Pasarica
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Stem Cells 26:969-78. 2008
    ..Thus, Ad-36 has the potential to induce adipogenesis in hASC, which may contribute to adiposity induced by the virus...
  14. ncbi request reprint Human adenovirus 36 induces adiposity, increases insulin sensitivity, and alters hypothalamic monoamines in rats
    Magdalena Pasarica
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 14:1905-13. 2006
    ..Involvement of the central nervous system (CNS) or adipose tissue in the mechanism of Ad-36-induced adiposity is unknown. The effects of Ad-36 on adiposity and on the neuroendocrine system were investigated in a rat model...
  15. ncbi request reprint A human adenovirus enhances preadipocyte differentiation
    Sharada D Vangipuram
    Department of Nutrition and Food Science, Wayne State University, Detroit, MI 48202, USA
    Obes Res 12:770-7. 2004
    ..The metabolic and molecular mechanisms responsible for Ad-36-induced adipogenesis are unknown. As a potential adipogenic mechanism, this study examined if Ad-36 enhanced differentiation of preadipocytes...
  16. ncbi request reprint Human adenovirus Ad-36 promotes weight gain in male rhesus and marmoset monkeys
    Nikhil V Dhurandhar
    Department of Nutrition and Food Science and the Center for Molecular Medicine and Genetics, Wayne State University, Detroit, MI, USA
    J Nutr 132:3155-60. 2002
    ..These studies illustrate that the adiposity-promoting effect of Ad-36 occurs in two nonhuman primate species and demonstrates the usefulness of nonhuman primates for further evaluation of Ad-36-induced adiposity...

Research Grants5

  1. Mechanism of Promotion of Adipogenesis by Adenovirus-36
    NIKHIL DHURANDHAR; Fiscal Year: 2007
    ..We believe that determining the role of viral infections in human obesity may influence the treatment, management, and possible prevention of such type of obesity. ..
  2. Mechanism of Promotion of Adipogenesis by Adenovirus-36
    NIKHIL DHURANDHAR; Fiscal Year: 2004
    ..We believe that determining the role of viral infections in human obesity may influence the treatment, management, and possible prevention of such type of obesity. ..
  3. Mechanism of Promotion of Adipogenesis by Adenovirus-36
    NIKHIL DHURANDHAR; Fiscal Year: 2005
    ..We believe that determining the role of viral infections in human obesity may influence the treatment, management, and possible prevention of such type of obesity. ..
  4. Mechanism of Promotion of Adipogenesis by Adenovirus-36
    NIKHIL DHURANDHAR; Fiscal Year: 2006
    ..We believe that determining the role of viral infections in human obesity may influence the treatment, management, and possible prevention of such type of obesity. ..
  5. Mechanism of Promotion of Adipogenesis by Adenovirus-36
    NIKHIL DHURANDHAR; Fiscal Year: 2005
    ..We believe that determining the role of viral infections in human obesity may influence the treatment, management, and possible prevention of such type of obesity. ..