G A Bray

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. ncbi request reprint Sibutramine produces dose-related weight loss
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obes Res 7:189-98. 1999
  2. ncbi request reprint Fat and carbohydrate balances during adaptation to a high-fat
    S R Smith
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 71:450-7. 2000
  3. ncbi request reprint Evaluation of body fat in fatter and leaner 10-y-old African American and white children: the Baton Rouge Children's Study
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 73:687-702. 2001
  4. ncbi request reprint Diet type and changes in food cravings following weight loss: findings from the POUNDS LOST Trial
    S D Anton
    Pennington Biomedical Research Center, LSU System, Baton Rouge, LA, USA
    Eat Weight Disord 17:e101-8. 2012
  5. ncbi request reprint A paradigm of experimentally induced mild hyperthyroidism: effects on nitrogen balance, body composition, and energy expenditure in healthy young men
    J C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    J Clin Endocrinol Metab 82:765-70. 1997
  6. ncbi request reprint Pharmaceutical cost savings of treating obesity with weight loss medications
    F L Greenway
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Obes Res 7:523-31. 1999
  7. ncbi request reprint Concurrent physical activity increases fat oxidation during the shift to a high-fat diet
    S R Smith
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 72:131-8. 2000
  8. ncbi request reprint Long-term calorie restriction reduces energy expenditure in aging monkeys
    J P DeLany
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    J Gerontol A Biol Sci Med Sci 54:B5-11; discussion B12-3. 1999
  9. ncbi request reprint Common apolipoprotein A-IV variants are associated with differences in body mass index levels and percentage body fat
    M Lefevre
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Int J Obes Relat Metab Disord 24:945-53. 2000
  10. doi request reprint Effect of a 3-day high-fat feeding period on carbohydrate balance and ad libitum energy intake in humans
    J E Galgani
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 34:886-91. 2010

Detail Information

Publications52

  1. ncbi request reprint Sibutramine produces dose-related weight loss
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obes Res 7:189-98. 1999
    ..This paper reports a 24-week dose-ranging study to determine the effect of sibutramine on body weight of patients with obesity...
  2. ncbi request reprint Fat and carbohydrate balances during adaptation to a high-fat
    S R Smith
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 71:450-7. 2000
    ..Failure to compensate for the positive fat balance that occurs during the shift to a high-fat, low-carbohydrate diet by increasing energy expenditure or by decreasing food intake may result in the gain of fat mass...
  3. ncbi request reprint Evaluation of body fat in fatter and leaner 10-y-old African American and white children: the Baton Rouge Children's Study
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 73:687-702. 2001
    ..We hypothesized that the preferred methods of determining body fat may differ in children with larger compared with smaller amounts of body fat, in boys compared with girls, and in African Americans compared with whites...
  4. ncbi request reprint Diet type and changes in food cravings following weight loss: findings from the POUNDS LOST Trial
    S D Anton
    Pennington Biomedical Research Center, LSU System, Baton Rouge, LA, USA
    Eat Weight Disord 17:e101-8. 2012
    ..05). Calorically restricted diets (regardless of their macronutrient composition) yielded significant reductions in cravings for fats, sweets, and starches whereas cravings for fruits and vegetables were increased...
  5. ncbi request reprint A paradigm of experimentally induced mild hyperthyroidism: effects on nitrogen balance, body composition, and energy expenditure in healthy young men
    J C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    J Clin Endocrinol Metab 82:765-70. 1997
    ..We conclude that although healthy men are able to adapt to mild hyperthyroidism in terms of nitrogen balance, they exhibit significant and persistent changes in fat and fat-free mass as well as energy balance...
  6. ncbi request reprint Pharmaceutical cost savings of treating obesity with weight loss medications
    F L Greenway
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Obes Res 7:523-31. 1999
    ....
  7. ncbi request reprint Concurrent physical activity increases fat oxidation during the shift to a high-fat diet
    S R Smith
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 72:131-8. 2000
    ..We hypothesized that concurrent physical activity would accelerate fat oxidation during an isoenergetic high-fat diet...
  8. ncbi request reprint Long-term calorie restriction reduces energy expenditure in aging monkeys
    J P DeLany
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    J Gerontol A Biol Sci Med Sci 54:B5-11; discussion B12-3. 1999
    ..We conclude that the process of preventing obesity by long-term caloric restriction causes a significant and sustained long-term reduction in energy expenditure, even when corrected for lean body mass...
  9. ncbi request reprint Common apolipoprotein A-IV variants are associated with differences in body mass index levels and percentage body fat
    M Lefevre
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Int J Obes Relat Metab Disord 24:945-53. 2000
    ..To determine the relationship between two common apoA-IV variants (Thr347-->Ser; Gln360-->His), and body mass index (BMI) and percentage body fat...
  10. doi request reprint Effect of a 3-day high-fat feeding period on carbohydrate balance and ad libitum energy intake in humans
    J E Galgani
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 34:886-91. 2010
    ..We assessed the effect of an isoenergetic switch from a 49%-carbohydrate to 50%-fat diet on nutrient balance and ad libitum food intake. We hypothesized that carbohydrate balance would be inversely related to ad libitum energy intake...
  11. ncbi request reprint Low-dose T(3) improves the bed rest model of simulated weightlessness in men and women
    J C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    Am J Physiol 277:E370-9. 1999
    ..In conclusion, addition of low-dose T(3) to the bed rest model of muscle unloading improves the ground-based simulation of spaceflight and unmasks several important gender differences...
  12. ncbi request reprint Physiological relationships of uncoupling protein-2 gene expression in human adipose tissue in vivo
    J H Pinkney
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808 4124, USA
    J Clin Endocrinol Metab 85:2312-7. 2000
    ..Reduced UCP-2 expression may be a maladaptive response to sustained energy surplus and could contribute to the pathogenesis and maintenance of obesity...
  13. ncbi request reprint Effect of topiramate on body weight and body composition of osborne-mendel rats fed a high-fat diet: alterations in hormones, neuropeptide, and uncoupling-protein mRNAs
    D A York
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Nutrition 16:967-75. 2000
    ..In conclusion, topiramate is an effective inhibitor of weight gain in rats on a high-fat diet, but the mechanism through which the change in energy balance is achieved is unclear...
  14. pmc Effect of diet composition on energy expenditure during weight loss: the POUNDS LOST Study
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 36:448-55. 2012
    ..Hypothesis: We tested the hypothesis that macronutrient composition of the diet might affect the partitioning of energy expenditure during weight loss...
  15. ncbi request reprint Contributions of total body fat, abdominal subcutaneous adipose tissue compartments, and visceral adipose tissue to the metabolic complications of obesity
    S R Smith
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Metabolism 50:425-35. 2001
    ..375). These data suggest that total body fat is a major contributor to the metabolic sequelae of obesity, with specific fat depots, VAT, and DSAT also making significant contributions...
  16. ncbi request reprint Testosterone administration preserves protein balance but not muscle strength during 28 days of bed rest
    J J Zachwieja
    Exercise and Nutrition Program and Inpatient Clinical Trials Unit, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    J Clin Endocrinol Metab 84:207-12. 1999
    ..These results suggest that in the absence of daily ambulatory activity, T administration will not increase or, in the case of this bed rest model, preserve muscle strength...
  17. ncbi request reprint Does vegetable oil attenuate the beneficial effects of fish oil in reducing risk factors for cardiovascular disease?
    D H Hwang
    Pennington Biomedical Research Center, Louisiana State University, Baton Route, USA
    Am J Clin Nutr 66:89-96. 1997
    ..Fibrinogen concentrations decreased with 15 g but not with 9 g fish oil/d fed at the same ratio of n-3 to n-6 PUFAs. The efficacy of fish oil in favorably modifying certain risk factors for CVD was not attenuated by vegetable oil...
  18. ncbi request reprint Exogenous androgens influence body composition and regional body fat distribution in obese postmenopausal women--a clinical research center study
    J C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70803, USA
    J Clin Endocrinol Metab 81:2198-203. 1996
    ..We conclude that administration of exogenous androgens modulates body composition in obese postmenopausal women and independently affects visceral and sc abdominal fat...
  19. ncbi request reprint Effect of pioglitazone on body composition and bone density in subjects with prediabetes in the ACT NOW trial
    G A Bray
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Diabetes Obes Metab 15:931-7. 2013
    ....
  20. ncbi request reprint Relationship of dietary fat and serum cholesterol ester and phospholipid fatty acids to markers of insulin resistance in men and women with a range of glucose tolerance
    J C Lovejoy
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808-4124, USA
    Metabolism 50:86-92. 2001
    ..Furthermore, enhancement of dihomo-gamma-linolenic and myristic acids in serum CE and PL, presumably markers for dietary intake, predicted insulin resistance...
  21. ncbi request reprint Medicinal strategies in the treatment of obesity
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Nature 404:672-7. 2000
    ..Currently approved drugs for long-term treatment of obesity include sibutramine, which inhibits food intake, and orlistat, which blocks fat digestion...
  22. pmc Sensitivity to the satiating effects of exendin 4 is decreased in obesity-prone Osborne-Mendel rats compared to obesity-resistant S5B/Pl rats
    S D Primeaux
    Dietary Obesity Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 34:1427-33. 2010
    ..GLP-1 is produced in the small intestine and is released in response to a meal. The current experiments examined the role of GLP-1 in OM and S5B rats...
  23. ncbi request reprint Differential oxidation of individual dietary fatty acids in humans
    J P DeLany
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Am J Clin Nutr 72:905-11. 2000
    ..Dietary fatty acids that are more prone to oxidation than to storage may be less likely to lead to obesity...
  24. ncbi request reprint Serial echocardiographic and clinical evaluation of valvular regurgitation before, during, and after treatment with fenfluramine or dexfenfluramine and mazindol or phentermine
    D H Ryan
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Obes Res 7:313-22. 1999
    ..We studied 86 patients who had echocardiograms before treatment with appetite suppressants to determine the incidence of new cases and to evaluate the clinical implication of the echocardiographic findings...
  25. ncbi request reprint Body composition of African American and white children: a 2-year follow-up of the BAROC study
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Obes Res 9:605-21. 2001
    ..To evaluate the 2-year changes in body composition of white and African American boys and girls...
  26. doi request reprint Calorie-sweetened beverages and fructose: what have we learned 10 years later
    G A Bray
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Pediatr Obes 8:242-8. 2013
    ..Sugar-sweetened drinks and the fructose they provide are associated with several health problems...
  27. ncbi request reprint Constitutive activation of STAT-3 and downregulation of SOCS-3 expression induced by adrenalectomy
    A M Madiehe
    Obesity Research Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Am J Physiol Regul Integr Comp Physiol 281:R2048-58. 2001
    ..In conclusion, ADX through activation of STAT-3 and inhibition of SOCS-3 activates the JAK-STAT signaling pathway. These effects most probably explain the ability to prevent the development of obesity by removal of adrenal steroids...
  28. ncbi request reprint Dietary fat preferences are inversely correlated with peripheral gustatory fatty acid sensitivity
    T A Gilbertson
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808 4124, USA
    Ann N Y Acad Sci 855:165-8. 1998
    ..This finding may provide insight into the mechanism for sensing dietary fat that allows the S5B rats to reduce fat intake on a high-fat diet and avoid the obesity which results when O-M rats eat a high-fat diet...
  29. ncbi request reprint Methods to maximize retention in weight loss studies
    F L Greenway
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Obes Res 7:593-6. 1999
    ..These three methods of retention were compared with a commercial weight loss clinic's practice of charging nonrefundable fees...
  30. ncbi request reprint Peripheral administration of human corticotropin-releasing hormone: a novel method to increase energy expenditure and fat oxidation in man
    S R Smith
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 86:1991-8. 2001
    ..Peripheral CRH administration offers a novel strategy to increase energy expenditure...
  31. ncbi request reprint Prediction of energy expenditure in a whole body indirect calorimeter at both low and high levels of physical activity
    L de Jonge
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Int J Obes Relat Metab Disord 25:929-34. 2001
    ..The objective of this study was to develop a method for predicting an individual's 24 h EE in a room calorimeter at both low (1.4xRMR) and high (1.8xRMR) levels of physical activity...
  32. ncbi request reprint Clinical evaluation of the overweight patient
    G A Bray
    Louisiana State University, Pennington Biomedical Research Center, Baton Rouge, USA
    Endocrine 13:167-86. 2000
    ..After assessing risk, the therapeutic choices can be selected from the age category of the patient. With any therapeutic activity, involvement of the patient in a realistic approach to the treatment process is essential...
  33. ncbi request reprint Consumption of a controlled low-fat diet containing olestra for 9 months improves health risk factors in conjunction with weight loss in obese men: the Ole' Study
    J C Lovejoy
    Pennington Biomedical Research Center, Baton Rouge, LA70808, USA
    Int J Obes Relat Metab Disord 27:1242-9. 2003
    ..To compare the effects of a standard American diet, a traditional low-fat diet, and a low-fat diet containing the fat substitute olestra on risk factors for heart disease and diabetes...
  34. pmc Pioglitazone treatment in type 2 diabetes mellitus when combined with portion control diet modifies the metabolic syndrome
    A K Gupta
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Diabetes Obes Metab 11:330-7. 2009
    ..Treatment with thiazolidinediones (TZDs) produces weight gain...
  35. ncbi request reprint Activation of hypothalamic serotonin receptors reduced intake of dietary fat and protein but not carbohydrate
    B K Smith
    Obesity, Diabetes and Metabolism Section, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Am J Physiol 277:R802-11. 1999
    ..These results demonstrate a selective effect of exogenous serotonergic drugs in the hypothalamus to reduce fat rather than carbohydrate intake and suggest that higher baseline fat intake enhances responsivity to serotonergic drugs...
  36. ncbi request reprint A concise review on the therapeutics of obesity
    G A Bray
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana, USA
    Nutrition 16:953-60. 2000
    ..In clinical trials other drugs that may modulate peptide-feeding systems are being developed...
  37. ncbi request reprint Macronutrient selection following 2-deoxy-D-glucose and mercaptoacetate administration in rats
    L K Singer
    Department of Obesity and Metabolism, Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Physiol Behav 65:115-21. 1998
    ..2-DG increases the intake of carbohydrate which may be necessary to overcome the central glucoprivation caused by this drug...
  38. ncbi request reprint Drug treatment of obesity
    G A Bray
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808, USA
    Rev Endocr Metab Disord 2:403-18. 2001
    ..Although there were differences in mean weight losses with these drugs, when the placebo effect was taken into account they all had a surprisingly similar magnitude of weight loss...
  39. ncbi request reprint Sibutramine and blood pressure: a therapeutic dilemma
    G A Bray
    Pennington Biomedical Research Center Baton Rouge, LA 70808, USA
    J Hum Hypertens 16:1-3. 2002
  40. doi request reprint Fructose: should we worry?
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Int J Obes (Lond) 32:S127-31. 2008
    ..This evidence suggests that we should worry about our current level of fructose consumption, which has been increasing steadily for over 200 years and now represents over 10% of the energy intake of some people...
  41. ncbi request reprint Obesity is a chronic, relapsing neurochemical disease
    G A Bray
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes Relat Metab Disord 28:34-8. 2004
    ..Treatments consist of techniques to alter the balance between energy intake and energy expenditure. This constellation of factors leads to the conclusion that obesity should be called a disease...
  42. ncbi request reprint Afferent signals regulating food intake
    G A Bray
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Proc Nutr Soc 59:373-84. 2000
    ..Many of these peptides act on gastrointestinal or hepatic receptors that relay messages to the brain via the afferent vagus nerve. As a group they provide a number of leads for potential drug development...
  43. ncbi request reprint The relation of gender, race and socioeconomic status to obesity and obesity comorbidities in a sample of US adults
    S Paeratakul
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Int J Obes Relat Metab Disord 26:1205-10. 2002
    ..To examine the obesity-related chronic diseases in the US adult population according to gender, race and socioeconomic status...
  44. ncbi request reprint Effect of a selective OX1R antagonist on food intake and body weight in two strains of rats that differ in susceptibility to dietary-induced obesity
    C L White
    Pennington Biomedical Research Center, Experimental Obesity Laboratory, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Peptides 26:2331-8. 2005
    ..These experiments demonstrate that an orexin antagonist (SB-334867) reduces food intake and has a greater effect in a rat strain that is susceptible to dietary-induced obesity, than in a resistant strain...
  45. ncbi request reprint Chamber for indirect calorimetry with accurate measurement and time discrimination of metabolic plateaus of over 20 min
    T Nguyen
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Med Biol Eng Comput 41:572-8. 2003
    ..81 min (-1) and 0.01 min). The successful integration of the algorithm into the Pennington chambers allows for traditional 24 h energy expenditure measurements and various metabolic experiments requiring rapid responses...
  46. ncbi request reprint Percent body fat measured by BIA and DEXA in obese, African-American adolescent girls
    R L Newton
    Pennington Biomedical Research Center, Louisiana State University, Baton Rogue, LA 70808, USA
    Int J Obes (Lond) 29:594-602. 2005
    ..To compare the estimation of body fat between bioelectrical impedance analysis (BIA) and dual energy X-ray absorptiometry (DEXA) in overweight, African-American female adolescents...
  47. ncbi request reprint Angiotensinogen genotype and blood pressure response in the Dietary Approaches to Stop Hypertension (DASH) study
    L P Svetkey
    Duke Hypertension Center and Sarah W Stedman Center for Nutritional Studies, Duke University Medical Center, Durham, North Carolina 27705, USA
    J Hypertens 19:1949-56. 2001
    ..The angiotensin converting enzyme (ACE) gene was also tested...
  48. pmc Altered body composition in type 2 diabetes mellitus
    S Heshka
    Obesity Research Center, St Luke s Roosevelt Hospital, New York, NY, USA
    Int J Obes (Lond) 32:780-7. 2008
    ..To identify differences in amount and distribution of fat and lean soft tissue in a cross-sectional study of subjects with and without type 2 diabetes and to determine whether any differences are affected by race/ethnicity or sex...
  49. ncbi request reprint Healthy Eating Index and obesity
    X Guo
    Constella Health Sciences, Constella Group, Inc, Durham, NC 27713, USA
    Eur J Clin Nutr 58:1580-6. 2004
    ..There is a continuing need to examine the relationship between diet quality and health in the population. The Healthy Eating Index (HEI) has been developed as a composite measure of diet quality by the US Department of Agriculture...
  50. ncbi request reprint Effects of diet and sodium intake on blood pressure: subgroup analysis of the DASH-sodium trial
    W M Vollmer
    Center for Health Research, 3800 North Interstate Avenue, Portland, OR 97227, USA
    Ann Intern Med 135:1019-28. 2001
    ..001) and by 3.7/1.5 mm Hg in those 45 years of age or younger (P < 0.05). CONCLUSION: The DASH diet plus reduced sodium intake is recommended to control blood pressure in diverse subgroups...
  51. ncbi request reprint Adrenalectomy in genetically obese ob/ob and db/db mice increases the proton conductance pathway
    N S Shargill
    Section of Diabetes and Clinical Nutrition, School of Medicine, University of Southern California, Los Angeles
    Horm Metab Res 21:463-7. 1989
    ..Thus adrenalectomy may inhibit the development of obesity by increasing the thermic activity in IBAT...
  52. ncbi request reprint Salivary gland weight and nerve growth factor in the genetically obese (ob/ob) mouse
    G A Bray
    Endocrinology 110:47-50. 1982
    ..Testosterone significantly increased the NGF concentration in salivary glands, but the values in treated male mice were only one tenth those in the treated lean animals...