Research Topics
| George BraySummaryAffiliation: Pennington Biomedical Research Center Country: USA Publications
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Publications
Beyond energy balance: there is more to obesity than kilocaloriesGeorge A Bray
Louisiana State University System, USA
J Am Diet Assoc 105:S17-23. 2005..Reversing the current trends of obesity requires a new look at the limits of the energy balance concept, and a better understanding of how environmental factors acutely and chronically change the responses of susceptible hosts...
Energy and fructose from beverages sweetened with sugar or high-fructose corn syrup pose a health risk for some peopleGeorge A Bray
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
Adv Nutr 4:220-5. 2013..By worsening blood lipids, contributing to obesity, diabetes, fatty liver, and gout, fructose in the amounts currently consumed is hazardous to the health of some people...- Fructose and risk of cardiometabolic diseaseGeorge A Bray
Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Curr Atheroscler Rep 14:570-8. 2012.... 
Effect of diet composition on energy expenditure during weight loss: the POUNDS LOST StudyG A Bray
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Int J Obes (Lond) 36:448-55. 2012..Hypothesis: We tested the hypothesis that macronutrient composition of the diet might affect the partitioning of energy expenditure during weight loss...- Actos Now for the prevention of diabetes (ACT NOW) studyRalph A DeFronzo
Texas Diabetes Institute and University of Texas Health Science Center, San Antonio, TX, USA
BMC Endocr Disord 9:17. 2009..TRIAL REGISTRATION: clinical trials.gov identifier: NCT00220961... - Dietary fat and obesity: a review of animal, clinical and epidemiological studiesGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Physiol Behav 83:549-55. 2004..Thus, dietary fat is an important contributor to obesity in some people... - Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesityGeorge A Bray
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
Am J Clin Nutr 79:537-43. 2004..Thus, the increase in consumption of HFCS has a temporal relation to the epidemic of obesity, and the overconsumption of HFCS in calorically sweetened beverages may play a role in the epidemic of obesity... - Hormonal responses to a fast-food meal compared with nutritionally comparable meals of different compositionGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Ann Nutr Metab 51:163-71. 2007..Fast food is consumed in large quantities each day. Whether there are differences in the acute metabolic response to these meals as compared to 'healthy' meals with similar composition is unknown... - Risks of obesityGeorge A Bray
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Endocrinol Metab Clin North Am 32:787-804, viii. 2003..The spectrum of medical, social, and psychologic disabilities includes a range of medical and behavioral problems... - Obesity and the Metabolic Syndrome: implications for dietetics practitionersGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, LA, USA
J Am Diet Assoc 104:86-9. 2004.... - Evaluation of obesity. Who are the obese?George A Bray
Louisiana State University, Pennington Biomedical Research Center, Baton Rouge, USA
Postgrad Med 114:19-27, 38. 2003..Here, Dr Bray reviews the characteristics that define overweight and obesity, the factors that contribute to the pathogenesis of obesity, and current approaches to its management... - Risks of obesityGeorge A Bray
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Prim Care 30:281-99, v-vi. 2003..The consequence of these two mechanisms is other diseases, such as diabetes mellitus, gallbladder disease, osteoarthritis, heart disease, and some forms of cancer... - Pharmacological treatment of the overweight patientGeorge A Bray
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Pharmacol Rev 59:151-84. 2007 - Medical consequences of obesityGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
J Clin Endocrinol Metab 89:2583-9. 2004..Increased cytokine release may play a role in other forms of proliferative growth. The combined effect of these pathogenetic consequences of increased fat stores is an increased risk of shortened life expectancy... - Drug treatment of the overweight patientGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
Gastroenterology 132:2239-52. 2007..In addition there are several drugs and drug combinations in phase 2 or phase 2 trials that will be reported on in the coming years... - Drug treatment of obesityGeorge A Bray
Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Psychiatr Clin North Am 28:193-217, ix-x. 2005 - Drug Insight: appetite suppressantsGeorge A Bray
Division of Clinical Obesity and Metabolism, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
Nat Clin Pract Gastroenterol Hepatol 2:89-95. 2005..Several new mechanisms for drug action are under investigation. Appetite suppressants should be viewed as useful adjuncts to diet and physical activity and might help selected patients to achieve and maintain weight loss... - How do we get fat? An epidemiologic and metabolic approachGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Clin Dermatol 22:281-8. 2004.... - Epidemiology, trends, and morbidities of obesity and the metabolic syndromeGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Endocrine 29:109-17. 2006..First, life span is shortened and the risk of sudden death increases. Second, the risk of diabetes, gall bladder disease, hypertension, heart disease, osteoarthritis, sleep apnea, and certain forms of cancer also increase... - Obesity: the diseaseGeorge A Bray
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
J Med Chem 49:4001-7. 2006 - Baseline characteristics of the randomised cohort from the Look AHEAD (Action for Health in Diabetes) studyGeorge Bray
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Diab Vasc Dis Res 3:202-15. 2006..5 years) of intensive weight loss intervention on the time to incidence of major cardiovascular events... - A further subgroup analysis of the effects of the DASH diet and three dietary sodium levels on blood pressure: results of the DASH-Sodium TrialGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, Lousiana, USA
Am J Cardiol 94:222-7. 2004.... - The epidemic of obesity and changes in food intake: the Fluoride HypothesisGeorge A Bray
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Physiol Behav 82:115-21. 2004..In this context, fluoride is also an acronym for treatment and prevention of obesity: For Lowering Universal Obesity Rates are Implement ideas that Don't demand Effort (FLUORIDE)... - Medical therapy for obesity--current status and future hopesGeorge A Bray
Pennington Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Med Clin North Am 91:1225-53, xi. 2007..Wherever the primary site of action may be, however, the net effect must be a reduction in food intake or an increase in energy expenditure... - A 6-month randomized, placebo-controlled, dose-ranging trial of topiramate for weight loss in obesityGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, Louisiana Baylor Hospital, Dallas, Texas, USA
Obes Res 11:722-33. 2003..To evaluate the efficacy and safety of topiramate (TPM) for weight loss in healthy obese subjects... - Are non-prescription medications needed for weight control?George A Bray
Pennington Biomedical Research Center of Louisiana State University, Baton Rouge, LA, USA
Obesity (Silver Spring) 16:509-14. 2008..The downside includes improper use of OTC orlistat that may not result in achieving individual expectations... - Fructose: pure, white, and deadly? Fructose, by any other name, is a health hazardGeorge A Bray
Pennington Biomedical Research Centre, Louisiana State University, Baton Rouge, Louisiana 70808, USA
J Diabetes Sci Technol 4:1003-7. 2010..Some claim that sugar is natural, but natural does not assure safety... - Medications for weight reductionGeorge A Bray
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Med Clin North Am 95:989-1008. 2011..Nevertheless, drug development that is now underway is more rapid than in the past, and we anticipate the discovery of safe and effective pharmacologic strategies for the management of obesity and its serious complications... - Sibutramine and blood pressure: a therapeutic dilemmaG A Bray
Pennington Biomedical Research Center Baton Rouge, LA 70808, USA
J Hum Hypertens 16:1-3. 2002 - Body composition of African American and white children: a 2-year follow-up of the BAROC studyG A Bray
Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
Obes Res 9:605-21. 2001..To evaluate the 2-year changes in body composition of white and African American boys and girls... - Evaluation of body fat in fatter and leaner 10-y-old African American and white children: the Baton Rouge Children's StudyG A Bray
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Am J Clin Nutr 73:687-702. 2001..We hypothesized that the preferred methods of determining body fat may differ in children with larger compared with smaller amounts of body fat, in boys compared with girls, and in African Americans compared with whites... - Clinical evaluation of the overweight patientG A Bray
Louisiana State University, Pennington Biomedical Research Center, Baton Rouge, USA
Endocrine 13:167-86. 2000..After assessing risk, the therapeutic choices can be selected from the age category of the patient. With any therapeutic activity, involvement of the patient in a realistic approach to the treatment process is essential... - A concise review on the therapeutics of obesityG A Bray
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA
Nutrition 16:953-60. 2000..In clinical trials other drugs that may modulate peptide-feeding systems are being developed... - Afferent signals regulating food intakeG A Bray
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
Proc Nutr Soc 59:373-84. 2000..Many of these peptides act on gastrointestinal or hepatic receptors that relay messages to the brain via the afferent vagus nerve. As a group they provide a number of leads for potential drug development... - Soft drink consumption and obesity: it is all about fructoseGeorge A Bray
Pennington Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
Curr Opin Lipidol 21:51-7. 2010..The purpose of the review is to suggest that fructose, a component of both sucrose (common sugar) and high fructose corn syrup, should be of concern to both healthcare providers and the public... - The influence of different fats and fatty acids on obesity, insulin resistance and inflammationGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
J Nutr 132:2488-91. 2002..One important conclusion from this review is that both total fat and individual fatty acids have to be considered when reaching conclusions about dietary fat and obesity... - Medications for weight reductionGeorge A Bray
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Endocrinol Metab Clin North Am 37:923-42. 2008..Treatment is aimed at palliation-that is, producing and maintaining weight loss. Regardless of the primary site of action, the net effect must be a reduction in food intake or increase in energy expenditure... - Corrective responses in human food intake identified from an analysis of 7-d food-intake recordsGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Am J Clin Nutr 88:1504-10. 2008..We tested the hypothesis that ad libitum food intake shows corrective responses over periods of 1-5 d... - Fructose: should we worry?G A Bray
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Int J Obes (Lond) 32:S127-31. 2008..This evidence suggests that we should worry about our current level of fructose consumption, which has been increasing steadily for over 200 years and now represents over 10% of the energy intake of some people... - Medications for obesity: mechanisms and applicationsGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Clin Chest Med 30:525-38, ix. 2009..Cannabinoid receptor antagonists, once a promising target, are no longer under study. Other medications are in clinical trials and on their way... - The underlying basis for obesity: relationship to cancerGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
J Nutr 132:3451S-3455S. 2002..Efforts to control obesity through preventive strategies and treatment can be expected to have a benefit in reducing the risk of cancer... - Prediction of body fat in 12-y-old African American and white children: evaluation of methodsGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Am J Clin Nutr 76:980-90. 2002..The prevalence of obesity is increasing in children. Validation of methods of predicting fatness in African American and white children could help to identify children at high risk... - A 9-mo randomized clinical trial comparing fat-substituted and fat-reduced diets in healthy obese men: the Ole StudyGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Am J Clin Nutr 76:928-34. 2002..Dietary fat has been implicated as a risk factor for cardiovascular disease and obesity... - Obesity is a chronic, relapsing neurochemical diseaseG A Bray
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Int J Obes Relat Metab Disord 28:34-8. 2004..Treatments consist of techniques to alter the balance between energy intake and energy expenditure. This constellation of factors leads to the conclusion that obesity should be called a disease... - Medicinal strategies in the treatment of obesityG A Bray
Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
Nature 404:672-7. 2000..Currently approved drugs for long-term treatment of obesity include sibutramine, which inhibits food intake, and orlistat, which blocks fat digestion... - Adipose tissue collagen VI in obesityMagdalena Pasarica
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
J Clin Endocrinol Metab 94:5155-62. 2009..We hypothesized in humans that increased collagen VI alpha3-subunit (COL6A3) mRNA is associated with adipose tissue macrophage chemotaxis and inflammation and that weight gain is accompanied by changes in the expression of COL6A3... - Energy expenditure and substrate oxidation predict changes in body fat in childrenJames P Delany
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Am J Clin Nutr 84:862-70. 2006..The hypothesis that alterations in energy metabolism predict body fat gain is controversial... - Effects of a high-fat diet and strain on hypothalamic gene expression in ratsAndrea O Schaffhauser
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
Obes Res 10:1188-96. 2002..This study was designed to investigate whether dietary fat and genetic background might differentially alter the expression of hypothalamic genes involved in food intake... - Effect on body weight of replacing dietary fat with olestra for two or ten weeks in healthy men and womenHeli J Roy
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
J Am Coll Nutr 21:259-67. 2002..To examine in two separate studies the effects of replacing dietary fat with Olestra on body composition and weight change in healthy young men and women... - Americans on diet: results from the 1994-1996 Continuing Survey of Food Intakes by IndividualsSahasporn Paeratakul
Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
J Am Diet Assoc 102:1247-51. 2002..Our results suggest that the dieters generally consumed a more nutrient-dense diet than the nondieters but still low in certain nutrients... - Effect of a beta-3 agonist on food intake in two strains of rats that differ in susceptibility to obesityChristy L White
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Physiol Behav 82:489-96. 2004..CONCLUSION: These experiments demonstrate that a beta3 agonist (CL 316,243) has a much greater effect in a strain of rats that resist fat-induced obesity... - Relation of central adiposity and body mass index to the development of diabetes in the Diabetes Prevention ProgramGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, LA, USA
Am J Clin Nutr 87:1212-8. 2008..Greater central adiposity is related to the risk of diabetes... - Metabolic flexibility in response to glucose is not impaired in people with type 2 diabetes after controlling for glucose disposal rateJose E Galgani
Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
Diabetes 57:841-5. 2008.... - A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscleLauren M Sparks
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Diabetes 54:1926-33. 2005..These changes mimic those observed in diabetes and insulin resistance and, if sustained, may result in mitochondrial dysfunction in the prediabetic/insulin-resistant state... - Family history of diabetes links impaired substrate switching and reduced mitochondrial content in skeletal muscleBarbara Ukropcova
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Diabetes 56:720-7. 2007.... - Effects of diet and time of the day on serum and CSF leptin levels in Osborne-Mendel and S5B/Pl ratsYuri Ishihara
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
Obes Res 12:1067-76. 2004.... - Overweight and obesity: the pathogenesis of cardiometabolic riskGeorge A Bray
Louisiana State University Medical Center Baton Rouge, Louisiana, USA
Clin Cornerstone 9:30-40; discussion 41-2. 2009..Understanding the role of obesity in the pathogenesis of cardiometabolic risk is crucial for the development of treatment strategies that will provide maximum benefit for patients with, or at risk for, type 2 DM and CVD... - Daily intake of multivitamins during long-term intake of olestra in men prevents declines in serum vitamins A and E but not carotenoidsRichard T Tulley
Pennington Biomedical Research Center, Baton Rouge, LA 70112, USA
J Nutr 135:1456-61. 2005..Olestra-induced decreases in serum beta-carotene, lycopene, and lutein + zeaxanthin were not prevented by the vitamin supplement used in this study... - Effects of diets enriched in saturated (palmitic), monounsaturated (oleic), or trans (elaidic) fatty acids on insulin sensitivity and substrate oxidation in healthy adultsJennifer C Lovejoy
Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
Diabetes Care 25:1283-8. 2002..Overweight individuals were more susceptible to developing insulin resistance on high-saturated fat diets... - Lower total adipocyte number but no evidence for small adipocyte depletion in patients with type 2 diabetesMagdalena Pasarica
Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
Diabetes Care 32:900-2. 2009..We hypothesized that, compared with obese subjects, patients with type 2 diabetes have a lower total adipocyte number with fewer small adipocytes... - High-fat/low-carbohydrate diets regulate glucose metabolism via a long-term transcriptional loopLauren M Sparks
Department of Biological Sciences, Louisiana State University and Agricultural and Mechanical College, Baton Rouge, LA, USA
Metabolism 55:1457-63. 2006..Combined, these results suggest a mechanism whereby HF/LCD regulates the genes necessary for glucose utilization and storage vis-á-vis transcriptional control... - Relation of adipose tissue to metabolic flexibilityLauren M Sparks
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Diabetes Res Clin Pract 83:32-43. 2009.... - Energy intake and energy expenditure: a controlled study comparing dietitians and non-dietitiansCatherine M Champagne
Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
J Am Diet Assoc 102:1428-32. 2002.... - Central administration of the RFamide peptides, QRFP-26 and QRFP-43, increases high fat food intake in ratsStefany D Primeaux
Dietary Obesity Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Peptides 29:1994-2000. 2008..These findings suggest that QRFP is a regulator of dietary fat intake and is influenced by the intake of a high fat diet... - Impact of a weight management program on health-related quality of life in overweight adults with type 2 diabetesDonald A Williamson
Health Psychology Department, Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Rd, Baton Rouge, LA 70808 4124, USA
Arch Intern Med 169:163-71. 2009..We tested the efficacy of a weight management program for improving HRQOL in overweight or obese adults diagnosed as having type 2 diabetes mellitus... - Sex, race/ethnicity, socioeconomic status, and BMI in relation to self-perception of overweightSahasporn Paeratakul
Nutritional Epidemiology, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
Obes Res 10:345-50. 2002.... - Pioglitazone, but not metformin, reduces liver fat in Type-2 diabetes mellitus independent of weight changesAlok K Gupta
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
J Diabetes Complications 24:289-96. 2010..Pioglitazone (Pio) treatment induces weight gain in Type 2 diabetes mellitus (T2DM), which could worsen hepatic lipid accumulation, and alter adiponectin and high-sensitivity C-reactive protein (hs-CRP)... - Preference for a high fat diet, but not hyperphagia following activation of mu opioid receptors is blocked in AgRP knockout miceMaria J Barnes
Pennington Biomedical Research Center, Nutrition and Neural Signaling Laboratory, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Brain Res 1317:100-7. 2010..These data demonstrate that the increased preference for a high fat diet after stimulation of MOR is attenuated in the absence of AgRP, but the increase in food intake (i.e. hyperphagia) is not... - Effect of pioglitazone on energy intake and ghrelin in diabetic patientsCorby K Martin
Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
Diabetes Care 33:742-4. 2010..To measure ghrelin and energy intake in the laboratory after pioglitazone treatment... - Medical therapy for obesityGeorge A Bray
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
Mt Sinai J Med 77:407-17. 2010..Its marketing has been suspended in Europe. Several drug combinations are on the horizon for treatment of obesity... - Energy expenditure in African American and white boys and girls in a 2-y follow-up of the Baton Rouge Children's StudyJames P Delany
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Am J Clin Nutr 79:268-73. 2004..Previously reported race and sex differences in energy expenditure (EE) may play a role in body fat gain... - The effect of pioglitazone on peroxisome proliferator-activated receptor-gamma target genes related to lipid storage in vivoIwona Bogacka
Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Diabetes Care 27:1660-7. 2004..The aim of this study was to define the effect of pioglitazone on the expression of genes related to carbohydrate and lipid metabolism in subcutaneous fat obtained from type 2 diabetic patients... - Olfactory bulbectomy increases food intake and hypothalamic neuropeptide Y in obesity-prone but not obesity-resistant ratsStefany D Primeaux
Dietary Obesity Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
Behav Brain Res 180:190-6. 2007..Therefore, strain specific alterations in hypothalamic NPY may account for increased food intake in the obesity-prone rats following OBX, and suggests a potential mechanism to explain the comorbidity of obesity and depression... - Comparison of the acute response to meals enriched with cis- or trans-fatty acids on glucose and lipids in overweight individuals with differing FABP2 genotypesMichael Lefevre
Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
Metabolism 54:1652-8. 2005.... - Effect of pioglitazone on body composition and energy expenditure: a randomized controlled trialSteven R Smith
Department of Molecular Endocrinology, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
Metabolism 54:24-32. 2005..Some, but not all, studies demonstrate reductions in visceral adipose tissue. Changes in body weight are the result of changes in energy intake, energy expenditure, or both... - Food deprivation increases the mRNA expression of micro-opioid receptors in the ventral medial hypothalamus and arcuate nucleusMaria J Barnes
Dietary Obesity Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
Am J Physiol Regul Integr Comp Physiol 295:R1385-90. 2008..These data demonstrate that hypothalamic micro-opioid receptors may contribute to the hyperphagia and increased preference for a high-fat diet that is associated with food deprivation... - Neuropeptide Y administration into the amygdala alters high fat food intakeStefany D Primeaux
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Peptides 27:1644-51. 2006..Intra-amygdalar NPY administration did not produce conditioned taste aversions to a novel saccharin solution. These results suggest that amygdalar NPY may have a role in macronutrient selection, without altering total caloric intake... - Effect of meta-chlorophenylpiperazine and cholecystokinin on food intake of Osborne-Mendel and S5B/P1 ratsChristy L White
Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Obesity (Silver Spring) 15:624-31. 2007.... - Nonsurgical weight loss for extreme obesity in primary care settings: results of the Louisiana Obese Subjects StudyDonna H Ryan
Pennington Biomedical Research Center of Louisiana State University System, Baton Rouge, LA 70808, USA
Arch Intern Med 170:146-54. 2010.... - Fast-food consumption among US adults and children: dietary and nutrient intake profileSahasporn Paeratakul
Nutritional Epidemiology, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
J Am Diet Assoc 103:1332-8. 2003..To examine the dietary profile associated with fast-food use. To compare the dietary intake of individuals on the day that they ate fast food with the day that fast food was not eaten... - Adherence is a multi-dimensional construct in the POUNDS LOST trialDonald A Williamson
Pennington Biomedical Research Center, LSU System, 6400 Perkins Rd, Baton Rouge, LA, USA
J Behav Med 33:35-46. 2010..The findings of this study indicated that adherence to a weight management program was best conceptualized as being multi-dimensional, with two dimensions: behavioral and dietary adherence... - The effects of triiodothyronine on bone metabolism in healthy ambulatory menSteven R Smith
Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
Thyroid 13:357-64. 2003..4% (p = 0.08). Bone mineral density showed no change. We conclude that T(3) accelerates bone turnover and that bone formation does not increase acutely to prevent bone loss... - Overexpression of neuropeptide Y in the central nucleus of the amygdala decreases ethanol self-administration in "anxious" ratsStefany D Primeaux
Department of Pharmacology, Physiology and Neuroscience, University of South Carolina School of Medicine, Columbia, South Carolina, USA
Alcohol Clin Exp Res 30:791-801. 2006..The current experiment investigated the predictive role of anxiety-like behaviors in ethanol self-administration and the relationship of NPY in the central nucleus of the amygdala (CeA) with anxiety and ethanol self-administration... - Pioglitazone induces mitochondrial biogenesis in human subcutaneous adipose tissue in vivoIwona Bogacka
Molecular Endocrinology Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA, USA
Diabetes 54:1392-9. 2005..Finally, the increased mitochondrial copy number and the higher expression of genes involved in fatty acid oxidation in human adipocytes may contribute to the hypolipidemic effects of pioglitazone... - Increased expression of mu opioid receptors in animals susceptible to diet-induced obesityMaria J Barnes
Pennington Biomedical Research Center, Dietary Obesity Laboratory, Baton Rouge, LA 70808, USA
Peptides 27:3292-8. 2006.... - Early behavioral adherence predicts short and long-term weight loss in the POUNDS LOST studyDonald A Williamson
Pennington Biomedical Research Center, LSU System, 6400 Perkins Rd, Baton Rouge, LA, USA
J Behav Med 33:305-14. 2010..Early dietary adherence was associated with changes in insulin at 6 months (R = 0.19), but not at 24 months (R = 0.08, ns). Early dietary adherence was not associated with changes in adiposity... - Combination drugs for treating obesityFrank L Greenway
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, 70808, USA
Curr Diab Rep 10:108-15. 2010..The advent of combination drug therapy for obesity treatment offers hope for increasing the efficacy of obesity pharmacotherapy... - Energy expenditure in preadolescent African American and white boys and girls: the Baton Rouge Children's StudyJames P Delany
Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
Am J Clin Nutr 75:705-13. 2002..Low energy expenditure has been identified as a potential risk factor for body fat gain... - Weight loss and blood pressure control (Pro)David W Harsha
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
Hypertension 51:1420-5; discussion 1425. 2008 - Racial differences in abdominal depot-specific adiposity in white and African American adultsPeter T Katzmarzyk
Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808 4124, USA
Am J Clin Nutr 91:7-15. 2010..There is increasing interest in understanding racial differences in adiposity in specific body depots as a way to explain differential health risks associated with obesity... - Regulation of ghrelin gene expression in stomach and feeding response to a ghrelin analogue in two strains of ratsXiaotuan Liu
Experimental Obesity Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Peptides 25:2171-7. 2004..In addition, a differential regulation of ghrelin gene expression between OM and S5B rats may be important in their differential sensitivity to HF diet-induced obesity... - Effect of a high or low ambient perinatal temperature on adult obesity in Osborne-Mendel and S5B/Pl ratsChristy L White
Pennington Biomedical Research Center, Louisiana State Univ System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
Am J Physiol Regul Integr Comp Physiol 288:R1376-84. 2005..The data suggest that OM rats are more susceptible to epigenetic programming than S5B rats... - Lifestyle and pharmacological approaches to weight loss: efficacy and safetyGeorge A Bray
Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
J Clin Endocrinol Metab 93:S81-8. 2008..Obesity results from a prolonged small positive energy balance, and its treatment needs to reverse this imbalance... - Prevention Conference VII: Obesity, a worldwide epidemic related to heart disease and stroke: Group III: worldwide comorbidities of obesityIan D Caterson
Circulation 110:e476-83. 2004 - How bad is fructose?George A Bray
Am J Clin Nutr 86:895-6. 2007 - Clinical efficacy of orlistat therapy in overweight and obese patients with insulin-treated type 2 diabetes: A 1-year randomized controlled trialDavid E Kelley
Montifiore Hospital, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA
Diabetes Care 25:1033-41. 2002.... - Clinical implications of obesity with specific focus on cardiovascular disease: a statement for professionals from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism: endorsed by the American College of Cardiology FoundSamuel Klein
Circulation 110:2952-67. 2004..The data demonstrate that weight loss and physical activity can prevent and treat obesity-related coronary heart disease risk factors and should be considered a primary therapy for obese patients with cardiovascular disease... - Achieving weight and activity goals among diabetes prevention program lifestyle participantsRena R Wing
Prevention Program Coordinating Center, The Biostatistics Center, George Washington University, 6110 Executive Boulevard, Suite 750, Rockville, MD 20852, USA
Obes Res 12:1426-34. 2004..This paper examines demographic, psychosocial, and behavioral factors related to achieving weight loss and physical activity goals in the DPP lifestyle participants... - Body size and shape changes and the risk of diabetes in the diabetes prevention programWilfred Y Fujimoto
Department of Medicine, University of Washington, Seattle, Washington, USA
Diabetes 56:1680-5. 2007..Reduced diabetes risk with lifestyle intervention may have been through effects upon both overall body fat and central body fat but with metformin appeared to be independent of body fat... - Dietary intake in the diabetes prevention program cohort: baseline and 1-year post randomizationElizabeth J Mayer-Davis
The Diabetes Prevention Program Coordinating Center, George Washington University Biostatistics Center, Rockville, MD 20852, USA
Ann Epidemiol 14:763-72. 2004..To describe usual dietary intake assessment at baseline and 1-year post-randomization in the ethnically diverse Diabetes Prevention Program cohort... - Extension of type 2 diabetes genome-wide association scan results in the diabetes prevention programAllan F Moore
Center for Human Genetic Research, Department of Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA
Diabetes 57:2503-10. 2008....
Research Grants
- Post-DPP Follow-up-StudyGeorge Bray; Fiscal Year: 2007..women, and in older subjects in the DPP. The current application is for 5 years of funding, although the some of the goals of the projects described will require a 10-year study. ..
- DIETARY OBESITYGeorge Bray; Fiscal Year: 2007..We now propose these well founded, important and exciting studies which will provide critical new insights into anatomical, physiological and molecular mechanisms by which high levels of dietary fat induce obesity. ..
- Health Outcomes of Weight loss: Look AHEAD -Action for Health in DiabetesGeorge Bray; Fiscal Year: 2007..These procedures will enable us to analyze the effects of the intervention on serious cardiovascular- related factors and complications, and cost-effectiveness of the intervention. ..