WALTER DEUTSCH

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. ncbi Phenobarbital, oxazepam and Wyeth 14,643 cause DNA damage as measured by the Comet assay
    W A Deutsch
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Mutagenesis 16:439-42. 2001
  2. ncbi DNA repair efficiency in transgenic mice over expressing ribosomal protein S3
    Vijay Hegde
    DNA Damage and Repair Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Mutat Res 666:16-22. 2009
  3. ncbi Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
    Anthony E Civitarese
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America
    PLoS Med 4:e76. 2007
  4. ncbi Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    JAMA 295:1539-48. 2006
  5. ncbi Knockdown of ribosomal protein S3 protects human cells from genotoxic stress
    Vijay Hegde
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    DNA Repair (Amst) 6:94-9. 2007
  6. ncbi Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress
    Sridevi Yadavilli
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    DNA Repair (Amst) 6:1453-62. 2007
  7. ncbi The high binding affinity of human ribosomal protein S3 to 7,8-dihydro-8-oxoguanine is abrogated by a single amino acid change
    Vijay Hegde
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
    DNA Repair (Amst) 5:810-5. 2006
  8. ncbi Human ribosomal protein S3 interacts with DNA base excision repair proteins hAPE/Ref-1 and hOGG1
    Vijay Hegde
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Biochemistry 43:14211-7. 2004
  9. ncbi Analysis of DNA strand cleavage at abasic sites
    Walter A Deutsch
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Methods Mol Biol 291:39-46. 2005
  10. ncbi Characterization of human ribosomal protein S3 binding to 7,8-dihydro-8-oxoguanine and abasic sites by surface plasmon resonance
    Vijay Hegde
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    DNA Repair (Amst) 3:121-6. 2004

Research Grants

  1. Oxidative DNA Damage and the Analysis of 8-Oxyog Repair
    WALTER DEUTSCH; Fiscal Year: 2009

Collaborators

Detail Information

Publications13

  1. ncbi Phenobarbital, oxazepam and Wyeth 14,643 cause DNA damage as measured by the Comet assay
    W A Deutsch
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Mutagenesis 16:439-42. 2001
    ....
  2. ncbi DNA repair efficiency in transgenic mice over expressing ribosomal protein S3
    Vijay Hegde
    DNA Damage and Repair Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Mutat Res 666:16-22. 2009
    ....
  3. ncbi Calorie restriction increases muscle mitochondrial biogenesis in healthy humans
    Anthony E Civitarese
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America
    PLoS Med 4:e76. 2007
    ..However, the mechanism responsible for this adaptation are poorly understood...
  4. ncbi Effect of 6-month calorie restriction on biomarkers of longevity, metabolic adaptation, and oxidative stress in overweight individuals: a randomized controlled trial
    Leonie K Heilbronn
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    JAMA 295:1539-48. 2006
    ..Studies of longer duration are required to determine if calorie restriction attenuates the aging process in humans. TRIAL REGISTRATION: ClinicalTrials.gov Identifier: NCT00099151...
  5. ncbi Knockdown of ribosomal protein S3 protects human cells from genotoxic stress
    Vijay Hegde
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    DNA Repair (Amst) 6:94-9. 2007
    ..Overall, these results raise the possibility that hS3 interferes with the repair of the DNA lesions produced by genotoxic agents that potentially could play a role in the onset of cancer and other pathological states such as aging...
  6. ncbi Translocation of human ribosomal protein S3 to sites of DNA damage is dependant on ERK-mediated phosphorylation following genotoxic stress
    Sridevi Yadavilli
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    DNA Repair (Amst) 6:1453-62. 2007
    ..Lastly, hS3 was traced in exposed cells to its co-localization with 8-oxoG foci, raising the possibility that hS3 is a member of a cellular DNA damage response pathway that results in its interaction with sites of DNA damage...
  7. ncbi The high binding affinity of human ribosomal protein S3 to 7,8-dihydro-8-oxoguanine is abrogated by a single amino acid change
    Vijay Hegde
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
    DNA Repair (Amst) 5:810-5. 2006
    ..Overall, the ability of OGG1 to repair 8-oxoG is compromised when hS3 is bound to 8-oxoG sites. Conversely, in the absence of DNA binding, hS3 interacts positively with OGG1 to produce a more robust removal of 8-oxoG residues in DNA...
  8. ncbi Human ribosomal protein S3 interacts with DNA base excision repair proteins hAPE/Ref-1 and hOGG1
    Vijay Hegde
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Biochemistry 43:14211-7. 2004
    ..These results raise the possibility that hS3 not only functions as a ribosomal protein but, in addition, may influence repair activities at sites of DNA damage...
  9. ncbi Analysis of DNA strand cleavage at abasic sites
    Walter A Deutsch
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Methods Mol Biol 291:39-46. 2005
    ..Here we describe a method for analyzing the manner in which repair endonucleases differ in the way they create nicks in DNA and how to distinguish between them using cellular crude extracts...
  10. ncbi Characterization of human ribosomal protein S3 binding to 7,8-dihydro-8-oxoguanine and abasic sites by surface plasmon resonance
    Vijay Hegde
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    DNA Repair (Amst) 3:121-6. 2004
    ..These results suggest that ribosomal protein hS3 may have a multifunctional role that may also affect functions associated with DNA base excision repair transactions...
  11. ncbi Characterization of enzymes that initiate base excision repair at abasic sites
    Walter A Deutsch
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Methods Mol Biol 314:355-64. 2006
    ..Here we describe a method for analyzing the manner in which repair endonucleases differ in the way they create nicks in DNA and how to distinguish between them using cellular crude extracts...
  12. ncbi Aging, resting metabolic rate, and oxidative damage: results from the Louisiana Healthy Aging Study
    Madlyn I Frisard
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    J Gerontol A Biol Sci Med Sci 62:752-9. 2007
    ..The current study was designed to test whether nonagenarians have a relatively low metabolic rate and whether it is associated with low levels of oxidative stress relative to age...
  13. ncbi Ribosomal protein S3: A multi-functional protein that interacts with both p53 and MDM2 through its KH domain
    Sridevi Yadavilli
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
    DNA Repair (Amst) 8:1215-24. 2009
    ....

Research Grants5

  1. Oxidative DNA Damage and the Analysis of 8-Oxyog Repair
    WALTER DEUTSCH; Fiscal Year: 2009
    ..Conversely, hS3 may act as a scaffold for OGG1 and APE/ref-1, thereby producing a positive outcome on BER. The successful completion of the aims proposed in this application should shed light on both of these scenarios. ..