George Bray

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. ncbi request reprint Beyond energy balance: there is more to obesity than kilocalories
    George A Bray
    Louisiana State University System, USA
    J Am Diet Assoc 105:S17-23. 2005
  2. doi request reprint Dietary sugar and body weight: have we reached a crisis in the epidemic of obesity and diabetes?: health be damned! Pour on the sugar
    George A Bray
    Corresponding author George A Bray
    Diabetes Care 37:950-6. 2014
  3. doi request reprint Calorie-sweetened beverages and fructose: what have we learned 10 years later
    G A Bray
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Pediatr Obes 8:242-8. 2013
  4. doi request reprint Why do we need drugs to treat the patient with obesity?
    George A Bray
    Pennington Biomedical Research Center Baton Rouge, LA, USA
    Obesity (Silver Spring) 21:893-9. 2013
  5. pmc Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some people
    George A Bray
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Adv Nutr 4:220-5. 2013
  6. doi request reprint Fructose and risk of cardiometabolic disease
    George A Bray
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Curr Atheroscler Rep 14:570-8. 2012
  7. pmc Effect of diet composition on energy expenditure during weight loss: the POUNDS LOST Study
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 36:448-55. 2012
  8. pmc Actos Now for the prevention of diabetes (ACT NOW) study
    Ralph A DeFronzo
    Texas Diabetes Institute and University of Texas Health Science Center, San Antonio, TX, USA
    BMC Endocr Disord 9:17. 2009
  9. ncbi request reprint Drug Insight: appetite suppressants
    George A Bray
    Division of Clinical Obesity and Metabolism, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Nat Clin Pract Gastroenterol Hepatol 2:89-95. 2005
  10. ncbi request reprint Drug treatment of obesity
    George A Bray
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Psychiatr Clin North Am 28:193-217, ix-x. 2005

Research Grants

  1. Post-DPP Follow-up-Study
    George Bray; Fiscal Year: 2007
  2. DIETARY OBESITY
    George Bray; Fiscal Year: 2007
  3. Health Outcomes of Weight loss: Look AHEAD -Action for Health in Diabetes
    George Bray; Fiscal Year: 2007

Collaborators

Detail Information

Publications115 found, 100 shown here

  1. ncbi request reprint Beyond energy balance: there is more to obesity than kilocalories
    George A Bray
    Louisiana State University System, USA
    J Am Diet Assoc 105:S17-23. 2005
    ..Reversing the current trends of obesity requires a new look at the limits of the energy balance concept, and a better understanding of how environmental factors acutely and chronically change the responses of susceptible hosts...
  2. doi request reprint Dietary sugar and body weight: have we reached a crisis in the epidemic of obesity and diabetes?: health be damned! Pour on the sugar
    George A Bray
    Corresponding author George A Bray
    Diabetes Care 37:950-6. 2014
    ..Consumption of calorie-sweetened beverages has continued to increase and plays a role in the epidemic of obesity, the metabolic syndrome, and fatty liver disease. Reducing intake of soft drinks is associated with less weight gain. ..
  3. doi request reprint Calorie-sweetened beverages and fructose: what have we learned 10 years later
    G A Bray
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Pediatr Obes 8:242-8. 2013
    ..Sugar-sweetened drinks and the fructose they provide are associated with several health problems...
  4. doi request reprint Why do we need drugs to treat the patient with obesity?
    George A Bray
    Pennington Biomedical Research Center Baton Rouge, LA, USA
    Obesity (Silver Spring) 21:893-9. 2013
    ..Obesity is a public health problem, which increases the risk of chronic diseases and mortality. Weight loss can reduce mortality and improve most of the detrimental health consequences of obesity...
  5. pmc Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some people
    George A Bray
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Adv Nutr 4:220-5. 2013
    ..By worsening blood lipids, contributing to obesity, diabetes, fatty liver, and gout, fructose in the amounts currently consumed is hazardous to the health of some people...
  6. doi request reprint Fructose and risk of cardiometabolic disease
    George A Bray
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Curr Atheroscler Rep 14:570-8. 2012
    ....
  7. pmc Effect of diet composition on energy expenditure during weight loss: the POUNDS LOST Study
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 36:448-55. 2012
    ..Hypothesis: We tested the hypothesis that macronutrient composition of the diet might affect the partitioning of energy expenditure during weight loss...
  8. pmc Actos Now for the prevention of diabetes (ACT NOW) study
    Ralph A DeFronzo
    Texas Diabetes Institute and University of Texas Health Science Center, San Antonio, TX, USA
    BMC Endocr Disord 9:17. 2009
    ..TRIAL REGISTRATION: clinical trials.gov identifier: NCT00220961...
  9. ncbi request reprint Drug Insight: appetite suppressants
    George A Bray
    Division of Clinical Obesity and Metabolism, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Nat Clin Pract Gastroenterol Hepatol 2:89-95. 2005
    ..Several new mechanisms for drug action are under investigation. Appetite suppressants should be viewed as useful adjuncts to diet and physical activity and might help selected patients to achieve and maintain weight loss...
  10. ncbi request reprint Drug treatment of obesity
    George A Bray
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Psychiatr Clin North Am 28:193-217, ix-x. 2005
  11. ncbi request reprint Epidemiology, trends, and morbidities of obesity and the metabolic syndrome
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Endocrine 29:109-17. 2006
    ..First, life span is shortened and the risk of sudden death increases. Second, the risk of diabetes, gall bladder disease, hypertension, heart disease, osteoarthritis, sleep apnea, and certain forms of cancer also increase...
  12. ncbi request reprint Dietary fat and obesity: a review of animal, clinical and epidemiological studies
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Physiol Behav 83:549-55. 2004
    ..Thus, dietary fat is an important contributor to obesity in some people...
  13. ncbi request reprint Drug treatment of the overweight patient
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Gastroenterology 132:2239-52. 2007
    ..In addition there are several drugs and drug combinations in phase 2 or phase 2 trials that will be reported on in the coming years...
  14. ncbi request reprint How do we get fat? An epidemiologic and metabolic approach
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Clin Dermatol 22:281-8. 2004
    ....
  15. ncbi request reprint A further subgroup analysis of the effects of the DASH diet and three dietary sodium levels on blood pressure: results of the DASH-Sodium Trial
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, Lousiana, USA
    Am J Cardiol 94:222-7. 2004
    ....
  16. ncbi request reprint The epidemic of obesity and changes in food intake: the Fluoride Hypothesis
    George A Bray
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Physiol Behav 82:115-21. 2004
    ..In this context, fluoride is also an acronym for treatment and prevention of obesity: For Lowering Universal Obesity Rates are Implement ideas that Don't demand Effort (FLUORIDE)...
  17. ncbi request reprint Medical consequences of obesity
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 89:2583-9. 2004
    ..Increased cytokine release may play a role in other forms of proliferative growth. The combined effect of these pathogenetic consequences of increased fat stores is an increased risk of shortened life expectancy...
  18. ncbi request reprint Obesity: the disease
    George A Bray
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
    J Med Chem 49:4001-7. 2006
  19. pmc Baseline characteristics of the randomised cohort from the Look AHEAD (Action for Health in Diabetes) study
    George Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Diab Vasc Dis Res 3:202-15. 2006
    ..5 years) of intensive weight loss intervention on the time to incidence of major cardiovascular events...
  20. ncbi request reprint Hormonal responses to a fast-food meal compared with nutritionally comparable meals of different composition
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Ann Nutr Metab 51:163-71. 2007
    ..Fast food is consumed in large quantities each day. Whether there are differences in the acute metabolic response to these meals as compared to 'healthy' meals with similar composition is unknown...
  21. doi request reprint Medications for weight reduction
    George A Bray
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Med Clin North Am 95:989-1008. 2011
    ..Nevertheless, drug development that is now underway is more rapid than in the past, and we anticipate the discovery of safe and effective pharmacologic strategies for the management of obesity and its serious complications...
  22. pmc Fructose: pure, white, and deadly? Fructose, by any other name, is a health hazard
    George A Bray
    Pennington Biomedical Research Centre, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Diabetes Sci Technol 4:1003-7. 2010
    ..Some claim that sugar is natural, but natural does not assure safety...
  23. doi request reprint Soft drink consumption and obesity: it is all about fructose
    George A Bray
    Pennington Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Curr Opin Lipidol 21:51-7. 2010
    ..The purpose of the review is to suggest that fructose, a component of both sucrose (common sugar) and high fructose corn syrup, should be of concern to both healthcare providers and the public...
  24. doi request reprint Medications for obesity: mechanisms and applications
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Clin Chest Med 30:525-38, ix. 2009
    ..Cannabinoid receptor antagonists, once a promising target, are no longer under study. Other medications are in clinical trials and on their way...
  25. doi request reprint Fructose: should we worry?
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Int J Obes (Lond) 32:S127-31. 2008
    ..This evidence suggests that we should worry about our current level of fructose consumption, which has been increasing steadily for over 200 years and now represents over 10% of the energy intake of some people...
  26. pmc Corrective responses in human food intake identified from an analysis of 7-d food-intake records
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 88:1504-10. 2008
    ..We tested the hypothesis that ad libitum food intake shows corrective responses over periods of 1-5 d...
  27. doi request reprint Medications for weight reduction
    George A Bray
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Endocrinol Metab Clin North Am 37:923-42. 2008
    ..Treatment is aimed at palliation-that is, producing and maintaining weight loss. Regardless of the primary site of action, the net effect must be a reduction in food intake or increase in energy expenditure...
  28. doi request reprint Are non-prescription medications needed for weight control?
    George A Bray
    Pennington Biomedical Research Center of Louisiana State University, Baton Rouge, LA, USA
    Obesity (Silver Spring) 16:509-14. 2008
    ..The downside includes improper use of OTC orlistat that may not result in achieving individual expectations...
  29. ncbi request reprint Medical therapy for obesity--current status and future hopes
    George A Bray
    Pennington Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Med Clin North Am 91:1225-53, xi. 2007
    ..Wherever the primary site of action may be, however, the net effect must be a reduction in food intake or an increase in energy expenditure...
  30. ncbi request reprint Pharmacological treatment of the overweight patient
    George A Bray
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Pharmacol Rev 59:151-84. 2007
  31. ncbi request reprint Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity
    George A Bray
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 79:537-43. 2004
    ..Thus, the increase in consumption of HFCS has a temporal relation to the epidemic of obesity, and the overconsumption of HFCS in calorically sweetened beverages may play a role in the epidemic of obesity...
  32. ncbi request reprint Obesity is a chronic, relapsing neurochemical disease
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes Relat Metab Disord 28:34-8. 2004
    ..Treatments consist of techniques to alter the balance between energy intake and energy expenditure. This constellation of factors leads to the conclusion that obesity should be called a disease...
  33. ncbi request reprint Body composition of African American and white children: a 2-year follow-up of the BAROC study
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Obes Res 9:605-21. 2001
    ..To evaluate the 2-year changes in body composition of white and African American boys and girls...
  34. ncbi request reprint Evaluation of body fat in fatter and leaner 10-y-old African American and white children: the Baton Rouge Children's Study
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 73:687-702. 2001
    ..We hypothesized that the preferred methods of determining body fat may differ in children with larger compared with smaller amounts of body fat, in boys compared with girls, and in African Americans compared with whites...
  35. ncbi request reprint Clinical evaluation of the overweight patient
    G A Bray
    Louisiana State University, Pennington Biomedical Research Center, Baton Rouge, USA
    Endocrine 13:167-86. 2000
    ..After assessing risk, the therapeutic choices can be selected from the age category of the patient. With any therapeutic activity, involvement of the patient in a realistic approach to the treatment process is essential...
  36. ncbi request reprint A concise review on the therapeutics of obesity
    G A Bray
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA
    Nutrition 16:953-60. 2000
    ..In clinical trials other drugs that may modulate peptide-feeding systems are being developed...
  37. ncbi request reprint A 6-month randomized, placebo-controlled, dose-ranging trial of topiramate for weight loss in obesity
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, Louisiana Baylor Hospital, Dallas, Texas, USA
    Obes Res 11:722-33. 2003
    ..To evaluate the efficacy and safety of topiramate (TPM) for weight loss in healthy obese subjects...
  38. ncbi request reprint A 9-mo randomized clinical trial comparing fat-substituted and fat-reduced diets in healthy obese men: the Ole Study
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 76:928-34. 2002
    ..Dietary fat has been implicated as a risk factor for cardiovascular disease and obesity...
  39. ncbi request reprint Afferent signals regulating food intake
    G A Bray
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Proc Nutr Soc 59:373-84. 2000
    ..Many of these peptides act on gastrointestinal or hepatic receptors that relay messages to the brain via the afferent vagus nerve. As a group they provide a number of leads for potential drug development...
  40. ncbi request reprint Risks of obesity
    George A Bray
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Prim Care 30:281-99, v-vi. 2003
    ..The consequence of these two mechanisms is other diseases, such as diabetes mellitus, gallbladder disease, osteoarthritis, heart disease, and some forms of cancer...
  41. ncbi request reprint The influence of different fats and fatty acids on obesity, insulin resistance and inflammation
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Nutr 132:2488-91. 2002
    ..One important conclusion from this review is that both total fat and individual fatty acids have to be considered when reaching conclusions about dietary fat and obesity...
  42. ncbi request reprint Medicinal strategies in the treatment of obesity
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Nature 404:672-7. 2000
    ..Currently approved drugs for long-term treatment of obesity include sibutramine, which inhibits food intake, and orlistat, which blocks fat digestion...
  43. ncbi request reprint The underlying basis for obesity: relationship to cancer
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Nutr 132:3451S-3455S. 2002
    ..Efforts to control obesity through preventive strategies and treatment can be expected to have a benefit in reducing the risk of cancer...
  44. ncbi request reprint Evaluation of obesity. Who are the obese?
    George A Bray
    Louisiana State University, Pennington Biomedical Research Center, Baton Rouge, USA
    Postgrad Med 114:19-27, 38. 2003
    ..Here, Dr Bray reviews the characteristics that define overweight and obesity, the factors that contribute to the pathogenesis of obesity, and current approaches to its management...
  45. ncbi request reprint Obesity and the Metabolic Syndrome: implications for dietetics practitioners
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    J Am Diet Assoc 104:86-9. 2004
    ....
  46. ncbi request reprint Prediction of body fat in 12-y-old African American and white children: evaluation of methods
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 76:980-90. 2002
    ..The prevalence of obesity is increasing in children. Validation of methods of predicting fatness in African American and white children could help to identify children at high risk...
  47. ncbi request reprint Risks of obesity
    George A Bray
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Endocrinol Metab Clin North Am 32:787-804, viii. 2003
    ..The spectrum of medical, social, and psychologic disabilities includes a range of medical and behavioral problems...
  48. ncbi request reprint Sibutramine and blood pressure: a therapeutic dilemma
    G A Bray
    Pennington Biomedical Research Center Baton Rouge, LA 70808, USA
    J Hum Hypertens 16:1-3. 2002
  49. pmc Adipose tissue collagen VI in obesity
    Magdalena Pasarica
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 94:5155-62. 2009
    ..We hypothesized in humans that increased collagen VI alpha3-subunit (COL6A3) mRNA is associated with adipose tissue macrophage chemotaxis and inflammation and that weight gain is accompanied by changes in the expression of COL6A3...
  50. ncbi request reprint Energy expenditure and substrate oxidation predict changes in body fat in children
    James P Delany
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Am J Clin Nutr 84:862-70. 2006
    ..The hypothesis that alterations in energy metabolism predict body fat gain is controversial...
  51. ncbi request reprint Americans on diet: results from the 1994-1996 Continuing Survey of Food Intakes by Individuals
    Sahasporn Paeratakul
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    J Am Diet Assoc 102:1247-51. 2002
    ..To examine the prevalence of dieting to lose weight or for a health reason in a representative sample of US adults...
  52. ncbi request reprint Effect on body weight of replacing dietary fat with olestra for two or ten weeks in healthy men and women
    Heli J Roy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    J Am Coll Nutr 21:259-67. 2002
    ..To examine in two separate studies the effects of replacing dietary fat with Olestra on body composition and weight change in healthy young men and women...
  53. ncbi request reprint Effects of a high-fat diet and strain on hypothalamic gene expression in rats
    Andrea O Schaffhauser
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Obes Res 10:1188-96. 2002
    ..This study was designed to investigate whether dietary fat and genetic background might differentially alter the expression of hypothalamic genes involved in food intake...
  54. pmc Relation of central adiposity and body mass index to the development of diabetes in the Diabetes Prevention Program
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Am J Clin Nutr 87:1212-8. 2008
    ..Greater central adiposity is related to the risk of diabetes...
  55. ncbi request reprint Effect of a beta-3 agonist on food intake in two strains of rats that differ in susceptibility to obesity
    Christy L White
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Physiol Behav 82:489-96. 2004
    ..Beta-3 agonists acutely reduce food intake, but the mechanism is not well understood...
  56. ncbi request reprint A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle
    Lauren M Sparks
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Diabetes 54:1926-33. 2005
    ..These changes mimic those observed in diabetes and insulin resistance and, if sustained, may result in mitochondrial dysfunction in the prediabetic/insulin-resistant state...
  57. pmc Metabolic flexibility in response to glucose is not impaired in people with type 2 diabetes after controlling for glucose disposal rate
    Jose E Galgani
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 57:841-5. 2008
    ....
  58. ncbi request reprint Family history of diabetes links impaired substrate switching and reduced mitochondrial content in skeletal muscle
    Barbara Ukropcova
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Diabetes 56:720-7. 2007
    ....
  59. ncbi request reprint Daily intake of multivitamins during long-term intake of olestra in men prevents declines in serum vitamins A and E but not carotenoids
    Richard T Tulley
    Pennington Biomedical Research Center, Baton Rouge, LA 70112, USA
    J Nutr 135:1456-61. 2005
    ..Olestra-induced decreases in serum beta-carotene, lycopene, and lutein + zeaxanthin were not prevented by the vitamin supplement used in this study...
  60. ncbi request reprint Overweight and obesity: the pathogenesis of cardiometabolic risk
    George A Bray
    Louisiana State University Medical Center Baton Rouge, Louisiana, USA
    Clin Cornerstone 9:30-40; discussion 41-2. 2009
    ..Understanding the role of obesity in the pathogenesis of cardiometabolic risk is crucial for the development of treatment strategies that will provide maximum benefit for patients with, or at risk for, type 2 DM and CVD...
  61. ncbi request reprint Effects of diet and time of the day on serum and CSF leptin levels in Osborne-Mendel and S5B/Pl rats
    Yuri Ishihara
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Obes Res 12:1067-76. 2004
    ....
  62. ncbi request reprint Effects of diets enriched in saturated (palmitic), monounsaturated (oleic), or trans (elaidic) fatty acids on insulin sensitivity and substrate oxidation in healthy adults
    Jennifer C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Diabetes Care 25:1283-8. 2002
    ..Diets high in total and saturated fat are associated with insulin resistance. This study examined the effects of feeding monounsaturated, saturated, and trans fatty acids on insulin action in healthy adults...
  63. doi request reprint Treatment of the obese patient in primary care: targeting and meeting goals and expectations
    George Bray
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA
    Postgrad Med 125:67-77. 2013
    ....
  64. pmc Lower total adipocyte number but no evidence for small adipocyte depletion in patients with type 2 diabetes
    Magdalena Pasarica
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Diabetes Care 32:900-2. 2009
    ..We hypothesized that, compared with obese subjects, patients with type 2 diabetes have a lower total adipocyte number with fewer small adipocytes...
  65. ncbi request reprint High-fat/low-carbohydrate diets regulate glucose metabolism via a long-term transcriptional loop
    Lauren M Sparks
    Department of Biological Sciences, Louisiana State University and Agricultural and Mechanical College, Baton Rouge, LA, USA
    Metabolism 55:1457-63. 2006
    ..Combined, these results suggest a mechanism whereby HF/LCD regulates the genes necessary for glucose utilization and storage vis-á-vis transcriptional control...
  66. pmc Central administration of the RFamide peptides, QRFP-26 and QRFP-43, increases high fat food intake in rats
    Stefany D Primeaux
    Dietary Obesity Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Peptides 29:1994-2000. 2008
    ..These findings suggest that QRFP is a regulator of dietary fat intake and is influenced by the intake of a high fat diet...
  67. pmc Preference for a high fat diet, but not hyperphagia following activation of mu opioid receptors is blocked in AgRP knockout mice
    Maria J Barnes
    Pennington Biomedical Research Center, Nutrition and Neural Signaling Laboratory, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Brain Res 1317:100-7. 2010
    ..These data demonstrate that the increased preference for a high fat diet after stimulation of MOR is attenuated in the absence of AgRP, but the increase in food intake (i.e. hyperphagia) is not...
  68. ncbi request reprint Energy intake and energy expenditure: a controlled study comparing dietitians and non-dietitians
    Catherine M Champagne
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    J Am Diet Assoc 102:1428-32. 2002
    ....
  69. doi request reprint Medical therapy for obesity
    George A Bray
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Mt Sinai J Med 77:407-17. 2010
    ..Its marketing has been suspended in Europe. Several drug combinations are on the horizon for treatment of obesity...
  70. pmc Relation of adipose tissue to metabolic flexibility
    Lauren M Sparks
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Diabetes Res Clin Pract 83:32-43. 2009
    ....
  71. pmc Effect of pioglitazone on energy intake and ghrelin in diabetic patients
    Corby K Martin
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Diabetes Care 33:742-4. 2010
    ..To measure ghrelin and energy intake in the laboratory after pioglitazone treatment...
  72. pmc Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetes
    Donald A Williamson
    Health Psychology Department, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808 4124, USA
    Arch Intern Med 169:163-71. 2009
    ..We tested the efficacy of a weight management program for improving HRQOL in overweight or obese adults diagnosed as having type 2 diabetes mellitus...
  73. pmc Pioglitazone, but not metformin, reduces liver fat in Type-2 diabetes mellitus independent of weight changes
    Alok K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    J Diabetes Complications 24:289-96. 2010
    ..Pioglitazone (Pio) treatment induces weight gain in Type 2 diabetes mellitus (T2DM), which could worsen hepatic lipid accumulation, and alter adiponectin and high-sensitivity C-reactive protein (hs-CRP)...
  74. ncbi request reprint Sex, race/ethnicity, socioeconomic status, and BMI in relation to self-perception of overweight
    Sahasporn Paeratakul
    Nutritional Epidemiology, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Obes Res 10:345-50. 2002
    ....
  75. pmc Food deprivation increases the mRNA expression of micro-opioid receptors in the ventral medial hypothalamus and arcuate nucleus
    Maria J Barnes
    Dietary Obesity Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Regul Integr Comp Physiol 295:R1385-90. 2008
    ..These data demonstrate that hypothalamic micro-opioid receptors may contribute to the hyperphagia and increased preference for a high-fat diet that is associated with food deprivation...
  76. ncbi request reprint Effect of meta-chlorophenylpiperazine and cholecystokinin on food intake of Osborne-Mendel and S5B/P1 rats
    Christy L White
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 15:624-31. 2007
    ....
  77. pmc Olfactory bulbectomy increases food intake and hypothalamic neuropeptide Y in obesity-prone but not obesity-resistant rats
    Stefany D Primeaux
    Dietary Obesity Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Behav Brain Res 180:190-6. 2007
    ..Therefore, strain specific alterations in hypothalamic NPY may account for increased food intake in the obesity-prone rats following OBX, and suggests a potential mechanism to explain the comorbidity of obesity and depression...
  78. ncbi request reprint Comparison of the acute response to meals enriched with cis- or trans-fatty acids on glucose and lipids in overweight individuals with differing FABP2 genotypes
    Michael Lefevre
    Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Metabolism 54:1652-8. 2005
    ....
  79. ncbi request reprint Neuropeptide Y administration into the amygdala alters high fat food intake
    Stefany D Primeaux
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Peptides 27:1644-51. 2006
    ..Intra-amygdalar NPY administration did not produce conditioned taste aversions to a novel saccharin solution. These results suggest that amygdalar NPY may have a role in macronutrient selection, without altering total caloric intake...
  80. ncbi request reprint Effect of pioglitazone on body composition and energy expenditure: a randomized controlled trial
    Steven R Smith
    Department of Molecular Endocrinology, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Metabolism 54:24-32. 2005
    ..Some, but not all, studies demonstrate reductions in visceral adipose tissue. Changes in body weight are the result of changes in energy intake, energy expenditure, or both...
  81. ncbi request reprint The effect of pioglitazone on peroxisome proliferator-activated receptor-gamma target genes related to lipid storage in vivo
    Iwona Bogacka
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Diabetes Care 27:1660-7. 2004
    ..The aim of this study was to define the effect of pioglitazone on the expression of genes related to carbohydrate and lipid metabolism in subcutaneous fat obtained from type 2 diabetic patients...
  82. ncbi request reprint Energy expenditure in African American and white boys and girls in a 2-y follow-up of the Baton Rouge Children's Study
    James P Delany
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 79:268-73. 2004
    ..Previously reported race and sex differences in energy expenditure (EE) may play a role in body fat gain...
  83. pmc Adherence is a multi-dimensional construct in the POUNDS LOST trial
    Donald A Williamson
    Pennington Biomedical Research Center, LSU System, 6400 Perkins Rd, Baton Rouge, LA, USA
    J Behav Med 33:35-46. 2010
    ..The findings of this study indicated that adherence to a weight management program was best conceptualized as being multi-dimensional, with two dimensions: behavioral and dietary adherence...
  84. doi request reprint Nonsurgical weight loss for extreme obesity in primary care settings: results of the Louisiana Obese Subjects Study
    Donna H Ryan
    Pennington Biomedical Research Center of Louisiana State University System, Baton Rouge, LA 70808, USA
    Arch Intern Med 170:146-54. 2010
    ....
  85. pmc Early behavioral adherence predicts short and long-term weight loss in the POUNDS LOST study
    Donald A Williamson
    Pennington Biomedical Research Center, LSU System, 6400 Perkins Rd, Baton Rouge, LA, USA
    J Behav Med 33:305-14. 2010
    ..Early dietary adherence was associated with changes in insulin at 6 months (R = 0.19), but not at 24 months (R = 0.08, ns). Early dietary adherence was not associated with changes in adiposity...
  86. doi request reprint Combination drugs for treating obesity
    Frank L Greenway
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
    Curr Diab Rep 10:108-15. 2010
    ..The advent of combination drug therapy for obesity treatment offers hope for increasing the efficacy of obesity pharmacotherapy...
  87. ncbi request reprint The effects of triiodothyronine on bone metabolism in healthy ambulatory men
    Steven R Smith
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Thyroid 13:357-64. 2003
    ..4% (p = 0.08). Bone mineral density showed no change. We conclude that T(3) accelerates bone turnover and that bone formation does not increase acutely to prevent bone loss...
  88. ncbi request reprint Energy expenditure in preadolescent African American and white boys and girls: the Baton Rouge Children's Study
    James P Delany
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Am J Clin Nutr 75:705-13. 2002
    ..Low energy expenditure has been identified as a potential risk factor for body fat gain...
  89. ncbi request reprint Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivo
    Iwona Bogacka
    Molecular Endocrinology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA, USA
    Diabetes 54:1392-9. 2005
    ..Finally, the increased mitochondrial copy number and the higher expression of genes involved in fatty acid oxidation in human adipocytes may contribute to the hypolipidemic effects of pioglitazone...
  90. ncbi request reprint Effect of a high or low ambient perinatal temperature on adult obesity in Osborne-Mendel and S5B/Pl rats
    Christy L White
    Pennington Biomedical Research Center, Louisiana State Univ System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Am J Physiol Regul Integr Comp Physiol 288:R1376-84. 2005
    ..The data suggest that OM rats are more susceptible to epigenetic programming than S5B rats...
  91. ncbi request reprint Fast-food consumption among US adults and children: dietary and nutrient intake profile
    Sahasporn Paeratakul
    Nutritional Epidemiology, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    J Am Diet Assoc 103:1332-8. 2003
    ..To examine the dietary profile associated with fast-food use. To compare the dietary intake of individuals on the day that they ate fast food with the day that fast food was not eaten...
  92. ncbi request reprint Regulation of ghrelin gene expression in stomach and feeding response to a ghrelin analogue in two strains of rats
    Xiaotuan Liu
    Experimental Obesity Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Peptides 25:2171-7. 2004
    ..In addition, a differential regulation of ghrelin gene expression between OM and S5B rats may be important in their differential sensitivity to HF diet-induced obesity...
  93. doi request reprint Racial differences in abdominal depot-specific adiposity in white and African American adults
    Peter T Katzmarzyk
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808 4124, USA
    Am J Clin Nutr 91:7-15. 2010
    ..There is increasing interest in understanding racial differences in adiposity in specific body depots as a way to explain differential health risks associated with obesity...
  94. ncbi request reprint Overexpression of neuropeptide Y in the central nucleus of the amygdala decreases ethanol self-administration in "anxious" rats
    Stefany D Primeaux
    Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, South Carolina, USA
    Alcohol Clin Exp Res 30:791-801. 2006
    ..The current experiment investigated the predictive role of anxiety-like behaviors in ethanol self-administration and the relationship of NPY in the central nucleus of the amygdala (CeA) with anxiety and ethanol self-administration...
  95. pmc Lifestyle and pharmacological approaches to weight loss: efficacy and safety
    George A Bray
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 93:S81-8. 2008
    ..Obesity results from a prolonged small positive energy balance, and its treatment needs to reverse this imbalance...
  96. ncbi request reprint Increased expression of mu opioid receptors in animals susceptible to diet-induced obesity
    Maria J Barnes
    Pennington Biomedical Research Center, Dietary Obesity Laboratory, Baton Rouge, LA 70808, USA
    Peptides 27:3292-8. 2006
    ....
  97. doi request reprint Weight loss and blood pressure control (Pro)
    David W Harsha
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Hypertension 51:1420-5; discussion 1425. 2008
  98. pmc Achieving weight and activity goals among diabetes prevention program lifestyle participants
    Rena R Wing
    Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Boulevard, Suite 750, Rockville, MD 20852, USA
    Obes Res 12:1426-34. 2004
    ..This paper examines demographic, psychosocial, and behavioral factors related to achieving weight loss and physical activity goals in the DPP lifestyle participants...
  99. ncbi request reprint Low-fat diets are preferred
    Eric Jéquier
    Institute of Physiology, University of Lausanne, Lausanne, Switzerland
    Am J Med 113:41S-46S. 2002
    ..There is no evidence showing that the small physiologic reduction of plasma highdensity lipoprotein cholesterol levels with a low-fat diet is detrimental...
  100. pmc Prediction equations for resting energy expenditure in overweight and normal-weight black and white children
    Jennifer R McDuffie
    Unit on Growth and Obesity, Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA
    Am J Clin Nutr 80:365-73. 2004
    ..Accurate estimation of children's resting energy expenditure (REE) is important for planning dietary therapy...

Research Grants5

  1. Post-DPP Follow-up-Study
    George Bray; Fiscal Year: 2007
    ..women, and in older subjects in the DPP. The current application is for 5 years of funding, although the some of the goals of the projects described will require a 10-year study. ..
  2. DIETARY OBESITY
    George Bray; Fiscal Year: 2007
    ..We now propose these well founded, important and exciting studies which will provide critical new insights into anatomical, physiological and molecular mechanisms by which high levels of dietary fat induce obesity. ..
  3. Health Outcomes of Weight loss: Look AHEAD -Action for Health in Diabetes
    George Bray; Fiscal Year: 2007
    ..These procedures will enable us to analyze the effects of the intervention on serious cardiovascular- related factors and complications, and cost-effectiveness of the intervention. ..