Claude Bouchard

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. pmc Genomics and genetics in the biology of adaptation to exercise
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Compr Physiol 1:1603-48. 2011
  2. pmc Adverse metabolic response to regular exercise: is it a rare or common occurrence?
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America
    PLoS ONE 7:e37887. 2012
  3. doi request reprint Genomic predictors of trainability
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Exp Physiol 97:347-52. 2012
  4. pmc Genomic predictors of the maximal O₂ uptake response to standardized exercise training programs
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Appl Physiol (1985) 110:1160-70. 2011
  5. pmc Overcoming barriers to progress in exercise genomics
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Exerc Sport Sci Rev 39:212-7. 2011
  6. ncbi request reprint Quantitative trait locus on chromosome 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Physiol Genomics 27:103-7. 2006
  7. ncbi request reprint Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Obes Res 13:829-34. 2005
  8. ncbi request reprint Genome-wide linkage scan for submaximal exercise heart rate in the HERITAGE family study
    Nadine Spielmann
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Am J Physiol Heart Circ Physiol 293:H3366-71. 2007
  9. ncbi request reprint Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: the HERITAGE Family Study
    Margarita Teran-Garcia
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 54:2251-5. 2005
  10. ncbi request reprint Resting metabolic rate and respiratory quotient: results from a genome-wide scan in the Quebec Family Study
    Peter Jacobson
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 84:1527-33. 2006

Collaborators

Detail Information

Publications84

  1. pmc Genomics and genetics in the biology of adaptation to exercise
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Compr Physiol 1:1603-48. 2011
    ..Likewise, progress in the use of exercise in therapeutic medicine will depend to a large extent on our ability to identify the favorable responders for given physiological properties to a given exercise regimen...
  2. pmc Adverse metabolic response to regular exercise: is it a rare or common occurrence?
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, United States of America
    PLoS ONE 7:e37887. 2012
    ..Individuals differ in the response to regular exercise. Whether there are people who experience adverse changes in cardiovascular and diabetes risk factors has never been addressed...
  3. doi request reprint Genomic predictors of trainability
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Exp Physiol 97:347-52. 2012
    ..Combining transcriptomic and genomic technologies has also yielded highly promising results concerning the ability to predict trainability among sedentary people...
  4. pmc Genomic predictors of the maximal O₂ uptake response to standardized exercise training programs
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Appl Physiol (1985) 110:1160-70. 2011
    ..These genomic predictors of the response of Vo(2max) to regular exercise provide new targets for the study of the biology of fitness and its adaptation to regular exercise. Large-scale replication studies are warranted...
  5. pmc Overcoming barriers to progress in exercise genomics
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Exerc Sport Sci Rev 39:212-7. 2011
    ....
  6. ncbi request reprint Quantitative trait locus on chromosome 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Physiol Genomics 27:103-7. 2006
    ..The present findings may be useful in the ongoing effort to search for genes contributing to inflammation and to identify individuals at an increased risk of chronic inflammatory diseases...
  7. ncbi request reprint Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Obes Res 13:829-34. 2005
    ..Gene-gene interactions between the PTPN1 and leptin receptor genes contributed to the phenotypic variability of insulin sensitivity. The PTPN1 Pro387Leu variant was associated with lower glucose tolerance...
  8. ncbi request reprint Genome-wide linkage scan for submaximal exercise heart rate in the HERITAGE family study
    Nadine Spielmann
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Am J Physiol Heart Circ Physiol 293:H3366-71. 2007
    ..The most promising regions for fine mapping in the HERITAGE Family Study were found on 2q33 for HR50 training response in whites, on 10q25-26 for baseline HR60 in blacks, and on 18q21-22 for both baseline HR50 and DeltaHR60 in whites...
  9. ncbi request reprint Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: the HERITAGE Family Study
    Margarita Teran-Garcia
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 54:2251-5. 2005
    ..The benefits from an exercise program on Si are likely to be substantial in the general population given the high frequency of the LIPC -514C allele, particularly in whites...
  10. ncbi request reprint Resting metabolic rate and respiratory quotient: results from a genome-wide scan in the Quebec Family Study
    Peter Jacobson
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 84:1527-33. 2006
    ....
  11. ncbi request reprint A quantitative trait locus on 7q31 for the changes in plasma insulin in response to exercise training: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Diabetes 52:1583-7. 2003
    ..The present findings may be important in identifying individuals at increased risk of developing type 2 diabetes and who are most likely to benefit from a physically active lifestyle...
  12. ncbi request reprint Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Quebec Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 85:26-34. 2007
    ..Despite adiponectin's presumed role in fatty acid oxidation and energy homeostasis, little is known about the effect of gene variants on substrate oxidation, energy expenditure, and adiposity-related phenotypes...
  13. ncbi request reprint The TNF-alpha G-308A polymorphism is associated with C-reactive protein levels: the HERITAGE Family Study
    Hanna Maaria Lakka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808 4124, USA
    Vascul Pharmacol 44:377-83. 2006
    ..Pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), stimulate the release of C-reactive protein (CRP). We investigated the association between the TNF-alpha G-308A polymorphism and plasma CRP levels...
  14. ncbi request reprint Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study
    Timo A Lakka
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808 4124, USA
    Diabetes 53:1603-8. 2004
    ..Similar interaction was observed in blacks (P = 0.046). Variations in the LEP and LEPR genes are associated with the magnitude of the effects of regular exercise on glucose homeostasis in nondiabetic individuals...
  15. doi request reprint Racial differences in abdominal depot-specific adiposity in white and African American adults
    Peter T Katzmarzyk
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808 4124, USA
    Am J Clin Nutr 91:7-15. 2010
    ..There is increasing interest in understanding racial differences in adiposity in specific body depots as a way to explain differential health risks associated with obesity...
  16. ncbi request reprint Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 82:1097-101. 2005
    ..Exogenous administration of AGRP in rodents predisposes to high fat and high sugar intakes...
  17. pmc FTO genotype is associated with exercise training-induced changes in body composition
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 18:322-6. 2010
    ..Resistance to exercise-induced reduction in total adiposity may represent one mechanism by which the FTO A allele promotes overweight and obesity...
  18. ncbi request reprint Role of ghrelin polymorphisms in obesity based on three different studies
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    Obes Res 10:782-91. 2002
    ..Associations between preproghrelin DNA variants and obesity-related phenotypes were studied in 3004 subjects from the Québec Family Study (QFS), the HERITAGE Family Study (HERITAGE), and the Swedish Obese Subjects (SOS) Study...
  19. ncbi request reprint Effect of regular exercise on homocysteine concentrations: the HERITAGE Family Study
    Tomohiro Okura
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Eur J Appl Physiol 98:394-401. 2006
    ..Men exhibit racial differences for tHcy responses to exercise training. Regular aerobic exercise has favorable effects on individuals with hyperhomocysteinemia, but tHcy slightly increased in individuals within the normal range...
  20. pmc Profiles of sedentary behavior in children and adolescents: the US National Health and Nutrition Examination Survey, 2001-2006
    Susan B Sisson
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Int J Pediatr Obes 4:353-9. 2009
    ..To describe the prevalence of time spent in sedentary behaviors (e.g., TV/video and computer use) among youth in the US...
  21. ncbi request reprint Adiponectin polymorphisms, adiposity and insulin metabolism: HERITAGE family study and Oulu diabetic study
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge 70808 4124, USA
    Ann Med 37:141-50. 2005
    ..Adiponectin is an adipocytokine with lowered blood levels in obesity and Type 2 diabetes mellitus. We sought to define the specific effects of different alleles of the gene encoding adiponectin...
  22. ncbi request reprint The human gene map for performance and health-related fitness phenotypes: the 2003 update
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 36:1451-69. 2004
    ..Moreover, there are 15 mitochondrial genes in which sequence variants have been shown to influence relevant fitness and performance phenotypes...
  23. pmc Clinical utility of visceral adipose tissue for the identification of cardiometabolic risk in white and African American adults
    Peter T Katzmarzyk
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Am J Clin Nutr 97:480-6. 2013
    ..Visceral adipose tissue (VAT) has been identified as a harmful fat depot, and sex and race differences in VAT have been reported in white and African Americans...
  24. pmc Consistency of fat mass--fat-free mass relationship across ethnicity and sex groups
    Stephanie T Broyles
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Br J Nutr 105:1272-6. 2011
    ..In conclusion, results from our large, biethnic sample of men and women found a FM-FFM relationship very close to that originally described by Forbes, absent of significant variability by ethnicity or sex...
  25. ncbi request reprint A genome-wide linkage scan for dietary energy and nutrient intakes: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family Study
    Agron Collaku
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Am J Clin Nutr 79:881-6. 2004
    ..A poor diet is a risk factor for chronic diseases such as obesity, cardiovascular disease, hypertension, and some cancers. Twin and family studies suggest that genetic factors potentially influence energy and nutrient intakes...
  26. pmc The relationship of waist circumference and BMI to visceral, subcutaneous, and total body fat: sex and race differences
    Sarah M Camhi
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 19:402-8. 2011
    ..Sex differences, and in some instances race differences, in the relationships between anthropometry and fat-specific depots demonstrate that these characteristics need to be considered when predicting adiposity from WC or BMI...
  27. ncbi request reprint The human gene map for performance and health-related fitness phenotypes: the 2005 update
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 38:1863-88. 2006
    ....
  28. ncbi request reprint Association of lipin 1 gene polymorphisms with measures of energy and glucose metabolism
    Ruth J F Loos
    Pennington Biomedical Research Center, Human Genomics Laboratory, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 15:2723-32. 2007
    ..Lpin1 was identified as the mutated gene in the fatty liver dystrophy mouse, which exhibits lipin deficiency and features of human lipodystrophy...
  29. ncbi request reprint Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort
    Peter Jacobson
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 87:4442-6. 2002
    ..In conclusion, our results do not support the prevailing notion that sequence variation in the melanocortin 4 receptor gene is a frequent cause of human obesity...
  30. ncbi request reprint Genome-wide linkage scan for exercise stroke volume and cardiac output in the HERITAGE Family Study
    Tuomo Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 10:57-62. 2002
    ..3, 3q13.3, 12q13.2) and one for baseline SV50 and Q50 (10p14). All these chromosomal regions include several potential candidate genes and therefore warrant further studies in the HERITAGE cohort and other studies...
  31. ncbi request reprint A quantitative trait locus for body fat on chromosome 1q43 in French Canadians: linkage and association studies
    Brahim Aissani
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 14:1605-15. 2006
    ..To explore a quantitative trait locus (QTL) on human chromosome 1q affecting BMI, adiposity, and fat-free mass phenotypes in the Quebec Family Study cohort...
  32. ncbi request reprint A dopamine D2 receptor gene polymorphism and physical activity in two family studies
    Riitta L Simonen
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Physiol Behav 78:751-7. 2003
    ..09, P=.023) and 27-33% lower work index (F=6.23, P=.004) than the CC homozygotes and CT heterozygotes. The results suggest that DNA sequence variation in the DRD2 gene is associated with physical activity levels among White women...
  33. ncbi request reprint CETP genotypes and HDL-cholesterol phenotypes in the HERITAGE Family Study
    Nadine Spielmann
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 31:25-31. 2007
    ..The CETP and APOE genotypes account for up to 9% of the variance in HDL-c phenotypes in the HERITAGE Family Study...
  34. pmc Ethnic-specific BMI and waist circumference thresholds
    Peter T Katzmarzyk
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 19:1272-8. 2011
    ..There are no apparent ethnic differences in men; however, in AA women the optimal BMI and WC values are ~3 kg/m2 and 5 cm higher than in white women...
  35. pmc Anthropometric markers of obesity and mortality in white and African American adults: the pennington center longitudinal study
    Peter T Katzmarzyk
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 21:1070-5. 2013
    ..The purpose of this study was to determine the association between anthropometric measures of obesity and all-cause mortality in white and African American men and women...
  36. ncbi request reprint Na+-K+-ATPase alpha 2-gene and skeletal muscle characteristics in response to long-term overfeeding
    Olavi Ukkola
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    J Appl Physiol (1985) 94:1870-4. 2003
    ..3-kb(-) subjects with overfeeding, suggesting more unfavorable metabolic changes compared with the 3.3-kb(+) subjects...
  37. ncbi request reprint Calcium intake is associated with adiposity in Black and White men and White women of the HERITAGE Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    J Nutr 134:1772-8. 2004
    ..04). No significant associations were found in Black women. Low Ca(2+) intake may be associated with higher adiposity, particularly in men and White women...
  38. pmc Trunk versus extremity adiposity and cardiometabolic risk factors in white and African American adults
    Gang Hu
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Diabetes Care 34:1415-8. 2011
    ..To determine contributions of trunk and extremity adiposity to cardiometabolic risk factors (blood pressure, fasting blood glucose, HDL cholesterol, and triglycerides) among white and African American adults...
  39. ncbi request reprint Genome-wide linkage scan for physical activity levels in the Quebec Family study
    Riitta L Simonen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 35:1355-9. 2003
    ..Four physical activity level phenotypes were used...
  40. ncbi request reprint Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Eur Heart J 26:2018-25. 2005
    ..To study the effect of exercise training on plasma C-reactive protein, a marker of inflammation...
  41. ncbi request reprint Cardiorespiratory fitness, BMI, and risk of hypertension: the HYPGENE study
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 39:1687-92. 2007
    ..Genetic factors contribute significantly to the interindividual differences in endurance training-induced changes in BP. However, similar data on the genotype-by-fitness interactions on the risk of hypertension are scarce...
  42. doi request reprint Genes, exercise, growth, and the sedentary, obese child
    Margarita Teran-Garcia
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Appl Physiol (1985) 105:988-1001. 2008
    ....
  43. pmc KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise
    George Argyropoulos
    Energy Balance Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Physiol Genomics 36:79-88. 2009
    ..Furthermore, training-induced changes in submaximal exercise stroke volume may be due to mitochondrial function and variation in KIF5B expression as determined by functional SNPs in its promoter...
  44. pmc Association of single-nucleotide polymorphisms from 17 candidate genes with baseline symptom-limited exercise test duration and decrease in duration over 20 years: the Coronary Artery Risk Development in Young Adults (CARDIA) fitness study
    Mark A Sarzynski
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Circ Cardiovasc Genet 3:531-8. 2010
    ..We examined the associations of gene variants with symptom-limited exercise test duration at baseline and decrease in duration over 20 years...
  45. pmc Leisure time sedentary behavior, occupational/domestic physical activity, and metabolic syndrome in U.S. men and women
    Susan B Sisson
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Metab Syndr Relat Disord 7:529-36. 2009
    ....
  46. doi request reprint Prevalence of risk factors for metabolic syndrome in adolescents: National Health and Nutrition Examination Survey (NHANES), 2001-2006
    William D Johnson
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Arch Pediatr Adolesc Med 163:371-7. 2009
    ..To investigate the prevalence of distinct combinations of components of the metabolic syndrome among adolescents...
  47. pmc Predicting adult body mass index-specific metabolic risk from childhood
    Sarah M Camhi
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Metab Syndr Relat Disord 8:165-72. 2010
    ..Metabolic risk varies within adult body mass index (BMI) categories; however, the development of BMI-specific metabolic risk from childhood is unknown...
  48. ncbi request reprint Titin is a candidate gene for stroke volume response to endurance training: the HERITAGE Family Study
    Tuomo Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 15:27-33. 2003
    ..Since TTN is the largest gene in the human genome, the challenge is to identify the DNA sequence variants contributing to the interindividual differences in cardiac adaptation to endurance training...
  49. ncbi request reprint Familial resemblance for muscle phenotypes in the HERITAGE Family Study
    Jesus Rico-Sanz
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 35:1360-6. 2003
    ..We hypothesized that skeletal muscle histological and biochemical phenotypes aggregate within families...
  50. ncbi request reprint Genome-wide linkage scan for the metabolic syndrome in the HERITAGE Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 88:5935-43. 2003
    ..Some of these chromosomal regions harbor promising potential candidate genes...
  51. pmc Effects of cholesterol ester transfer protein (CETP) gene on adiposity in response to long-term overfeeding
    Margarita Teran-Garcia
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Atherosclerosis 196:455-60. 2008
    ....
  52. ncbi request reprint The human obesity gene map: the 2005 update
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Obesity (Silver Spring) 14:529-644. 2006
    ..The obesity gene map shows putative loci on all chromosomes except Y. The electronic version of the map with links to useful publications and relevant sites can be found at http://obesitygene.pbrc.edu...
  53. ncbi request reprint MC4R marker associated with stature in children and young adults: a longitudinal study
    Nicola Santoro
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808 4124, USA
    J Pediatr Endocrinol Metab 18:859-63. 2005
    ..These results suggest that DNA sequence variation in the MC4R locus may contribute to the gain in body height from childhood to adulthood...
  54. pmc The pediatric obesity epidemic continues unabated in Bogalusa, Louisiana
    Stephanie Broyles
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Pediatrics 125:900-5. 2010
    ..To examine 35-year trends in the prevalence of overweight and obesity among children and adolescents from Bogalusa, Louisiana...
  55. doi request reprint Advances in exercise, fitness, and performance genomics
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 42:835-46. 2010
    ..We conclude from this first installment that exercise scientists need to prioritize high-quality research designs and that replication studies with large sample sizes are urgently needed...
  56. pmc CREB1 is a strong genetic predictor of the variation in exercise heart rate response to regular exercise: the HERITAGE Family Study
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808 4124, USA
    Circ Cardiovasc Genet 3:294-9. 2010
    ..A genome-wide linkage scan identified a quantitative trait locus for exercise training-induced changes in submaximal exercise (50 W) heart rate (DeltaHR50) on chromosome 2q33.3-q34 in the HERITAGE Family Study (n=472)...
  57. pmc Subclinical atherosclerosis and metabolic risk: role of body mass index and waist circumference
    Sarah M Camhi
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Metab Syndr Relat Disord 9:119-25. 2011
    ..However, the influence of body mass index (BMI) or waist circumference (WC) on the relationship between IMT and metabolic risk is unclear...
  58. ncbi request reprint Mutations in the adiponectin gene in lean and obese subjects from the Swedish obese subjects cohort
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808 4124, USA
    Metabolism 52:881-4. 2003
    ..In conclusion, adiponectin DNA sequence variations might play a role in the complications of morbid obesity and should be further investigated...
  59. pmc Trends over 5 decades in U.S. occupation-related physical activity and their associations with obesity
    Timothy S Church
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, United States of America
    PLoS ONE 6:e19657. 2011
    ..The objective of this analysis was to examine trends in occupational physical activity during the past 5 decades and explore how these trends relate to concurrent changes in body weight in the U.S...
  60. ncbi request reprint Effect of endothelin 1 genotype on blood pressure is dependent on physical activity or fitness levels
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Hypertension 50:1120-5. 2007
    ..Our study provides an illustrative example of how physical activity and fitness level modifies the associations between a candidate gene and outcome phenotype...
  61. pmc A major haplotype block at the rho-associated kinase 2 locus is associated with a lower risk of hypertension in a recessive manner: the HYPGENE study
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Hypertens Res 31:1651-7. 2008
    ..Identification of functional mutation(s) could thus help in the development of ROCK2-specific treatments...
  62. pmc Anthropometric correlates of total body fat, abdominal adiposity, and cardiovascular disease risk factors in a biracial sample of men and women
    Tiago V Barreira
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Mayo Clin Proc 87:452-60. 2012
    ..To investigate associations between anthropometric measurements and total body fat, abdominal adipose tissue, and cardiovascular disease risk factors in a large biracial sample...
  63. pmc Volume of exercise and fitness nonresponse in sedentary, postmenopausal women
    Susan B Sisson
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 41:539-45. 2009
    ..There is a wide individual heterogeneity in the maximal aerobic fitness (V x O 2max) response to exercise training...
  64. doi request reprint Association of GWAS-based candidate genes with HDL-cholesterol levels before and after bariatric surgery in the Swedish obese subjects study
    Mark A Sarzynski
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, Louisiana 70808 4124, USA
    J Clin Endocrinol Metab 96:E953-7. 2011
    ..We examined the associations of eight candidate genes, identified by genome-wide association studies, with HDL-C at baseline and 10 yr after bariatric surgery in the Swedish Obese Subjects study...
  65. pmc Ethnic differences in subcutaneous adiposity and waist girth in children and adolescents
    Susan B Sisson
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 17:2075-81. 2009
    ..Differences in adiposity between ethnic groups should be considered in disease risk assessment and stratification as they are observed even for a given BMI level...
  66. pmc Functional identification of the promoter of SLC4A5, a gene associated with cardiovascular and metabolic phenotypes in the HERITAGE Family Study
    Adrian M Stütz
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, USA
    Eur J Hum Genet 17:1481-9. 2009
    ..Summarizing, the observed associations with resting and submaximal-exercise cardiovascular and metabolic traits in the HERITAGE Family Study are likely due to neither variation in the promoter nor known coding SNPs of SLC4A5...
  67. ncbi request reprint The human obesity gene map: the 2003 update
    Eric E Snyder
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    Obes Res 12:369-439. 2004
    ..Overall, more than 430 genes, markers, and chromosomal regions have been associated or linked with human obesity phenotypes. The electronic version of the map with links to useful sites can be found at http://obesitygene.pbrc.edu...
  68. ncbi request reprint Peroxisome proliferator-activated receptor-delta polymorphisms are associated with physical performance and plasma lipids: the HERITAGE Family Study
    Arto J Hautala
    Pennington Biomedical Research Center, Human Genomics Laboratory, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Am J Physiol Heart Circ Physiol 292:H2498-505. 2007
    ..DNA sequence variation in the PPARdelta locus is a potential modifier of changes in cardiorespiratory fitness and plasma HDL-C in healthy individuals in response to regular exercise...
  69. ncbi request reprint Effects of long-term overfeeding on plasma lipoprotein levels in identical twins
    Margarita Teran-Garcia
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Atherosclerosis 173:277-83. 2004
    ..69, P<0.01). These results strongly suggest that the response of plasma lipoproteins to chronic energy surplus has a significant genetic component as does the detrimental effect of chronic caloric affluence on CHD risk...
  70. ncbi request reprint Effects of long-term negative energy balance with exercise on plasma lipid and lipoprotein levels in identical twins
    Hanna Maaria Lakka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Atherosclerosis 172:127-33. 2004
    ..Furthermore, within-pair resemblance among twin brothers strongly suggests that genetic differences partially account for the variation in the response of lipids and lipoproteins to the negative energy balance protocol...
  71. ncbi request reprint The human gene map for performance and health-related fitness phenotypes: the 2001 update
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 34:1219-33. 2002
    ..Finally, 13 sequence variants in mitochondrial DNA have been shown to influence relevant fitness and performance phenotypes...
  72. ncbi request reprint The human obesity gene map: the 2001 update
    Tuomo Rankinen
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    Obes Res 10:196-243. 2002
    ..Likewise, the number of negative studies, which are only partially reviewed here, is also on the rise...
  73. ncbi request reprint Skeletal muscle characteristics predict body fat gain in response to overfeeding in never-obese young men
    Guang Sun
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Metabolism 51:451-6. 2002
    ..43 to 0.53, and account for 18% to 28% of the variance in the response to overfeeding. The results suggest that an elevated skeletal muscle oxidative capacity plays a protective role in the response to long-term positive energy balance...
  74. ncbi request reprint G protein beta 3 polymorphism and hemodynamic and body composition phenotypes in the HERITAGE Family Study
    Tuomo Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 8:151-7. 2002
    ..The GNB3 genotype may play a minor role in HR and body fatness regulation in blacks and in responsiveness of resting BP to endurance training in black women...
  75. ncbi request reprint Time to move on
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 15:797. 2007
  76. ncbi request reprint Invited commentary: Physical activity, mortality, and genetics
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Epidemiol 166:260-2. 2007
    ....
  77. doi request reprint International conference on physical activity and obesity in children: summary statement and recommendations
    Peter T Katzmarzyk
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA, USA
    Int J Pediatr Obes 3:3-21. 2008
    ..Promising physical activity interventions among children were presented, and important research, policy and practice recommendations to address the issue of physical inactivity and obesity were provided...
  78. pmc Gene-physical activity interactions: overview of human studies
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 16:S47-50. 2008
    ..Progress is likely to come when studies will be designed to truly address gene-exercise or physical activity interaction issues and with sample sizes that will provide adequate statistical power...
  79. pmc Childhood obesity: are genetic differences involved?
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Am J Clin Nutr 89:1494S-1501S. 2009
    ..It is possible that the prevalence of childhood obesity is increasing across generations as a result of positive assortative mating with obese husbands and wives contributing more obese offspring than normal-weight parents...
  80. ncbi request reprint Genetics of food intake and eating behavior phenotypes in humans
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Annu Rev Nutr 26:413-34. 2006
    ..Understanding the relative contribution of global genetic variation and of DNA sequence variants in specific genes is important in the effort to influence dietary habits in a healthier direction...
  81. pmc Ethnic differences in self-reported and measured obesity
    William D Johnson
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 17:571-7. 2009
    ..However, comparisons depend on the true prevalence within ethnicity-gender groups. After controlling for obesity prevalence, disparity in underestimation was greater in EA than in AA men (P < 0.003) but not women...
  82. doi request reprint Gene-environment interactions in the etiology of obesity: defining the fundamentals
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 16:S5-S10. 2008
    ..It was the purpose of the workshop to define the conditions under which gene-behavior interaction effects of relevance to human obesity could be reliably identified...
  83. doi request reprint Sitting time and mortality from all causes, cardiovascular disease, and cancer
    Peter T Katzmarzyk
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 41:998-1005. 2009
    ..We prospectively examined sitting time and mortality in a representative sample of 17,013 Canadians 18-90 yr of age...
  84. ncbi request reprint A polymorphism in the human agouti-related protein is associated with late-onset obesity
    George Argyropoulos
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 87:4198-202. 2002
    ..The c.199G-->A polymorphism in hAGRP could, therefore, play a role in the development of human obesity in an age-dependent fashion...