William T Cefalu

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. doi request reprint Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial
    William T Cefalu
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Lancet 382:941-50. 2013
  2. pmc Personalized management of hyperglycemia in type 2 diabetes: reflections from a Diabetes Care Editors' Expert Forum
    Itamar Raz
    Diabetes Unit, Department of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Diabetes Care 36:1779-88. 2013
  3. pmc Skeletal muscle protein tyrosine phosphatase 1B regulates insulin sensitivity in African Americans
    April J Stull
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 61:1415-22. 2012
  4. doi request reprint Evolving treatment strategies for the management of type 2 diabetes
    William T Cefalu
    Joint Program on Diabetes, Endocrinology and Metabolism, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Am J Med Sci 343:21-6. 2012
  5. doi request reprint Patients' perceptions of subcutaneous insulin in the OPTIMIZE study: a multicenter follow-up study
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Diabetes Technol Ther 10:25-38. 2008
  6. ncbi request reprint Efficacy of dietary supplementation with botanicals on carbohydrate metabolism in humans
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Endocr Metab Immune Disord Drug Targets 8:78-81. 2008
  7. pmc Botanicals and cardiometabolic risk: positioning science to address the hype
    William T Cefalu
    NIH Center for the Study of Botanicals and Metabolic Syndrome, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S1-2. 2008
  8. ncbi request reprint The physiologic role of incretin hormones: clinical applications
    William T Cefalu
    Pennington Biomedical Research Center in Baton Rouge, Louisiana, LA, USA
    J Am Osteopath Assoc 110:S8-S14. 2010
  9. pmc Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus
    William T Cefalu
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 59:755-62. 2010
  10. pmc An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-A(y) mice
    Zhong Q Wang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    J Nutr Biochem 22:71-8. 2011

Collaborators

Detail Information

Publications92

  1. doi request reprint Efficacy and safety of canagliflozin versus glimepiride in patients with type 2 diabetes inadequately controlled with metformin (CANTATA-SU): 52 week results from a randomised, double-blind, phase 3 non-inferiority trial
    William T Cefalu
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Lancet 382:941-50. 2013
    ..We compared the efficacy and safety of canagliflozin, an SGLT2 inhibitor, with glimepiride in patients with type 2 diabetes inadequately controlled with metformin...
  2. pmc Personalized management of hyperglycemia in type 2 diabetes: reflections from a Diabetes Care Editors' Expert Forum
    Itamar Raz
    Diabetes Unit, Department of Internal Medicine, Hadassah Hebrew University Hospital, Jerusalem, Israel
    Diabetes Care 36:1779-88. 2013
    ....
  3. pmc Skeletal muscle protein tyrosine phosphatase 1B regulates insulin sensitivity in African Americans
    April J Stull
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 61:1415-22. 2012
    ..These data show that skeletal muscle PTP1B gene expression is increased in African American subjects with T2DM, is negatively associated with whole-body insulin sensitivity, and contributes to modulation of insulin signaling...
  4. doi request reprint Evolving treatment strategies for the management of type 2 diabetes
    William T Cefalu
    Joint Program on Diabetes, Endocrinology and Metabolism, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Am J Med Sci 343:21-6. 2012
    ..These therapies are proposed to treat the key metabolic abnormalities associated with type 2 diabetes mellitus and minimize the side effects noted with conventional therapies...
  5. doi request reprint Patients' perceptions of subcutaneous insulin in the OPTIMIZE study: a multicenter follow-up study
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Diabetes Technol Ther 10:25-38. 2008
    ....
  6. ncbi request reprint Efficacy of dietary supplementation with botanicals on carbohydrate metabolism in humans
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Endocr Metab Immune Disord Drug Targets 8:78-81. 2008
    ..Thus, well defined randomized clinical trials are warranted in this area...
  7. pmc Botanicals and cardiometabolic risk: positioning science to address the hype
    William T Cefalu
    NIH Center for the Study of Botanicals and Metabolic Syndrome, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S1-2. 2008
  8. ncbi request reprint The physiologic role of incretin hormones: clinical applications
    William T Cefalu
    Pennington Biomedical Research Center in Baton Rouge, Louisiana, LA, USA
    J Am Osteopath Assoc 110:S8-S14. 2010
    ..These therapies treat the key metabolic abnormalities associated with T2DM but do so with reduced rates of hypoglycemia and do not promote weight gain as compared with conventional therapies...
  9. pmc Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus
    William T Cefalu
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 59:755-62. 2010
    ..Thus, modulation of lipid metabolism by Cr in peripheral tissues may represent a novel mechanism of action...
  10. pmc An extract of Artemisia dracunculus L. enhances insulin receptor signaling and modulates gene expression in skeletal muscle in KK-A(y) mice
    Zhong Q Wang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    J Nutr Biochem 22:71-8. 2011
    ..PMI 5011 may modulate skeletal muscle protein degradation and phosphatase activity as a possible mode of action...
  11. pmc Modulation of skeletal muscle insulin signaling with chronic caloric restriction in cynomolgus monkeys
    Zhong Q Wang
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Diabetes 58:1488-98. 2009
    ..We sought to examine insulin receptor signaling and transcriptional alterations in skeletal muscle of nonhuman primates subjected to CR over a 4-year period...
  12. pmc Bioactives of Artemisia dracunculus L enhance cellular insulin signaling in primary human skeletal muscle culture
    Zhong Q Wang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S58-64. 2008
    ....
  13. pmc Dietary methionine restriction increases fat oxidation in obese adults with metabolic syndrome
    Eric P Plaisance
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 96:E836-40. 2011
    ..The present report is the outcome of a "proof of concept" study to evaluate the efficacy of dietary methionine restriction (MR) in humans with metabolic syndrome...
  14. pmc Artemisia scoparia extract attenuates non-alcoholic fatty liver disease in diet-induced obesity mice by enhancing hepatic insulin and AMPK signaling independently of FGF21 pathway
    Zhong Q Wang
    Nutrition and Diabetes Research Laboratory, Pennington Biomedical Research Center, LSU System, Baton Rouge, LA 70808, USA
    Metabolism 62:1239-49. 2013
    ..In this regard, we sought to evaluate the effects of extracts of Artemisia santolinaefolia (SANT) and Artemisia scoparia (SCO) on hepatic lipid deposition and cellular signaling in a diet-induced obesity (DIO) animal model...
  15. pmc Human adenovirus type 36 enhances glucose uptake in diabetic and nondiabetic human skeletal muscle cells independent of insulin signaling
    Zhong Q Wang
    Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 57:1805-13. 2008
    ..Human adenovirus type 36 (Ad-36) increases adiposity but improves insulin sensitivity in experimentally infected animals. We determined the ability of Ad-36 to increase glucose uptake by human primary skeletal muscle (HSKM) cells...
  16. pmc Butyrate improves insulin sensitivity and increases energy expenditure in mice
    Zhanguo Gao
    Antioxidant and Gene Regulation Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Diabetes 58:1509-17. 2009
    ..We examined the role of butyric acid, a short-chain fatty acid formed by fermentation in the large intestine, in the regulation of insulin sensitivity in mice fed a high-fat diet...
  17. pmc An extract of Artemisia dracunculus L. inhibits ubiquitin-proteasome activity and preserves skeletal muscle mass in a murine model of diabetes
    Heather Kirk-Ballard
    Ubiquitin Biology Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    PLoS ONE 8:e57112. 2013
    ....
  18. pmc Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice
    Zhong Q Wang
    Nutrition and Diabetes Research Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Int J Nanomedicine 7:2999-3012. 2012
    ..To compare the effects of dietary fibers on hepatic cellular signaling in mice...
  19. ncbi request reprint The contribution of race and diabetes status to metabolic flexibility in humans
    April J Stull
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 59:1358-64. 2010
    ....
  20. pmc Bioactives in blueberries improve insulin sensitivity in obese, insulin-resistant men and women
    April J Stull
    Center for the Study of Botanicals and Metabolic Syndrome, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    J Nutr 140:1764-8. 2010
    ..In conclusion, daily dietary supplementation with bioactives from whole blueberries improved insulin sensitivity in obese, nondiabetic, and insulin-resistant participants...
  21. pmc Effect of Shilianhua extract and its fractions on body weight of obese mice
    Jun Yin
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S47-51. 2008
    ..The weight reduction observed with the over-the-counter SLH tablet in the pilot studies may be secondary to other components in the tablet, but not from the SLH extract...
  22. pmc Proteomic analysis reveals cellular pathways regulating carbohydrate metabolism that are modulated in primary human skeletal muscle culture due to treatment with bioactives from Artemisia dracunculus L
    Peter Scherp
    Protein Structural Biology, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    J Proteomics 75:3199-210. 2012
    ..These findings provide a molecular mechanism by which a botanical extract improves insulin stimulated glucose uptake, transport and metabolism at the cellular level resulting in enhanced whole body insulin sensitivity...
  23. doi request reprint Impaired insulin sensitivity and elevated ectopic fat in healthy obese vs. nonobese prepubertal children
    Brian Bennett
    School of Public Health, Louisiana State University Health Sciences Center, New Orleans, Louisiana, USA
    Obesity (Silver Spring) 20:371-5. 2012
    ..nonobese children prior to puberty. Excessive adiposity during early development appears concomitant with precursors of type 2 diabetes and the metabolic syndrome...
  24. pmc Phenotype of subjects with type 2 diabetes mellitus may determine clinical response to chromium supplementation
    Zhong Q Wang
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 56:1652-5. 2007
    ..4038) (P = .0004). Subject phenotype appears to be very important when assessing the clinical response to Cr because baseline insulin sensitivity was found to account for nearly 40% of the variance in the clinical response to Cr...
  25. pmc Molecular mechanisms for activation of the agouti-related protein and stimulation of appetite
    Olha Ilnytska
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, USA
    Diabetes 60:97-106. 2011
    ..The objective of this study was to determine molecular mechanisms for the activation of hypothalamic Agrp and identify compounds that stimulate appetite...
  26. pmc Effects of stevia, aspartame, and sucrose on food intake, satiety, and postprandial glucose and insulin levels
    Stephen D Anton
    Pennington Biomedical Research Center, Baton Rouge, LA, United States
    Appetite 55:37-43. 2010
    ..When consuming stevia and aspartame preloads, participants did not compensate by eating more at either their lunch or dinner meal and reported similar levels of satiety compared to when they consumed the higher calorie sucrose preload...
  27. pmc Quercetin transiently increases energy expenditure but persistently decreases circulating markers of inflammation in C57BL/6J mice fed a high-fat diet
    Laura K Stewart
    Division of Experimental Obesity, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Metabolism 57:S39-46. 2008
    ..However, quercetin at the levels provided was effective in reducing circulating markers of inflammation observed in animals on an HF diet at 8W...
  28. pmc Bioactives from bitter melon enhance insulin signaling and modulate acyl carnitine content in skeletal muscle in high-fat diet-fed mice
    Zhong Q Wang
    Center for the Study of Botanicals and Metabolic Syndrome, Pennington Biomedical Research Center, LSU System, Baton Rouge, LA 70808, USA
    J Nutr Biochem 22:1064-73. 2011
    ..Nutritional supplementation with this extract, if validated for human studies, may offer an adjunctive therapy for diabetes...
  29. ncbi request reprint Clinical research observations with use of exubera in patients with type 1 and 2 diabetes
    William T Cefalu
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808, USA
    Diabetes Technol Ther 9:S28-40. 2007
  30. pmc Effects of dietary fibers on weight gain, carbohydrate metabolism, and gastric ghrelin gene expression in mice fed a high-fat diet
    Zhong Q Wang
    Pennington Biomedical Research Center, Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 56:1635-42. 2007
    ....
  31. pmc Metabolically favorable remodeling of human adipose tissue by human adenovirus type 36
    Pamela M Rogers
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 57:2321-31. 2008
    ..To exploit the potential of the viral proteins as a therapeutic target for treating insulin resistance, this study investigated the ability of Ad-36 to induce metabolically favorable changes in human adipose tissue...
  32. ncbi request reprint Clinical management strategies for type 2 diabetes
    William T Cefalu
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    JAAPA . 2007
    ..The possibility that they may also be able to affect the course of this devastating metabolic disorder should also be fully explored...
  33. pmc Bioactives of Artemisia dracunculus L. mitigate the role of ceramides in attenuating insulin signaling in rat skeletal muscle cells
    Diana N Obanda
    Botanical Research Center, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes 61:597-605. 2012
    ..PMI 5011 attenuates the reduction in insulin signaling induced by ceramide accumulation, but the mechanism of improved insulin signaling is independent of ceramide formation...
  34. doi request reprint Regulation of insulin action by an extract of Artemisia dracunculus L. in primary human skeletal muscle culture: a proteomics approach
    Indu Kheterpal
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Phytother Res 24:1278-84. 2010
    ..These data demonstrate that a well characterized botanical extract of Artemisia dracunculus L. significantly modulates proteins involved in regulating inflammatory pathways, particularly the NFkappaB complex system...
  35. pmc Effects of chromium picolinate on food intake and satiety
    Stephen D Anton
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA
    Diabetes Technol Ther 10:405-12. 2008
    ..Chromium picolinate (CrPic) has been shown to attenuate weight gain, but the mechanism underlying this effect is unknown...
  36. ncbi request reprint Modulation of cellular insulin signaling and PTP1B effects by lipid metabolites in skeletal muscle cells
    Diana N Obanda
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Nutr Biochem 24:1529-37. 2013
    ..A clear relationship between PTP1B phosphorylation levels at Ser 50 and its negative effect on insulin signaling is shown. ..
  37. pmc Defining insulin resistance from hyperinsulinemic-euglycemic clamps
    Charmaine S Tam
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Diabetes Care 35:1605-10. 2012
    ..e., insulin sensitivity...
  38. ncbi request reprint Bioactives from Artemisia dracunculus L. enhance insulin sensitivity via modulation of skeletal muscle protein phosphorylation
    Indu Kheterpal
    Protein Structural Biology and Proteomics and Metabolomics Core Facility, Pennington Biomedical Research Center, Louisiana State University System, Louisiana, USA
    Nutrition 30:S43-51. 2014
    ....
  39. pmc An ethanolic extract of Artemisia dracunculus L. regulates gene expression of ubiquitin-proteasome system enzymes in skeletal muscle: Potential role in the treatment of sarcopenic obesity
    Heather Kirk-Ballard
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Nutrition 30:S21-5. 2014
    ..The aim of this study was to examine the effect of PMI 5011 on the ubiquitin-proteasome system, a central regulator of muscle protein degradation...
  40. pmc Reducing the glycemic index or carbohydrate content of mixed meals reduces postprandial glycemia and insulinemia over the entire day but does not affect satiety
    Ann G Liu
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Diabetes Care 35:1633-7. 2012
    ..We evaluated the effects of mixed meals differing in glycemic index (GI) and carbohydrate content on postprandial serum glucose and insulin response, hunger, and satiety over the course of a 12-h day...
  41. ncbi request reprint Chromium picolinate enhances skeletal muscle cellular insulin signaling in vivo in obese, insulin-resistant JCR:LA-cp rats
    Zhong Q Wang
    Pennington Biomedical Research Center, Division of Nutrition and Chronic Diseases, Louisiana State University System, Baton Rouge, LA, USA
    J Nutr 136:415-20. 2006
    ..Our data suggest that chromium supplementation of obese, insulin-resistant rats may improve insulin action by enhancing intracellular signaling...
  42. doi request reprint Redefining treatment success in type 2 diabetes mellitus: Comprehensive targeting of core defects
    William T Cefalu
    Joint Program on Diabetes, Endocrinology and Metabolism, Louisiana State University Health Science Center, New Orleans, LA, USA
    Cleve Clin J Med 76:S39-47. 2009
    ..A redefinition of treatment success may be warranted as more data become available...
  43. doi request reprint Current concepts about chromium supplementation in type 2 diabetes and insulin resistance
    Zhong Q Wang
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Curr Diab Rep 10:145-51. 2010
    ....
  44. ncbi request reprint Botanicals and the metabolic syndrome
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 87:481S-7S. 2008
    ..With the completion of our research, we anticipate a better understanding of the cellular mechanisms by which insulin resistance develops and the role of botanicals in modulating the progression to metabolic syndrome...
  45. ncbi request reprint Caloric restriction and cardiovascular aging in cynomolgus monkeys (Macaca fascicularis): metabolic, physiologic, and atherosclerotic measures from a 4-year intervention trial
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    J Gerontol A Biol Sci Med Sci 59:1007-14. 2004
    ..Thus, further studies are needed to determine if improved insulin sensitivity might decrease arterial inflammation and improve endothelial function, despite no changes in atherosclerosis extent...
  46. ncbi request reprint Controlling hypoglycemia in type 2 diabetes: which agent for which patient?
    Charles A Cefalu
    Section of Geriatric Medicine, Department of Family Medicine, Louisiana State University Health Sciences Center, New Orleans, LA 70808, USA
    J Fam Pract 54:855-62. 2005
  47. ncbi request reprint The new diabetes inhalers: new tools for the clinician
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Curr Diab Rep 7:165-7. 2007
  48. ncbi request reprint Inactivation of PKCtheta leads to increased susceptibility to obesity and dietary insulin resistance in mice
    Zhanguo Gao
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Am J Physiol Endocrinol Metab 292:E84-91. 2007
    ..This study suggests that loss of PKCtheta reduces energy expenditure and increases the risk of dietary obesity and insulin resistance in mice...
  49. ncbi request reprint Assessment of long-term immunological and pulmonary safety of inhaled human insulin with up to 24 months of continuous therapy
    William T Cefalu
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Curr Med Res Opin 24:3073-83. 2008
    ..This study was performed to characterize the long-term safety and efficacy of inhaled human insulin (EXU; Exubera * (insulin human [rDNA origin]) Inhalation Powder). * Pfizer Inc, New York, NY, USA...
  50. ncbi request reprint Concept, strategies, and feasibility of noninvasive insulin delivery
    William T Cefalu
    University of Vermont College of Medicine, Burlington, Vermont, USA
    Diabetes Care 27:239-46. 2004
    ..To comprehensively review the progress to date on the development of alternative routes for insulin delivery...
  51. pmc Bioactives of Artemisia dracunculus L. enhance insulin sensitivity by modulation of ceramide metabolism in rat skeletal muscle cells
    Diana N Obanda
    Diabetes and Nutrition Research Laboratory, Pennington Biomedical Research Center, LSU System, Baton Rouge, Louisiana, USA
    Nutrition 30:S59-66. 2014
    ..The aim of this study was to determine whether the mechanism by which the bioactive compounds in PMI 5011 improve insulin signaling is through regulation of ceramide metabolism...
  52. pmc Screening native botanicals for bioactivity: An interdisciplinary approach
    Anik Boudreau
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Nutrition 30:S11-6. 2014
    ..The aim of this study was to identify native Louisiana plants from Creole folk medicine as a potential source of therapeutic compounds for the treatment of insulin resistance, type 2 diabetes, and related disorders...
  53. pmc Lipid in skeletal muscle myotubes is associated to the donors' insulin sensitivity and physical activity phenotypes
    Sudip Bajpeyi
    Pennington Biomedical Research Center, LSU System, 6400 Perkins Road, Baton Rouge, Louisiana, 70808, USA
    Obesity (Silver Spring) 22:426-34. 2014
    ..This study investigated the relationship between in vitro lipid content in myotubes and in vivo whole body phenotypes of the donors such as insulin sensitivity, intramyocellular lipids (IMCL), physical activity, and oxidative capacity...
  54. ncbi request reprint Blood pressure and stroke risk among diabetic patients
    Wenhui Zhao
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 98:3653-62. 2013
    ..Blood pressure (BP) control can reduce the risk of stroke among diabetic patients; however, it is not known whether the lowest risk of stroke is among diabetic patients with the lowest BP level...
  55. pmc Perceptions community residents have about partner institutions and clinical research
    Betty M Kennedy
    The Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Clin Transl Sci 6:469-73. 2013
    ..Engaging community residents to obtain their feedback in conducting clinical research, and including them as leaders in implementing applicable health advances is crucial for success and sustaining large center awards...
  56. ncbi request reprint Botanicals as epigenetic modulators for mechanisms contributing to development of metabolic syndrome
    Heather Kirk
    Botanical Research Center, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S16-23. 2008
    ....
  57. ncbi request reprint Animal models of type 2 diabetes: clinical presentation and pathophysiological relevance to the human condition
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    ILAR J 47:186-98. 2006
    ..Use of the appropriate animal model based on these similarities can provide much needed data on pathophysiological mechanisms operative in human T2D...
  58. ncbi request reprint The Hurricane Katrina aftermath and its impact on diabetes care: observations from "ground zero": lessons in disaster preparedness of people with diabetes
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, Louisiana 70808, USA
    Diabetes Care 29:158-60. 2006
  59. pmc Increased hypothalamic protein tyrosine phosphatase 1B contributes to leptin resistance with age
    Christopher D Morrison
    Neurosignaling Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Endocrinology 148:433-40. 2007
    ..05). These data are consistent with the hypothesis that increases in PTP1B contribute to hypothalamic leptin resistance as rats transition into middle age...
  60. pmc Modulation of peroxisome proliferator-activated receptor gamma stability and transcriptional activity in adipocytes by resveratrol
    Z Elizabeth Floyd
    Ubiquitin Biology Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Metabolism 57:S32-8. 2008
    ..These results indicate that the resveratrol-mediated effects in adipocytes involve regulation of PPARgamma expression and transcriptional activity along with decreased responsiveness to insulin...
  61. ncbi request reprint Artemisia supplementation differentially affects the mucosal and luminal ileal microbiota of diet-induced obese mice
    Shawna Wicks
    Gene Nutrient Interactions Laboratory, Pennington Biomedical Research Center, LSU System, Baton Rouge, LA, USA
    Nutrition 30:S26-30. 2014
    ..The aim of this study was to characterize the mucosal and luminal bacterial populations in the terminal ileum with or without supplementation with Artemisia extracts...
  62. ncbi request reprint Point: Pulmonary inhalation of insulin: another "brick in the wall"
    William T Cefalu
    Division of Nutrition and Chronic Diseases, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Diabetes Care 30:439-41. 2007
  63. doi request reprint Complications of type 1 diabetes
    L Yvonne Melendez-Ramirez
    Joint Program on Diabetes, Endocrinology and Metabolism, Louisiana State University Health Sciences Center School of Medicine, New Orleans, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Endocrinol Metab Clin North Am 39:625-40. 2010
    ..For purposes of this article, the authors focus on a brief review of the major complications...
  64. pmc Inactivation of the mitochondrial carrier SLC25A25 (ATP-Mg2+/Pi transporter) reduces physical endurance and metabolic efficiency in mice
    Rea P Anunciado-Koza
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Biol Chem 286:11659-71. 2011
    ..However, in the absence of UCP1-based thermogenesis, induction of Slc25a25 in mice with an intact gene may contribute to an alternative thermogenic pathway for the maintenance of body temperature during cold stress...
  65. ncbi request reprint Evolving strategies for insulin delivery and therapy
    William T Cefalu
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Drugs 64:1149-61. 2004
    ..Recent evidence shows that delivery of insulin via the oral cavity with uptake occurring in the pulmonary alveoli may be the most viable clinical option in the future...
  66. ncbi request reprint Role of chromium in human health and in diabetes
    William T Cefalu
    Division of NutritionChronic Disease, The Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes Care 27:2741-51. 2004
  67. ncbi request reprint Exubera. Inhale therapeutic systems
    Sanjit Bindra
    University of Vermont College of Medicine, Department of Medicine, Burlington 05405, USA
    Curr Opin Investig Drugs 3:758-62. 2002
    ..By October 2001, Deutsche Bank predicted sales of $50 million in 2004 and $250 million in 2005. In September 2001, Morgan Stanley predicted sales of $500 million in 2002, rising to $1250 million in 2006...
  68. ncbi request reprint Oral chromium picolinate improves carbohydrate and lipid metabolism and enhances skeletal muscle Glut-4 translocation in obese, hyperinsulinemic (JCR-LA corpulent) rats
    William T Cefalu
    Department of Medicine, University of Vermont College of Medicine, Burlington, VT, USA
    J Nutr 132:1107-14. 2002
    ..Thus, CrPic supplementation enhances insulin sensitivity and glucose disappearance, and improves lipids in male obese hyperinsulinemic JCR:LA-corpulent rats...
  69. ncbi request reprint Treatment satisfaction in type 2 diabetes: a comparison between an inhaled insulin regimen and a subcutaneous insulin regimen
    Joseph C Cappelleri
    Pfizer Inc, Global Research and Development, Groton, Connecticut 06340, USA
    Clin Ther 24:552-64. 2002
    ..It is unknown whether inhalation delivery of insulin improves patient satisfaction...
  70. ncbi request reprint Inhaled insulin: a novel route for insulin delivery
    William T Cefalu
    University of Vermont College of Medicine, Burlington, VT, USA
    Expert Opin Investig Drugs 11:687-91. 2002
    ..The pharmacokinetics of inhaled insulin show a more physiological profile compared to conventional insulin; however, further studies to confirm long-term pulmonary safety and efficacy are needed...
  71. ncbi request reprint Improved glucose control decreases the interaction of plasma low-density lipoproteins with arterial proteoglycans
    Iris J Edwards
    Department of Pathology Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Metabolism 51:1223-9. 2002
    ..05). These data demonstrate that combination treatment with glipizide GITS/metformin will further improve glucose control in type 2 diabetic subjects and may favorably improve diabetes-associated modification of LDL-arterial PG binding...
  72. ncbi request reprint Evaluation of alternative strategies for optimizing glycemia: progress to date
    William T Cefalu
    University of Vermont College of Medicine, Burlington, Vermont 05401, USA
    Am J Med 113:23S-35S. 2002
    ..These innovative delivery systems may help overcome the barriers to insulin use...
  73. ncbi request reprint Effect of combination glipizide GITS/metformin on fibrinolytic and metabolic parameters in poorly controlled type 2 diabetic subjects
    William T Cefalu
    Department of Medicine, University of Vermont College of Medicine, Burlington 05401, USA
    Diabetes Care 25:2123-8. 2002
    ..We sought to determine whether metabolic control, independent of its oral mode of implementation, affects PAI-1 in patients with marked hyperglycemia...
  74. pmc Two-year pulmonary safety and efficacy of inhaled human insulin (Exubera) in adult patients with type 2 diabetes
    Julio Rosenstock
    Dallas Diabetes and Endocrine Center, Dallas, Texas, USA
    Diabetes Care 31:1723-8. 2008
    ..The purpose of this study was to evaluate the 2-year pulmonary safety of inhaled human insulin (Exubera [EXU]) in 635 nonsmoking adults with type 2 diabetes...
  75. ncbi request reprint Evaluation of botanicals for improving human health
    David M Ribnicky
    Biotechnology Center for Agriculture and the Environment, Cook College, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901 8520, USA
    Am J Clin Nutr 87:472S-5S. 2008
    ..Standardization of botanical therapeutics can only be achieved when the active compounds are identified and biological activity is confirmed, thus ensuring a consistent product...
  76. doi request reprint Glycemic targets and cardiovascular disease
    William T Cefalu
    N Engl J Med 358:2633-5. 2008
  77. ncbi request reprint Polyphenolic compounds from Artemisia dracunculus L. inhibit PEPCK gene expression and gluconeogenesis in an H4IIE hepatoma cell line
    Dmitry Govorko
    Rutgers University, Biotech Center, 59 Dudley Road, New Brunswick, NJ 08901, USA
    Am J Physiol Endocrinol Metab 293:E1503-10. 2007
    ..These results indicate that the isolated compounds may be responsible for much of the glucose-lowering activity of the Artemisia dracunculus extract...
  78. ncbi request reprint Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes
    Julie Martin
    Division of Endocrinology and Metabolism, University of Vermont, Burlington, USA
    Diabetes Care 29:1826-32. 2006
    ..We sought to determine the effect of CrPic on insulin sensitivity, glycemic control, and body composition in subjects with type 2 diabetes...
  79. ncbi request reprint Long-term glycemic control measurements in diabetic patients receiving hemodialysis
    Melanie S Joy
    Division of Nephrology and Hypertension, University of North Carolina, School of Medicine, Chapel Hill, NC 27599 7155, USA
    Am J Kidney Dis 39:297-307. 2002
    ..Thus, diabetic patients receiving hemodialysis may have long-term BG that are more properly controlled than previously determined, reducing their risks of the macro- and microvascular complications of diabetes mellitus...
  80. ncbi request reprint Glycemic control and cardiovascular disease--should we reassess clinical goals?
    William T Cefalu
    N Engl J Med 353:2707-9. 2005
  81. ncbi request reprint Efficacy of inhaled insulin in patients with type 2 diabetes not controlled with diet and exercise: a 12-week, randomized, comparative trial
    Ralph A DeFronzo
    University of Texas Health Science Center, Diabetes Division, 7703 Floyd Curl Dr, San Antonio, TX 78284, USA
    Diabetes Care 28:1922-8. 2005
    ..This study investigates whether inhaled insulin (INH; Exubera) can achieve target glycemic control in patients failing on diet and exercise...
  82. ncbi request reprint Inhaled insulin improves glycemic control when substituted for or added to oral combination therapy in type 2 diabetes: a randomized, controlled trial
    Julio Rosenstock
    Dallas Diabetes and Endocrine Center at Medical City, Dallas, Texas 75230, USA
    Ann Intern Med 143:549-58. 2005
    ..Patients with type 2 diabetes who do not achieve glycemic control with oral agent therapy eventually require insulin...
  83. ncbi request reprint Diabetes, the metabolic syndrome, and angiographic progression of coronary arterial disease in postmenopausal women
    Philip B Mellen
    Department of Internal Medicine Cardiology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Arterioscler Thromb Vasc Biol 26:189-93. 2006
    ..We sought to determine whether the MS predicts angiographic progression of coronary heart disease in a cohort of postmenopausal women...
  84. doi request reprint Multidisciplinary interventions: mapping new horizons in diabetes care
    Edward Horton
    Vice President and Director of Clinical Research, Joslin Diabetes Center, Harvard Medical School, One Joslin Place, Boston, MA 02215, USA
    Diabetes Educ 34:78S-89S. 2008
    ....
  85. ncbi request reprint Intensive glycemic control and cardiovascular disease observations from the ACCORD study: now what can a clinician possibly think?
    William T Cefalu
    Diabetes 57:1163-5. 2008
  86. pmc A natural history of botanical therapeutics
    Barbara Schmidt
    Biotechnology Center for Agriculture and the Environment, Cook College, Rutgers, The State University of New Jersey, New Brunswick, NJ 08901 8520, USA
    Metabolism 57:S3-9. 2008
    ..A primary advantage of botanicals is their complex composition consisting of collections of related compounds having multiple activities that interact for a greater total activity...
  87. pmc Phytochemical composition and metabolic performance-enhancing activity of dietary berries traditionally used by Native North Americans
    Tristan F Burns Kraft
    Division of Nutritional Sciences and Department of Natural Resources and Environmental Sciences, University of Illinois at Urbana Champaign, 1201 South Dorner Drive, Urbana, Illinois 61801, USA
    J Agric Food Chem 56:654-60. 2008
    ..The results demonstrate that these berries traditionally consumed by tribal cultures contain a rich array of phytochemicals that have the capacity to promote health and protect against chronic diseases, such as diabetes...
  88. ncbi request reprint Models of growth hormone and IGF-1 deficiency: applications to studies of aging processes and life-span determination
    Christy S Carter
    Department of Physiology and Pharmacology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1083, USA
    J Gerontol A Biol Sci Med Sci 57:B177-88. 2002
    ..Finally, we propose an integrated explanation of growth hormone and IGF-1's contribution to the aging phenotype and life-span determination...
  89. ncbi request reprint Elevated pregnancy losses at high and low extremes of maternal glucose in early normal and diabetic pregnancy: evidence for a protective adaptation in diabetes
    Lois Jovanovic
    University of Washington, 325 Ninth Ave, Box 359720, Seattle, WA 98104, USA
    Diabetes Care 28:1113-7. 2005
    ..To test this hypothesis, we examined relationships of proximate measures of prior glycemia, glycated protein and fructosamine, to pregnancy loss...
  90. ncbi request reprint Overcoming the barriers for achieving standards of diabetes care: the formation of CADRE
    William T Cefalu
    University of Vermont College of Medicine, Burlington, Vermont 05401, USA
    Diabetes Technol Ther 5:385-92. 2003
    ..This article will focus on the formation of CADRE, and, in particular, identification of the problem contributing to the obstacles of care, and review various surveys conducted by CADRE designed in an effort to identify the problem...