C Bouchard

Summary

Affiliation: Pennington Biomedical Research Center
Country: USA

Publications

  1. ncbi request reprint Time to move on
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 15:797. 2007
  2. pmc Childhood obesity: are genetic differences involved?
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Am J Clin Nutr 89:1494S-1501S. 2009
  3. ncbi request reprint Genomic scan for maximal oxygen uptake and its response to training in the HERITAGE Family Study
    C Bouchard
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    J Appl Physiol 88:551-9. 2000
  4. doi request reprint How much progress have we made over the last few decades?
    C Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 32:S2-7. 2008
  5. ncbi request reprint Individual differences in response to regular physical activity
    C Bouchard
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 33:S446-51; discussion S452-3. 2001
  6. doi request reprint Gene-environment interactions in the etiology of obesity: defining the fundamentals
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 16:S5-S10. 2008
  7. ncbi request reprint The biological predisposition to obesity: beyond the thrifty genotype scenario
    C Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Int J Obes (Lond) 31:1337-9. 2007
  8. ncbi request reprint Lipoprotein lipase polymorphisms and responses to long-term overfeeding
    O Ukkola
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808 4124, USA
    J Intern Med 251:429-36. 2002
  9. ncbi request reprint Interactions among the beta2- and beta3- adrenergic receptor genes and total body fat and abdominal fat level in the HERITAGE Family Study
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes Relat Metab Disord 27:389-93. 2003
  10. ncbi request reprint Is adiposity at normal body weight relevant for cardiovascular disease risk?
    S Tanaka
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Int J Obes Relat Metab Disord 26:176-83. 2002

Research Grants

  1. HERITAGE--GENETICS, RESPONSE TO EXERCISE, RISK FACTORS
    Claude Bouchard; Fiscal Year: 2000
  2. HERITAGE-GENETICS, RESPONSE TO EXERCISE, RISK FACTORS-3
    Claude Bouchard; Fiscal Year: 2003
  3. HERITAGE FAMILY STUDY, PHASE 4
    Claude Bouchard; Fiscal Year: 2007

Collaborators

Detail Information

Publications142 found, 100 shown here

  1. ncbi request reprint Time to move on
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 15:797. 2007
  2. pmc Childhood obesity: are genetic differences involved?
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Am J Clin Nutr 89:1494S-1501S. 2009
    ..It is possible that the prevalence of childhood obesity is increasing across generations as a result of positive assortative mating with obese husbands and wives contributing more obese offspring than normal-weight parents...
  3. ncbi request reprint Genomic scan for maximal oxygen uptake and its response to training in the HERITAGE Family Study
    C Bouchard
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    J Appl Physiol 88:551-9. 2000
    ..These chromosomal regions harbor many genes that may qualify as candidate genes for these quantitative traits. They should be investigated in this and other cohorts...
  4. doi request reprint How much progress have we made over the last few decades?
    C Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 32:S2-7. 2008
    ....
  5. ncbi request reprint Individual differences in response to regular physical activity
    C Bouchard
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 33:S446-51; discussion S452-3. 2001
    ..The purpose of this review was to address the question of interindividual variation in responsiveness to regular exercise training and to define the contributions of age, sex, race, and pretraining phenotype level to this variability...
  6. doi request reprint Gene-environment interactions in the etiology of obesity: defining the fundamentals
    Claude Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 16:S5-S10. 2008
    ..It was the purpose of the workshop to define the conditions under which gene-behavior interaction effects of relevance to human obesity could be reliably identified...
  7. ncbi request reprint The biological predisposition to obesity: beyond the thrifty genotype scenario
    C Bouchard
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Int J Obes (Lond) 31:1337-9. 2007
  8. ncbi request reprint Lipoprotein lipase polymorphisms and responses to long-term overfeeding
    O Ukkola
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808 4124, USA
    J Intern Med 251:429-36. 2002
    ..The role of the lipoprotein lipase (LPL) gene Hind III, S447X, Bam HI and Pvu II polymorphisms on body composition and lipid and lipoprotein changes in response to long-term overfeeding was studied...
  9. ncbi request reprint Interactions among the beta2- and beta3- adrenergic receptor genes and total body fat and abdominal fat level in the HERITAGE Family Study
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes Relat Metab Disord 27:389-93. 2003
    ....
  10. ncbi request reprint Is adiposity at normal body weight relevant for cardiovascular disease risk?
    S Tanaka
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Int J Obes Relat Metab Disord 26:176-83. 2002
    ..To examine the relation between adiposity and risk factors for cardiovascular disease (CVD) in normal weight (NW) individuals...
  11. ncbi request reprint Beta-2 adrenergic receptor variants are associated with subcutaneous fat accumulation in response to long-term overfeeding
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808-4124, USA
    Int J Obes Relat Metab Disord 25:1604-8. 2001
    ..Genetic variation at the ADRB2 locus could thus be one of the factors responsible for the large inter-individual differences observed in the response to long-term alterations in energy balance and should be further investigated...
  12. ncbi request reprint Interactions among the glucocorticoid receptor, lipoprotein lipase and adrenergic receptor genes and abdominal fat in the Québec Family Study
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Int J Obes Relat Metab Disord 25:1332-9. 2001
    ....
  13. ncbi request reprint Variations in the four and a half LIM domains 1 gene (FHL1) are associated with fasting insulin and insulin sensitivity responses to regular exercise
    M Teran-Garcia
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Diabetologia 50:1858-66. 2007
    ....
  14. ncbi request reprint Age, body mass index, race and other determinants of steroid hormone variability: the HERITAGE Family Study
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Eur J Endocrinol 145:1-9. 2001
    ..Sample sizes varied from 676 to 750 per hormone. Incremental regression methods were used to examine the contributions of the variables to steroid hormone variability...
  15. ncbi request reprint Genomic scan for exercise blood pressure in the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) Family Study
    T Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808 4124, USA
    Hypertension 38:30-7. 2001
    ..All the detected chromosomal regions include several potential candidate genes and therefore warrant further studies in the Health, Risk Factors, Exercise Training and Genetics (HERITAGE) cohort and other studies...
  16. ncbi request reprint The agouti-related protein and body fatness in humans
    G Argyropoulos
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808, USA
    Int J Obes Relat Metab Disord 27:276-80. 2003
    ....
  17. ncbi request reprint NOS3 Glu298Asp genotype and blood pressure response to endurance training: the HERITAGE family study
    T Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA, USA
    Hypertension 36:885-9. 2000
    ....
  18. ncbi request reprint Polymorphisms in the leptin and leptin receptor genes in relation to resting metabolic rate and respiratory quotient in the Québec Family Study
    R J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 30:183-90. 2006
    ..Leptin (LEP) is an endocrine hormone that participates in many metabolic pathways, including those associated with the central regulation of energy homeostasis...
  19. ncbi request reprint Genome-wide linkage scan for submaximal exercise heart rate in the HERITAGE family study
    Nadine Spielmann
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Am J Physiol Heart Circ Physiol 293:H3366-71. 2007
    ..The most promising regions for fine mapping in the HERITAGE Family Study were found on 2q33 for HR50 training response in whites, on 10q25-26 for baseline HR60 in blacks, and on 18q21-22 for both baseline HR50 and DeltaHR60 in whites...
  20. ncbi request reprint Associations between cardiorespiratory responses to exercise and the C34T AMPD1 gene polymorphism in the HERITAGE Family Study
    J Rico-Sanz
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808, USA
    Physiol Genomics 14:161-6. 2003
    ..Furthermore, the training response of ventilatory phenotypes during maximal exercise is more limited in TT...
  21. ncbi request reprint Genetic variation at the uncoupling protein 1, 2 and 3 loci and the response to long-term overfeeding
    O Ukkola
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808-4124, USA
    Eur J Clin Nutr 55:1008-15. 2001
    ..A longer period of exposure to chronic positive energy balance conditions may be necessary before sequence variation in UCP2 and UCP3 makes an impact on thyroid metabolism to influence body mass and composition changes...
  22. ncbi request reprint Genetic variation at the lipoprotein lipase locus and plasma lipoprotein and insulin levels in the Québec Family Study
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Atherosclerosis 158:199-206. 2001
    ..In addition, genetic variation at the LPL locus may, by an unknown mechanism, influence insulin metabolism but not body fat variability...
  23. ncbi request reprint Protein tyrosine phosphatase 1B variant associated with fat distribution and insulin metabolism
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Obes Res 13:829-34. 2005
    ..Gene-gene interactions between the PTPN1 and leptin receptor genes contributed to the phenotypic variability of insulin sensitivity. The PTPN1 Pro387Leu variant was associated with lower glucose tolerance...
  24. ncbi request reprint The Na(+)-K(+)-ATPase alpha2 gene and trainability of cardiorespiratory endurance: the HERITAGE family study
    T Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    J Appl Physiol 88:346-51. 2000
    ..017). These data suggest that genetic variation at the Na(+)-K(+)-ATPase alpha2 locus influences the trainability of VO(2 max) in sedentary Caucasian subjects...
  25. ncbi request reprint A quantitative trait locus on 7q31 for the changes in plasma insulin in response to exercise training: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Diabetes 52:1583-7. 2003
    ..The present findings may be important in identifying individuals at increased risk of developing type 2 diabetes and who are most likely to benefit from a physically active lifestyle...
  26. ncbi request reprint Quantitative trait locus on chromosome 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Physiol Genomics 27:103-7. 2006
    ..The present findings may be useful in the ongoing effort to search for genes contributing to inflammation and to identify individuals at an increased risk of chronic inflammatory diseases...
  27. ncbi request reprint Na+-K+-ATPase alpha 2-gene and skeletal muscle characteristics in response to long-term overfeeding
    Olavi Ukkola
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    J Appl Physiol 94:1870-4. 2003
    ..3-kb(-) subjects with overfeeding, suggesting more unfavorable metabolic changes compared with the 3.3-kb(+) subjects...
  28. ncbi request reprint The human gene map for performance and health-related fitness phenotypes
    T Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808-4124, USA
    Med Sci Sports Exerc 33:855-67. 2001
    ..A yearly update of this human gene map will be published...
  29. ncbi request reprint Quantitative trait loci for maximal exercise capacity phenotypes and their responses to training in the HERITAGE Family Study
    J Rico-Sanz
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808, USA
    Physiol Genomics 16:256-60. 2004
    ..These chromosomal regions harbor several candidate genes that deserve further investigation...
  30. ncbi request reprint Melanocortin-4 receptor gene and physical activity in the Québec Family Study
    R J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Int J Obes (Lond) 29:420-8. 2005
    ..Physical inactivity is a risk factor for numerous chronic diseases. Low compliance with interventions to increase activity suggests involvement of biological systems...
  31. ncbi request reprint Role of ghrelin polymorphisms in obesity based on three different studies
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    Obes Res 10:782-91. 2002
    ..Associations between preproghrelin DNA variants and obesity-related phenotypes were studied in 3004 subjects from the Québec Family Study (QFS), the HERITAGE Family Study (HERITAGE), and the Swedish Obese Subjects (SOS) Study...
  32. ncbi request reprint A quantitative trait locus for body fat on chromosome 1q43 in French Canadians: linkage and association studies
    Brahim Aissani
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 14:1605-15. 2006
    ..To explore a quantitative trait locus (QTL) on human chromosome 1q affecting BMI, adiposity, and fat-free mass phenotypes in the Quebec Family Study cohort...
  33. ncbi request reprint Role of candidate genes in the responses to long-term overfeeding: review of findings
    O Ukkola
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808 4124, USA
    Obes Rev 5:3-12. 2004
    ..Further research with larger sample sizes should make it possible to identify the specific contributions of DNA sequence variations at multiple candidate gene loci in the complex response to chronic positive energy balance...
  34. ncbi request reprint A 12-year follow-up study of treated obese children in Japan
    K Togashi
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Int J Obes Relat Metab Disord 26:770-7. 2002
    ....
  35. ncbi request reprint Interactions among the glucocorticoid receptor, lipoprotein lipase, and adrenergic receptor genes and plasma insulin and lipid levels in the Quebec Family Study
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Metabolism 50:246-52. 2001
    ..The LPL locus appears to determine the pattern of interactions with ADR and GRL loci. These results suggest that gene-gene interaction effects could play a role in the etiology of risk factors for common chronic diseases...
  36. doi request reprint Associations of markers in 11 obesity candidate genes with maximal weight loss and weight regain in the SOS bariatric surgery cases
    M A Sarzynski
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Int J Obes (Lond) 35:676-83. 2011
    ..To test whether DNA sequence variation in 11 obesity genes is associated with maximum weight loss and weight regain over 6 years of follow-up in bariatric surgery patients of the Swedish obese subjects (SOS) intervention study...
  37. ncbi request reprint Leptin receptor Gln223Arg variant is associated with a cluster of metabolic abnormalities in response to long-term overfeeding
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    J Intern Med 248:435-9. 2000
    ..The role of the leptin receptor (LEPR) gene Gln223Arg polymorphism on the metabolic and body composition changes in response to overfeeding was studied...
  38. ncbi request reprint Adiponectin and adiponectin receptor gene variants in relation to resting metabolic rate, respiratory quotient, and adiposity-related phenotypes in the Quebec Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 85:26-34. 2007
    ..Despite adiponectin's presumed role in fatty acid oxidation and energy homeostasis, little is known about the effect of gene variants on substrate oxidation, energy expenditure, and adiposity-related phenotypes...
  39. ncbi request reprint Effect of regular exercise on homocysteine concentrations: the HERITAGE Family Study
    Tomohiro Okura
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Eur J Appl Physiol 98:394-401. 2006
    ..Men exhibit racial differences for tHcy responses to exercise training. Regular aerobic exercise has favorable effects on individuals with hyperhomocysteinemia, but tHcy slightly increased in individuals within the normal range...
  40. ncbi request reprint Adiponectin polymorphisms, adiposity and insulin metabolism: HERITAGE family study and Oulu diabetic study
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge 70808 4124, USA
    Ann Med 37:141-50. 2005
    ..Adiponectin is an adipocytokine with lowered blood levels in obesity and Type 2 diabetes mellitus. We sought to define the specific effects of different alleles of the gene encoding adiponectin...
  41. ncbi request reprint Glucocorticoid receptor Bcl I variant is associated with an increased atherogenic profile in response to long-term overfeeding
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, LA 70808-4124, USA
    Atherosclerosis 157:221-4. 2001
    ..5/2.3 kb subjects in response to overfeeding. These data suggest that overfeeding induces an atherogenic profile in subjects who are homozygotes for the 2.3 kb allele...
  42. ncbi request reprint Plasma ghrelin concentration and energy balance: overfeeding and negative energy balance studies in twins
    E Ravussin
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    J Clin Endocrinol Metab 86:4547-51. 2001
    ..However, studies in free-living individuals are needed to clarify this question...
  43. ncbi request reprint Mutations in the adiponectin gene in lean and obese subjects from the Swedish obese subjects cohort
    Olavi Ukkola
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808 4124, USA
    Metabolism 52:881-4. 2003
    ..In conclusion, adiponectin DNA sequence variations might play a role in the complications of morbid obesity and should be further investigated...
  44. ncbi request reprint A dopamine D2 receptor gene polymorphism and physical activity in two family studies
    Riitta L Simonen
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Physiol Behav 78:751-7. 2003
    ..09, P=.023) and 27-33% lower work index (F=6.23, P=.004) than the CC homozygotes and CT heterozygotes. The results suggest that DNA sequence variation in the DRD2 gene is associated with physical activity levels among White women...
  45. ncbi request reprint A genome-wide linkage scan for dietary energy and nutrient intakes: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family Study
    Agron Collaku
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Am J Clin Nutr 79:881-6. 2004
    ..A poor diet is a risk factor for chronic diseases such as obesity, cardiovascular disease, hypertension, and some cancers. Twin and family studies suggest that genetic factors potentially influence energy and nutrient intakes...
  46. ncbi request reprint Resting metabolic rate and respiratory quotient: results from a genome-wide scan in the Quebec Family Study
    Peter Jacobson
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 84:1527-33. 2006
    ....
  47. ncbi request reprint The human gene map for performance and health-related fitness phenotypes: the 2005 update
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 38:1863-88. 2006
    ....
  48. ncbi request reprint Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: the HERITAGE Family Study
    Margarita Teran-Garcia
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 54:2251-5. 2005
    ..The benefits from an exercise program on Si are likely to be substantial in the general population given the high frequency of the LIPC -514C allele, particularly in whites...
  49. ncbi request reprint Clustering of metabolic abnormalities in obese individuals: the role of genetic factors
    O Ukkola
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge 70808-4124, USA
    Ann Med 33:79-90. 2001
    ..The reduction of excess body fat, the most common clinical feature among the cluster of metabolic abnormalities, should be the focus of the prevention and treatment of the metabolic syndrome...
  50. pmc Tsp509I polymorphism in exon 2 of the glucocorticoid receptor gene in relation to obesity and cortisol secretion: cohort study
    R Rosmond
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    BMJ 322:652-3. 2001
  51. pmc Functional dimorphism of two hAgRP promoter SNPs in linkage disequilibrium
    F Bai
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Med Genet 41:350-3. 2004
    ..The region encompassing the -38C>T SNP had approximately 1000-fold higher activity than the region encompassing the -3019G>A SNP, potentially determining the net functional effect between these two SNPs...
  52. pmc SNP-by-fitness and SNP-by-BMI interactions from seven candidate genes and incident hypertension after 20 years of follow-up: the CARDIA Fitness Study
    M A Sarzynski
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    J Hum Hypertens 25:509-18. 2011
    ..We found that SNPs in these candidate genes did not modify the association between baseline fitness or BMI and risk of hypertension in CARDIA participants...
  53. doi request reprint Genes, exercise, growth, and the sedentary, obese child
    Margarita Teran-Garcia
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    J Appl Physiol 105:988-1001. 2008
    ....
  54. ncbi request reprint Calcium intake is associated with adiposity in Black and White men and White women of the HERITAGE Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA, USA
    J Nutr 134:1772-8. 2004
    ..04). No significant associations were found in Black women. Low Ca(2+) intake may be associated with higher adiposity, particularly in men and White women...
  55. ncbi request reprint BMI, fat mass, abdominal adiposity and visceral fat: where is the 'beef'?
    C Bouchard
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Int J Obes (Lond) 31:1552-3. 2007
  56. ncbi request reprint Mutations in the preproghrelin/ghrelin gene associated with obesity in humans
    O Ukkola
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    J Clin Endocrinol Metab 86:3996-9. 2001
    ..In conclusion, the data provide evidence that a low frequency sequence variation in the ghrelin gene could play a role in the etiology of obesity...
  57. ncbi request reprint Genetics and blood pressure response to exercise, and its interactions with adiposity
    T Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808 4124, USA
    Prev Cardiol 5:138-44. 2002
    ..The current knowledge regarding the role of genetic factors in the modification of blood pressure responses to endurance training will be summarized and discussed...
  58. ncbi request reprint Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 82:1097-101. 2005
    ..Exogenous administration of AGRP in rodents predisposes to high fat and high sugar intakes...
  59. ncbi request reprint MC4R marker associated with stature in children and young adults: a longitudinal study
    Nicola Santoro
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808 4124, USA
    J Pediatr Endocrinol Metab 18:859-63. 2005
    ..These results suggest that DNA sequence variation in the MC4R locus may contribute to the gain in body height from childhood to adulthood...
  60. ncbi request reprint CETP genotypes and HDL-cholesterol phenotypes in the HERITAGE Family Study
    Nadine Spielmann
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 31:25-31. 2007
    ..The CETP and APOE genotypes account for up to 9% of the variance in HDL-c phenotypes in the HERITAGE Family Study...
  61. ncbi request reprint Association of lipin 1 gene polymorphisms with measures of energy and glucose metabolism
    Ruth J F Loos
    Pennington Biomedical Research Center, Human Genomics Laboratory, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Obesity (Silver Spring) 15:2723-32. 2007
    ..Lpin1 was identified as the mutated gene in the fatty liver dystrophy mouse, which exhibits lipin deficiency and features of human lipodystrophy...
  62. ncbi request reprint Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish Obese Subjects, the HERITAGE Family Study, and a Memphis cohort
    Peter Jacobson
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 87:4442-6. 2002
    ..In conclusion, our results do not support the prevailing notion that sequence variation in the melanocortin 4 receptor gene is a frequent cause of human obesity...
  63. pmc KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise
    George Argyropoulos
    Energy Balance Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Physiol Genomics 36:79-88. 2009
    ..Furthermore, training-induced changes in submaximal exercise stroke volume may be due to mitochondrial function and variation in KIF5B expression as determined by functional SNPs in its promoter...
  64. pmc Ethnic differences in subcutaneous adiposity and waist girth in children and adolescents
    Susan B Sisson
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 17:2075-81. 2009
    ..Differences in adiposity between ethnic groups should be considered in disease risk assessment and stratification as they are observed even for a given BMI level...
  65. ncbi request reprint Genome-wide linkage scan for physical activity levels in the Quebec Family study
    Riitta L Simonen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 35:1355-9. 2003
    ..Four physical activity level phenotypes were used...
  66. ncbi request reprint Familial resemblance for muscle phenotypes in the HERITAGE Family Study
    Jesus Rico-Sanz
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 35:1360-6. 2003
    ..We hypothesized that skeletal muscle histological and biochemical phenotypes aggregate within families...
  67. ncbi request reprint Genome-wide linkage scan for the metabolic syndrome in the HERITAGE Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 88:5935-43. 2003
    ..Some of these chromosomal regions harbor promising potential candidate genes...
  68. doi request reprint Measured maximal heart rates compared to commonly used age-based prediction equations in the heritage family study
    M A Sarzynski
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, 70808
    Am J Hum Biol 25:695-701. 2013
    ..The purpose of this study was to examine how well two commonly used age-based prediction equations for maximal heart rate (HRmax ) estimate the actual HRmax measured in Black and White adults from the HERITAGE Family Study...
  69. ncbi request reprint Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA, USA
    Eur Heart J 26:2018-25. 2005
    ..To study the effect of exercise training on plasma C-reactive protein, a marker of inflammation...
  70. pmc Effects of cholesterol ester transfer protein (CETP) gene on adiposity in response to long-term overfeeding
    Margarita Teran-Garcia
    Pennington Biomedical Research Center, Louisiana State University System, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Atherosclerosis 196:455-60. 2008
    ....
  71. ncbi request reprint Effects of long-term overfeeding on plasma lipoprotein levels in identical twins
    Margarita Teran-Garcia
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Atherosclerosis 173:277-83. 2004
    ..69, P<0.01). These results strongly suggest that the response of plasma lipoproteins to chronic energy surplus has a significant genetic component as does the detrimental effect of chronic caloric affluence on CHD risk...
  72. ncbi request reprint The human gene map for performance and health-related fitness phenotypes: the 2001 update
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 34:1219-33. 2002
    ..Finally, 13 sequence variants in mitochondrial DNA have been shown to influence relevant fitness and performance phenotypes...
  73. ncbi request reprint Effects of long-term negative energy balance with exercise on plasma lipid and lipoprotein levels in identical twins
    Hanna Maaria Lakka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Atherosclerosis 172:127-33. 2004
    ..Furthermore, within-pair resemblance among twin brothers strongly suggests that genetic differences partially account for the variation in the response of lipids and lipoproteins to the negative energy balance protocol...
  74. pmc Profiles of sedentary behavior in children and adolescents: the US National Health and Nutrition Examination Survey, 2001-2006
    Susan B Sisson
    Pennington Biomedical Research Center, Baton Rouge, LA, USA
    Int J Pediatr Obes 4:353-9. 2009
    ..To describe the prevalence of time spent in sedentary behaviors (e.g., TV/video and computer use) among youth in the US...
  75. ncbi request reprint Insulin-like growth factor 2 (IGF2 ) and IGF-binding protein 1 (IGFBP1) gene variants are associated with overfeeding-induced metabolic changes
    O Ukkola
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Diabetologia 44:2231-6. 2001
    ....
  76. ncbi request reprint How obesity develops: insights from the new biology
    D York
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Endocrine 13:143-54. 2000
    ..This information, combined with knowledge of the chromosomal location of genes identified from animal studies, has made it possible to identify specific mutations that contribute to the development of obesity in humans...
  77. ncbi request reprint A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic-pituitary-adrenal axis
    R Rosmond
    Department of Heart and Lung Diseases, Goteborg University, Sweden
    Obes Res 8:211-8. 2000
    ....
  78. ncbi request reprint Relationship between lipid peroxidation and plasma fibrinogen in middle-aged men
    T Rankinen
    Kuopio Research Institute of Exercise Medicine and Department of Physiology, University of Kuopio, Finland
    Thromb Res 99:453-9. 2000
    ..6%, 9.7%, 5.5%, and 2.3%, respectively. WHR, serum triglycerides, and age did not enter the model. These data suggest that increased lipid peroxidation is associated with elevated plasma fibrinogen level in middle-aged men...
  79. ncbi request reprint Invited commentary: Physical activity, mortality, and genetics
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Epidemiol 166:260-2. 2007
    ....
  80. ncbi request reprint Skeletal muscle characteristics predict body fat gain in response to overfeeding in never-obese young men
    Guang Sun
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, LA 70808, USA
    Metabolism 51:451-6. 2002
    ..43 to 0.53, and account for 18% to 28% of the variance in the response to overfeeding. The results suggest that an elevated skeletal muscle oxidative capacity plays a protective role in the response to long-term positive energy balance...
  81. pmc The pediatric obesity epidemic continues unabated in Bogalusa, Louisiana
    Stephanie Broyles
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808, USA
    Pediatrics 125:900-5. 2010
    ..To examine 35-year trends in the prevalence of overweight and obesity among children and adolescents from Bogalusa, Louisiana...
  82. pmc Ethnic differences in self-reported and measured obesity
    William D Johnson
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 17:571-7. 2009
    ..However, comparisons depend on the true prevalence within ethnicity-gender groups. After controlling for obesity prevalence, disparity in underestimation was greater in EA than in AA men (P < 0.003) but not women...
  83. ncbi request reprint Genetics of food intake and eating behavior phenotypes in humans
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808 4124, USA
    Annu Rev Nutr 26:413-34. 2006
    ..Understanding the relative contribution of global genetic variation and of DNA sequence variants in specific genes is important in the effort to influence dietary habits in a healthier direction...
  84. ncbi request reprint The human obesity gene map: the 2001 update
    Tuomo Rankinen
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    Obes Res 10:196-243. 2002
    ..Likewise, the number of negative studies, which are only partially reviewed here, is also on the rise...
  85. ncbi request reprint Cardiorespiratory fitness, BMI, and risk of hypertension: the HYPGENE study
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 39:1687-92. 2007
    ..Genetic factors contribute significantly to the interindividual differences in endurance training-induced changes in BP. However, similar data on the genotype-by-fitness interactions on the risk of hypertension are scarce...
  86. ncbi request reprint Effect of endothelin 1 genotype on blood pressure is dependent on physical activity or fitness levels
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Hypertension 50:1120-5. 2007
    ..Our study provides an illustrative example of how physical activity and fitness level modifies the associations between a candidate gene and outcome phenotype...
  87. pmc Predicting adult body mass index-specific metabolic risk from childhood
    Sarah M Camhi
    Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    Metab Syndr Relat Disord 8:165-72. 2010
    ..Metabolic risk varies within adult body mass index (BMI) categories; however, the development of BMI-specific metabolic risk from childhood is unknown...
  88. ncbi request reprint Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study
    Timo A Lakka
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808 4124, USA
    Diabetes 53:1603-8. 2004
    ..Similar interaction was observed in blacks (P = 0.046). Variations in the LEP and LEPR genes are associated with the magnitude of the effects of regular exercise on glucose homeostasis in nondiabetic individuals...
  89. doi request reprint Racial differences in abdominal depot-specific adiposity in white and African American adults
    Peter T Katzmarzyk
    Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808 4124, USA
    Am J Clin Nutr 91:7-15. 2010
    ..There is increasing interest in understanding racial differences in adiposity in specific body depots as a way to explain differential health risks associated with obesity...
  90. pmc FTO genotype is associated with exercise training-induced changes in body composition
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 18:322-6. 2010
    ..Resistance to exercise-induced reduction in total adiposity may represent one mechanism by which the FTO A allele promotes overweight and obesity...
  91. doi request reprint Advances in exercise, fitness, and performance genomics
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 42:835-46. 2010
    ..We conclude from this first installment that exercise scientists need to prioritize high-quality research designs and that replication studies with large sample sizes are urgently needed...
  92. doi request reprint Prevalence of risk factors for metabolic syndrome in adolescents: National Health and Nutrition Examination Survey (NHANES), 2001-2006
    William D Johnson
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808, USA
    Arch Pediatr Adolesc Med 163:371-7. 2009
    ..To investigate the prevalence of distinct combinations of components of the metabolic syndrome among adolescents...
  93. doi request reprint Sitting time and mortality from all causes, cardiovascular disease, and cancer
    Peter T Katzmarzyk
    Pennington Biomedical Research Center, Baton Rouge, LA 70808 4124, USA
    Med Sci Sports Exerc 41:998-1005. 2009
    ..We prospectively examined sitting time and mortality in a representative sample of 17,013 Canadians 18-90 yr of age...
  94. pmc Gene-physical activity interactions: overview of human studies
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Obesity (Silver Spring) 16:S47-50. 2008
    ..Progress is likely to come when studies will be designed to truly address gene-exercise or physical activity interaction issues and with sample sizes that will provide adequate statistical power...
  95. pmc Volume of exercise and fitness nonresponse in sedentary, postmenopausal women
    Susan B Sisson
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 41:539-45. 2009
    ..There is a wide individual heterogeneity in the maximal aerobic fitness (V x O 2max) response to exercise training...
  96. pmc CREB1 is a strong genetic predictor of the variation in exercise heart rate response to regular exercise: the HERITAGE Family Study
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, LA 70808 4124, USA
    Circ Cardiovasc Genet 3:294-9. 2010
    ..A genome-wide linkage scan identified a quantitative trait locus for exercise training-induced changes in submaximal exercise (50 W) heart rate (DeltaHR50) on chromosome 2q33.3-q34 in the HERITAGE Family Study (n=472)...
  97. ncbi request reprint G protein beta 3 polymorphism and hemodynamic and body composition phenotypes in the HERITAGE Family Study
    Tuomo Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 8:151-7. 2002
    ..The GNB3 genotype may play a minor role in HR and body fatness regulation in blacks and in responsiveness of resting BP to endurance training in black women...
  98. ncbi request reprint The TNF-alpha G-308A polymorphism is associated with C-reactive protein levels: the HERITAGE Family Study
    Hanna Maaria Lakka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808 4124, USA
    Vascul Pharmacol 44:377-83. 2006
    ..Pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), stimulate the release of C-reactive protein (CRP). We investigated the association between the TNF-alpha G-308A polymorphism and plasma CRP levels...
  99. ncbi request reprint A polymorphism in the human agouti-related protein is associated with late-onset obesity
    George Argyropoulos
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 87:4198-202. 2002
    ..The c.199G-->A polymorphism in hAGRP could, therefore, play a role in the development of human obesity in an age-dependent fashion...
  100. ncbi request reprint The human obesity gene map: the 2003 update
    Eric E Snyder
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808 4124, USA
    Obes Res 12:369-439. 2004
    ..Overall, more than 430 genes, markers, and chromosomal regions have been associated or linked with human obesity phenotypes. The electronic version of the map with links to useful sites can be found at http://obesitygene.pbrc.edu...
  101. ncbi request reprint Titin is a candidate gene for stroke volume response to endurance training: the HERITAGE Family Study
    Tuomo Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 15:27-33. 2003
    ..Since TTN is the largest gene in the human genome, the challenge is to identify the DNA sequence variants contributing to the interindividual differences in cardiac adaptation to endurance training...

Research Grants8

  1. HERITAGE--GENETICS, RESPONSE TO EXERCISE, RISK FACTORS
    Claude Bouchard; Fiscal Year: 2000
    ..This application is from the Laval University Clinical Center which also serves as the HERITAGE consortium Coordinating Center. ..
  2. HERITAGE-GENETICS, RESPONSE TO EXERCISE, RISK FACTORS-3
    Claude Bouchard; Fiscal Year: 2003
    ..This application is submitted from the Pennington Biomedical Research Center which also serves as the HERITAGE Consortium Coordinating Center. ..
  3. HERITAGE FAMILY STUDY, PHASE 4
    Claude Bouchard; Fiscal Year: 2007
    ....